Citations to this article

High skeletal muscle adenylate cyclase in malignant hyperthermia.
J H Willner, … , C G Cerri, D S Wood
J H Willner, … , C G Cerri, D S Wood
Published November 1, 1981
Citation Information: J Clin Invest. 1981;68(5):1119-1124. https://doi.org/10.1172/JCI110355.
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Research Article

High skeletal muscle adenylate cyclase in malignant hyperthermia.

Abstract

Malignant hyperthermia occurs in humans with several congenital myopathies, usually in response to general anesthesia. Commonly, individuals who develop this syndrome lack symptoms of muscle disease, and their muscle lacks specific pathological changes. A biochemical marker for this myopathy has not previously been available; we found activity of adenylate cyclase and content of cyclic AMP to be abnormally high in skeletal muscle. Secondary modification of protein phosphorylation could explain observed abnormalities of phosphorylase activation and sarcoplasmic reticulum function.

Authors

J H Willner, C G Cerri, D S Wood

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Citations to this article (18)

Title and authors Publication Year
Skeletal muscle disorders as risk factors for type 2 diabetes
Tammineni ER, Manno C, Oza G, Figueroa L 		Molecular and cellular endocrinology 2025
Effects of Theophylline on Anesthetized Malignant Hyperthermia-Susceptible Pigs
M Fiege, R Weisshorn, K Kolodzie, F Wappler, MU Gerbershagen 		Journal of Biomedicine and Biotechnology 2011
Malignant Hyperthermia
BW Brandom 		Smith s Anesthesia for Infants and Children 2006
Phosphodiesterase-III-inhibition with amrinone leads to contracture development in skeletal muscle preparations of malignant hyperthermia susceptible swine
M Fiege, F Wappler, R Weisshorn, MU Gerbershagen, K Kolodzie, JS Esch 		European Journal of Anaesthesiology 2005
In Vitro and In Vivo Effects of the Phosphodiesterase-III Inhibitor Enoximone on Malignant Hyperthermia–susceptible Swine
M Fiege, F Wappler, R Weisshorn, MU Gerbershagen, K Kolodzie, JS Esch 		Anesthesiology 2003
Rhabdomyolysis following Cardiopulmonary Bypass and Treatment with Enoximone in a Patient Susceptible to Malignant Hyperthermia
FC Riess, M Fiege, S Moshar, H Bergmann, N Bleese, J Kormann, R Weihorn, F Wappler 		Anesthesiology 2001
Effects of the phosphodiesterase-III inhibitor enoximone on skeletal muscle specimens from malignant hyperthermia susceptible patients
M Fiege, F Wappler, J Scholz, R Weisshorn, V Richthofen, JS Esch 		Journal of Clinical Anesthesia 2000
Metabolic response to exercise in malignant hyperthermia-sensitive patients measured by31P magnetic resonance spectroscopy
DW Webster, T Thompson, DR Gravelle, MJ Laschuk, AA Driedger 		Magnetic Resonance in Medicine 1990
Calcium regulation in muscle diseases; the influence of innervation and activity
A Martonosi 		Biochimica et Biophysica Acta (BBA) - General Subjects 1989
Stress-induced malignant hyperthermia in a head-injured patient
T Feuerman, GF Gade, R Reynolds 		Journal of Neurosurgery 1988
Skeletal muscle contraction characteristicsin vivoin malignant hyperthermia susceptible subjects
E Bäckman, C Lennmarken, H Rutberg, KG Henriksson 		Acta Neurologica Scandinavica 1988
Skeletal muscle sarcolemma in malignant hyperthermia: evidence for a defect in calcium regulation
JR Mickelson, JA Ross, RJ Hyslop, EM Gallant, CF Louis 		Biochimica et Biophysica Acta (BBA) - Biomembranes 1987
Abnormal relaxation rates in subjects susceptible to malignant hyperthermia
C Lennmarken, H Rutberg, KG Henriksson 		Acta Neurologica Scandinavica 1987
Calmodulin in porcine malignant hyperpyrexia
SP Collins, MD White, MA Denborough 		International Journal of Biochemistry 1987
Porcine malignant hyperthermia susceptibility: increased calcium-sequestering activity of skeletal muscle sarcoplasmic reticulum
PJ O'Brien 		Canadian journal of veterinary research = Revue canadienne de recherche vétérinaire 1986
Clinical Implications of Guanine Nucleotide–Binding Proteins as Receptor–Effector Couplers
JS Flier, LH Underhill, AM Spiegel, P Gierschik, MA Levine, RW Downs 		New England Journal of Medicine 1985
Myoadenylate deaminase deficiency and malignant hyperthermia susceptibility: Is there a relationship?
WN Fishbein, SM Muldoon, PA Deuster, VW Armbrustmacher 		Biochemical Medicine 1985
Membrane Fluidity
M Kates, LA Manson 		1984

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