Citations to this article

Autologous mixed lymphocyte reaction in the peripheral blood and pleural effusions of cancer patients.
A Uchida, M Micksche
A Uchida, M Micksche
Published July 1, 1982
Citation Information: J Clin Invest. 1982;70(1):98-104. https://doi.org/10.1172/JCI110608.
View: Text | PDF
Research Article

Autologous mixed lymphocyte reaction in the peripheral blood and pleural effusions of cancer patients.

Abstract

T cells proliferate in response to autologous non-T cells in the autologous mixed lymphocyte reaction (AMLR). AMLR was impaired in the peripheral blood of patients with advanced lung cancer (4,159 +/- 3,878 delta cpm vs. 11,221 +/- 4,156 delta cpm for normal donors) but normal or even higher in their malignant pleural effusions (13,257 +/- 7,075 delta cpm vs. 10, 870 +/- 5,013 delta cpm for nonmalignant control effusions). Blood T cells also failed to respond to autologous effusion non-T cells, while effusion T cells strongly responded to autologous erythrocytes blood non-T cells. The presence of blood T cells did not inhibit effusion AMLR of the same patients. A subset of T cells that form rosettes with autologous erythrocytes if found to proliferate in AMLR. The number of autorosette-forming cells was lower in blood T cells of cancer patients than in blood T cells of normal donors and in effusion T cells of the patients. After enrichment of autorosette-forming cells, there was no difference in AMLR of normal blood and cancer blood and effusions. These results indicate that the loss of AMLR in the blood of cancer patients is due to a reduction of number of autoreactive T cells and not to a defect of autologous stimulator non-T cells.

Authors

A Uchida, M Micksche

×

Total citations by year

Year: 1997 1993 1992 1991 1990 1988 1987 1985 1984 1983 Total
Citations: 1 1 3 1 1 2 2 2 2 1 16
Citation information

Citations to this article (16)

Title and authors Publication Year
Granulocyte-macrophage colony-stimulating factor improves immunological parameters in patients with refractory solid tumours receiving second-line chemotherapy: Correlation with clinical responses
C Baxevanis 		European Journal of Cancer 1997
Elevated prostaglandin E2 production by monocytes is responsible for the depressed levels of natural killer and lymphokine-activated killer cell function in patients with breast cancer
CN Baxevanis, GJ Reclos, AD Gritzapis, GV Dedousis, I Missitzis, M Papamichail 		Cancer 1993
Defective autologous mixed lymphocyte reaction (AMLR) and killer activity generated in the AMLR in cancer patients
M Iwahashi, H Tanimura, H Yamaue, T Tsunoda, M Tani, M Tamai, K Noguchi, T Hotta 		International Journal of Cancer 1992
Does the Selenium (SE) Level and Se-Dependent Enzyme Activity in Blood Plasma Correlate with Human Lymphocyte Subpopulations and Function?
Z Baj, K Zeman, E Majewska, W Wasowicz, M Sklodowska, J Gromadzinska, H Tchórzewski 		International journal of immunopathology and pharmacology 1992
In vitro generation of activated natural killer cells and cytotoxic macrophages with lentinan
M Tani, H Tanimura, H Yamaue, M Iwahashi, T Tsunoda, M Tamai, K Noguchi, K Arii 		European Journal of Clinical Pharmacology 1992
Suppression by Human Placental Protein 14 of Natural Killer Cell Activity
N Okamoto, A Uchida, K Takakura, Y Kariya, H Kanzaki, L Riittinen, R Koistinen, M Seppälä, T Mori 		American Journal of Reproductive Immunology 1991
Impairment of autologous mixed lymphocyte reaction in the spleen and peripheral blood lymphocytes of patients with idiopathic portal hypertension
H Yamaue, H Tanimura, M Iwahashi, T Tsunoda, M Tani, M Tamai, M Inoue 		Gastroenterologia Japonica 1990
Autologous mixed lymphocyte-tumor reaction and autologous mixed lymphocyte reaction. II. Generation of specific and non-specific killer T cells capable of lysing autologous tumor
A Uchida, M Moore, E Klein 		International Journal of Cancer 1988
Autologous Immune Response of Tonsillar Lymphocytes
T Ikawa, T Maehara, M Eura, Y Kitao, T Ishikawa 		Acta Oto-laryngologica 1988
Autologous mixed lymphocyte-tumor reaction and autologous mixed lymphocyte reaction. I. Proliferation of two distinct T-cell subsets
A Uchida, M Moore, E Klein 		International Journal of Cancer 1987
Characterization of cells from invaded lymph nodes in patients with solid tumors. Lymphokine requirement for tumor-specific lymphoproliferative response
F Cozzolino, M Torcia, AM Carossino, R Giordani, C Selli, G Talini, E Reali, A Novelli, V Pistoia, M Ferrarini 		Journal of Experimental Medicine 1987
Impaired killer cell generation in the autologous mixed leukocyte reaction by rheumatoid arthritis lymphocytes
M Goto, NJ Zvaifler 		Arthritis & Rheumatism 1985
Lysis of fresh human tumour cells by autologous tumour-associated lymphocytes: Two distinct types of autologous tumour killer cells induced by co-culture with autologous tumour
A Uchida, M Moore 		Cancer Immunology, Immunotherapy 1985
Monoclonal Antibody Analysis of Responder and Stimulator Cells in the Human Autologous Mixed Lymphocyte Reaction
A Nikaein, G Stelzer, RJ Duquesnoy, JH Wallace 		Immunobiology 1984
Role of Autorosette Forming Cells in Antibody Synthesis in vitro: Suppressive Activity of ARFC in Humoral Immune Response
N Khansari, M Petrini, F Ambrogii, P Goldschmidt-Clermont, HH Fudenberg 		Immunobiology 1984
Lysis of fresh human tumor cells by autologous large granular lymphocytes from peripheral blood and pleural effusions
A Uchida, M Micksche 		International Journal of Cancer 1983

Advertisement