Citations to this article

Separate Mechanisms of Deformability Loss in ATP-depleted and Ca-loaded Erythrocytes
Margaret R. Clark, … , Mark S. Jacobs, Stephen B. Shohet
Margaret R. Clark, … , Mark S. Jacobs, Stephen B. Shohet
Published February 1, 1981
Citation Information: J Clin Invest. 1981;67(2):531-539. https://doi.org/10.1172/JCI110063.
View: Text | PDF
Research Article

Separate Mechanisms of Deformability Loss in ATP-depleted and Ca-loaded Erythrocytes

Abstract

Membrane rigidity has been widely accepted as the dominant cause of reduced deformability both of ATP-depleted erythrocytes and erythrocytes containing excess calcium (Ca). However, recent studies have shown normal membrane deformability in ATP-depleted erythrocytes. In addition, Ca accumulation causes massive ion and water loss, and it has been shown that extensive dehydration causes an increase in intracellular viscosity with attendant loss of whole cell deformability. To obtain a detailed understanding of the processes accompanying ATP depletion and/or Ca accumulation that limit cell deformability, we have used a viscodiffractometric method to identify the cellular factors contributing to reduced whole cell deformability.

Authors

Margaret R. Clark, Narla Mohandas, Claude Feo, Mark S. Jacobs, Stephen B. Shohet

×

Total citations by year

Year: 2022 2021 2020 2018 2017 2016 2015 2014 2012 2011 2010 2007 2005 2001 1999 1995 1994 1993 1992 1991 1990 1989 1988 1987 1986 1985 1984 1983 1982 Total
Citations: 1 2 2 1 1 1 1 1 2 3 2 1 1 3 2 2 1 3 3 3 5 3 3 4 4 5 3 7 2 72
Citation information

Citations to this article (72)

