To increase our understanding of the pathophysiology of reflux esophagitis, we sought the early sequence of changes in mucosal structure and function in acutely acid-damage rabbit esophagus. Using a perfused catheter technique esophageal potential difference (PD) profiles were obtained in anesthetized rabbits before, during, and after perfusion of the lower one-half of the esophagus with phosphate-buffered saline or 80 mM NaCl. When acid perfusion reduced the lower esophageal PD by 40-50% or 80-100% of the initial values, the esophagus was removed, sectioned, and the mucosa studied with light microscopy, transmission electron microscopy, and Ussing chamber technique for evaluation of sodium and mannitol transport. The earlier stage of acid damage (PD 40-50%) was associated with reduced mucosal resistance fom 2,180 +/- 199 to 673 +/- 157 ohm cm2 and increased passive transport of sodium (0.10 +/- 0.06 to 1.82 +/- 0.48 microeq/h.cm2) and mannitol (0.008 +/- 0.003 to 0.051 +/- 0.012 microM/h.cm2) (p less than 0.05). There was no significant change in shirt circuit current (0.35 +/- 0.05 to 0.35 +/- 0.04) or net sodium transport (0.32 +/- 0.06 to 0.37 +/- 0.12) at this stage, and the only morphologic finding was dilated intercellular spaces on electron microscopy. The later stage of acid damage (PD 80-100%) exhibited a further reduction in resistance to 299 +/- 65 ohm.cm2 (p less than 0.05), a finding now accompanied by a reduction in short circuit current (0.35 +/- 0.05 to 0.21 +/- 0.04 microeq/h.cm2) and complete inhibition of net sodium transport (0.32 +/- 0.06 to 0.01 +/- 0.13) (p less than 0.05). Morphologic studies at this time revealed cellular necrosis, edema, and vesicle formation in the stratum spinosum. Both gross mucosal changes and transmural necrosis were notably absent. When esophageal perfusion was performed with a combination of acid (80 mM HCl-80 mM NaCl) and pepsin (100 microgram/ml), the morphologic and physiologic findings were essentially the same as with acid alone; however, the time of perfusion to reach either the 50 or 100% reduction in PD was shortened. The findings in this model can be explained on an initial increase in cellular and/or paracellular permeability followed by inhibition of active sodium transport. The resulting loss of osmolar regulation leads to cell necrosis in the stratum spinosum.
R C Orlando, D W Powell, C N Carney
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The epithelial barrier theory and its associated diseases
Sun N, Ogulur I, Mitamura Y, Yazici D, Pat Y, Bu X, Li M, Zhu X, Babayev H, Ardicli S, Ardicli O, D'Avino P, Kiykim A, Sokolowska M, van de Veen W, Weidmann L, Akdis D, Ozdemir BG, Brüggen MC, Biedermann L, Straumann A, Kreienbühl A, Guttman\u2010Yassky E, Santos AF, Del Giacco S, Traidl\u2010Hoffmann C, Jackson DJ, Wang D, Lauerma A, Breiteneder H, Zhang L, O'Mahony L, Pfaar O, O'Hehir R, Eiwegger T, Fokkens WJ, Cabanillas B, Ozdemir C, Kistler W, Bayik M, Nadeau KC, Torres MJ, Akdis M, Jutel M, Agache I, Akdis CA |
Allergy | 2024 |
NF-κB: A novel therapeutic pathway for gastroesophageal reflux disease?
