Growth Hormone Responses to Thyroid Hormone in the Neonatal Rat: RESISTANCE AND ANAMNESTIC RESPONSE

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Abstract

Differences in the growth hormone (GH) responses to primary and to secondary stimulation with triiodothyronine (T3) were studied in rats deprived of thyroid hormone from birth. Neonatal hypothyroidism was induced in pups by feeding pregnant rats an iodine-deficient, propylthiouracil-containing diet. T3 stimulation was carried out in pups by subcutaneous injection of a single dose of 50 μg T3/100 g body wt. Pituitary GH content, rate of GH synthesis in vitro, and GH messenger (m)RNA activity in a cellfree translation system were measured.

Authors

Hisao Seo, Caryn Wunderlich, Gilbert Vassart, Samuel Refetoff