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Immunological studies of aging. Decreased production of and response to T cell growth factor by lymphocytes from aged humans.

S Gillis, … , M Durante, M E Weksler

S Gillis, … , M Durante, M E Weksler

Published April 1, 1981
Citation Information: J Clin Invest. 1981;67(4):937-942. https://doi.org/10.1172/JCI110143.

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Expression of IFN-gamma in Cerebrovascular Endothelial Cells from Aged Mice YP Wei, M Kita, K Shinmura, XQ Yan, R Fukuyama, S Fushiki, J Imanishi	Journal of Interferon & Cytokine Research	2000
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The immune system in the elderly L Ginaldi, MD Martinis, A D’Ostilio, L Marini, MF Loreto, D Quaglino	Immunologic Research	1999
T cell immunosenescence in vitro and in vivo G Pawelec, W Wagner, M Adibzadeh, A Engel	Experimental Gerontology	1999
The influence of age and gender on serum dehydroepiandrosterone sulphate (DHEA-S), IL-6, IL-6 soluble receptor (IL-6 sR) and transforming growth factor beta 1 (TGF-beta1) levels in normal healthy blood donors DG Young, G Skibinski, JI Mason, K James	Clinical & Experimental Immunology	1999
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Aging and T-cell-mediated immunity B Chakravarti, GN Abraham	Mechanisms of Ageing and Development	1999
Age-related defects in Th1 and Th2 cytokine production by human T cells can be dissociated from altered frequencies of CD45RA+ and CD45RO+ T cell subsets CI Karanfilov, B Liu, CC Fox, RR Lakshmanan, RL Whisler	Mechanisms of Ageing and Development	1999
Age-related impairments in TCR/CD3 activation of ZAP-70 are associated with reduced tyrosine phosphorylations of ζ-chains and p59fyn/p56lck in human T cells RL Whisler, M Chen, B Liu, YG Newhouse	Mechanisms of Ageing and Development	1999
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CD28 Expression in T Cell Aging and Human Longevity N Boucher, T Dufeu-Duchesne, E Vicaut, D Farge, RB Effros, F Schächter	Experimental Gerontology	1998
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Cancer Chemotherapy in the Elderly I Sekine, H Fukuda, H Kunitoh, N Saijo	Japanese Journal of Clinical Oncology	1998
Chlamydia pneumoniae and its role in chronic obstructive pulmonary disease LC von Hertzen	Annals of Medicine	1998
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Effect of age on mitogen induced protein tyrosine phosphorylation in human T cell and its subsets: down-regulation of tyrosine phosphorylation of ZAP-70 B Chakravarti, DN Chakravarti, J Devecis, B Seshi, GN Abraham	Mechanisms of Ageing and Development	1998
Dehydroepiandrosterone synergizes with antioxidant supplements for immune restoration in old as well as retrovirus-infected mice S Jiang, J Lee, Z Zhang, P Inserra, D Solkoff, RR Watson	The Journal of Nutritional Biochemistry	1998
Phosphorylation and coupling of ζ-chains to activated T-cell receptor (TCR)/CD3 complexes from peripheral blood T-cells of elderly humans RL Whisler, CI Karanfilov, YG Newhouse, CC Fox, RR Lakshmanan, B Liu	Mechanisms of Ageing and Development	1998
Altered cytokine production in the elderly L Rink, I Cakman, H Kirchner	Mechanisms of Ageing and Development	1998
Age-related loss of immunoregulatory function in peripheral blood CD8 T cells GM Crisi, LZ Chen, C Huang, GJ Thorbecke	Mechanisms of Ageing and Development	1998
The biology of aging WB Ershler, DL Longo	Cancer	1997
Co-receptor and accessory regulation of B-cell antigen receptor signal transduction AM Buhl, JC Cambier	Immunological Reviews	1997
Failure of aged rats to accumulate eosinophils in allergic inflammation of the airway T Yagi, A Sato, H Hayakawa, K Ide	Journal of Allergy and Clinical Immunology	1997
Reductions in the Activation of ERK and JNK Are Associated with Decreased IL-2 Production in T Cells from Elderly Humans Stimulated by the TCR/CD3 Complex and Costimulatory Signals L Beiqing, KW Carle, RL Whisler	Cellular Immunology	1997
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ALLERGIC DISEASE IN AN AGING POPULATION A Montanaro	Immunology and Allergy Clinics of North America	1997
Promotion of interleukin-2 activity as a strategy for ‘rejuvenating’ geriatric immune function MF McCarty	Medical Hypotheses	1997
Exercise, free radical generation, and aging RA Fielding, M Meydani	Aging clinical and experimental research	1997
Effect of aging on cytokine production in normal and experimental systemic lupus erythematosus afflicted mice R Segal, M Dayan, A Globerson, B Habut, GM Shearer, E Mozes	Mechanisms of Ageing and Development	1997
T lymphocyte proliferative capability to defined stimuli and costimulatory CD28 pathway is not impaired in healthy centenarians P Sansoni, F Fagnoni, R Vescovini, M Mazzola, V Brianti, G Bologna, E Nigro, G Lavagetto, A Cossarizza, D Monti, C Franceschi, M Passeri	Mechanisms of Ageing and Development	1997
Influenza (H1N1)–ISCOMs enhance immune responses and protection in aged mice S Sambhara, S Woods, R Arpino, A Kurichh, A Tamane, KL Bengtsson, B Morein, B Underdown, M Klein, D Burt	Mechanisms of Ageing and Development	1997
