Peripheral blood lymphocytes and splenocytes of patients with autoimmune disease were used to prepare human-human hybridomas that produce autoantibodies. Because exogenous immunization was not used, the hybridoma antibodies were derived from B cells that spontaneously produced autoantibodies. 108 hybrids grew from 4,254 wells (2.5%). Optimal conditions for obtaining hybridomas with the GM 4672 myeloma line included initial growth in 2-ml wells, the use of 44% polyethylene glycol, a mononuclear cell/GM 4672 cell ratio 5:1, and prior stimulation of the B lymphocytes with pokeweed mitogen. Hybridoma supernatants had activity against ssDNA, platelets, and erythrocytes. The results demonstrate the feasibility of producing human-human hybridomas from lymphocytes of patients with various autoimmune diseases.
Y Shoenfeld, S C Hsu-Lin, J E Gabriels, L E Silberstein, B C Furie, B Furie, B D Stollar, R S Schwartz
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16/6-idiotype expressing antibodies induce brain inflammation and cognitive impairment in mice: the mosaic of central nervous system involvement in lupus
S Kivity, A Katzav, MT Arango, M Landau-Rabi, Y Zafrir, N Agmon-Levin, M Blank, JM Anaya, E Mozes, J Chapman, Y Shoenfeld |
BMC Medicine | 2013 |
Methods in Enzymology
JD Stone, AS Chervin, DH Aggen, DM Kranz |
Protein Engineering for Therapeutics Part B | 2012 |
Advances in Clinical Chemistry
M Mahler |
Advances in Clinical Chemistry Volume 54 | 2011 |
Advances in Immunology
E Pinaud, M Marquet, R Fiancette, S Péron, C Vincent-Fabert, Y Denizot, M Cogné |
Advances in Immunology Volume 110 | 2011 |
Development trends for human monoclonal antibody therapeutics
AL Nelson, E Dhimolea, JM Reichert |
Nature Reviews Drug Discovery | 2010 |
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
Systemic Lupus Erythematosus
M Petri |
JCR: Journal of Clinical Rheumatology | 2006 |
Laboratory Techniques in Biochemistry and Molecular Biology
S Chen, KM Madsen, CC Tisher, A Agarwal |
Laboratory Techniques in Biochemistry and Molecular Biology | 2005 |
A Peptide Based on the Complementarity Determining Region 1 of a Human Monoclonal Autoantibody Ameliorates Spontaneous and Induced Lupus Manifestations in Correlation with Cytokine Immunomodulation
D Luger, M Dayan, H Zinger, JP Liu, E Mozes |
Journal of Clinical Immunology | 2004 |
Autoreactive responses to an environmental factor: 1. phthalate induces antibodies exhibiting anti-DNA specificity
SY Lim, SK Ghosh |
Immunology | 2003 |
Modulation of autoreactive responses of peripheral blood lymphocytes of patients with systemic lupus erythematosus by peptides based on human and murine anti-DNA autoantibodies
ZM Sthoeger, M Dayan, A Tcherniack, L Green, S Toledo, R Segal, O Elkayam, E Mozes |
Clinical & Experimental Immunology | 2003 |
Endothelial Cell Binding by Systemic Lupus Antibodies: Functional Properties and Relationship with Anti-DNA Activity
S Moscato, F Pratesi, F Bongiorni, MC Scavuzzo, D Chimenti, S Bombardieri, P Migliorini |
Journal of Autoimmunity | 2002 |
Systematic analysis of sequences of anti-DNA antibodies—relevance to theories of origin and pathogenicity
A Rahman, I Giles, J Haley, D Isenberg |
Lupus | 2002 |
The mechanism by which a peptide based on complementarity-determining region-1 of a pathogenic anti-DNA auto-Ab ameliorates experimental systemic lupus erythematosus
E Eilat, M Dayan, H Zinger, E Mozes |
Proceedings of the National Academy of Sciences | 2001 |
Antibody convergence along a common idiotypic axis in immunodeficiency virus and hepatitis C virus infections
MD Grant |
Journal of Medical Virology | 2001 |
The clonal analysis of anticardiolipin antibodies in a single patient with primary antiphospholipid syndrome reveals an extreme antibody heterogeneity
P Lieby, A Soley, H Levallois, B Hugel, JM Freyssinet, M Cerutti, JL Pasquali, T Martin |
Blood | 2001 |
Critical self-epitopes are key to the understanding of self-tolerance and autoimmunity
G Dighiero, NR Rose |
Immunology Today | 1999 |
Isolation and Characterization of Two Human Monoclonal Anti-Phospholipid IgG from Patients with Autoimmune Disease
C Landenberg, KJ Lackner, P Landenberg, B Lang, G Schmitz |
Journal of Autoimmunity | 1999 |
Human monoclonal antibodies: A tool for cancer detection in vivo
HJ Ditzel |
APMIS | 1999 |
Immunoglobulin variable region sequences of humanmonoclonal anti-DNA, antibodies
A Rahman, DS Latchman, DA Isenberg |
Seminars in Arthritis and Rheumatism | 1998 |
Anti‐DNA autoantibodies from an MRL//<i>Ipr</i> mouse
JS Park, YT Kim, CH Lee, JK Youn, YJ Jang |
Korean Journal of Biological Sciences | 1998 |
Immunomodulation of murine experimental SLE-like disease by interferon-γ