Title and authors Publication Year
Contraction of the rigor actomyosin complex drives bulk hemoglobin expulsion from hemolyzing erythrocytes.
Shirakashi R, Sisario D, Taban D, Korsa T, Wanner SB, Neubauer J, Djuzenova CS, Zimmermann H, Sukhorukov VL 		Biomechanics and Modeling in Mechanobiology 2022
Calcium/protein kinase C signaling mechanisms in shear-induced mechanical responses of red blood cells
E Ugurel, ZB Kisakurek, Y Aksu, E Goksel, N Cilek, O Yalcin 		Microvascular Research 2021
Donor Age and Red Cell Age Contribute to the Variance in Lorrca Indices in Healthy Donors for Next Generation Ektacytometry: A Pilot Study
AM van Cromvoirt, S Fenk, A Sadafi, EV Melnikova, DA Lagutkin, K Dey, IY Petrushanko, I Hegemann, JS Goede, A Bogdanova 		Frontiers in physiology 2021
Active modulation of erythrocyte mechanics
L Kuck, JN Peart, MJ Simmonds 		American journal of physiology. Cell physiology 2020
Calcium dynamically alters erythrocyte mechanical response to shear
L Kuck, JN Peart, MJ Simmonds 		Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 2020
Protective effect of Chaetomorpha gracilis aqueous extract against erythrocytes oxidative damage induced by high fat diet in treated mice
N Brahmi, M Saoudi, Y Kadri, C Kallel, AE Euch, FM Ayadi, AH Harrath, AE Feki, MS Allagui 		Archives Of Physiology And Biochemistry 2018
Dynamic fatigue measurement of human erythrocytes using dielectrophoresis
Y Qiang, J Liu, E Du 		Acta Biomaterialia 2017
Quality of red cells after combination of prion reduction and treatment with the intercept system for pathogen inactivation: INTERCEPT-treated red cells
M Wiltshire, A Meli, MA Schott, A Erickson, N Mufti, S Thomas, R Cardigan 		Transfusion Medicine 2016
Inability to Maintain GSH Pool in G6PD-Deficient Red Cells Causes Futile AMPK Activation and Irreversible Metabolic Disturbance
H Tang, H Ho, P Wu, S Chen, FA Kuypers, M Cheng, DT Chiu 		Antioxidants & Redox Signaling 2015
Toxic effects of silver nanoparticles and nanowires on erythrocyte rheology
MJ Kim, S Shin 		Food and Chemical Toxicology 2014
Methods in Enzymology
JD Stone, AS Chervin, DH Aggen, DM Kranz 		Protein Engineering for Therapeutics Part B 2012
Caffeine inhibits erythrocyte membrane derangement by antioxidant activity and by blocking caspase 3 activation
E Tellone, S Ficarra, A Russo, E Bellocco, D Barreca, G Laganà, U Leuzzi, D Pirolli, MC de Rosa, B Giardina, A Galtieri 		Biochimie 2012
Alterations in Ca2+ homeostasis and oxidative damage induced by ethion in erythrocytes of Wistar rats: Ameliorative effect of vitamin E
GK Bhatti, JS Bhatti, R Kiran, R Sandhir 		Environmental Toxicology and Pharmacology 2011
Increased calcium deposits and decreased Ca2+-ATPase in erythrocytes of ascitic broiler chickens
K Li, L Zhao, G Geng, L Ma, S Dong, T Xu, J Wang, H Wang, Y Tian, J Qiao 		Research in Veterinary Science 2011
Erythrocyte oxidative damage in rat treated with CCl 4: protective role of vanillin
M Makni, Y Chtourou, H Fetoui, EM Garoui, M Barkallah, C Marouani, C Kallel, N Zeghal 		Toxicology and industrial health 2011
Treatment of whole blood (WB) and red blood cells (RBC) with S-303 inactivates pathogens and retains in vitro quality of stored RBC
NA Mufti, AC Erickson, AK North, D Hanson, L Sawyer, LM Corash, L Lin 		Biologicals 2010
Alterations in Ca2+ homeostasis in rat erythrocytes with atrazine treatment: positive modulation by vitamin E
M Singh, R Sandhir, R Kiran 		Molecular and Cellular Biochemistry 2010
Investigation on the early events of apoptosis in senescent erythrocytes with special emphasis on intracellular free calcium and loss of phospholipid asymmetry in chronic renal failure
R Sakthivel, SM Farooq, P Kalaiselvi, P Varalakshmi 		Clinica Chimica Acta 2007
Ion transport pathology in the mechanism of sickle cell dehydration
VL Lew, RM Bookchin 		Physiological reviews 2005
Familial phosphofructokinase deficiency is associated with a disturbed calcium homeostasis in erythrocytes
G Ronquist, O Rudolphi, I Engstrom, A Waldenstrom 		Journal of Internal Medicine 2001
Temperature transition of human hemoglobin at body temperature: effects of calcium
