Fc and C3 Receptors Induced by Herpes Simplex Virus on Cultured Human Endothelial Cells

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Abstract

The mechanism by which immune complexes deposit in vascular tissue is uncertain. Several human viruses, including herpes simplex virus, have recently been demonstrated to replicate in human endothelial cells. Such viruses may injure vascular tissue and could play a role in the pathogenesis of immune complex deposition. Therefore, we studied the expression of receptors for immune complexes containing IgG and C3 on endothelial cells after infection with herpes simplex virus type I.

Authors

Douglas B. Cines, Alan P. Lyss, Mahin Bina