H Amital, Y Levi, M Blank, V Barak, P Langevitz, A Afek, F Nicoletti, J Kopolovic, B Gilburd, PL Meroni, Y Shoenfeld |
Lupus | 1998 |
Natural Autoantibodies, Tolerance, and Autoimmunity
G Dighiero |
Annals of the New York Academy of Sciences | 1997 |
Modulation of murine systemic lupus erythematosus with peptides based on complementarity determining regions of a pathogenic anti-DNA monoclonal antibody
A Waisman, PJ Ruiz, E Israeli, E Eilat, S Könen-Waisman, H Zinger, M Dayan, E Mozes |
Proceedings of the National Academy of Sciences | 1997 |
The Role of Autoreactivity in B Cell Selection
BD Stollar, JM Lecerf, Y Hirabayashi |
Annals of the New York Academy of Sciences | 1997 |
Immunoregulation in Health and Disease
L Tomašević, E Maggi, S Romagnani |
Immunoregulation in Health and Disease | 1997 |
Idiotypes in Medicine: Autoimmunity, Infection and Cancer
TJ Kunicki, DJ Nugent |
Idiotypes in Medicine: Autoimmunity, Infection and Cancer | 1997 |
The role of antibodies to DNA in systemic lupus erythematosus— A review and introduction to an international workshop on DNA antibodies held in London, May 1996
DA Isenberg, CT Ravirajan, A Rahman, J Kalsi |
Lupus | 1997 |
Dietary vitamin A deficiency and the immune system in a murine model of systemic lupus erythematosus
CH Liao, JW Erdman, EW Voss, PV Johnston |
Nutrition Research | 1996 |
Expression of a Human Fetal Anti-DNA Antibody Idiotype BEG-2β in the Families of Patients with Rheumatoid Arthritis
CT Ravirajan, P Youinou, PL Goff, RA Watts, DA Isenberg |
Autoimmunity | 1995 |
Monthly Update: Biologicals & Immunologicals: The autoimmunity of cancer as applied to drug development
ME McKnight, MC Glassy |
Expert Opinion on Investigational Drugs | 1995 |
Heparan sulphate-ELISA gives false positive results for anti-DNA-DNA/histone immune complexes in sera of patients with SLE
R Suenaga, NI Abdou |
Lupus | 1995 |
Antiphospholipid syndrome and the idiotypic network
R Bakimer, M Blank, D Kosashvilli, K Ichikawa, MA Khamashta, GR Hughes, T Koike, Y Shoenfeld |
Lupus | 1995 |
Induction of experimental systemic lupus erythematosus in mice by immunization with the F(ab′)2 fragment of the human anti-DNA monoclonal antibody carrying the 166 idiotype
PJ Ruiz, H Zinger, E Mozes |
Immunology Letters | 1994 |
Autoimmune Disease Models
C Putterman, Y Naparstek |
Autoimmune Disease Models | 1994 |
The use of the clinical immunology laboratory
S H Yoshida, B C Veit, L E Mansfield, M E Gershwin |
Clinical Reviews in Allergy | 1994 |
Variable region sequences of autoantibodies from mice with experimental systemic lupus erythematosus
A Waisman, E Mozes |
European Journal of Immunology | 1993 |
Pathogenic natural autoantibodies
Y Shoenfeld |
Clinical Immunology Newsletter | 1993 |
Comparison of indirect and direct in-situ polymerase chain reaction in cell preparations and tissue sections: Detection of viral DNA, gene rearrangements and chromosomal translocations
AA Long, P Komminoth, E Lee, HJ Wolfe |
Histochemistry | 1993 |
Pathogenic serum IgG anticardiolipin antibodies and the idiotypic network
J Cohen, R Bakimer, M Blank, G Valesini, Y Shoenfeld |
Annals of the rheumatic diseases | 1993 |
Induction of primary antiphospholipid syndrome in mice by immunization with a human monoclonal anticardiolipin antibody (H-3)
R Bakimer, P Fishman, M Blank, B Sredni, M Djaldetti, Y Shoenfeld |
Journal of Clinical Investigation | 1992 |
Expression of inactive stage anti-dsDNA idiotypes on anti-ssDNA antibodies in a lupus patient during active stage of lupus cerebritis
R Suenaga, NI Abdou |
Journal of Autoimmunity | 1992 |
Immortalisation of Human Antibody Producing Cells
JK Kalsi, DA Isenberg |
Autoimmunity | 1992 |
The putative role of cytokines in the induction of primary anti-phospholipid syndrome in mice
P Fishman, R Bakimer, M Blank, D Sredni, M Djaldetti, Y Shoenfeld |
Clinical & Experimental Immunology | 1992 |
Autoantibodies in the Sera of Patients with Lymphoma
M Swissa, Y Cohen, Y Shoenfeld |
Leukemia & Lymphoma | 1992 |
Human monoclonal antibodies against Plasmodium falciparum: production, stabilization and characterization
M Kamber, M Blackman, PS Lin, J Brown, H Whittle, R Schmidt-Ullrich |
Parasite Immunology | 1992 |
Generation of human monoclonal autoantibody-producing cell lines by epstein-barr virus transformation of autoreactive B lymphocytes and by somatic cell hybridization techniques: Application to the analysis of the autoimmune B cell repertoire
M Nakamura, P Casali |
ImmunoMethods | 1992 |
Lupus-Derived Human Monoclonal IgM anti-DNA Antibody Displays Monospecificity, High Affinity and Private Idiotype Specificity
R Suenaga, NI Abdou |
Lupus | 1992 |
The putative role of cytokines in the induction of primary anti-phospholipid syndrome in mice.
