A small subpopulation of human peripheral blood T lymphocytes has the capacity to adhere selectively to myelinated sections of human and nonhuman brain tissue. Adherence of lymphocytes from patients with multiple sclerosis is significantly greater than adherence of control lymphocytes. Monocytes inhibit binding in controls. This function appears to be lost by multiple sclerosis monocytes.
P Dore-Duffy, V Goertz, B L Rothman
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Cellular immune surveillance of central nervous system bypasses blood-brain barrier and blood-cerebrospinal-fluid barrier: Revealed with the New Marburg cerebrospinal-fluid model in healthy humans: Human CSF Thoracic Duct Chyle Immune Surveillance
TO Kleine |
Cytometry Part A | 2015 |
Multiple Sclerosis
W Kim, HJ Kim |
Journal of the Korean Medical Association | 2009 |
Adhesion of mononuclear cells from multiple sclerosis patients to cerebral vessels in cryostat sections of normal human brain
M Zaffaroni, S Martinazzi, F Crivelli, A Ghezzi, A Zampieri, M Martinazzi, A Zibetti, N Canal |
European Journal of Neurology | 1999 |
A lymphocyte homing receptor (L-selectin) mediates the in vitro attachment of lymphocytes to myelinated tracts of the central nervous system
K Huang, JS Geoffroy, MS Singer, SD Rosen |
Journal of Clinical Investigation | 1991 |
The role of prostaglandins in altered leukocyte function in multiple sclerosis
P Dore-Duffy, SY Ho, M Longo |
Springer Seminars in Immunopathology | 1985 |
Lymphocyte adherence in multiple sclerosis: Lack of virus specificity
P Dore-Duffy, RB Zurier |
Cellular Immunology | 1983 |
Immunology of Multiple Sclerosis
J Oger, R Roos, JP Antel |
Neurologic Clinics | 1983 |
Inflammation and Demyelination in the Central Nervous System
BH Waksman, T Yonezawa, H Lassmann |
1983 | |
Cell-mediated cytotoxicity by peripheral blood lymphocytes against basic protein of myelin, encephalitogenic peptide, cerebrosides and gangliosides in multiple sclerosis
E Frick |
Journal of the Neurological Sciences | 1982 |