Citations to this article

Studies of the Transferrin Receptor on both Human Reticulocytes and Nucleated Human Cells in Culture: COMPARISON OF FACTORS REGULATING RECEPTOR DENSITY
Janet L. Frazier, … , Mark Yoffe, Paul A. Seligman
Janet L. Frazier, … , Mark Yoffe, Paul A. Seligman
Published April 1, 1982
Citation Information: J Clin Invest. 1982;69(4):853-865. https://doi.org/10.1172/JCI110525.
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Studies of the Transferrin Receptor on both Human Reticulocytes and Nucleated Human Cells in Culture: COMPARISON OF FACTORS REGULATING RECEPTOR DENSITY

Abstract

The transferrin receptor, present on reticulocytes and nucleated cells in tissue culture, has been measured with both immunoassay techniques and transferrin binding studies. The total cellular immunoreactive receptor is rapidly lost from erythrocytes during the process of reticulocyte maturation (from as many as 400,000 molecules to <20,000 molecules/reticulocyte). This event parallels the loss of cell surface transferrin binding sites and RNA content, and correlates with previous studies that have measured the decline in hemoglobin synthesis.

Authors

Janet L. Frazier, Jennifer H. Caskey, Mark Yoffe, Paul A. Seligman

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Citations to this article (101)