Fishman P, Bakimer R, Blank M, Sredni D, Djaldetti M, Shoenfeld Y |
Clinical & Experimental Immunology | 1992 |
Pathogenic anti-DNA idiotype (16/6 Id) in systemic lupus erythematosus
Y Shoenfeld, E Mozes |
Rheumatology International | 1991 |
A systemic lupus erythematosus-derived human hybridoma autoantibody reactive with antigens expressed on ADP-activated platelets
Q Meng, J Rauch |
Journal of Autoimmunity | 1991 |
Nucleotide sequence of the human autoantibody 2E7 specific for the platelet integrin IIb heavy chain
TJ Kunicki, DS Annis, J Gorski, DJ Nugent |
Journal of Autoimmunity | 1991 |
Modulation of SLE induction in naive mice by specific T cells with suppressor activity to pathogenic anti-DNA idiotype
M Blank, M Ben-Bassat, Y Shoenfeld |
Cellular Immunology | 1991 |
The production of human monoclonal anti-MMTV antibodies by in vitro immunization with anti-idiotypic antibodies
M Blank, IN Smorodinsky, I Keydar, S Chaitchik, Y Shoenfeld |
Immunology Letters | 1991 |
Antinuclear Autoantibodies in Healthy Nonpregnant and Pregnant Women and Their Offspring
B Piura, E Tauber, Y Dror, B Sarov, D Buskila, H Slor, Y Shoenfeld |
American Journal of Reproductive Immunology | 1991 |
Sequence Analysis and Idiotypic Relationships of BEG-2, a Human Fetal Antibody Reactive with DNA
RA Watts, JL Hillson, IR Oppliger, L Mackenzie, PM Lydyard, CG Young, C Brown, NA Staines, DA Isenberg |
Lupus | 1991 |
Sulfated glycolipids are the platelet autoantigens for human platelet-binding monoclonal anti-DNA autoantibodies
H Murakami, Z Lam, BC Furie, VN Reinhold, T Asano, B Furie |
The Journal of biological chemistry | 1991 |
The relationship between cd5-expressing b lymphocytes and serologic abnormalities in rheumatoid arthritis patients and their relatives
P Youinou, L Mackenzie, P Katsikis, G Merdrignac, DA Isenberg, N Tuaillon, A Lamour, PL Goff, J Jouquan, A Drogou, S Muller, B Genetet, HM Moutsopoulos, PM Lydyard |
Arthritis & Rheumatism | 1990 |
Idiotype-mediated intervention in systemic lupus erythematosus
M Zouali, B Diamond |
Journal of Autoimmunity | 1990 |
Autoantibodies in neoplasia an unresolved enigma
M Swissa, H Amital-Teplizki, N Haim, Y Cohen, Y Shoenfeld |
Cancer | 1990 |
Differences Between Human Hybridoma Platelet-Binding Antibodies Derived from Systemic Lupus Erythematosus Patients and Normal Individuals
QH Meng, J Rauch |
Autoimmunity | 1990 |
The Importance of the Pathogenic 16/6 Idiotype in the Induction of SLE in Naive Mice
M Blank, M Krup, S Mendlovic, H Fricke, E Mozes, N Talal, AR Coates, Y Shoenfeld |
Scandinavian Journal of Immunology | 1990 |
A human fetal monoclonal DNA-binding antibody shares idiotypes with fetal and adult murine monoclonal DNA-binding antibodies
RA Watts, CT Ravirajan, NA Staines, DA Isenberg |
Immunology | 1990 |
Immune thrombocytopenia in pregnancy
J Browning, D James |
Fetal and Maternal Medicine Review | 1990 |
Human monoclonal antibody derived from an autoimmune thrombocytopenic purpura patient, recognizing an intermediate filament's determinant common to vimentin and desmin
D Varon, S Linder, E Gembom, L Guedg, H Langbeheim, A Berrebi, Z Eshhar |
Clinical Immunology and Immunopathology | 1990 |
Therapeutic Monoclonal Antibodies
CA Borrebaeck, JW Larrick |
1990 | |
Molecular and genetic characteristics of pathogenic autoantibodies
F Tron, JF Bach |
Journal of Autoimmunity | 1989 |
Binding of Monoclonal Anti-DNA and Anti-TB Glycolipids to Brain Tissue
H Amital-Teplizki, I Avinoach, AR Coates, O Kooperman, M Blank, Y Shoenfeld |
Autoimmunity | 1989 |
Microplate elsa for detection of antibodies to DNA in patients with systemic lupus erythematosus: Specificity and correlation with farr radioimmunoassay
M Sutjita, A Hohmann, ML Boey, J Bradley |
Journal of Clinical Laboratory Analysis | 1989 |
Autoantibody production by patients infected with Leishmania
S Argov, CL Jaffe, M Krupp, H Slor, Y Shoenfeld |
Clinical & Experimental Immunology | 1989 |
Natural autoantibodies in the serum of healthy women--a five-year follow-up
O Yadin, B Sarov, L Naggan, H Slor, Y Shoenfeld |