Zhang ML, Ran LQ, Wu MJ, Jia QC, Qin ZM, Peng YG |
World journal of clinical cases | 2022 |
Protective and regenerative effects of a novel medical device against esophageal mucosal damage using in vitro and ex vivo models
C Agostinis, F Bossi, A Mangogna, A Balduit, M Pacor, E Giacomello, B Belmonte, D Greco, V Rodolico, D Voinovich, FD Seta, G Ricci, R Bulla |
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie | 2020 |
Pathophysiology and treatment options for gastroesophageal reflux disease: looking beyond acid
P Sharma, R Yadlapati |
Annals of the New York Academy of Sciences | 2020 |
OEsophageal Ion Transport Mechanisms and Significance Under Pathological Conditions
E Becskeházi, MM Korsós, B Erőss, P Hegyi, V Venglovecz |
Frontiers in physiology | 2020 |
Ussing Chamber Methods to Study the Esophageal Epithelial Barrier
Solange M Abdulnour-Nakhoul, Nazih L Nakhoul |
Methods in molecular biology (Clifton, N.J.) | 2020 |
Pathophysiology and treatment options for gastroesophageal reflux disease: looking beyond acid.
Sharma P, Yadlapati R |
Annals of the New York Academy of Sciences | 2020 |
Esophageal Baseline Impedance Reflects Mucosal Integrity and Predicts Symptomatic Outcome With Proton Pump Inhibitor Treatment
C Xie, D Sifrim, Y Li, M Chen, Y Xiao |
Journal of Neurogastroenterology and Motility | 2018 |
A severe case of epigastric pain, diarrhea and coffee ground vomitus
C Marinucci, F Zardo, A Musso, P Strignano, SM di Cella, M Porta |
Internal and Emergency Medicine | 2018 |
A weakly acidic solution containing deoxycholic acid induces esophageal epithelial apoptosis and impairs integrity in an in vivo perfusion rabbit model
NA Pardon, M Vicario, H Vanheel, T Vanuytsel, LJ Ceulemans, M Vieth, M Jimenez, J Tack, R Farré |
AJP Gastrointestinal and Liver Physiology | 2016 |
Role of ion transporters in the bile acid-induced esophageal injury
D Laczkó, A Rosztóczy, K Birkás, M Katona, Z Rakonczay, L Tiszlavicz, R Róka, T Wittmann, P Hegyi, V Venglovecz |
AJP Gastrointestinal and Liver Physiology | 2016 |
Bile Salts at Low pH Cause Dilation of Intercellular Spaces in In Vitro Stratified Primary Esophageal Cells, Possibly by Modulating Wnt Signaling
S Ghatak, M Reveiller, L Toia, AI Ivanov, Z Zhou, EM Redmond, TE Godfrey, JH Peters |
Journal of Gastrointestinal Surgery | 2015 |
Estrogen Enhances Esophageal Barrier Function by Potentiating Occludin Expression
J Honda, K Iijima, K Asanuma, N Ara, T Shiroki, Y Kondo, W Hatta, K Uno, N Asano, T Koike, T Shimosegawa |
Digestive Diseases and Sciences | 2015 |
Esophageal Mucosal Integrity in Nonerosive Reflux Disease:
P Woodland, D Sifrim |
Journal of Clinical Gastroenterology | 2014 |
Medical Treatments of GERD
MF Vela |
Gastroenterology Clinics of North America | 2014 |
Mucosal Impedance Discriminates GERD From Non-GERD Conditions
F Ates, ES Yuksel, T Higginbotham, JC Slaughter, J Mabary, RT Kavitt, CG Garrett, D Francis, MF Vaezi |
Gastroenterology | 2014 |
Dilated Intercellular Spaces in Eosinophilic Esophagitis:
A Ravelli, V Villanacci, M Cadei, M Fuoti, G Gennati, M Salemme |
2014 | |
Hypersensitivity to acid is associated with impaired esophageal mucosal integrity in patients with gastroesophageal reflux disease with and without esophagitis
PW Weijenborg, AJ Smout, C Verseijden, HA van Veen, J Verheij, WJ de Jonge, AJ Bredenoord |
AJP Gastrointestinal and Liver Physiology | 2014 |
Pathophysiology of gastro-esophageal reflux disease: a role for mucosa integrity?
R Farré |
Neurogastroenterology & Motility | 2013 |
Tissue resistance in the normal and diseased esophagus: Esophageal tissue resistance
AM Bellizzi, G Nardone, D Compare, S Bor, D Capanoglu, R Farré, H Neumann, MF Neurath, M Vieth, H Chen, X Chen |
Annals of the New York Academy of Sciences | 2013 |
Gastroesophageal reflux activates the NF-κB pathway and impairs esophageal barrier function in mice
Y Fang, H Chen, Y Hu, Z Djukic, W Tevebaugh, NJ Shaheen, RC Orlando, J Hu, X Chen |
AJP Gastrointestinal and Liver Physiology | 2013 |
Duodenogastroesophageal Reflux
D Sifrim, R Penagini |
The Esophagus Richter/The Esophagus | 2012 |
Esophageal Epithelial Resistance
RC Orlando |
The Esophagus Richter/The Esophagus | 2012 |
Use of Direct, Endoscopic-Guided Measurements of Mucosal Impedance in Diagnosis of Gastroesophageal Reflux Disease
ES Yuksel, T Higginbotham, JC Slaughter, J Mabary, RT Kavitt, CG Garrett, MF Vaezi |
Clinical Gastroenterology and Hepatology | 2012 |
Toll-like receptor 3 signaling enables human esophageal epithelial cells to sense endogenous danger signals released by necrotic cells
DM Lim, ML Wang |
AJP Gastrointestinal and Liver Physiology | 2011 |
Role of E-cadherin in the Pathogenesis of Gastroesophageal Reflux Disease
B Jovov, J Que, NA Tobey, Z Djukic, BL Hogan, RC Orlando |
The American Journal of Gastroenterology | 2011 |
The mechanism of MAP kinase activation under acidic condition in feline esophageal smooth muscle cells
SY Park, YJ Lee, Y Min, HR Kim, JH Jeong, UD Sohn |
Archives of Pharmacal Research | 2011 |
Acid-induced COX-2 expression and prostaglandin E2 production via activation of ERK1/2 and p38 MAPK in cultured feline esophageal smooth muscle cells
JG Woo, SY Park, JC Lim, MJ Joo, HR Kim, UD Sohn |
Archives of Pharmacal Research | 2011 |
Simulated reflux decreases vocal fold epithelial barrier resistance
E Erickson, M Sivasankar |
The Laryngoscope | 2010 |
Viewpoints on Acid-Induced Inflammatory Mediators in Esophageal Mucosa
KM Harnett, F Rieder, J Behar, P Biancani |
Journal of Neurogastroenterology and Motility | 2010 |
A Case of Acute Esophageal Necrosis with Gastric Outlet Obstruction
IK Kim, JS Kim, IS Song |
The Korean Journal of Gastroenterology | 2010 |
Refractory Heartburn: Comparison of Intercellular Space Diameter in Documented GERD vs. Functional Heartburn
MF Vela, BM Craft, N Sharma, J Freeman, D Hazen-Martin |
The American Journal of Gastroenterology | 2010 |
Factors influencing intercellular spaces in the rat esophageal epithelium
DH Zhang, LY Zhou, XY Dong, RL Cui, Y Xue, SR Lin |
World journal of gastroenterology : WJG | 2010 |
Acute oesophageal necrosis: A case report and review of the literature
A Day, M Sayegh |
International Journal of Surgery | 2010 |
HCl-induced inflammatory mediators in esophageal mucosa increase migration and production of H 2 O 2 by peripheral blood leukocytes
J Ma, A Altomare, S la Monte, M Tong, F Rieder, C Fiocchi, J Behar, H Shindou, P Biancani, KM Harnett |
AJP Gastrointestinal and Liver Physiology | 2010 |
Gastroesophageal Reflux Might Cause Esophagitis Through a Cytokine-Mediated Mechanism Rather Than Caustic Acid Injury
RF Souza, X Huo, V Mittal, CM Schuler, SW Carmack, HY Zhang, X Zhang, C Yu, K Hormi–Carver, RM Genta, SJ Spechler |
Gastroenterology | 2009 |
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
Emerging Concepts of Bile Reflux in the Constellation of Gastroesophageal Reflux Disease
WK Kauer, HJ Stein |
Journal of Gastrointestinal Surgery | 2009 |
Dilated intercellular spaces as a marker of GERD
LA Orlando, RC Orlando |
Current Gastroenterology Reports | 2009 |
Experimental oesophagitis in the rat is associated with decreased voluntary movement
miwa, oshima, sakurai, tomita, matsumoto, iizuka, koseki |
Neurogastroenterology & Motility | 2009 |
Diagnosing Gastroesophageal Reflux Disease
DS Allende, LM Yerian |
Advances in Anatomic Pathology | 2009 |
Reactive nitrogen oxide species induce dilatation of the intercellular space of rat esophagus
H Ito, K Iijima, N Ara, K Asanuma, H Endo, N Asano, T Koike, Y Abe, A Imatani, T Shimosegawa |
Scandinavian Journal of Gastroenterology | 2009 |
Nonerosive reflux disease: A pathophysiologic perspective
JD Long, RC Orlando |
Current Gastroenterology Reports | 2008 |
Esophageal Dilated Intercellular Spaces (DIS) and Nonerosive Reflux Disease
H Malenstein, R Farré, D Sifrim |
The American Journal of Gastroenterology | 2008 |
Pathophysiology of Gastroesophageal Reflux Disease
RC Orlando |
Journal of Clinical Gastroenterology | 2008 |
Mechanisms of heartburn
D Ang, D Sifrim, J Tack |
Nature Clinical Practice Gastroenterology & Hepatology | 2008 |
Physicochemical basis for dilated intercellular spaces in non-erosive acid-damaged rabbit esophageal epithelium
NA Tobey, TM Gambling, XC Vanegas, JL Carson, RC Orlando |
Diseases of the Esophagus | 2008 |
Histopathologic Features of Eosinophilic Esophagitis
MH Collins |
Gastrointestinal Endoscopy Clinics of North America | 2008 |
A Pilot Study of Efficacy and Safety of Continuous Intravenous Infusion of Pantoprazole in the Treatment of Severe Erosive Esophagitis
Q Cai, M Barrie, H Olejeme, MD Rosenberg |
Digestive Diseases and Sciences | 2007 |
Esophageal Damage and Repair in GERD
RC Orlando |
Journal of Clinical Gastroenterology | 2007 |
Dilated intercellular spaces and acid reflux at the distal and proximal oesophagus in patients with non-erosive gastro-oesophageal reflux disease
R Caviglia, M Ribolsi, M Gentile, C Rabitti, S Emerenziani, MP Guarino, T Petitti, M Cicala |
Alimentary Pharmacology & Therapeutics | 2007 |
Electrical parameters and ion species for active transport in human esophageal stratified squamous epithelium and Barrett's specialized columnar epithelium
NA Tobey, CM Argote, XC Vanegas, W Barlow, RC Orlando |
AJP Gastrointestinal and Liver Physiology | 2007 |
Effect of luminal acidity on the apical cation channel in rabbit esophageal epithelium
NA Tobey, CM Argote, MS Awayda, XC Vanegas, RC Orlando |
AJP Gastrointestinal and Liver Physiology | 2007 |
Free radical production in the esophago-gastro-duodenal mucosa in response to acid and bile
L Boni, A Benevento, SM Shimi, A Cuschieri |
Diseases of the Esophagus | 2006 |
Dilated Intercellular Spaces
AM Ravelli, V Villanacci, N Ruzzenenti, P Grigolato, P Tobanelli, C Klersy, G Rindi |
Journal of Pediatric Gastroenterology and Nutrition | 2006 |
Acid Challenge to the Human Esophageal Mucosa: Effects on Epithelial Architecture in Health and Disease
M Bove, M Vieth, F Dombrowski, L Ny, M Ruth, L Lundell |
Digestive Diseases and Sciences | 2005 |
The pathogenesis of heartburn in nonerosive reflux disease: A unifying hypothesis
WJ Barlow, RC Orlando |
Gastroenterology | 2005 |
ACUTE ESOPHAGEAL NECROSIS
M Carneiro, M Lescano, L Romanello, J Modena, F Carneiro, L Ramalho, A Martinelli, A Franca |
Digestive Endoscopy | 2005 |
Dilated Intercellular Spaces of Esophageal Epithelium in Nonerosive Reflux Disease Patients with Physiological Esophageal Acid Exposure
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The American Journal of Gastroenterology | 2005 |
Effect of topical esophageal acidification on salivary secretion: Identification of the mechanism of action
A Shafik, O El-Sibai, AA Shafik, R Mostafa |
Journal of Gastroenterology and Hepatology | 2005 |
Bile Reflux in the Constellation of Gastroesophageal Reflux Disease
WK Kauer, HJ Stein |
Thoracic Surgery Clinics | 2005 |
Acute esophageal necrosis caused by alcohol abuse
T Endo |
World journal of gastroenterology : WJG | 2005 |
How to Make a Barrett Esophagus: Pathophysiology of Columnar Metaplasia of the Esophagus
PG Guillem |
Digestive Diseases and Sciences | 2005 |
Acid Challenge to the Esophageal Mucosa: Effects on Local Nitric Oxide Formation and Its Relation to Epithelial Functions
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Digestive Diseases and Sciences | 2005 |
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Endo T, Sakamoto J, Sato K, Takimoto M, Shimaya K, Mikami T, Munakata A, Shimoyama T, Fukuda S |
World Journal of Gastroenterology | 2005 |
Stretta procedure and esophageal sensitivity
J Tack |
Gastroenterology | 2004 |
Dilated Intercellular Spaces and Shunt Permeability in Nonerosive Acid-Damaged Esophageal Epithelium
NA Tobey, SS Hosseini, CM Argote, AM Dobrucali, MS Awayda, RC Orlando |
The American Journal of Gastroenterology | 2004 |
Acute esophageal necrosis and liver pathology, a rare combination
AM Khan |
World journal of gastroenterology : WJG | 2004 |
Acute esophageal necrosis and liver pathology, a rare combination.
Khan AM, Hundal R, Ramaswamy V, Korsten M, Dhuper S |
World Journal of Gastroenterology | 2004 |
Effects of hydrochloric, acetic, butyric, and propionic acids on pathogenesis of ulcers in the nonglandular portion of the stomach of horses
JA Nadeau, FM Andrews, CS Patton, RA Argenzio, AG Mathew, AM Saxton |
American Journal of Veterinary Research | 2003 |
Direct measurement of acid permeation into rat oesophagus
S Tanaka, S Chu, M Hirokawa, MH Montrose, JD Kaunitz |
Gut | 2003 |
Effect of hydrochloric acid, pepsin, or taurocholate on bioelectric properties of gastric squamous mucosa in horses
TV Widenhouse, GD Lester, AM Merritt |
American Journal of Veterinary Research | 2002 |
Effect of acid perfusion on passive electrophysiological properties of rabbit esophagus in vivo
Ingemar Jacobson, Nadereh Poorkhalkali, Ann-Cathrine Jönsson-Rylander, Roy C Orlando |
Digestive Diseases and Sciences | 2002 |
The role of pepsin in acid injury to esophageal epithelium
NA Tobey, SS Hosseini, C Caymaz-Bor, HR Wyatt, GS Orlando, RC Orlando |
The American Journal of Gastroenterology | 2001 |
Increased taurine content in esophageal mucosa of children affected by gastroesophageal reflux
P D'Eufemia, G Corrado, R Finocchiaro, M Celli, M Cavaliere, P Troiani, J Tote, E Cardi, O Giardini |
Digestive Diseases and Sciences | 2001 |
Mechanisms of reflux-induced epithelial injuries in the esophagus
RC Orlando |
The American Journal of Medicine | 2000 |
Area under pH 4: a more sensitive parameter for the quantitative analysis of esophageal acid exposure in adults
M Dinelli, S Passaretti, I Francia, D Fossati, A Tittobello |
The American Journal of Gastroenterology | 1999 |
Comparative pathophysiology of nonglandular ulcer disease: a review of experimental studies
RA Argenzio |
Equine Veterinary Journal | 1999 |
Role of duodenal reflux in nonglandular gastric ulcer disease of the mature horse
HM Berschneider, AT Blikslager, MC Roberts |
Equine Veterinary Journal | 1999 |
Acid and the esophagus
DM McCarthy |
The Yale journal of biology and medicine | 1999 |
Acute esophageal necrosis: report of two cases and a review of the literature
BE Lacy, A Toor, SP Bensen, RI Rothstein, Y Maheshwari |
Gastrointestinal Endoscopy | 1999 |
Effect of heat stress on rabbit esophageal epithelium
NA Tobey, D Sikka, E Marten, C Caymaz-Bor, SS Hosseini, RC Orlando |
AJP Gastrointestinal and Liver Physiology | 1999 |
Acute acid exposure increases rabbit esophageal cell proliferation
DR Carpizo, AJ Reaka, WR Glaws, N Pooley, L Schmidt, AG Halline, JL Goldstein, TJ Layden |
Journal of Laboratory and Clinical Medicine | 1998 |
Helicobacter pylori in gastro-oesophageal reflux disease: causal agent, independent or protective factor?
J Labenz, P Malfertheiner |
Gut | 1997 |
The Influence of Circulatory and Gut Luminal Challenges on Bidirectional Intestinal Barrier Permeability in Rats
ZW Sun, XD Wang, XM Deng, R Wallen, L Gefors, E Hallberg, R Andersson |
Scandinavian Journal of Gastroenterology | 1997 |
Gastrointestinale Funktionsstörungen
KH Fuchs, HJ Stein, A Thiede |
1997 | |
Bidirectional small intestinal permeability changes to different-sized molecules after HCl-induced injury in the rat
P D Lundin, B R Weström, N Pantzar, B W Karlsson |
Digestive Diseases and Sciences | 1997 |
Effect of HCl on transmembrane potentials and intracellular pH in rabbit esophageal epithelium
WE Khalbuss, CG Marousis, M Subramanyam, RC Orlando |
Gastroenterology | 1995 |
Role of acid and duodenogastric reflux in esophageal mucosal injury: A review of animal and human studies
MF Vaezi, S Singh, JE Richter |
Gastroenterology | 1995 |
HCl-induced cell edema in rabbit esophageal epithelium: A bumetanide-sensitive process
NA Tobey, EJ Cragoe, RC Orlando |
Gastroenterology | 1995 |
A comparison of membrane enzymes of human and pig oesophagus; the pig oesophagus is a good model for studies of the gullet in man
KN Christie, C Thomson, D Hopwood |
The Histochemical Journal | 1995 |
A comparative study of cisapride and ranitidine at controlling oesophageal acid exposure in erosive oesophagitis
P Pouderoux, PJ Kahrilas |
Alimentary Pharmacology & Therapeutics | 1995 |
The Pathophysiology of Gastro-oesophageal Reflux Disease: An Overview
JP Galmiche, J Janssens |
Scandinavian Journal of Gastroenterology | 1995 |
Roles of Gastric Acid and pH in the Pathogenesis of Gastro-Oesophageal Reflux Disease
J Dent |
Scandinavian Journal of Gastroenterology | 1994 |
Rabbit esophageal cells show regulatory volume decrease: Ionic basis and effect of pH
JC Snow, JL Goldstein, LN Schmidt, P Lisitza, TJ Layden |
Gastroenterology | 1993 |
Mechanisms of HCI-Induced lowering of intracellular pH in rabbit esophageal epithelial cells