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VI Chandran, L Matesic, JM Locke, D Skropeta, M Ranson, KL Vine 		Cancer Letters 2011
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D Su, JM May, MJ Koury, H Asard 		The Journal of biological chemistry 2006
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T Tanaka, S Shiramoto, M Miyashita, Y Fujishima, Y Kaneo 		International Journal of Pharmaceutics 2004
Failure of red blood cell maturation in mice with defects in the high-density lipoprotein receptor SR-BI
TM Holm, A Braun, BL Trigatti, C Brugnara, M Sakamoto, M Krieger, NC Andrews 		Blood 2002
Encyclopedia of Molecular Biology
B Mannervik 		Encyclopedia of Molecular Biology 2002
Reticulocyte analysis by flow cytometry and other techniques
RS Riley, JM Ben-Ezra, A Tidwell, G Romagnoli 		Hematology/Oncology Clinics of North America 2002
Receptor Mediated Endocytosis and Cytotoxicity of Transferrin-Mitomycin C Conjugate in the HepG2 Cell and Primary Cultured Rat Hepatocyte
T TANAKA, Y FUJISHIMA, Y KANEO 		Biological & Pharmaceutical Bulletin 2001
Impact of acute malaria on plasma concentrations of transferrin receptors
R Beesley, S Filteau, A Tomkins, T Doherty, H Ayles, A Reid, T Ellman, S Parton 		Transactions of the Royal Society of Tropical Medicine and Hygiene 2000
The acute-phase protein alpha 1-antitrypsin inhibits transferrin-receptor binding and proliferation of human skin fibroblasts
I Graziadei, C M Kähler, C J Wiedermann, W Vogel 		Biochimica et Biophysica Acta 1998
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P Gascard, G Lee, L Coulombel, I Auffray, M Lum, M Parra, JG Conboy, N Mohandas, JA Chasis 		Blood 1998
Erythrocyte membrane vesiculation: model for the molecular mechanism of protein sorting
D W Knowles, L Tilley, N Mohandas, J A Chasis 		Proceedings of the National Academy of Sciences 1997
Erythrocyte membrane vesiculation: Model for the molecular mechanism of protein sorting
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P Suominen, K Punnonen, A Rajamäki, K Irjala 		Clinical chemistry 1997
Tissue-Specific Regulation of Iron Metabolism and Heme Synthesis: Distinct Control Mechanisms in Erythroid Cells
P Ponka 		Blood 1997
Simple and reliable enumeration of micronucleated reticulocytes with a single-laser flow cytometer
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Loss of glucose transporters is an early event in differentiation of HD3 cells
A Mathew, M Grdisa, PJ Robbins, MK White, RM Johnstone 		American journal of physiology. Cell physiology 1994
The hepatic acute-phase proteins alpha 1-antitrypsin and alpha 2-macroglobulin inhibit binding of transferrin to its receptor
I Graziadei, R Kaserbacher, H Braunsteiner, W Vogel 		Biochemical Journal 1993
Regulation of transferrin receptor expression and distribution in in vitro cultured human cytotrophoblasts
JS Starreveld, HP van Dijk, MJ Kroos, HG van Eijk 		Clinica Chimica Acta 1993
Identification of CD71 (transferrin receptor) expressing erythrocytes by multiparameter-flow-cytometry (MP-FCM): correlation to the quantitation of reticulocytes as determined by conventional microscopy and by MP-FCM using a RNA-staining dye
S Serke, D Huhn 		British Journal of Haematology 1992
Inhibition of human lymphoproliferative responses and altered lymphocyte membrane phenotype by succinylacetone
A Winkelstein, RA Hess, KD Leichtling, MO Jackson, RM Blaese, LD Weaver 		Immunopharmacology 1992
Expression of transferrin receptors during differentiation of human placental trophoblast cells in vitro
ML Kennedy, GC Douglas, BF King 		Placenta 1992
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Exosome formation during maturation of mammalian and avian reticulocytes: Evidence that exosome release is a major route for externalization of obsolete membrane proteins
RM Johnstone, A Mathew, AB Mason, K Teng 		Journal of Cellular Physiology 1991
Plasma membrane and intracellular pools of transferrin receptors decline during in vitro cultivation of U937 cells
TW Salcedo, HB Fleit 		Cell Proliferation 1991
Shedding of vesicular material from the cell surface of eukaryotic cells: different cellular phenomena
AR Beaudoin, G Grondin 		Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes 1991
Intracellular localization of newly synthesized transferrin receptors in the peripheral sheep reticulocyte
J Ahn, RM Johnstone 		Archives of Biochemistry and Biophysics 1991
The biology of transferrin
G Jong, JP Dijk, HG Eijk 		Clinica Chimica Acta 1990
Cell Membrane and Volume Changes during Red Cell Development and Aging
N Mohandas, W Groner 		Annals of the New York Academy of Sciences 1989
Chicken transferrin receptor expression during erythroid differentiation and by retrovirus transformed cells
K Kline, LA Plante, TJ Morgan, BG Sanders 		Developmental & Comparative Immunology 1989
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B Yuan, MH Klein, RS Contiguglia, JL Mishell, PA Seligman, NL Miller, BA Molitoris, AC Alfrey, JI Shapiro 		Renal Failure 1989
Transferrin synthesis by small cell lung cancer cells acts as an autocrine regulator of cellular proliferation
M Vostrejs, PL Moran, PA Seligman 		Journal of Clinical Investigation 1988
Endocytosis of the transferrin receptor is altered during differentiation of murine erythroleukemic cells
CA Mulford, HF Lodish 		The Journal of biological chemistry 1988
Increase in surface expression of transferrin receptors on cultured hepatocytes of adult rats in response to iron deficiency
U Muller-Eberhard, HH Liem, JA Grasso, S Giffhorn-Katz, MG DeFalco, NR Katz 		The Journal of biological chemistry 1988
Identification of high affinity folate binding proteins in human erythrocyte membranes
AC Antony, RS Kincade, RS Verma, SR Krishnan 		Journal of Clinical Investigation 1987
Cyclic activity of the receptors of cobalamin bound to transcobalamin II
CA Hall, PD Colligan, JA Begley 		Journal of Cellular Physiology 1987
Transferrin receptor numbers and transferrin and iron uptake in cultured chick muscle cells at different stages of development
LM Sorokin, EH Morgan, GC Yeoh 		Journal of Cellular Physiology 1987
Erythroblast transferrin receptors and transferrin kinetics in iron deficiency and various anemias
K Muta, J Nishimura, H Ideguchi, T Umemura, H Ibayashi 		American Journal of Hematology 1987
Protein kinase C does not phosphorylate the externalized form of the transferrin receptor