Clinical & Experimental Immunology | 1989 |
A common anti-cardiolipin antibody idiotype in autoimmune disease: identification using a mouse monoclonal antibody directed against a naturally-occurring anti-phospholipid antibody
M Sutjita, A Hohmann, R Comacchio, ML Boey, J Bradley |
Clinical & Experimental Immunology | 1989 |
Serum monoclonal antibodies derived from patients with multiple myeloma react with mycobacterial phosphoinositides and nuclear antigens
D Buskila, M Abu-Shakra, H Amital-Teplizki, AR Coates, M Krupp, S Sukenik, Y Shoenfeld |
Clinical & Experimental Immunology | 1989 |
Establishment of an anti-A human monoclonal antibody from a blood group A lung cancer patient: evidence for the occurrence of autoimmune response to difucosylated type-2 chain A
H Inoue, S Hirohashi, Y Shimosato, M Enjoji, H Clausen, SI Hakomori |
European Journal of Immunology | 1989 |
Reproductive failure because of autoantibodies: Unexplained infertility and pregnancy wastage
N Gleicher, A El-Roeiy, E Confino, J Friberg |
American Journal of Obstetrics and Gynecology | 1989 |
The role of the human anti-DNA idiotype in autoimmunity
Y Shoenfeld, HA Teplizki, S Mendlovic, M Blank, E Mozes, DA Isenberg |
Clinical Immunology and Immunopathology | 1989 |
Productive Ascites Growth of Heterohybridomas between Epstein-Barr Virus-Transformed Human B Cells and Murine P3×63Ag8.653 Myeloma Cells
M Matsumoto, K Mochizuki, Y Kobayashi |
Microbiology and Immunology | 1989 |
Sequential anti-idiotypes define reciprocal idiotopes on the same anti-DNA antibody
Y Naparstek, C Mackworth-Young, L Breitman, RS Schwartz |
Clinical Immunology and Immunopathology | 1989 |
Immunointervention in Autoimmune Diseases
R Nussenblatt |
Immunointervention in Autoimmune Diseases | 1989 |
Serological abnormalities, including common idiotype PR4, in families with rheumatoid arthritis
P Youinou, W Williams, PL Goff, N Tuaillon, J Jouquan, S Muller, DA Isenberg |
Annals of the rheumatic diseases | 1989 |
Monoklonale Antikörper
R von Baehr, HP Ferber, T Porstmann |
1989 | |
Binding specificity of antiidiotypic autoantibodies to anti-DNA antibodies in humans
T Sasaki, T Muryoi, O Takai, E Tamate, H Saito, K Yoshinaga |
Journal of Clinical Investigation | 1988 |
Polyvalent Anti-DNA Autoantibodies: Immunochemical and Biological Significance
RS Schwartz |
International Reviews of Immunology | 1988 |
Induction of SLE-like disease in naive mice with a monoclonal anti-DNA antibody derived from a patient with polymyositis carrying the 166 ID
M Blank, S Mendelovic, E Mozes, Y Shoenfeld |
Journal of Autoimmunity | 1988 |
Studies of a common idiotype pr4 in autoimmune rheumatic disease
W Williams, A Zumla, R Behrens, M Locniskar, A Voller, KP Mcadam, DA Isenberg |
Arthritis & Rheumatism | 1988 |
Human Monoclonal Antibodies to Phenolic Glycolipid-1 from Leprosy Patients Cross React with poly(ADP-Ribose), Polynucleotides and Tissue Bound Antigens
A Zumla, W Williams, S Shall, M Locniskar, I Leigh, KP McAdam, D Isenberg |
Autoimmunity | 1988 |
An idiotope-specific autoantibody in SLE
CG Mackworth-Young, RS Schwartz |
Clinical & Experimental Immunology | 1988 |
Human monoclonal antibodies to phenolic glycolipid-I derived from patients with leprosy, and production of specific anti-idiotypes
M Locniskar, A Zumla, DW Mudd, DA Isenberg, W Williams, KP McAdam |
Immunology | 1988 |
Naturally-occurring tumor-reactive autoantibodies: a monoclonal antibody from normal mice reacts with tumor cells and with DNA
NI Smorodinsky, L Cahalon, S Argov, IP Witz, Y Shoenfeld |
Immunology Letters | 1988 |
Autoimmune diseases other than lupus share common anti-DNA idiotypes
Y Shoenfeld, O Ben-Yehuda, Y Messinger, Z Bentwitch, J Rauch, DI Isenberg, NG Gadoth |
Immunology Letters | 1988 |
The significance of HLA studies in human-human hybridomas
Y Shoenfeld, R Zamir |
Tissue Antigens | 1988 |
A human monoclonal anti-DNA antibody derived from a patient with polymyositis having the common lupus 16/6 idiotype
Y Shoenfeld, A Livne, M Blank, S Argov, M Krup, E Fleishmakher, S Sukenik, H Teplizki |
Immunology Letters | 1988 |