C Kelemen, S Chien, GM Artmann 		Biophysical Journal 2001
Temperature Transition of Human Hemoglobin at Body Temperature: Effects of Calcium
C Kelemen, S Chien, GM Artmann 		Biophysical Journal 2001
Age-dependent differences in cation-osmotic haemolysis in rats
J Mojžiŝ, A Nicák, G Mojžiŝová, L Mirossay 		Comparative Haematology International 1999
Effects of Salicylic Acid Derivatives on Red Blood Cell Membranes
A Li, H Seipelt, C Müller, Y Shi, GM Artmann 		Pharmacology & Toxicology 1999
A new method to study shape recovery of red blood cells using multiple optical trapping
PJ Bronkhorst, GJ Streekstra, J Grimbergen, EJ Nijhof, JJ Sixma, GJ Brakenhoff 		Biophysical Journal 1995
Separation and characterization of red blood cells with different membrane deformability using steric field-flow fractionation
X Tong, KD Caldwell 		Journal of Chromatography B: Biomedical Sciences and Applications 1995
Relationship between erythrocyte deformability and glutathione under oxidative stress
K Masaaki, S Masatoshi, H Koichi, T Keisuke 		Comparative Biochemistry and Physiology Part A: Physiology 1994
Transbilayer mobility and distribution of red cell phospholipids during storage
D Geldwerth, FA Kuypers, P Bütikofer, M Allary, BH Lubin, PF Devaux 		Journal of Clinical Investigation 1993
Quantitative Evaluation of Irregularly Spiculated Red Blood Cells in the Dog
DJ Weiss, A Kristensen, N Papenfuss 		Veterinary Clinical Pathology 1993
The effect of flunarizine on erythrocyte suspension viscosity under conditions of extreme hypoxia, low pH, and lactate treatment
BD Kavanagh, BE Coffey, D Needham, RM Hochmuth, MW Dewhirst 		British Journal of Cancer 1993
Influence of calcium permeabilization and membrane-attached hemoglobin on erythrocyte deformability
E Friederichs, RA Farley, HJ Meiselman 		American Journal of Hematology 1992
Changed Purine Nucleotide Concentrations and Enzyme Activities in Erythrocytes of Haemodialysis Patients Undergoing Erythropoietin Therapy
W Siems, T Grune, H Hampl, G Wendel, G Gerber, E Riedel 		Clinical Chemistry and Laboratory Medicine 1992
Red cell filterability determined using the cell transit time analyzer (CTTA): effects of ATP depletion and changes in calcium concentration
M Rendell, T Luu, E Quinlan, S Knox, M Fox, S Kelly, K Kahler 		Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1992
An EPR study on erythrocyte deformability
S Noji, S Taniguchi, H Kon 		Progress in Biophysics and Molecular Biology 1991
The Role of Glycolysis and Univalent Ions in Phthalocyanine-sensitized Photohaemolysis of Human Erythrocytes
E Ben-Hur, A Freud, A Canfi, A Livne 		International Journal of Radiation Biology 1991
Decreased Erythrocyte (Ca 2+ + Mg 2+ )-ATPase Activity in Hemodialyzed Uremic Patients
O Shalev 		Renal Failure 1991
Erythrocyte rheology
T Shiga, N Maeda, K Kon 		Critical Reviews in Oncology/Hematology 1990
Quantitative Evaluation of Echinocytes in the Dog
DJ Weiss, A Kristensen, N Papenfuss, CB McClay 		Veterinary Clinical Pathology 1990
Influence of 2,3-diphosphoglycerate on the deformability of human erythrocytes
Y Suzuki, T Nakajima, T Shiga, N Maeda 		Biochimica et Biophysica Acta (BBA) - Biomembranes 1990
Bile salt-induced intracellular Ca++ accumulation in type II pneumocytes
DG Oelberg, SA Downey, MM Flynn 		Lung 1990
Bile salt-induced intracellular Ca++ accumulation in type II pneumocytes
DG Oelberg, SA Downey, MM Flynn 		Lung 1990
An NMR Assessment of the Rheological Properties of Blood and Its Constituents: A Review
C Berling, LD Hall 		NMR in Biomedicine 1989
Cell Shape
TL Steck 		Cell Shape 1989
Trends in Colloid and Interface Science III
P Bothorel, EJ Dufourc 		1989
Red Cell Membrane Changes During Storage
RT Card 		Transfusion Medicine Reviews 1988
A flow EPR study of deformation and orientation characteristics of erythrocyte ghosts: Effects of lysing and resealing conditions
Y Fukushima, H Kon 		The Journal of Membrane Biology 1988
Molecular mechanisms of the red cell storage lesion
WC Horne 		Plasma Therapy and Transfusion Technology 1988
Bile salts induce calcium uptakein vitro by human erythrocytes
