Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact

Citations to this article

Heterogeneity of b lymphocyte differentiation in severe combined immunodeficiency disease.
S G Pahwa, … , R N Pahwa, R A Good
S G Pahwa, … , R N Pahwa, R A Good
Published September 1, 1980
Citation Information: J Clin Invest. 1980;66(3):543-550. https://doi.org/10.1172/JCI109886.
View: Text | PDF
Research Article

Heterogeneity of b lymphocyte differentiation in severe combined immunodeficiency disease.

  • Text
  • PDF
Abstract

Pokeweed mitogen-induced B lymphocyte differentiation in vitro into antibody secreting plaque-forming cells (PFC) was investigated in nine patients with severe combined immunodeficiency having variable proportions of circulating B lymphocytes. When cultured by themselves, the peripheral blood mononuclear cells did not respond to stimulation with pokeweed mitogen in any patient. In the presence of irradiated allogeneic T cells as helpers, however, PFC responses were elicited in lymphocyte cultures from peripheral blood and/or bone marrow in some patients. In one of these patients, results of allogeneic co-culture experiments were suggestive of genetically restricted suppressor cells. In a single patient with deficiency of the enzyme adenosine deaminase, PFC were generated in bone marrow lymphocyte cultures only when they were supplemented with exogenous adenosine deaminase and allogeneic helper cells. A parallel study of T lymphocyte differentiation in vitro performed in fractionated bone marrow cells was suggestive of arrested differentiation at different steps along the differentiation pathway. In two patients with evidence of functional B cell precursors, deficiencies of helper T cell function could be attributed to differentiation defects at the level of the stem cells in one and the thymus in the other. The findings reported here further substantiate the heterogeneity of the severe combined immunodeficiency disease syndromes.

Authors

S G Pahwa, R N Pahwa, R A Good

×

Total citations by year

Year: 1991 1990 1989 1988 1987 1986 1985 1984 1982 1971 Total
Citations: 3 1 3 3 2 2 1 2 3 1 21
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article (21)

Title and authors Publication Year
Genetics of human X-linked immunodeficiency diseases
RW Hendriks, RK Schuurman
Clinical & Experimental Immunology 1991
X-Linked Immunodeficiencies Involving the Lymphoid System
YL Lau
Pediatric Asthma, Allergy & Immunology 1991
Genetics of human X-linked immunodeficiency diseases.
Hendriks RW, Schuurman RK
Clinical & Experimental Immunology 1991
Severe combined immunodeficiency in man with an absence of immunoglobulin gene rearrangements but normal T cell receptor assembly
A Thompson, RW Hendriks, ME Kraakman, F Koning, RL Bergh, JM Vossen, CM Weemaes, RK Schuurman
European Journal of Immunology 1990
Management of a novel immune deficiency with IL-2 therapy
R Pahwa, C Paradise, RA Good
Cancer Treatment Reviews 1989
Recombinant interleukin 2 therapy in severe combined immunodeficiency disease
R Pahwa, T Chatila, S Pahwa, C Paradise, NK Day, R Geha, SA Schwartz, H Slade, N Oyaizu, RA Good
Proceedings of the National Academy of Sciences 1989
Characterization of B cells in severe combined immunodeficiency disease
TN Small, C Keever, N Collins, B Dupont, RJ O'Reilly, N Flomenberg
Human Immunology 1989
Nonrandom X chromosome inactivation in B cells from carriers of X chromosome-linked severe combined immunodeficiency
ME Conley, A Lavoie, C Briggs, P Brown, C Guerra, JM Puck
Proceedings of the National Academy of Sciences 1988
Transient T-cell abnormality in a selective IgM-immunodeficient patient with Brucella infection
S Raziuddin, N Bilal, B Benjamin
Clinical Immunology and Immunopathology 1988
Abnormalities in DNA rearrangements of immunoglobulin gene loci in precursor B cells derived from X-linked agammaglobulinemia patient and a severe combined immunodeficiency patient
Y Ichihara, H Matsuoka, I Tsuge, J Okada, S Torii, H Yasui, Y Kurosawa
Immunogenetics 1988
Evaluation of Immunity
R Hong
Immunological Investigations 1987
Prematurity, hypogammaglobulinemia, and neuropathology with human immunodeficiency virus (HIV) infection
R Pahwa, RA Good, S Pahwa
Proceedings of the National Academy of Sciences 1987
Defective expression of T cell-associated glycoprotein in severe combined immunodeficiency
LK Jung, SM Fu, T Hara, N Kapoor, RA Good
Journal of Clinical Investigation 1986
Natural killer cell function and interferon generation in patients with primary immunodeficiencies
C Messina, D Kirkpatrick, PA Fitzgerald, RJ O'Reilly, FP Siegal, C Cunningham-Rundles, M Blaese, J Oleske, S Pahwa, C Lopez
Clinical Immunology and Immunopathology 1986
Severe combined immunodeficiency: treatment by bone marrow transplantation in 15 infants using HLA-haploidentical donors
W Friedrich, SF Goldmann, W Ebell, R Bltters-Sawatzki, G Gaedicke, A Raghavachar, HH Peter, B Belohradsky, W Kreth, B Kubanek, E Kleihauer
European Journal of Pediatrics 1985
Severe combined immunodeficiency with natural killer-cell predominance: Abrogation of graft-versus-host disease and immunologic reconstitution with HLA-identical bone marrow cells
LJ Sindel, RH Buckley, SE Schiff, FE Ward, GH Mickey, AT Huang, C Naspitz, H Koren
Journal of Allergy and Clinical Immunology 1984
Thymic Hormones and Lymphokines
AL Goldstein
1984
Lymphocyte subpopulations in primary immunodeficiency disorders
S Gupta
The Indian Journal of Pediatrics 1982
Severe combined immunodeficiency with disbalance and functional abnormalities in the T-lymphocyte subsets
G Fontán, EG la Concha, MC Rodriguez, JM Zabay, S Carrasco, J Alba, D Pascual-Salcedo, JA Ojeda
Clinical Immunology and Immunopathology 1982
Differentiation of precursor T lymphocytes in man and delineation of the selective abnormalities in severe combined immune deficiency disease
EW Gelfand, HM Dosch
Clinical Immunology and Immunopathology 1982
Progress in Immunology
IH Lepow
Progress in Immunology 1971

Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts