In Vivo Effects of Protease Inhibitors on Chickens with Hereditary Muscular Dystrophy

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Abstract

Beginning on day 4 ex ovo, and every 3 d thereafter, genetically dystrophic Line 413 chickens were given intraperitoneal injections (4 mg/kg body wt) of a protease inhibitor, leupeptin, pepstatin, or antipain. Experimental chickens received protease inhibitors dissolved in a water:ethanol:dimethyl sulfoxide solution (50:40:10, vol:vol:vol). Control untreated animals received diluent injections.

Authors

Michael S. Hudecki, Catherine M. Pollina, Reid R. Heffner