MA Adam, RM Johnstone 		Biochemical Journal 1987
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GW Bates, G Graybill, M Chidambaram 		Control of Animal Cell Proliferation 1987
Rapid Communication: Nonspecific Adsorption of Transferrin to K562 Cell Membrane
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Vesicle formation during reticulocyte maturation. Association of plasma membrane activities with released vesicles (exosomes)
RM Johnstone, M Adam, JR Hammond, L Orr, C Turbide 		The Journal of biological chemistry 1987
Iron metabolism during infection and neoplasia.
Letendre ED 		Cancer metastasis reviews 1987
Effects of different transferrin forms on transferrin receptor expression, iron uptake, and cellular proliferation of human leukemic HL60 cells. Mechanisms responsible for the specific cytotoxicity of transferrin-gallium
CR Chitambar, PA Seligman 		Journal of Clinical Investigation 1986
Evidence for a pool of non-recycling transferrin receptors in peripheral sheep reticulocytes
M Adam, C Wu, C Turbide, J Larrick, RM Johnstone 		Journal of Cellular Physiology 1986
Transferrin receptor is inversely correlated with estrogen receptor in breast cancer
SE Tonik, JE Shindelman, HH Sussman 		Breast Cancer Research and Treatment 1986
Chick embryo myotubes contain transferrin receptors and internalize and recycle transferrin
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Human natural killer cell lysis of virus-infected cells. Relationship to expression of the transferrin receptor
LK Borysiewicz, S Graham, JG Sissons 		European Journal of Immunology 1986
Control of erythroid differentiation: Possible role of the transferrin cycle
JA Schmidt, J Marshall, MJ Hayman, P Ponka, H Beug 		Cell 1986
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A Bomford, J Isaac, S Roberts, A Edwards, S Young, R Williams 		Biochemical Journal 1986
Transferrin receptors in the basal plasma membrane of the human placental syncytiotrophoblast
OA Vanderpuye, LK Kelley, CH Smith 		Placenta 1986
Improved purification of the human placental transferrin receptor and a novel immunoradiometric assay for receptor protein
GJ Anderson, A Mackerras, LW Powell, JW Halliday 		Biochimica et Biophysica Acta (BBA) - General Subjects 1986
Transferrin-Mediated Transcellular Transport of 59 Fe Across Confluent Epithelial Sheets of Sertoli Cells Grown in Bicameral Cell Culture Chambers
D Djakiew, MA Hadley, SW Byers, M Dym 		Journal of andrology 1986
Albumin inhibition of transferrin low-affinity binding to K562 cells
T Kishimoto, M Tavassoli 		Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1986
14C-Desferrioxamine B: Uptake into erythrocytes infected withPlasmodium falciparum
G Fritsch, A Jung 		Zeitschrift für Parasitenkunde 1986
Selective externalization of an ATP-binding protein structurally related to the clathrin-uncoating ATPase/heat shock protein in vesicles containing terminal transferrin receptors during reticulocyte maturation
JQ Davis, D Dansereau, RM Johnstone, V Bennett 		The Journal of biological chemistry 1986
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E Pelosi, U Testa, F Louache, P Thomopoulos, G Salvo, P Samoggia, C Peschle 		The Journal of biological chemistry 1986
Intracellular pathways of endocytosed transferrin and non-specific tracers in epithelial cells lining the rete testis of the rat
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Redistribution of cell surface transferrin receptors prior to their concentration in coated pits as revealed by immunoferritin labels
TP Cheng 		Cell and Tissue Research 1986
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R Taetle, K Rhyner, J Castagnola, D To, J Mendelsohn 		Journal of Clinical Investigation 1985
Discordance between transferrin receptor expression and susceptibility to lysis by natural killer cells
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Iron deficiency and iron overload
A Jacobs, AV Hoffbrand 		Critical Reviews in Oncology/Hematology 1985
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The iron-chelating agent picolinic acid enhances transferrin receptors expression in human erythroleukaemic cell lines
U Testa, F Louache, M Titeux, P Thomopoulos, H Rochant 		British Journal of Haematology 1985
Regulation of K562 cell transferrin receptors by exogenous iron
NS Rudolph, BM Ohlsson-Wilhelm, JF Leary, PT Rowley 		Journal of Cellular Physiology 1985
Transferrin receptor regulation is coupled to intracellular ferritin in proliferating and differentiating HL60 leukemia cells
K Rhyner, R Taetle, H Bering, D To 		Journal of Cellular Physiology 1985
Electron microscopic evidence for externalization of the transferrin receptor in vesicular form in sheep reticulocytes
BT Pan, K Teng, C Wu, M Adam, RM Johnstone 		The Journal of Cell Biology 1985
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Metalloproteins
PM Harrison 		1985
Human erythrocyte clathrin and clathrin-uncoating protein
JQ Davis, V Bennett 		The Journal of biological chemistry 1985
Inhibition of transferrin receptor expression by interferon-alpha in human lymphoblastoid cells and mitogen-induced lymphocytes
F Besancon, MF Bourgeade, U Testa 		The Journal of biological chemistry 1985
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Target structure for natural killer cells: evidence against a unique role for transferrin receptor
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L M Marshall, A Thureson-Klein, R C Hunt 		The Journal of Cell Biology 1984
Binding of transferrin and uptake of iron by K-562 cells
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Exclusion of erythrocyte-specific membrane proteins from clathrin- coated pits during differentiation of human erythroleukemic cells
The Journal of Cell Biology 1984
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S Pollack 		British Journal of Haematology 1983
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YE Miller, C Jones, C Scoggin, H Morse, P Seligman 		The American Journal of Human Genetics 1983
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J H Caskey, C Jones, Y E Miller, P A Seligman 		Proceedings of the National Academy of Sciences 1983
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PA Small, RH Waldman 		Protides of the Biological Fluids 1969

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