We have examined rotary shadowed, purified plasmic fragments of human fibrinogen with the electron microscope and have determined the relation of these fragments to the intact fibrinogen molecule. Both intact fibrinogen and its earliest cleavage product, fragment X, are trinodular. The next largest product, fragment Y, consists of two linked nodules. The two terminal products, fragments D and E, are single nodules. From measurements of simultaneously shadowed specimens of these different species, we conclude that the outer nodules of the trinodular fibrinogen molecule are the fragment D-containing regions and the central nodule is the fragment E-containing region.
W E Fowler, L J Fretto, H P Erickson, P A McKee
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A unique proteolytic fragment of human fibrinogen containing the A alpha COOH-terminal domain of the native molecule
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Thrombosis Research | 1989 |
Molecular morphology of fibrin monomers and early oligomers during fibrin polymerization
EB Hunziker, PW Straub, A Haeberli |
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European Journal of Biochemistry | 1987 |
Evidence for two functionally different fibrinogen receptors on hemopoietic cells: The glycoprotein IIb-IIIa and the mitogenic fibrinogen receptor
JP Levesque, A Hatzfeld, G Hudry-Clergeon, GD Wilner, J Hatzfeld |
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AZ Budzynski, JR Shainoff |
Critical Reviews in Oncology/Hematology | 1986 |
Localization of segments essential for polymerization and for calcium binding in the .gamma.-chain of human fibrinogen
A Varadi, HA Scheraga |
Biochemistry | 1986 |
Substructure of human von Willebrand factor. Proteolysis by V8 and characterization of two functional domains
LJ Fretto, WE Fowler, DR McCaslin, HP Erickson, PA McKee |
The Journal of biological chemistry | 1986 |
Substructure of human von Willebrand factor
WE Fowler, LJ Fretto, KK Hamilton, HP Erickson, PA McKee |
Journal of Clinical Investigation | 1985 |
Platelet Membrane Glycoproteins
JN George, AT Nurden, DR Phillips |
1985 | |
Blood Coagulation and Coagulation Tests
JS Bennett |
Medical Clinics of North America | 1984 |
Structural biochemistry: Correlation of structure and function at the molecular level by use of electron microscopy
WE Fowler |
1984 | |
ELECTRON MICROSCOPY OF FIBRINOGEN, ITS PLASMIC FRAGMENTS AND SMALL POLYMERS
HP Erickson, WE Fowler |
Annals of the New York Academy of Sciences | 1983 |
ANALYSIS OF HUMAN FIBRINOGEN BY SCANNING TRANSMISSION ELECTRON MICROSCOPY
J Wall, J Hainfeld, RH Haschemeyer, MW Mosesson |
Annals of the New York Academy of Sciences | 1983 |
IMMUNOCHEMICAL ANALYSIS OF THE CONFORMATION OF FIBRINOGEN
EF Plow, TS Edgington, CS Cierniewski |
Annals of the New York Academy of Sciences | 1983 |
ELECTRON MICROSCOPIC STUDIES OF FIBRINOGEN STRUCTURE: HISTORICAL PERSPECTIVES AND RECENT EXPERIMENTS
HS Slayter |
Annals of the New York Academy of Sciences | 1983 |
THE RELATIONSHIP OF FIBRINOGEN STRUCTURE TO PLASMINOGEN ACTIVATION AND PLASMIN ACTIVITY DURING FIBRINOLYSIS
MA Lucas, LJ Fretto, PA McKee |
Annals of the New York Academy of Sciences | 1983 |
New Comprehensive Biochemistry
S Yamamoto |
New Comprehensive Biochemistry | 1983 |
Location of plasminogen-binding sites in human fibrin(ogen)
A Varadi, L Patthy |
Biochemistry | 1983 |
The Physiology of Hemostasis
D Ogston |
1983 | |
Electron microscopy of human factor VIII/Von Willebrand glycoprotein: effect of reducing reagents on structure and function
K Ohmori, LJ Fretto, RL Harrison, ME Switzer, HP Erickson, PA McKee |
The Journal of Cell Biology | 1982 |
Structural study of modified fibrinogen microcrystals by electron microscopy
EA Hewat, L Tranqui, RH Wade |
Journal of Molecular Biology | 1982 |
Steady-state fluorescence polarization of dansylcadaverine-fibrinogen: evidence for flexibility
RR Hantgan |
Biochemistry | 1982 |
Monoclonal antibodies to fibrinogen: modulation of determinants expressed in fibrinogen by .gamma.-chain crosslinking
GD Wilner, MS Mudd, KH Hsieh, DW Thomas |
Biochemistry | 1982 |
OBSERVATIONS ON STRUCTURE-FUNCTION RELATIONSHIPS OF HUMAN ANTIHEMOPHILIC/VON WILLEBRAND FACTOR PROTEIN
PA McKee |
Annals of the New York Academy of Sciences | 1981 |
Structure of the fibrin protofibril
WE Fowler, RR Hantgan, J Hermans, HP Erickson |
Proceedings of the National Academy of Sciences | 1981 |
Observation of the α-chain extensions of fibrinogen through a new electron microscope specimen preparation technique
ML Rudee, TM Price |
Ultramicroscopy | 1981 |
Identification and mass analysis of human fibrinogen molecules and their domains by scanning transmission electron microscopy
MW Mosesson, J Hainfeld, J Wall, RH Haschemeyer |
Journal of Molecular Biology | 1981 |
Immunochemical mapping of the conformation of human fibrinogen. The gamma 95-264 segment in inaccessible to antibody in native fibrinogen but progressively exposed by plasmic cleavage
DS Fair, TS Edgington, EF Plow |
The Journal of biological chemistry | 1981 |