Citations to this article

Evidence for a Direct Stimulatory Effect of Prostacyclin on Renin Release in Man
Carlo Patrono, … , Giovanni Ciabattoni, Paola Patrignani
Carlo Patrono, … , Giovanni Ciabattoni, Paola Patrignani
Published January 1, 1982
Citation Information: J Clin Invest. 1982;69(1):231-239. https://doi.org/10.1172/JCI110435.
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Research Article

Evidence for a Direct Stimulatory Effect of Prostacyclin on Renin Release in Man

Abstract

The objectives of this investigation were: (a) to characterize the time and dose dependence of the effects of prostacyclin (PGI2) on renin release in healthy men; (b) to define whether PGI2-induced renin release is secondary to hemodynamic changes; (c) to determine the plasma and urine concentrations of 6-keto-PGF1α (the stable breakdown product of PGI2) associated with renin release induced by exogenous or pharmacologically enhanced endogenous PGI2. Intravenous PGI2 or 6-keto-PGF1α infusions at nominal rates of 2.5, 5.0, 10.0, and 20.0 ng/kg per min were performed in each of six normal human subjects; in three of them, PGI2 infusion was repeated after β-adrenergic blockade and cyclooxygenase inhibition. PGI2, but not 6-keto-PGF1α, caused a time- and dose-dependent increase of plasma renin activity, which reached statistical significance at 5.0 ng/kg per min and was still significantly elevated 30 min after discontinuing the infusion. Although combined propranolol and indomethacin treatment significantly enhanced the hypotensive effects of infused PGI2, it did not modify the dose-related pattern of PGI2-induced renin release.