Polyspecificity of human monoclonal antibodies reactive with Mycobacterium leprae, mitochondria, ssDNA, cytoskeletal proteins, and the acetylcholine receptor
DB Duggan, C Mackworth-Young, A Kari-Lefvert, J Andre-Schwartz, D Mudd, KP McAdam, RS Schwartz |
Clinical Immunology and Immunopathology | 1988 |
Autoimmunity in infertile patients with endometriosis
SC Meek, DD Hodge, JR Musich |
American Journal of Obstetrics and Gynecology | 1988 |
The reproductive autoimmune failure syndrome
N Gleicher, A El-Roeiy |
American Journal of Obstetrics and Gynecology | 1988 |
Immunoglibulin secretion of mononuclear cells induced by various mitogens
Y Shoenfeld, H Teplizki, D Buskila, J Luedemann, W Gross |
International Journal of Immunopharmacology | 1988 |
Antinuclear Autoantibodies in Sera of Healthy Pregnant Women and Their Offspring
B Piura, E Tauber, B Sarov, L Naggan, Y Shoenfeld |
American Journal of Reproductive Immunology and Microbiology | 1988 |
Breast Cancer: Scientific and Clinical Progress
MA Rich, JC Hager, DM Lopez |
1988 | |
In vitro T-cell functions specific to an anti-DNA idiotype and serological markers in patients with systemic lupus erythematosus (SLE)
S Mendlovic, Y Shoenfeld, R Bakimer, R Segal, M Dayan, E Mozes |
Journal of Clinical Immunology | 1988 |
Reviews on Immunoassay Technology
SB Pal |
1988 | |
Idiotypic markers of polyclonal B cell activation. Public idiotypes shared by monoclonal antibodies derived from patients with systemic lupus erythematosus or leprosy
C Mackworth-Young, J Sabbaga, RS Schwartz |
Journal of Clinical Investigation | 1987 |
Purification of antigens and monoclonal antibodies
RN Maini, D Williams |
Clinical Rheumatology | 1987 |
The Immunogenicity of Platelet Membrane Glycoproteins
TJ Kunicki, K Furihata, B Bull, DJ Nugent |
Transfusion Medicine Reviews | 1987 |
Human monoclonal antibodies as cellular and molecular probes: a review
MJ O'Hare, CY Yiu |
Molecular and Cellular Probes | 1987 |
DNA antibody idiotypes: A review of their genetic, clinical, and immunopathologic features
Y Shoenfeld, DA Isenberg |
Seminars in Arthritis and Rheumatism | 1987 |
Platelet antibodies in systemic lupus erythematosus
C Kaplan, P Champeix, D Blanchard, JY Muller, JP Cartron |
British Journal of Haematology | 1987 |
Description and partial characterization of a nucleolar RNA-associated autoantigen defined by a human monoclonal antibody
N Chiorazzi, WH Reeves |
Journal of Experimental Medicine | 1987 |
A common anti-DNA idiotype and other autoantibodies in sera of offspring of mothers with systemic lupus erythematosus
A el-Roeiy, N Gleicher, D Isenberg, RC Kennedy, Y Shoenfeld |
Clinical & Experimental Immunology | 1987 |
Parallel sets of autoantibodies in MRL-lpr/lpr mice. An anti-DNA, anti-SmRNP, anti-gp70 network
P Migliorini, B Ardman, J Kaburaki, RS Schwartz |
Journal of Experimental Medicine | 1987 |
Estimation of Heterokaryon Formation and Hybridoma Growth in Murine and Human Cell Fusions
SS Alkan, F Mestel, J Jiricka, K Blaser |
Hybridoma | 1987 |
Anti-platelet and Anti-DNA IgM in waldenström macroglobulinemia and ITP
L Vartlcovski, AI Pick, A Schattner, Y Shoenfeld |
American Journal of Hematology | 1987 |
Human monoclonal antibodies derived from lymph nodes of a patient with breast carcinoma react with MuMTV polypeptides
Y Shoenfeld, A Hizi, R Tal, NI Smorodinsky, G Lavie, C Mor, S Schteren, Z Mammon, J Pinkhas, T Keydar |
Cancer | 1987 |
Specificity of anti-polynucleotide monoclonal antibodies from human-human hybridomas
S Hashizume, H Murakami, M Kamei, S Hirose, T Shirai, K Yamada, H Omura |
In Vitro Cellular & Developmental Biology | 1987 |
Immunization of normal human splenocytes in vitro to produce human monoclonal antibodies to cellular antigens
CM Hulette, RB Effros, RL Walford |
Tissue Antigens | 1987 |
Human monoclonal antibody production
K James, GT Bell |
Journal of Immunological Methods | 1987 |
Polyspecific reactivity of a murine monoclonal antibody that binds to nuclear matrix-associated, chromatin-bound autoantigens
AJ Laster, DS Pisetsky, BF Haynes |
Clinical Immunology and Immunopathology | 1987 |
