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Citations to this article

In vitro parasite-monocyte interactions in human leishmaniasis. Evidence for an active role of the parasite in attachment.
D J Wyler
D J Wyler
Published July 1, 1982
Citation Information: J Clin Invest. 1982;70(1):82-88. https://doi.org/10.1172/JCI110606.
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Research Article

In vitro parasite-monocyte interactions in human leishmaniasis. Evidence for an active role of the parasite in attachment.

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Abstract

Leishmania are obligate intracellular parasites of mononuclear phagocytes in the mammalian host. To more clearly define features of the early events in host-parasite interaction, human monocytes were so-cultured with Leishmania tropica amastigotes in vitro. Infection of monocytes was time dependent and inhibited at 4 degrees C and in the presence of cytochalasin B. Pretreatment of amastigotes with cytochalasins prevented their attachment to normal monocytes. Untreated amastigotes attached normally but could not enter cytochalasin-pretreated monocytes. This suggests that amastigotes actively participate in attachment but require host cell participation for interiorization.

Authors

D J Wyler

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Total citations by year

Year: 2014 2011 2008 2006 2000 1997 1991 1990 1988 1986 1985 1984 1983 Total
Citations: 1 2 1 1 2 1 1 1 2 3 3 1 3 22
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article (22)

Title and authors Publication Year
Integrity of the Actin Cytoskeleton of Host Macrophages is Essential for Leishmania donovani Infection
S Roy, GA Kumar, M Jafurulla, C Mandal, A Chattopadhyay
Biochimica et Biophysica Acta (BBA) - Biomembranes 2014
Interleukin-13 reduces hyperalgesia and the level of interleukin-1β in BALB/c mice infected with Leishmania major with an up-regulation of interleukin-6
MC Karam, JE Al-Kouba, SI Bazzi, CB Smith, L Leung
Journal of Neuroimmunology 2011
The Influence of Low Oxygen on Macrophage Response to Leishmania Infection
A Degrossoli, WW Arrais-Silva, MC Colhone, FR Gadelha, PP Joazeiro, S Giorgio
Scandinavian Journal of Immunology 2011
Novartis Foundation Symposia
EJ Campbell
Ciba Foundation Symposium 44 - Research and Medical Practice: Their Interaction 2008
Leishmania Infection Impairs β1-Integrin Function and Chemokine Receptor Expression in Mononuclear Phagocytes
NF Pinheiro, MD Hermida, MP Macedo, J Mengel, A Bafica, WL dos-Santos
Infection and immunity 2006
Preformed membrane-associated stores of interleukin (IL)-12 are a previously unrecognized source of bioactive IL-12 that is mobilized within minutes of contact with an intracellular parasite
M Quinones, SK Ahuja, PC Melby, L Pate, RL Reddick, SS Ahuja
Journal of Experimental Medicine 2000
Preformed Membrane-Associated Stores of Interleukin (Il)-12 Are a Previously Unrecognized Source of Bioactive IL-12 That Is Mobilized within Minutes of Contact with an Intracellular Parasite
M Quinones, SK Ahuja, PC Melby, L Pate, RL Reddick, SS Ahuja
Journal of Experimental Medicine 2000
Advances in Molecular and Cell Biology
KJ Clemetson
Advances in Molecular and Cell Biology 1997
Strategies of obligate intracellular parasites for evading host defences
BF Hall, KA Joiner
Parasitology Today 1991
An assay to quantitate the binding of leishmania amastigotes to macrophages
DM Mosser
Journal of Immunological Methods 1990
Roles of CR3 and mannose receptors in the attachment and ingestion of Leishmania donovani by human mononuclear phagocytes
ME Wilson, RD Pearson
Infection and immunity 1988
The major surface protein ofleishmania promastigotes is a fibronectin-like molecule
FS Rizvi, MA Ouaissi, B Marty, F Santoro, A Capron
European Journal of Immunology 1988
Flow cytometric analysis of the effects exerted by monoclonal antibodies on binding and uptake of Leishmania mexicana subsp. mexicana promastigotes by murine peritoneal macrophages
KM Williams, JB Sacci, RL Anthony
Infection and immunity 1986
Imunologia da Leishmaniose tegumentar
M Barral-Netto, R Badaró, A Barrai, EM Carvalho
Revista da Sociedade Brasileira de Medicina Tropical 1986
Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques
E Jucker
1986
The Leishmania receptor for macrophages is a lipid-containing glycoconjugate
E Handman, JW Goding
The EMBO Journal 1985
In vitro parasite-monocyte interactions in human leishmaniasis: possible role of fibronectin in parasite attachment
DJ Wyler, JP Sypek, JA McDonald
Infection and immunity 1985
Receptors and recognition mechanisms of Leishmania species
JM Blackwell
Transactions of the Royal Society of Tropical Medicine and Hygiene 1985
Stage-specific variations in lectin binding to Leishmania donovani
ME Wilson, RD Pearson
Infection and immunity 1984
In vitro parasite-monocyte interactions in human leishmaniasis: effect of enzyme treatments on attachment
DJ Wyler, K Suzuki
Infection and immunity 1983
Interaction of high-density lipoprotein with Trypanosoma brucei: Effect of membrane stabilizers
MR Rifkin
Journal of Cellular Biochemistry 1983
The macrophage and parasitic protozoa
JM Blackwell, J Alexander
Transactions of the Royal Society of Tropical Medicine and Hygiene 1983

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