Senescence and cytokines modulate the NK cell expression R Krishnaraj	Mechanisms of Ageing and Development	1997
Expression and catalytic activities of protein tyrosine kinases (PTKs) Fyn and Lck in peripheral blood T cells from elderly humans stimulated through the T cell receptor (TCR)/CD3 complex1This work was supported by United States Public Health Service Grant AG03763 from the National Institutes of Health.1 RL Whisler, SE Bagenstose, YG Newhouse, KW Carle	Mechanisms of Ageing and Development	1997
Age-related changes in CD4 T cells of T cell receptor transgenic mice L Haynes, PJ Linton, SL Swain	Mechanisms of Ageing and Development	1997
Macrophage prostaglandin production contributes to the age-associated decrease in T cell function which is reversed by the dietary antioxidant vitamin E AA Beharka, D Wu, SN Han, SN Meydani	Mechanisms of Ageing and Development	1997
IL-6, DHEA and the ageing process K James, N Premchand, A Skibinska, G Skibinski, M Nicol, JI Mason	Mechanisms of Ageing and Development	1997
Dysregulation of IL-10 production with aging: Possible linkage to the age-associated decline in DHEA and its sulfated derivative NF Spencer, SD Norton, LL Harrison, GZ Li, RA Daynes	Experimental Gerontology	1996
Cytokine production pathway in the elderly C Caruso, G Candore, D Cigna, G Lorenzo, G Sireci, F Dieli, A Salerno	Immunologic Research	1996
Exercise and Immunity: A Review with Emphasis on the Horse MT Hines, HC Schott, WM Bayly, AJ Leroux	Journal of Veterinary Internal Medicine	1996
Ultrastructural study of thymic microenvironment involution in aging mice B Nabarra, I Andrianarison	Experimental Gerontology	1996
The influence of age on the canine immune system EH Greeley, RD Kealy, JM Ballam, DF Lawler, M Segre	Veterinary Immunology and Immunopathology	1996
Age-dependent changes in the expression of dopamine receptor subtypes in human peripheral blood lymphocytes P Barili, E Bronzetti, L Felici, F Ferrante, A Ricci, D Zaccheo, F Amenta	Journal of Neuroimmunology	1996
Glutamine metabolism is changed in lymphocytes from aged rats AF Almeida, LF Rosa, R Curi	Physiology & Behavior	1996
Colorectal cancer—a multivariate analysis of prognostic factors U Wolters, H Stützer, HW Keller, U Schröder, H Pichlmaier	European Journal of Surgical Oncology (EJSO)	1996
The effect of age on hemopoiesis D Quaglino, L Ginaldi, N Furia, M Martinis	Aging clinical and experimental research	1996
Excessive apoptosis of mature T lymphocytes is a characteristic feature of human immune senescence MA Phelouzat, A Arbogast, T Laforge, RA Quadri, JJ Proust	Mechanisms of Ageing and Development	1996
Age-related tyrosine-specific protein phosphorylation defect in human T lymphocytes activated through CD3, CD4, CD8 or the IL-2 receptor RA Quadri, O Plastre, MA Phelouzat, A Arbogast, JJ Proust	Mechanisms of Ageing and Development	1996
In vitro T cell activation in elderly individuals: failure in CD69 and CD71 expression D Lio, G Candore, D Cigna, C D'Anna, GD Lorenzo, C Giordano, G Lucania, P Mansueto, M Melluso, MA Modica, C Caruso	Mechanisms of Ageing and Development	1996
The effect of age on the expression of Interleukin-2 MA Pahlavani, A Richardson	Mechanisms of Ageing and Development	1996
Influenza vaccination in the elderly R Morgan, D King	Postgraduate medical journal	1996
Molecular Gerontology SI Rattan, O Toussaint		1996
The Aging Immune System: Primer and Prospectus RA Miller	Science	1996
Aging and Haemopoiesis: Implications for Treatment with Haemopoietic Growth Factors GS Chatta, DC Dale	Drugs & Aging	1996
Cytokine production pathway in the elderly C Caruso, G Candore, D Cigna, GD Lorenzo, G Sireci, F Dieli, A Salerno	Immunologic Research	1996
Does DHEAS Restore Immune Competence in Aged Animals through Its Capacity to Function as a Natural Modulator of Peroxisome Activities?a NF Spencer, ME Poynter, JD Hennebold, HH Mu, RA Daynes	Annals of the New York Academy of Sciences	1995
Immunosenescence in Humans: Deterioration or Remodelling? C Franceschi, D Monti, D Barbieri, E Grassilli, L Troiano, S Salvioli, P Negro, M Capri, M Guido, R Azzi, P Sansoni, R Paganelli, U Fagiolo, G Baggio, S Donazzan, S Mariotti, S D'addato, A Gaddi, C Ortolani, A Cossarizza	International Reviews of Immunology	1995
Acute Respiratory Illness in Older Community Residents SL Hodder, AB Ford, PA FitzGibbon, PK Jones, ML Kumar, EA Mortimer	Journal of the American Geriatrics Society	1995
The Impact of Age on the Quality of Life in Persons with HIV Infection J Piette, TJ Wachtel, V Mor, K Mayer	Journal of Aging and Health	1995
Molecular and cell biological studies of ageing and their application to considerations of T lymphocyte immunosenescence G Pawelec	Mechanisms of Ageing and Development	1995
Role of immune response as determinant of tumor progression in function of host age in the B16 melanoma N Donin, J Sinai, M Michowitz, J Hiss, J Nordenberg, J Leibovici	Mechanisms of Ageing and Development	1995