DG Oelberg, WP Dubinsky, JW Sackman, LB Wang, EW Adcock, R Lester 		Hepatology 1987
Modulation of red cell vesiculation by protease inhibitors
P Bütikofer, U Brodbeck, P Ott 		Biochimica et Biophysica Acta (BBA) - Biomembranes 1987
Spin label study of erythrocyte deformability. Ca2+-induced loss of deformability and the effects of stomatocytogenic reagents on the deformability loss in human erythrocytes in shear flow
S Noji, S Taniguchi, H Kon 		Biophysical Journal 1987
The Erythrocyte Sedimentation Rate in End-Stage Renal Failure
J Bathon, J Graves, P Jens, R Hamrick, M Mayes 		American Journal of Kidney Diseases 1987
Red blood cell phagocytosis and lysis following oxidative damage by phenylhydrazine
M Magnani, V Stocchi, L Cucchiarini, L Chiarantini, G Fornaini 		Cell Biochemistry and Function 1986
A contribution of calmodulin to cellular deformability of calcium-loaded human erythrocytes
J Murakami, N Maeda, K Kon, T Shiga 		Biochimica et Biophysica Acta (BBA) - Biomembranes 1986
Blood Viscosity: A Pathogenetic Factor in the Development of Essential Hypertension?
V Hossmann, G Bönner, G Wambach, U Laaser, W Kaufmann 		Clinical and Experimental Hypertension 1986
Calcium and Cell Function
B Hellman, E Gylfe 		Calcium and Cell Function 1986
Cell age-dependent changes in deformability and calcium accumulation of human erythrocytes
T Shiga, M Sekiya, N Maeda, K Kon, M Okazaki 		Biochimica et Biophysica Acta (BBA) - Biomembranes 1985
Erythrocyte (Ca+2+Mg+2)-ATPase activity: Increased sensitivity to oxidative stress in glucose-6-phosphate dehydrogenase deficiency
O Shalev, V Lavi, RP Hebbel, JW Eaton 		American Journal of Hematology 1985
Following association to the membrane, human erythrocyte procalpain is converted and released as fully active calpain
S Pontremoli, F Salamino, B Sparatore, M Michetti, O Sacco, E Melloni 		Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology 1985
The Red Cell Membrane and the Storage Lesion
L Wolfe 		Clinics in Haematology 1985
Erythrocyte Membrane Alterations in β -Thalassaemia
EA Rachmilewitz, E Shinar, O Shalev, U Galili, SL Schrier 		Clinics in Haematology 1985
An electro-optic study of human erythrocyte spectrin dimers
A Mikkelsen, BT Stokke, A Elgsaeter 		Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology 1984
Erythrocyte membrane in protein-energy malnutrition: A23187-induced changes in osmotic fragility of human and rat erythrocytes
SS Kaplay 		Biochemical Medicine 1984
Calcium Entry Blockers in Cardiovascular and Cerebral Dysfunctions
T Godfraind, AG Herman, D Wellens 		1984
Increased adsorption of cytoplasmic proteins to the erythrocyte membrane in ATP-depleted normal and pyruvate kinase-deficient mature cells and reticulocytes
DW Allen, JD Groat, B Finkel, BH Rank, PA Wood, JW Eaton 		American Journal of Hematology 1983
The effect of malonyldialdehyde, a product of lipid peroxidation, on the deformability, dehydration and51Cr-survival of erythrocytes
SK Jain, N Mohandas, MR Clark, SB Shohet 		British Journal of Haematology 1983
Binding of autologous IgG to human red blood cells before and after ATP-depletion. Selective exposure of binding sites (autoantigens) on spectrin-free vesicles
H Müller, HU Lutz 		Biochimica et Biophysica Acta (BBA) - Biomembranes 1983
Effect of parathyroid hormone and uremic sera on the autoagglutination and sedimentation of human red blood cells
Y Earon, M Blum, E Bogin 		Clinica Chimica Acta 1983
Muscle and Nonmuscle Motility
WB Gratzer 		Muscle and Nonmuscle Motility 1983
Erythrocyte membrane in rats fed high erucic acid-containing mustard oil: Osmotic fragility, lipid composition, and (Na+, K+)- and (Ca2+, Mg2+)-ATPases
A Vajreswari, PS Rao, SS Kaplay, PG Tulpule 		Biochemical Medicine 1983
Heart Perfusion, Energetics, and Ischemia
L Dintenfass, DG Julian, GV Seaman 		1983
Heterogeneity in filterability of erythrocytes from malaria (Plasmodium berghei)-infected blood
S Pattanakitsakul, Y Yuthavong 		Experientia 1982
Deformability of isolated red blood cell membranes
BP Heath, N Mohandas, JL Wyatt, SB Shohet 		Biochimica et Biophysica Acta (BBA) - Biomembranes 1982

Advertisement