Usage Information

Epidermal growth factor receptor number decreases during rat liver regeneration.
H S Earp, E J O'Keefe
H S Earp, E J O'Keefe
Published May 1, 1981
Citation Information: J Clin Invest. 1981;67(5):1580-1583. https://doi.org/10.1172/JCI110190.
View: Text | PDF
Rapid Publication

Epidermal growth factor receptor number decreases during rat liver regeneration.

Abstract

The potential role of epidermal growth factor (EGF) in the regulation of rat liver regeneration was examined by assessing the binding of 125I-EGF to hepatic membranes isolated at various times after partial hepatectomy. The results demonstrated a fall in 125I-EGF binding detectable as early as 8 h after partial hepatectomy. The nadir in EGF binding, less than 40% of that observed in sham-operated control rats, was seen 36 and 48 h after partial hepatectomy. Scatchard analysis showed that the decrease in binding capacity was due to a fall in receptor number. The specificity of the observed loss of EGF receptors was substantiated in parallel studies of 125I-insulin and 125I-wheat germ lectin binding; the binding of these ligands did not decrease appreciably during liver regeneration. The data are consistent with the hypothesis that EGF or a similar substance is one component of the complex humoral signal that regulates liver regeneration.

Authors

H S Earp, E J O'Keefe

×

Usage data is cumulative from January 2024 through January 2025.

Usage JCI PMC
Text version 90 1
PDF 50 23
Scanned page 118 5
Citation downloads 41 0
Totals 299 29
Total Views 328
(Click and drag on plot area to zoom in. Click legend items above to toggle)

Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

Various methods are used to distinguish robotic usage. For example, Google automatically scans articles to add to its search index and identifies itself as robotic; other services might not clearly identify themselves as robotic, or they are new or unknown as robotic. Because this activity can be misinterpreted as human readership, data may be re-processed periodically to reflect an improved understanding of robotic activity. Because of these factors, readers should consider usage information illustrative but subject to change.

Advertisement