NA Tobey, SP Reddy, TO Keku, EJ Cragoe, RC Orlando |
Gastroenterology | 1993 |
Rabbit esophageal cells possess K+ channels: Effect of hyposmotic stress on channel activity
JL Goldstein, BG Fogelson, JC Snow, LN Schmidt, H Mozwecz, TJ Layden |
Gastroenterology | 1993 |
BILE ACIDS DO NOT MODIFY THE EFFECTS OF PEPSIN ON THE FINE STRUCTURE OF HUMAN OESOPHAGEAL EPITHELIUM
DC Gotley, B Flaks, MJ Cooper |
ANZ Journal of Surgery | 1992 |
Barriers to paracellular permeability in rabbit esophageal epithelium
RC Orlando, ER Lacy, NA Tobey, K Cowart |
Gastroenterology | 1992 |
Microvascular permeability increases early in the course of acid-induced esophageal injury
FG Zijlstra, TT Hynna-Liepert, PK Dinda, IT Beck, WG Paterson |
Gastroenterology | 1991 |
Mechanisms of acid injury to rabbit esophageal epithelium
NA Tobey, RC Orlando |
Gastroenterology | 1991 |
Mechanisms of acid damage to oesophageal epithelium: role of the paracellular pathway
RC Orlando |
Journal of Internal Medicine | 1990 |
Rabbit esophageal cells possess an Na+,H+ antiport
TJ Layden, LM Agnone, LN Schmidt, B Hakim, JL Goldstein |
Gastroenterology | 1990 |
Why Does Sucralfate Improve Healing in Reflux Esophagitis?: The Role of Sucrose Octasulfate
RC Orlando, NA Tobey |
Scandinavian Journal of Gastroenterology | 1990 |
Esophageal Mucosal Resistance
JL Goldstein, PK Schlesinger, HL Mozwecz, TJ Layden |
Gastroenterology Clinics of North America | 1990 |
Nonsteroidal antiinflammatory drugs and esophageal injury
EL Semble, WC Wu, DO Castell |
Seminars in Arthritis and Rheumatism | 1989 |
Serosal bicarbonate protects against acid injury to rabbit esophagus
NA Tobey, DW Powell, VJ Schreiner, RC Orlando |
Gastroenterology | 1989 |
In vivo alkaline secretion by mammalian esophagus
BH Hamilton, RC Orlando |
Gastroenterology | 1989 |
Aetiology, Pathogenesis, and Clinical Manifestations of Gastro-oesophageal Reflux Disease
JR Bennett |
Scandinavian Journal of Gastroenterology | 1988 |
MORPHOLOGICAL CHANGES CAUSED BY EXPOSURE OF RABBIT OESOPHAGEAL MUCOSA TO HYDROCHLORIC ACID AND SODIUM TAUROCHOLATE
GK Kiroff, TM Mukerjhee, B Dixon, PG Devitt, GG Jamieson |
ANZ Journal of Surgery | 1987 |
Cytoprotection by Sucralfate in Acid-exposed Esophagus: A Review
RC Orlando |
Scandinavian Journal of Gastroenterology | 1987 |
Mucosal protection by sucralfate and its components in acid-exposed rabbit esophagus
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Gastroenterology | 1987 |
Effect of cigarette smoke on esophageal epithelium of the rabbit
RC Orlando, JC Bryson, DW Powell |
Gastroenterology | 1986 |
Barrett's oesophagus
TP Hennessy |
British Journal of Surgery | 1985 |
Barrett's Esophagus: Clinical, Endoscopic, Histologic, Manometric, and Electrical Potential Difference Characteristics
KJ Herlihy, RC Orlando, JC Bryson, EM Bozymski, CN Carney, DW Powell |
Gastroenterology | 1984 |
Alkaline esophagitis: A comparison of the ability of components of gastroduodenal contents to injure the rabbit esophagus
KD Lillemoe, LF Johnson, JW Harmon |
Gastroenterology | 1983 |
Esophageal Potential Difference Measurements in Esophageal Disease
RC Orlando, DW Powell, JC Bryson, HB Kinard, CN Carney, JD Jones, EM Bozymski |
Gastroenterology | 1982 |
The Esophagus
FJ Ingelfinger |
Gastroenterology | 1961 |