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Citations to this article

In vivo comparison of cerebral tissue PO2 and cytochrome aa3 reduction-oxidation state in cats during hemorrhagic shock.
K Kariman, … , S R Burns, H A Saltzman
K Kariman, … , S R Burns, H A Saltzman
Published July 1, 1981
Citation Information: J Clin Invest. 1981;68(1):21-27. https://doi.org/10.1172/JCI110237.
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Research Article

In vivo comparison of cerebral tissue PO2 and cytochrome aa3 reduction-oxidation state in cats during hemorrhagic shock.

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Abstract

To assess the adequacy of oxygen availability and utilization within the cerebral cortex in vivo, we have measured the partial pressure of oxygen in tissue (PtO2), as well as the reduction oxidation state of cytochrome c oxidase (cyt aa3) during shock induced by slow or rapid hemorrhage in anesthetized cats. PtO2 was measured with pyrenebutyric acid-generated fluorescence in cerebral cortical cells. Cyt aa3 redox state was measured by the absorption of monochromatic light at 605 nm absorption peak of the enzyme reflected from the same cortical field. The PtO2 remained within the normal range until either 30 +/- 1.5 ml blood/kg was removed or the mean arterial pressure fell by 70 +/- 5% of base line. Beyond either point, the PtO2 fell rapidly to a low value approximating zero. By contrast, the reduction of cyt aa3 began early when as little as 5 ml blood/kg was removed. Thereafter, the shift toward reduction was progressive and continuous with a slow rate at first and a rapid rate later. This accelerated rate of cyt aa3 reduction preceded the rapid fall of PtO2. We concluded that, under these experimental conditions, cyt aa3 reduction is a much earlier and more sensitive indicator of perturbed intracellular aerobic metabolism due to hemorrhage that is PtO2.

Authors

K Kariman, F G Hempel, F F Jöbsis, S R Burns, H A Saltzman

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Total citations by year

Year: 2013 2001 2000 1999 1996 1995 1994 1993 1991 1986 1985 1983 1982 Total
Citations: 1 1 1 1 1 1 1 2 1 1 3 1 1 16
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article (16)

Title and authors Publication Year
Monitoring Tissue Perfusion, Oxygenation, and Metabolism in Critically Ill Patients
NJ Ekbal, A Dyson, C Black, M Singer
Chest 2013
Cytochrome Spectroscopy in Scattering Suspensions Containing Mitochondria and Red Blood Cells
EL Hull, TH Foster
Applied Spectroscopy 2001
Escherichia coli endotoxin reduces cytochrome aa3 redox status in pig skeletal muscle:
AP Forget, J Mangalaboyi, S Mordon, B Guery, B Vallet, F Fourrier, C Chopin
Critical Care Medicine 2000
Redox status of cytochrome a,a3: A noninvasive indicator of dysoxia in regional hypoxic or ischemic hypoxia
BP Guery, J Mangalaboyi, P Menager, S Mordon, B Vallet, C Chopin
Critical Care Medicine 1999
Significance of elevated cytochrome aa3 in a state of endotoxemia in dogs
H Ogata, M Mishio, XX Luo, X Xu
Resuscitation 1996
Neurochemical Monitoring in the Intensive Care Unit
T Tsubokawa, A Marmarou, C Robertson, G Teasdale
1995
Physiological Aspects of Biosynthesis of Lignin Peroxidases by Phanerochaete chrysosporium
D Lestan, M Lestan, A Perdih
Applied and environmental microbiology 1994
Analysis of Fungal Pellets by UV-Visible Spectrum Diffuse Reflectance Spectroscopy
D Lestan, H Podgornik, A Perdih
Applied and environmental microbiology 1993
Mitochondrial Dysfunction
T Inoue, K Tagawa
Mitochondrial Dysfunction 1993
Cerebral oxygen monitoring with near infrared spectroscopy: Clinical application to neonates
JE Brazy
Journal of Clinical Monitoring 1991
Uncoupling effects of 2,4-dinitrophenol on electron transfer reactions and cell bioenergetics in rat brain in situ
K Kariman, B Chance, DS Burkhart, LA Bolinger
Brain Research 1986
Non-invasive in vivo spectrophotometric monitoring of brain cytochrome aa3 revisited
K Kariman, DS Burkhart
Brain Research 1985
Heme-copper relationship of cytochrome oxidase in rat brain
K Kariman, DS Burkhart
Biochemical and Biophysical Research Communications 1985
Evidence for Adenosine Triphosphate Degradation in Critically-Ill Patients
CM Grum, RH Simon, DR Dantzker, IH Fox
Chest 1985
Cytochrome a,a3 reoxidation. Early indicator of metabolic recovery from hemorrhagic shock in rats
K Kariman, FF Jöbsis, HA Saltzman
Journal of Clinical Investigation 1983
Effect of Acute Arterial Hypo- and Hypertension on Cerebrocortical NAD/NADH Redox State and Vascular Volume
E Dóra, AG Kovách
Journal of Cerebral Blood Flow & Metabolism 1982

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