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Citations to this article

Duration and characteristics of treatment of premature lambs with natural surfactant.
A Jobe, … , E Diakomanolis, J Padbury
A Jobe, … , E Diakomanolis, J Padbury
Published February 1, 1981
Citation Information: J Clin Invest. 1981;67(2):370-375. https://doi.org/10.1172/JCI110044.
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Research Article

Duration and characteristics of treatment of premature lambs with natural surfactant.

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Abstract

Premature lambs were treated with 50 mg/kg of natural surfactant lipid by tracheal instillation either at birth or shortly thereafter when respiratory failure was documented. All lambs were delivered by cesarean section and supported on infant ventilators with 100% oxygen under conditions to mimic the care of human infants with the respiratory distress syndrome. The natural surfactant used for therapy was recovered by lavage from sheep lung. Six 120-d gestational age lambs treated at birth had an initial mean oxygen pressure (pO2) value of 270 +/- 35 mm Hg; this fell within 3 h to less than 100 mm Hg. By 8.3 +/- 0.3 h after birth the lambs were in severe respiratory failure with a mean pH less than 7.1 and a mean pCO2 greater than 70 mm Hg. Six untreated lambs had pH values below 7.0 within 40 min of life despite more intensive respiratory support than was given the treated animals. Treatment with natural surfactant of 17 lambs of 120 and 130 d gestational age after early respiratory failure resulted in a prompt increase in pO2 values from about 35 mm Hg to values over 200 mm Hg and a fall in pCO2 values to normal levels in the majority of animals. This response lasted only approximately 3 h, and a second treatment was less predictably effective.

Authors

A Jobe, M Ikegami, T Glatz, Y Yoshida, E Diakomanolis, J Padbury

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Total citations by year

Year: 2022 2021 2018 2017 2013 2012 2011 2009 2006 2005 2000 1999 1998 1997 1996 1994 1993 1992 1991 1990 1989 1988 1987 1986 1985 1984 1983 1982 1981 1978 Total
Citations: 1 1 2 1 1 1 2 1 2 2 2 7 1 3 3 1 3 4 5 8 6 10 9 5 5 4 5 2 1 1 99
Citation information
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Citations to this article in year 2012 (1)

Title and authors Publication Year
Neonatal non-invasive respiratory support: Physiological implications
TH Shaffer, D Alapati, JS Greenspan, MR Wolfson
Pediatric Pulmonology 2012

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