Cytokine production and lymphocyte subpopulations in aged humans. An assessment during nocturnal sleep J Born, D Uthgenannt, C Dodt, D Nünninghoff, E Ringvolt, T Wagner, HL Fehm	Mechanisms of Ageing and Development	1995
Interrelationship of fever, immune response and aging in mice DC Norman, S Castle, RH Yamamura, TT Yoshikawa	Mechanisms of Ageing and Development	1995
Clinical immunology of aging H Fillit	Reviews in Clinical Gerontology	1994
Immune senescence ME Weksler	Annals of Neurology	1994
Effect of age on serum immunoglobulin G subclass antibody responses to inactivated influenza virus vaccine DC Powers	Journal of Medical Virology	1994
Modulating Effects of the Synthetic Thymic Dipeptide Pidotimod on the Immune System in the Aging Rat A Chiarenza, MP Iurato, N Barbera, L Lempereur, G Cantarella, U Scapagnini, R Bernardini	Pharmacology & Toxicology	1994
Age-related increase in the fraction of CD27-CD4+ T cells and IL-4 production as a feature of CD4+ T cell differentiation in vivo EW Nijhuis, EJ Remarque, B Hinloopen, TV der Pouw-Kraan, RA van Lier, GJ Ligthart, L Nagelkerken	Clinical & Experimental Immunology	1994
Ageing alters the competence of the immune system to control parasitic infection JW Albright, JF Albright	Immunology Letters	1994
Age-associated changes in human T cell phenotype and function DR Jackola, JK Ruger, RA Miller	Aging clinical and experimental research	1994
Handbook of B and T Lymphocytes DJ Cohen, PA Henkart	Handbook of B and T Lymphocytes	1994
Efficacy of an Influenza Hemagglutinin-Diphtheria Toxoid Conjugate Vaccine in Elderly Nursing Home Subjects During an Influenza Outbreak S Gravenstein, P Drinka, EH Duthie, BA Miller, CS Brown, M Hensley, R Circo, E Langer, WB Ershler	Journal of the American Geriatrics Society	1994
Advances in Psychoneuroimmunology I Berczi, J Szélenyi		1994
Immune senescence and adrenal steroids: immune dysregulation and the action of dehydroepiandrosterone (DHEA) in old animals ME Weksler	European Journal of Clinical Pharmacology	1993
Age-related effects in T cell activation and proliferation L Song, YH Kim, RK Chopra, JJ Proust, JE Nagel, AA Nordin, WH Adler	Experimental Gerontology	1993
Age distribution of histologic types of breast carcinoma H Stalsberg, DB Thomas	International Journal of Cancer	1993
Increased cytokine production in mononuclear cells of healthy elderly people U Fagiolo, A Cossarizza, E Scala, E Fanales-Belasio, C Ortolani, E Cozzi, D Monti, C Franceschi, R Paganelli	European Journal of Immunology	1993
Immunohistochemical and ultrastructural characterization of autoimmune sialoadenitis in aging BDF1mice K Fujiwara, Å Larsson, T Watanabe	Pathology International	1993
γ-Interferon, Interleukin-4 and Interleukin-6 In Vitro Production in Old Subjects G Candore, GD Lorenzo, M Melluso, D Cigna, AT Colucci, MA Modica, C Caruso	Autoimmunity	1993
Reversal of age-associated decline in immune response to Pnu-imune vaccine by supplementation with the steroid hormone dehydroepiandrosterone M Garg, S Bondada	Infection and immunity	1993
Immunohistochemical and ultrastructural characterization of autoimmune sialoadenitis in aging BDF 1 mice K Fujiwara, Å Larsson, T Watanabe	Pathology International	1993
Effect of vitamin E supplementation on cellular immune functions decreased with aging in spontaneously hypertensive rats S Moriguchi, K Maekawa, H Miwa, Y Kishino	Nutrition Research	1993
Investigations of the lymphokine system in elderly individuals J Sindermann, A Kruse, HJ Frercks, RM Schütz, H Kirchner	Mechanisms of Ageing and Development	1993
Age-dependent changes in transmembrane signalling: Identification of G proteins in human lymphocytes and polymorphonuclear leukocytes T Fulop, G Barabas, Z Varga, C József, S Csabina, S Szucs, I Seres, E Szikszay, Z Jeney, A Penyige	Cellular Signalling	1993
Nephrology and Urology in the Aged Patient DG Oreopoulos, MF Michelis, S Herschorn		1993
The Underlying Molecular, Cellular and Immunological Factors in Cancer and Aging SS Yang, HR Warner		1993
COMMUNITY-ACQUIRED PNEUMONIA IN THE ELDERLY PATIENT JT Granton, RF Grossman	Clinics in Chest Medicine	1993
IMMUNOLOGY OF THE AGING LUNG MR Gyetko, GB Toews	Clinics in Chest Medicine	1993
Immune Senescence: Mechanisms and Clinical Implications A Ben-Yehuda, ME Weksler	Cancer Investigation	1992
Alteration of cell cycle kinetics by reducing agents in human peripheral blood lymphocytes from adult and senescent donors M Kubbies	Cell Proliferation	1992
Explanations for reduced tumor proliferative capacity with age WB Ershler	Experimental Gerontology	1992
The impairment of natural killer function in the healthy aged is due to a postbinding deficient mechanism M Vitale, L Zamai, LM Neri, A Galanzi, A Facchini, R Rana, A Cataldi, S Papa	Cellular Immunology	1992
Zinc reverses the increased sensitivity of lymphocytes from aged subjects to the antiproliferative effect of prostaglandin E2 L Santos-Neto, CE Tosta, JG Dorea	Clinical Immunology and Immunopathology	1992