Hematologic Complications of Rheumatic Disease
KE Richert-Boe |
Hematology/Oncology Clinics of North America | 1987 |
A study of human-human hybridomas from patients with autoimmune thyroid disease
E de Bernardo, TF Davies |
Journal of Clinical Immunology | 1987 |
Increased presence of common systemic lupus erythematosus (SLE) anti-DNA idiotypes (16/6 Id, 32/15 Id) is induced by procainamide
Y Shoenfeld, Y Vilner, T Reshef, A Klajman, A Skibin, O Kooperman, RC Kennedy |
Journal of Clinical Immunology | 1987 |
Methods of Hybridoma Formation
AH Bartal, Y Hirshaut |
1987 | |
Immunological Approaches to the Diagnosis and Therapy of Breast Cancer
RL Ceriani |
1987 | |
Specificity of anti-polynucleotide monoclonal antibodies from human-human hybridomas
S Hashizume, H Murakami, M Kamei, S Hirose, T Shirai, K Yamada, H Omura |
In Vitro Cellular & Developmental Biology – Animal | 1987 |
Human Monoclonal Antibodies as Probes to Study Autoimmune and Allergic Disorders
N Chiorazzi |
Bio/Technology | 1986 |
Antibodies to DNA. A perspective
W Emlen, DS Pisetsky, RP Taylor |
Arthritis & Rheumatism | 1986 |
Monoclonal Anti-DNA Antibodies The Targets and Origins of SLE Autoantibodies
BD Stollar, RS Schwartz |
Annals of the New York Academy of Sciences | 1986 |
A monoclonal antibody reactive with a subset of human plasma cells
NJ Gonchoroff, JA Katzmann, JP Garton, GJ Ruiz-Argüelles, CR Eilers, PR Greipp, RA Kyle |
British Journal of Haematology | 1986 |
A human monoclonal macroglobulin with specificity for alpha(2----8)-linked poly-N-acetyl neuraminic acid, the capsular polysaccharide of group B meningococci and Escherichia coli K1, which crossreacts with polynucleotides and with denatured DNA
EA Kabat, KG Nickerson, J Liao, L Grossbard, EF Osserman, E Glickman, L Chess, JB Robbins, R Schneerson, YH Yang |
Journal of Experimental Medicine | 1986 |
Monoclonal anti-tuberculosis antibodies react with DNA, and monoclonal anti-DNA autoantibodies react with Mycobacterium tuberculosis
Y Shoenfeld, Y Vilner, AR Coates, J Rauch, G Lavie, D Shaul, J Pinkhas |
Clinical & Experimental Immunology | 1986 |
A single germline VH gene segment of normal A/J mice encodes autoantibodies characteristic of systemic lupus erythematosus
Y Naparstek, J André-Schwartz, T Manser, LJ Wysocki, L Breitman, BD Stollar, M Gefter, RS Schwartz |
Journal of Experimental Medicine | 1986 |
Human-human hybridomas secreting monoclonal antibodies to the Mr 195,000 Plasmodium falciparum blood stage antigen
R Schmidt-Ullrich, J Brown, H Whittle, PS Lin |
Journal of Experimental Medicine | 1986 |
Preparation and characterization of human monoclonal antibodies directed against the hepatitis B virus surface antigen
G Colucci, DS Kohtz, SD Waksal |
Liver | 1986 |
Monoclonal Antibodies to Acetylcholine Receptor Secreted by Human X Human Hybridomas Derived from Lymphocytes of a Patient with Myasthenia Gravis
DA Blair, DP Richman, CJ Taves, S Koethe |
Immunological Investigations | 1986 |
Anti-DNA antibodies and the problem of autoimmunity
RS Schwartz |
Cellular Immunology | 1986 |
In vitro stimulation prior to fusion generates antigen-binding human-human hybridomas
RL Wasserman, RD Budens, ES Thaxton |
Journal of Immunological Methods | 1986 |
Effects of interferon-α on the expression of a lupus idiotype in normal humans
A Schattner, D Duggan, Y Naparstek, RS Schwartz |
Clinical Immunology and Immunopathology | 1986 |
The analyses of common idiotypes of human monoclonal anti-DNA autoantibodies in SLE and related conditions
Y Schoenfeld |
Clinical Immunology Newsletter | 1986 |
Recent Advances in Laboratory Tests and the Significance of Autoantibodies to Nuclear Antigens in Systemic Rheumatic Diseases
RM Nakamura, EM Tan |
Clinics in Laboratory Medicine | 1986 |
The detection of a common idiotype of anti-DNA antibodies in the sera of patients with monoclonal gammopathies
Y Shoenfeld, O Ben-Yehuda, Y Napartstek, Y Wilner, R Frolichman, A Schattner, G Lavie, H Joshua, J Pinkhas, RC Kennedy, RS Schwartz, AI Pick |
Journal of Clinical Immunology | 1986 |
