Chronic Lymphocytic Leukemia Cells Lack the 185,000-Dalton Macromolecular Insoluble Cold Globulin Present on Normal B Lymphocytes

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Abstract

We have recently characterized two lymphocyte-associated membrane proteins which have been termed 225,000-dalton and 185,000-dalton macromolecular insoluble cold globulin (225-MICG and 185-MICG, respectively) to distinguish their major physicochemical properties. These proteins differ antigenically, structurally, and in their cellular distribution. T cells can be distinguished by the synthesis and presence in the plasma membrane of 225-MICG, Null cells by the appearance of 185-MICG, and B cells by the appearance of both 225- and 185-MICG. The characterization of these two proteins in the monoclonal B lymphocytes of chronic lymphocytic leukemia forms the basis of this report.

Authors

Mary A. Simmonds, Gloria Sobczak, Stephen P. Hauptman