Long-term Consequences of 239 PuO 2 Exposure in Dogs: Persistent T Lymphocyte Dysfunction DR Davila, RA Guilmette, DE Bice, BA Muggenburg, DS Swafford, PJ Haley	International Journal of Radiation Biology	1992
Differential age-change in the numbers of CD4+CD45RA+ DC4+CD29+ T cell subsets in human peripheral blood M Utsuyama, K Hirokawa, C Kurashima, M Fukayama, T Inamatsu, K Suzuki, W Hashimoto, K Sato	Mechanisms of Ageing and Development	1992
Host Resistance and The Immune System A Ben-Yehuda, ME Weksler	Clinics in Geriatric Medicine	1992
Combination Therapies AL Goldstein, E Garaci		1992
Phorbol Myristate Acetate Corrects Impaired NK Function of Old Mice M Ghoneum, K Suzuki, S Gollapudi	Scandinavian Journal of Immunology	1991
Cellular immunosenescence: An overview T Makinodan, TJ Hahn, S McDougall, DT Yamaguchi, M Fang, A Iida-Klein	Experimental Gerontology	1991
Dietary modulation of the immune response in the aged SN Meydani	AGE	1991
Immunostimulatory Activity of Prothymosin-Alpha in Senescence D Marić, BD Janković, J Veljić	Annals of the New York Academy of Sciences	1991
Age-related changes in lymphokine production related to a decreased number of CD45RBhi CD4+ T cells L Nagelkerken, A Hertogh-Huijbregts, R Dobber, A Dräger	European Journal of Immunology	1991
Serum interleukin-2 levels in patients with dementia of the Alzheimer type E Esumi, S Araga, K Takahashi	Acta Neurologica Scandinavica	1991
Impaired responsiveness of IL-2 receptor-expressing T lymphocytes from aged mice ML Thoman	Cellular Immunology	1991
International Review of Cytology RA Miller	International Review of Cytology	1991
Loss of interleukin-2—Producing intestinal CD4+ T cells in inflammatory bowel disease K Kusugami, T Matsuura, GA West, KR Youngman, D Rachmilewitz, C Fiocchi	Gastroenterology	1991
Special Focus on the Biology of Aging VJ Cristofalo, MP Lawton		1991
The Effect of Aging on Host Defences: Implications for Therapy A Scordamaglia, G Ciprandi, F Indiveri, GW Canonica	Drugs & Aging	1991
Immunohistochemical Examination of Peyer's Patches in Senescence-Accelerated Mice H Yoshioka, T Takeda, K Higuchi, G Ohshio, T Miyake, T Sugiyama, T Kita	Autoimmunity	1990
The expression of granulocyte/macrophage colony-stimulating factor in activated mouse lymphocytes declines with age NS Cai, DD Li, HT Cheung, A Richardson	Cellular Immunology	1990
Kinetics of germinal center development in lymph nodes of young and aging immune mice AK Szakal, JK Taylor, JP Smith, MH Kosco, GF Burton, JJ Tew	The Anatomical Record	1990
Soluble Interleukin-2 Receptors and Auto Antibodies in the Serum of Healthy Elderly Individuals MN Manoussakis, ED Stavropoulos, GS Germanidis, CA Papasteriades, KL Garalea, A Dontas, HM Moutsopoulos	Autoimmunity	1990
Quantification of proliferative and suppressive responses of human T lymphocytes following ConA stimulation M Nikš, M Otto, B Bušová, J Štefanović	Journal of Immunological Methods	1990
Aging effect on the immune functions of murine gut-associated lymphoid tissues K Koyama, T Hosokawa, A Aoike	Developmental & Comparative Immunology	1990
Phosphatidylserine counteracts physiological and pharmacological suppression of humoral immune response V Guarcello, G Triolo, M Cioni, MC Morale, Z Farinella, U Scapagnini, B Marchetti	Immunopharmacology	1990
Immune dysfunction in the elderly: Effect of thymic hormone administration on several in vivo and in vitro immune function parameters U Fagiolo, A Amadori, F Borghesan, R Zamarchi, ML Veronese, G Silvestro, E Passarella, G Crepaldi	Aging clinical and experimental research	1990
Micronutrients and Immune Function in the Elderlya SN Meydani	Annals of the New York Academy of Sciences	1990
The Effect of Vitamin B 6 on the Immune Response of Healthy Elderlya SN Meydani, JD Ribaya-Mercado, RM Russell, N Sahyoun, FD Morrow, SN Gershoff	Annals of the New York Academy of Sciences	1990
Decreased specific antibody synthesis in old adults: Decreased potency of antigen-specific B cells with aging EA Burns, LG Lum, MC Seigneuret, BR Giddings, JS Goodwin	Mechanisms of Ageing and Development	1990
Biomedical Advances in Aging AL Goldstein		1990
Geriatric Medicine CK Cassel, DE Riesenberg, LB Sorensen, JR Walsh		1990
Antioxidant Nutrients and Immune Functions A Bendich, M Phillips, RP Tengerdy		1990
Diminished heat-shock protein synthesis following mitogen stimulation of lymphocytes from aged donors AE Faassen, JJ O'Leary, KJ Rodysill, N Bergh, HM Hallgren	Experimental Cell Research	1989
Reduced proliferation in T lymphocytes in aged humans is predominantly in the CD8+ subset, and is unrelated to defects in transmembrane signaling which are predominantly in the CD4+ subset A Grossmann, JA Ledbetter, PS Rabinovitch	Experimental Cell Research	1989
Aging and deffective lymphoid cell activation FD Coffman, S Cohen	Experimental Gerontology	1989
Defective control of cytoplasmic calcium concentration in T lymphocytes from old mice RA Miller, B Philosophe, I Ginis, G Weil, B Jacobson	Journal of Cellular Physiology	1989
Pgp-1hi T lymphocytes accumulate with age in mice and respond poorly to concanavalin A A Lerner, T Yamada, RA Miller	European Journal of Immunology	1989