A study of anti-poly (ADP-ribose) antibodies and an anti-DNA antibody idiotype and other immunological abnormalities in lupus family members
C Dudeney, Y Shoenfeld, J Rauch, M Jones, CM Young, M Tavassoli, S Shall, DA Isenberg |
Annals of the rheumatic diseases | 1986 |
Human monoclonal antibody: Construction of stable clones reactive with human breast cancer
AJ Strelkauskas, CL Taylor |
Cancer Immunology, Immunotherapy | 1986 |
Origins of anti-DNA autoantibodies
RS Schwartz, BD Stollar |
Journal of Clinical Investigation | 1985 |
Homology of the NH2-terminal amino acid sequences of the heavy and light chains of human monoclonal lupus autoantibodies containing the dominant 16/6 idiotype
PM Atkinson, GW Lampman, BC Furie, Y Naparstek, RS Schwartz, BD Stollar, B Furie |
Journal of Clinical Investigation | 1985 |
Applications of monoclonal antibodies in the diagnosis and treatment of primary brain tumors
DE Bullard, DD Bigner |
Journal of Neurosurgery | 1985 |
Human monoclonal anti-DNA antibodies react as lymphocytotoxic antibodies
Y Shoenfeld, R Zamir, H Joshua, G Lavie, J Pinkhas |
European Journal of Immunology | 1985 |
A Human Monoclonal IgG1lamba Anti-Hepatitis B Surface Antibody
EA Stricker, RF Tiebout, PN Lelie, WP Zeijlemaker |
Scandinavian Journal of Immunology | 1985 |
In vivo clearance and tissue uptake of an anti-DNA monoclonal antibody and its complexes with DNA
EB Chetrit, EH Dunsky, S Wollner, D Eilat |
Clinical & Experimental Immunology | 1985 |
Immunochemical similarities between monoclonal antibacterial Waldenstrom's macroglobulins and monoclonal anti-DNA lupus autoantibodies
Y Naparstek, D Duggan, A Schattner, MP Madaio, F Goni, B Frangione, BD Stollar, EA Kabat, RS Schwartz |
Journal of Experimental Medicine | 1985 |
A Combination of IgG and IgM Autoantibodies in Chronic Cold Agglutinin Disease: Immunologic Studies and Response to Splenectomy
LE Silberstein, Y Shoenfeld, RS Schwartz, EM Berkman |
Vox Sanguinis | 1985 |
Detection of cross-reactive anti-DNA antibody idiotypes in the serum of systemic lupus erythematosus patients and of their relatives
DA Isenberg, Y Shoenfeld, M Walport, C Mackworth-Young, C Dudeney, A Todd-Pokropek, S Brill, A Weinberger, J Pinkas |
Arthritis & Rheumatism | 1985 |
Production of monoclonal antibodies against prostatic acid phosphatase by in vitro immunization of human spleen cells
N Yamaura, M Makino, LJ Walsh, AW Bruce, BK Choe |
Journal of Immunological Methods | 1985 |
Autoimmunity and Pregnancy
A El-Roeiy, Y Shoenfeld |
American Journal of Reproductive Immunology and Microbiology | 1985 |
Monoclonal Antibodies in Cancer
S Sell, RA Reisfeld |
1985 | |
Human Hybridomas and Monoclonal Antibodies
EG Engleman, SK Foung, JW Larrick, AA Raubitschek |
1985 | |
Anti-DNA autoantibody-producing hybridomas of normal human lymphoid cell origin
E Cairns, J Block, DA Bell |
Journal of Clinical Investigation | 1984 |
Twenty-five years of immunosuppression
RS Schwartz |
Springer Seminars in Immunopathology | 1984 |
ANTI-DNA ANTIBODY IDIOTYPES IN SYSTEMIC LUPUS ERYTHEMATOSUS
DA Isenberg, MP Madaio, M Reichlin, Y Shoenfeld, J Rauch, BD Stollar, RS Schwartz |
The Lancet | 1984 |
Multiple serologic reactions and their relationship to clinical activity in systemic lupus erythematosus
DA Isenberg, Y Shoenfeld, RS Schwartz |
Arthritis & Rheumatism | 1984 |
Further immunological studies of sera containing anti-mitochondrial antibodies, type M 5
R Norberg, B Gårdlund, R Thorstensson, K Lidman |
Clinical & Experimental Immunology | 1984 |
Production of human monoclonal IgG antibodies against Rhesus (D) antigen
D Bron, MB Feinberg, NN Teng, HS Kaplan |
Proceedings of the National Academy of Sciences | 1984 |
In vitro stimulated lymphocytes as a source of human hybridomas
D Kozbor, JC Roder |
European Journal of Immunology | 1984 |
Generation of hybridoma antibodies to double-stranded DNA from non-autoimmune BALB/c strain: studies on anti-idiotype
JC Monier, J Brochier, A Moreira, C Sault, B Roux |
Immunology Letters | 1984 |
A monoclonal antibody to the double-stranded polyribonucleotide complex poly(A) · poly(U)