Authors

Carlo Patrono, Francesco Pugliese, Giovanni Ciabattoni, Paola Patrignani

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JM Ritter 		British Journal of Pharmacology 1984
The influence of indomethacin and sulindac on some pharmacological actions of atenolol in hypertensive patients
A Salvetti, R Pedrinelli, P Alberici, A Magagna, B Abdel-Haq 		British Journal of Clinical Pharmacology 1984
Effects of phospholipases A2 from Vipera russelli snake venom on blood pressure, plasma prostacyclin level and renin activity in rats
HC Huang 		Toxicon 1984
Comparison of radioimmunoassay and high-resolution gas chromatography mass spectrometry for the quantitative determination of serum thromboxane B2 and 6-keto-PGF1α after pharmacological blockade of thromboxane synthetase
C Chiabrando, MN Castagnoli, A Noseda, R Fanelli, G Rajtar, C Cerletti, G Gaetano 		Prostaglandins, Leukotrienes and Medicine 1984
The rat urinaryprostacyclin as well as other
JY Jeremy, DP Mikhailidis, P Dandona 		Prostaglandins, Leukotrienes and Medicine 1984
Plasma prostaglandin levels and circulating fuel levels in rats with diabetic ketoacidosis: Effects of cyclooxygenase inhibitors and of alpha and beta adrenergic blockade
L Axelrod, P Cornelius 		Prostaglandins 1984
Maternal smoking and prostacyclin production by cultured endothelial cells from umbilical arteries
M Busacca, G Balconi, A Pietra, M Vergara-Dauden, G Gaetano, E Dejana 		American Journal of Obstetrics and Gynecology 1984
Effects of Sulindac and Ibuprofen in Patients with Chronic Glomerular Disease: Evidence for the Dependence of Renal Function on Prostacyclin
G Ciabattoni, GA Cinotti, A Pierucci, BM Simonetti, M Manzi, F Pugliese, P Barsotti, G Pecci, F Taggi, C Patrono 		New England Journal of Medicine 1984
Schock
W Bleifeld, WD Bussmann, H Djonlagic, U Geßler, UF Gruber, H Herzog, W Kupper, HG Lasch, G Müller-Esch, G Oehler, G Paumgartner, A Perruchoud, G Riecker, HP Schuster, PC Scriba, D Seybold 		1984
Disease, Metabolism and Reproduction in the Toxic Response to Drugs and Other Chemicals
PL Chambers, P Preziosi, CM Chambers 		1984
Reduced platelet thromboxane formation in uremia. Evidence for a functional cyclooxygenase defect
G Remuzzi, A Benigni, P Dodesini, A Schieppati, M Livio, GD Gaetano, SS Day, WL Smith, E Pinca, P Patrignani, C Patrono 		Journal of Clinical Investigation 1983
RELEASE OF PROSTACYCLIN IN VIVO AND ITS ROLE IN MAN
JM Ritter, IA Blair, SE Barrow, CT Dollery 		The Lancet 1983
BLOOD CAN SYNTHESISE PROSTACYCLIN
MA Orchard, IA Blair, CT Dollery, PJ Lewis 		The Lancet 1983
PROSTACYCLIN PRODUCTION AUGMENTED IN THE SHORT TERM BY NICOTINIC ACID
AG Olsson, LA Carlson, E Änggard, G Ciabattoni 		The Lancet 1983
Release of two vasodilators, adenosine and prostacyclin, from isolated rabbit hearts during controlled hypoxia
A Edlund, BB Fredholm, P Patrignani, C Patrono, A Wennmalm, M Wennmalm 		The Journal of Physiology 1983
The effect of adrenergic stimulation on urinary prostaglandin E2 and 6 keto PGF1α in man
J Nadler, RD Zipser, R Horton 		Prostaglandins 1983
Diuresis and respiratory distress syndrome:Physiologic mechanisms and therapeutic implications
WD Engle, BS Arant, S Wiriyathian, CR Rosenfeld 		The Journal of Pediatrics 1983
Plasma 6-keto-PGF1α in acute myocardial infarction
G Davì, M Traina, B Candela, S Novo, A Raineri, A Strano 		Prostaglandins, Leukotrienes and Medicine 1983
Levels of plasma 6-keto-PGF1α in normotensive and essential hypertensive males with and without a family history of hypertension
S Gotoh, T Ogihara, M Nakamaru, K Masuo, T Hata, Y Kumahara 		Prostaglandins, Leukotrienes and Medicine 1983
Analysis of prostacyclin and thromboxane biosynthesis in cardiovascular disease
GA FitzGerald, AK Pedersen, C Patrono 		Circulation 1983
Factors modifying the early nondiuretic vascular effects of furosemide in man. The possible role of renal prostaglandins
GD Johnston, WR Hiatt, AS Nies, NA Payne, RC Murphy, JG Gerber 		Circulation research 1983
SYSTEMIC PROSTAGLANDIN I2 SYNTHESIS IS NORMAL IN PATIENTS WITH BARTTER'S SYNDROME
ML Watson, RA Branch, JR Gill, JA Oates, AR Brash 		Lancet 1983
Das Bartter Syndrom
R Dsing, FC Bartter, JR Gill, F Krck, HJ Kramer 		Klinische Wochenschrift 1983
Selective cumulative inhibition of platelet thromboxane production by low-dose aspirin in healthy subjects
P Patrignani, P Filabozzi, C Patrono 		Journal of Clinical Investigation 1982
Cardiac formation of prostacyclin during cardioplegia in man
A Edlund, W Bomfin, L Kaijser, C Olin, C Patrono, E Pinca, Å Wennmalm 		Prostaglandins 1982
Pharmacologic modulation of arachidonic acid metabolism in man. A minireview with emphasis on radioimmunological methods used to quantitate drug effects
C Patrono, P Patrignani 		International Journal of Immunopharmacology 1982
Effect of prostacyclin infusion on active and inactive renin release in the isolated perfused kidney
H Ohde, T Ogihara, M Nakamaru, J Higaki, S Gotoh, K Masuo, A Ohtsuka, S Saeki, Y Kumahara 		Life Sciences 1982
In vitro prostaglandin synthesis by human glomeruli and papillae
J Sraer, N Ardaillou, JD Sraer, R Ardaillou 		Prostaglandins 1982
Contemporary Nephrology
S Klahr, SG Massry 		1981
Ergebnisse der Inneren Medizin und Kinderheilkunde / Advances in Internal Medicine and Pediatrics
P Frick, GA von Harnack, GA Martini, A Prader, HP Wolff 		1980
Prostaglandins and the Kidney
JC Mcgiff, HD ITSKOVITZ 		Circulation research 1973
The Kidney in Pregnancy
MD Lindheimer, AI Katz 		New England Journal of Medicine 1970

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