Autoimmune abnormalities in a murine model of accelerated senescence H Yoshioka, H Yoshida, T Doi, E Muso, G Ohshio, K Higuchi, M Inada, T Miyake, T Kita, Y Hamashima	Clinical & Experimental Immunology	1989
Chromosomes of older humans are more prone to aminopterine-induced breakage D Esposito, G Fassina, P Szabo, PD Angelis, L Rodgers, M Weksler, M Siniscalco	Proceedings of the National Academy of Sciences	1989
Associations of genetics and sampling time with levels of interleukin-2 Activity KL Knudtson, SJ Lamont	Veterinary Immunology and Immunopathology	1989
Comparative mitogenic response of old and young Rhesus monkey T cells to lectin from Erythrina cristagalli EH Eylar, F Molina, C Quiñones, M Zapata, M Kessler	Immunology Letters	1989
Expression of interleukin 2 and the interleukin 2 receptor in aging rats NJ Holbrook, RK Chopra, MT McCoy, JE Nagel, DC Powers, WH Adler, EL Schneider	Cellular Immunology	1989
Effect of IL-2 in vitro on CTL generation in spleen cells of young and old mice: Asialo GM1+ cells are required for the apparent restoration of the CTL response ET Bloom, LF Kubota	Cellular Immunology	1989
In situ hybridization analysis of the age-associated decline in IL-2 mRNA expressing murine T cells TC Fong, T Makinodan	Cellular Immunology	1989
Comparison of mitogenic responses of young and old rhesus monkey T cells to lectins and interleukins 2 and 4 EH Eylar, F Molina, C Quinones, M Zapata, M Kessler	Cellular Immunology	1989
Interleukin 2 receptor expression by T cells in human aging FM Orson, CK Saadeh, DE Lewis, DL Nelson	Cellular Immunology	1989
Extremely low frequency pulsed electromagnetic fields increase interleukin-2 (IL-2) utilization and IL-2 receptor expression in mitogen-stimulated human lymphocytes from old subjects A Cossarizza, D Monti, F Bersani, R Paganelli, G Montagnani, R Cadossi, M Cantini, C Franceschi	FEBS Letters	1989
Intracellular mechanisms of lymphoid cell activation K Fresa, M Hameed, S Cohen	Clinical Immunology and Immunopathology	1989
Interleukin 2, interleukin 2 receptor, and interferon-γ synthesis and mRNA expression in phorbol myristate acetate and calcium lonophore A23187-stimulated T cells from elderly humans RK Chopra, NJ Holbrook, DC Powers, MT McCoy, WH Adler, JE Nagel	Clinical Immunology and Immunopathology	1989
An In Vitro Analogue of Immune Dysfunction with Altered Immunoglobulin Production in the Aged J Crawford, S Dates, LA Wolfe, HJ Cohen	Journal of the American Geriatrics Society	1989
Lymphocyte immunophenotyping in an elderly population: Age, sex and medication effects — a flow cytometry study R Dworsky, A Paganini-Hill, B Ducey, M Hechinger, JW Parker	Mechanisms of Ageing and Development	1989
Decreased proliferation, interleukin 2 synthesis, and interleukin 2 receptor expression are accompanied by decreased mRNA expression in phytohemagglutinin-stimulated cells from elderly donors JE Nagel, RK Chopra, FJ Chrest, MT McCoy, EL Schneider, NJ Holbrook, WH Adler	Journal of Clinical Investigation	1988
Serum thymulin in human zinc deficiency AS Prasad, S Meftah, J Abdallah, J Kaplan, GJ Brewer, JF Bach, M Dardenne	Journal of Clinical Investigation	1988
Immune Senescence Contributes to the Slow Growth of Tumors in Elderly Subjects ME Weksler, T Tsuda, W Ershler, YT Kim, GW Siskind, D Esposito, G Fassina, M Siniscalco	Annals of the New York Academy of Sciences	1988
An Overview of Chronic Adult Periodontitis: Its Implications for the Elderly1 OF Alvares	Gerodontology	1988
Psychoimmunologic and Endorphin Function in the Aged GF Solomon, MA Fiatarone, D Benton, JE Morley, E Bloom, T Makinodan	Annals of the New York Academy of Sciences	1988
Biomarkers of aging: Immunological events WB Ershler	Experimental Gerontology	1988
Specific antibody synthesis in vitro. IV. The correlation of in vitro and in vivo antibody response to influenza vaccine in rhesus monkeys WB Ershler, CL Coe, S Gravenstein, KT Schultz, RG Klopp	Clinical & Experimental Immunology	1988
Age-associated alterations in human natural killer cells R Krishnaraj, G Blandford	Cellular Immunology	1988
Impaired autoreactive T cell-induced T cell-T cell interaction in aged mice V Udhayakumar, B Subbarao, A Seth, M Nagarkatti, PS Nagarkatti	Cellular Immunology	1988
Decline in the production of interleukin-3 with age in mice MP Chang, M Utsuyama, K Hirokawa, T Makinodan	Cellular Immunology	1988
Partial restoration of Con A-induced proliferation, IL-2 receptor expression, and IL-2 synthesis in aged murine lymphocytes by phorbol myristate acetate and lonomycin ML Thoman, WO Weigle	Cellular Immunology	1988
Phytohemagglutinin induced proliferation by aged lymphocytes: Reduced expression of high affinity interleukin-2 receptors and interleukin-2 secretion CJ Froelich, JS Burkett, S Guiffaut, R Kingsland, D Brauner	Life Sciences	1988
Advances in Genetics BH Bowman, F Yang, GS Adrian	Advances in genetics	1988
In vivo immunopotentiating activity of thymopentin in aging humans: Modulation of IL-2 receptor expression W Barcellini, PL Meroni, MO Borghi, D Frasca, R Perego, G Doria, C Zanussi	Clinical Immunology and Immunopathology	1988