G Delage, E Nahon, T Huynh, J Jeusset, F Lacour |
Molecular Immunology | 1984 |
Influence of Fusion Cell Ratio and Cell Plating Density on Production of Human-Human Hybridomas Secreting Anti-DNA Autoantibodies from Patients with Systemic Lupus Erythematosus
H Massicotte, J Rauch, Y Shoenfeld, H Tannenbaum |
Hybridoma | 1984 |
Establishment of human monoclonal anti-DNA antibody producing cell lines
T Sasaki, F Endo, M Mikami, Y Sekiguchi, K Tada, Y Ono, N Ishida, K Yoshinaga |
Journal of Immunological Methods | 1984 |
The production of human monoclonal autoantibodies from patients with rheumatoid arthritis by the EBV-hybridoma technique
DO Haskard, JR Archer |
Journal of Immunological Methods | 1984 |
Novel Approaches to Cancer Chemotherapy
V Petrow, GM Padilla |
Novel Approaches to Cancer Chemotherapy | 1984 |
Monoclonal Antibodies and Functional Cell Lines
RH Kennett, KB Bechtol, TJ McKearn |
1984 | |
Recent Advances in Immunology
AÜ Müftüoğlu, N Barlas |
1984 | |
Human monoclonal antibodies
SP Cole, BG Campling, T Atlaw, D Kozbor, JC Roder |
Molecular and Cellular Biochemistry | 1984 |
Human monoclonal antibodies: Methods of production and some aspects of their application in oncology
L Olsson |
Medical Oncology | 1984 |
Monoclonal lupus autoantibody secretion by human-human hybridomas. Selection of hybrids by conventional and novel techniques
BH Littman, AV Muchmore, AD Steinberg, WC Greene |
Journal of Clinical Investigation | 1983 |
The rheumatologic complications of hematologic disorders
DA Isenberg, Y Shoenfeld |
Seminars in Arthritis and Rheumatism | 1983 |
SYSTEMIC LUPUS ERYTHEMATOSUS: 25 YEARS OF TREATMENT RELATED TO IMMUNOPATHOLOGY
WJ Morrow, DA Isenberg, P Youinou, ML Snaith |
The Lancet | 1983 |
Idiotypic cross-reactions of monoclonal human lupus autoantibodies
Y Shoenfeld, DA Isenberg, J Rauch, MP Madaio, BD Stollar, RS Schwartz |
Journal of Experimental Medicine | 1983 |
Detection of cell surface and intracellular antigens by human monoclonal antibodies. Hybrid cell lines derived from lymphocytes of patients with malignant melanoma
AN Houghton, H Brooks, RJ Cote, MC Taormina, HF Oettgen, LJ Old |
Journal of Experimental Medicine | 1983 |
Construction and testing of mouse--human heteromyelomas for human monoclonal antibody production
NN Teng, KS Lam, FC Riera, HS Kaplan |
Proceedings of the National Academy of Sciences | 1983 |
Antibodies reactive with surface membranes of cellular elements in the blood
DB Cines |
Human Pathology | 1983 |
Monoclonal Antibodies in Clinical Immunobiology
L Olsson |
Allergy | 1983 |
Immunology: Aetiology of autoimmunity
AD Steinberg |
Nature | 1983 |
Novel Approach to Construction of Human "Myeloma Analogues" for Production of Human Monoclonal Antibodies
M Posner, S Schlossman, H Lazarus |
Hybridoma | 1983 |
Antibody producing human-human hybridomas. I. Technical aspects
L Olsson, H Kronstrøm, AC Mouzon, C Honzik, T Brodin, B Jakobsen |
Journal of Immunological Methods | 1983 |
Polyspecificity of Monoclonal Lupus Autoantibodies Produced by Human-Human Hybridomas
Y Shoenfeld, J Rauch, H Massicotte, SK Datta, J André-Schwartz, BD Stollar, RS Schwartz |
New England Journal of Medicine | 1983 |
Human Monoclonal Autoantibodies That React with Multiple Endocrine Organs
J Satoh, BS Prabhakar, MV Haspel, F Ginsberg-Fellner, AL Notkins |
New England Journal of Medicine | 1983 |
Monoclonal lupus autoantibodies
RS Schwartz |
Immunology Today | 1983 |
The production of monoclonal antibodies from human lymphocytes
D Kozbor, JC Roder |
Immunology Today | 1983 |
Monoclonal Antibodies
DS Pisetsky |
Monoclonal Antibodies | 1983 |
A new look at antifertility vaccines**The work described in this article, Publication No. 1253 of the Oregon Regional Primate Research Center, was supported by National Institutes of Health grants RR-00163 and CA-32132
EE Wallach, DJ Anderson, NJ Alexander |
Fertility and Sterility | 1983 |
Immune Thrombocytopenia
R Mcmillan |
Clinics in Haematology | 1983 |
Antinuclear Antibodies
LL Lorincz, K Soltani, JE Bernstein |
International Journal of Dermatology | 1981 |