Citations to this article
Citation Information: J Clin Invest. 1981;67(5):1500-1506. https://doi.org/10.1172/JCI110180.
Abstract
Prompted by recognition of the similar structures of riboflavin (vitamin B2), phenothiazine drugs, and tricyclic antidepressants, our studies sought to determine effects of drugs of these two types upon the conversion of riboflavin into its active coenzyme derivative, flavin adenine dinucleotide (FAD) in rat tissues. Chlorpromazine, a phenothiazine derivative, and imipramine and amitriptyline, both tricyclic antidepressants, each inhibited the incorporation of [14C]riboflavin into [14C]FAD in liver, cerebrum, cerebellum, and heart. A variety of psychoactive drugs structurally unrelated to riboflavin were ineffective. Chlorpromazine, imipramine, and amitriptyline in vitro inhibited hepatic flavokinase, the first of two enzymes in the conversion of riboflavin to FAD.
Authors
John Pinto, Yee Ping Huang, Richard S. Rivlin
Total citations by year
Citations to this article in year 2013 (2)
| Title and authors | Publication | Year |
|---|---|---|
|
Handbook of Vitamins, Fifth Edition
R Rucker, K Bauerly |
Handbook of Vitamins, Fifth Edition | 2013 |
|
Differentiation-dependent regulation of intestinal vitamin B 2 uptake: studies utilizing human-derived intestinal epithelial Caco-2 cells and native rat intestine
VS Subramanian, A Ghosal, SB Subramanya, C Lytle, HM Said |
AJP Gastrointestinal and Liver Physiology | 2013 |
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