Pharmacologic immunoenhancement in the elderly: In vitro effects of isoprinosine JC Delafuente, RS Panush	Clinical Immunology and Immunopathology	1988
Heterogeneity of immune responsiveness in healthy elderly subjects W Barcellini, MO Borghi, C Sguotti, R Palmieri, D Frasca, PL Meroni, G Doria, C Zanussi	Clinical Immunology and Immunopathology	1988
Sex differences in lectin-induced interleukin-2 synthesis in aging rats DR Davila, KW Kelley	Mechanisms of Ageing and Development	1988
The phytohemagglutinin response of human peripheral blood lymphocytes as a function of donor age: A re-examination using BrdU-Hoechst flow cytometry D Schindler, M Kubbies, RE Priest, H Hoehn, PS Rabinovitch	Mechanisms of Ageing and Development	1988
Blood Cells, Rheology, and Aging D Platt		1988
Krebs im Alter B Kark, H Werner		1988
Increased number of circulating Leu 11+ (CD 16) large granular lymphocytes and decreased NK activity during human ageing A Facchini, E Mariani, AR Mariani, S Papa, M Vitale, FA Manzoli	Clinical & Experimental Immunology	1987
Impaired phorbol ester and calcium ionophore induced proliferation of T cells from old humans RK Chopra, JE Nagel, FJ Chrest, WH Adler	Clinical & Experimental Immunology	1987
Bullous pemphigoid: Disease of the aging immune system M Yaar, BA Gilchrest	Clinics in Dermatology	1987
CD4+ T cell activation in multiple sclerosis SJ Verselis, JM Goust	Journal of Neuroimmunology	1987
Sensitive Sandwich Enzyme Immunoassay of Human Interleukin-2 Produced <u>In Vitro</u> by Peripheral Blood Mononuclear Cells S Hashida, E Ishikawa, H Umehara, S Kumagai, H Imura, Y Ohmoto, Y Hirai	Analytical Letters	1987
Augmentation of the antibody response in aged mice with an 8-derivatized guanosine nucleoside and its effect on immunological memory WO Weigle, ML Thoman, MG Goodman	Cellular Immunology	1987
Sensitive Sandwich Enzyme Immunoassay of Human Interleukin-2 Produced In Vitro by Peripheral Blood Mononuclear Cells S Hashida, E Ishikawa, H Umehara, S Kumagai, H Imura, Y Ohmoto, Y Hirai	Analytical Letters	1987
1 The limits of normality in elderly patients A Kruger	Baillière's Clinical Haematology	1987
Individual changes in T lymphocyte parameters of old human subjects S Brill, T Kukulansky, E Tal, L Abel, Y Polgin, C Dassa, A Globerson	Mechanisms of Ageing and Development	1987
Nutrition and Immune Function in the Geriatric Population JS Thompson, J Robbins, JK Cooper	Clinics in Geriatric Medicine	1987
Signal Transduction Mechanisms in the immune System: Potential Implication in Immunosenescence AA Nordin, JJ Proust	Endocrinology and metabolism clinics of North America	1987
Reversal by lymphokines of the age-related hyporesponsiveness to contact sensitization and reduced Ia expression on Langerhans cells DV Belsito, RM Dersarkissian, GJ Thorbecke, RL Baer	Archives of Dermatological Research	1987
Expression of intracellular biochemical defects of lymphocytes in aging: Proposal of a general aging mechanism which is not cell-specific TO Tollefsbol, HJ Cohen	Experimental Gerontology	1986
The Capacity of Lymphokine Production by Peripheral Blood Lymphocytes from Aged Humans C Weifeng, L Shulin, G Xiaomei, P Xuewen	Immunological Investigations	1986
Mechanisms of immunosuppression associated with severe nonthermal traumatic injuries in man: Production of interleukin 1 and 2 ML Rodrick, J Wood, JB O'Mahony, CF Davis, JT Grbic, RH Demling, NM Moss, I Saporoschetz, A Jordan, P D'Eon, JA Mannick	Journal of Clinical Immunology	1986
Age-associated decline of immune functions in mice congenic at the H-2 locus IK Thomas, T Imamura	AGE	1986
The age-related decline in antibody response is transferred by old to young bone marrow transplantation WB Ershler, DL Robbins, AL Moore, JC Hebert	Experimental Gerontology	1986
Influence of age on cellular differentiation: A T cell model T Makinodan, MP Chang, N Kinohara	Experimental Gerontology	1986
GH3 pituitary adenoma cells can reverse thymic aging in rats KW Kelley, S Brief, HJ Westly, J Novakofski, PJ Bechtel, J Simon, EB Walker	Proceedings of the National Academy of Sciences	1986
The effect of aging on the expression of interleukin 2 messenger ribonucleic acid W Wu, M Pahlavani, HT Cheung, A Richardson	Cellular Immunology	1986
Function of T cells from elderly humans: Reductions of membrane events and proliferative responses mediated via T3 determinants and diminished elaboration of soluble T-cell factors for B-cell growth RL Whisler, YG Newhouse	Cellular Immunology	1986
Infections in the elderly RA Garibaldi, BA Nurse	The American Journal of Medicine	1986
Current Topics in Pathology GG Steinmann	Current Topics in Pathology	1986
Advances in Immunopharmacology R Lewis, K Austen	Advances in Immunopharmacology	1986
Intestinal immunity and inflammation: Recent progress CO Elson, MF Kagnoff, C Fiocchi, AD Befus, S Targan	Gastroenterology	1986
Effect of Age on Epidermal Immune Function DN Sander	Dermatologic Clinics	1986
Drug Studies in the Elderly NR Cutler, PK Narang		1986
Internistische Geriatrie KH Tragl		1986
The Immunology of Ageing PM Ford	Clinics in rheumatic diseases	1986
In vitro effect of interleukin 2 on depression of cell-mediated immune response after surgery T Akiyoshi, F Koba, S Arinaga, T Wada, H Tsuji	The Japanese Journal of Surgery	1985
Human Interleukin 2: Biochemistry, Physiology, and Possible Pathogenetic Role in Immunodeficiency Syndromes K Welte, R Mertelsmann	Cancer Investigation	1985
Strain differences in the response of normal murine spleen cells to interleukin-2 (IL-2) WK Dowjat, LJ Quackenbush, MB Zaleski	Immunological Investigations	1985
Normalization of defective interleukin 1 and interleukin 2 production in patients with pemphigus vulgaris following chrysotherapy E Blitstein-Willinger	Clinical & Experimental Immunology	1985
Influence of age on the production and regulation of interleukin-1 in mice T Inamizu, MP Chang, T Makinodan	Immunology	1985
Impaired production of interleukin-2 after surgery T Akiyoshi, F Koba, S Arinaga, S Miyazaki, T Wada, H Tsuji	Clinical & Experimental Immunology	1985
The aging thyroid. Relationship between elevated serum thyrotropin level and thyroid antibodies in elderly patients CT Sawin, ST Bigos, S Land, P Bacharach	The American Journal of Medicine	1985
Interleukin-2 and aging: Decreased interleukin-2 production in healthy older people does not correlate with reduced helper cell numbers or antibody response to influenza vaccine and is not corrected in vitro by Thymosin α1 WB Ershler, AL Moore, K Roessner, GE Ranges	Immunopharmacology	1985
Changes in the macrophage function with aging MD la Fuente	Comparative Biochemistry and Physiology Part A: Physiology	1985
Life Extension EL Schneider, JD Reed	New England Journal of Medicine	1985
Aging in Rodents Fed Restricted Diets*,† R Weindruch	Journal of the American Geriatrics Society	1985
Immunosenescence: Clinical and Pharmacologic Considerations JC Delafuente	Medical Clinics of North America	1985
Defect of autologous mixed lymphocyte reaction and interleukin-2 in aged individuals GW Canonica, G Ciprandi, M Caria, W Dirienzo, A Shums, B Norton-koger, HH Fudenberg	Mechanisms of Ageing and Development	1985
Interleukin-2 production and activity in aged humans H Rabinowich, Y Goses, T Reshef, A Klajman	Mechanisms of Ageing and Development	1985
Aging Immunocytes and Immunity MS Finkelstein	Clinics in Geriatric Medicine	1985
Impairment of T immunoregulatory activities in the induction of antibody specific response in aged humans S Antonaci, E Jirillo, M Gallitelli, AR Garofalo, L Bonomo	Mechanisms of Ageing and Development	1985
Interleukin-2 production by persons with the generalized lymphadenopathy syndrome or the acquired immune deficiency syndrome CH Kirkpatrick, KC Davis, CR Horsburgh, DL Cohn, K Penley, FN Judson	Journal of Clinical Immunology	1985
Aging 2000: Our Health Care Destiny CM Gaitz, T Samorajski		1985
Proliferative and cytotoxic immune functions in aging mice. III. Exogenous interleukin-2 rich supernatant only partially restores alloreactivity in vitro SR Gottesman, RL Walford, GJ Thorbecke	Mechanisms of Ageing and Development	1985
Molecular Biology of Aging AD Woodhead, AD Blackett, A Hollaender	Molecular Biology of Aging	1985
The Interleukins S Gillis, FP Inman		1985
Immunodepression after surgery: Impaired production of interleukin 2 T Akiyoshi, F Koba, S Miyazaki, S Arinaga, T Wada, H Tsuji	The Japanese Journal of Surgery	1984
Decreased Cloning of Lymphocytes from Elderly Individuals A Chrysostomou, R Seshadri, AA Morley	Scandinavian Journal of Immunology	1984
Investigations on the Age-Dependence of T-Lymphocyte Subpopulations and Lymphocyte Reactivity JJ Reiter, G Ehrlich, U Bicker	Immunopharmacology and Immunotoxicology	1984
Inadequate interleukin 2 production. A fundamental immunological deficiency in patients with major burns JJ Wood, ML Rodrick, JB O'Mahony, SB Palder, I Saporoschetz, P D'Eon, JA Mannick	Annals of Surgery	1984
Thymosin increases production of T-cell growth factor by normal human peripheral blood lymphocytes MM Zatz, J Oliver, C Samuels, AB Skotnicki, MB Sztein, AL Goldstein	Proceedings of the National Academy of Sciences	1984
Antibodies of predetermined specificity against chemically synthesized peptides of human interleukin 2 A Altman, JM Cardenas, RA Houghten, FJ Dixon, AN Theofilopoulos	Proceedings of the National Academy of Sciences	1984
Cell-mediated immunodeficiency in Down's syndrome: normal IL-2 production but inverted ratio of T cell subsets R Karttunen, T Nurmi, J Ilonen, HM Surcel	Clinical & Experimental Immunology	1984
A simple rapid method for detection of IL-2 in a physiological medium CD Vos, W Libert	Journal of Immunological Methods	1984
The effect of age on the antigen-presenting mechanism in limiting dilution precursor cell frequency analysis RB Effros, RL Walford	Cellular Immunology	1984
Autologous Mixed Lymphocyte Reaction in Man: IX. Autologous Mixed Lymphocyte Reaction and Lymphocyte Subsets in Aging Humans S Gupta	Scandinavian Journal of Immunology	1984
Interleukin 2 deficiencies in rheumatoid arthritis and systemic lupus erythematosus N Miyasaka, T Nakamura, IJ Russell, N Talal	Clinical Immunology and Immunopathology	1984
The Immune Status of Healthy Centenarians JS Thompson, DR Wekstein, JL Rhoades, C Kirkpatrick, SA Brown, T Roszman, R Straus, N Tietz	Journal of the American Geriatrics Society	1984
Interleukin-1 synthesis and activity in aged mice M Bruley-Rosset, I Vergnon	Mechanisms of Ageing and Development	1984
Lymphoid abnormalities in rats with adjuvant-induced arthritis. I. Mitogen responsiveness and lymphokine synthesis SC Gilman, JF Daniels, RE Wilson, RP Carlson, AJ Lewis	Annals of the rheumatic diseases	1984
Differences in the production of and/or the response to interleukin-2 by T lymphocytes from patients with the various connective tissue diseases J Alcocer-Varela, A Laffn, D Alarcn-Segovia	Rheumatology International	1984
Nutritional Intervention in the Aging Process HJ Armbrecht, JM Prendergast, RM Coe		1984
Thymic Hormones and Lymphokines AL Goldstein		1984
IUPHAR 9th International Congress of Pharmacology London 1984 W Paton, J Mitchell, P Turner, C Padgham, E Ashcroft		1984
Interleukin 2 Activity of Human Intestinal Mucosa Mononuclear Cells C Fiocchi, ML Hilfiker, KR Youngman, NC Doerder, JH Finke	Gastroenterology	1984
Lymphocyte proliferation, lymphokine production, and lymphocyte receptors in ageing and various clinical conditions AL de Weck, F Kristensen, F Joncourt, F Bettens, C Walker, Y Wang	Springer Seminars in Immunopathology	1984
Extrachromosomal circular copies of an ‘inter-Alu’ unstable sequence in human DNA are amplified during in vitro and in vivo ageing RJ Reis, CK Lumpkin, JR McGill, KT Riabowol, S Goldstein	Nature	1983
Mechanism of the age-related decline in lymphocyte proliferation: Role of IL-2 production and protein synthesis HT Cheung, JS Twu, A Richardson	Experimental Gerontology	1983
Immunomodulation by isoprinosine: effects on in vitro immune functions of lymphocytes from humans with autoimmune diseases T Nakamura, N Miyasaka, RM Pope, N Talal, IJ Russell	Clinical & Experimental Immunology	1983
Diminished T-cell response to influenza virus in aged mice RB Effros, RL Walford	Immunology	1983
Aging and the immune system B Cinader	Clinical Biochemistry	1983
The immune response of aged mice to influenza: Diminished T-cell proliferation, interleukin 2 production and cytotoxicity RB Effros, RL Walford	Cellular Immunology	1983
L'immunologie du vieillissement N Gualde, JS Goodwin	La Revue de Médecine Interne	1983
Cytofluorographic Analysis of Pokeweed Mitogen-stimulated Human Peripheral Blood Cells in Culture: Age-related Characteristics RG Otte, S Wormsley, JW Hollingsworth	Journal of the American Geriatrics Society	1983
Senescence of the Immune System ME Weksler	Medical Clinics of North America	1983
Cellular immunosenescence in F344 rats: Decline in responsiveness to phytohemagglutini involves changes in both T cells and macrophages JA Bash	Mechanisms of Ageing and Development	1983
Regulatory effects of thymus humoral factor on T cell growth factor in aging mice J Grinblat, K Schauenstein, E Saltz, N Trainin, A Globerson	Mechanisms of Ageing and Development	1983
Lymphocyte activation in human ageing: V. Acquisition of response to T cell growth factor and production of growth factors by mitogen-stimulated lymphocytes B Kennes, D Brohée, P Nève	Mechanisms of Ageing and Development	1983
Defective T-cell response to PHA and mitogenic monoclonal antibodies in male homosexuals with acquired immunodeficiency syndrome and itsin vitro correction by interleukin 2 N Ciobanu, K Welte, G Kruger, S Venuta, J Gold, SP Feldman, CY Wang, B Koziner, MA Moore, B Safai, R Mertelsmann	Journal of Clinical Immunology	1983
Decreased production of and response to interleukin-2 by cultured lymphocytes from patients with systemic lupus erythematosus J Alcocer-Varela, D Alarcón-Segovia	Journal of Clinical Investigation	1982
Accelerated development of a Th-2 type factor in animals with and without an imbalance between help and suppression T Matsuzawa, B Cinader	Experientia	1982
Mitogenic activity of 12-O-tetradecanoyl phorbol-13-acetate on peripheral blood lymphocytes from young and aged adults JE Nagel, FJ Chrest, WH Adler	Clinical & Experimental Immunology	1982
Lymphocyte dysfunction in cartilage hair hypoplasia. II. Evidence for a cell cycle specific defect in T cell growth GF Pierce, SH Polmar	Clinical & Experimental Immunology	1982
Restoration of impaired immune functions in aging animals. VI. Differential potentiating effect of 2-mercaptoethanol on young and old murine spleen cells MP Chang, JL Tanaka, S Stosic-Grujicic, EK Yamamoto, EH Perkins, BL Strehler, T Makinodan	International Journal of Immunopharmacology	1982
Changes in human T lymphocytes after thymectomy and during senescence RJ van de Griend, M Carreno, R van Doorn, CJ Leupers, A van den Ende, P Wijermans, HJ Oosterhuis, A Astaldi	Journal of Clinical Immunology	1982

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