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Citations to this article

Mechanisms of insulin resistance in human obesity: evidence for receptor and postreceptor defects.
O G Kolterman, … , M Saekow, J M Olefsky
O G Kolterman, … , M Saekow, J M Olefsky
Published June 1, 1980
Citation Information: J Clin Invest. 1980;65(6):1272-1284. https://doi.org/10.1172/JCI109790.
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Mechanisms of insulin resistance in human obesity: evidence for receptor and postreceptor defects.

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Abstract

To assess the mechanisms of the insulin resistance in human obesity, we have determined, using a modification of the euglycemic glucose clamp technique, the shape of the in vivo insulin-glucose disposal dose-response curves in 7 control and 13 obese human subjects. Each subject had at least three euglycemic studies performed at insulin infusion rates of 15, 40, 120, 240, or 1,200 mU/M2/min. The glucose disposal rate was decreased in all obese subjects compared with controls (101 +/- 16 vs. 186 +/- 16 mg/M2/min) during the 40 mU/M2/min insulin infusion. The mean dose-response curve for the obese subjects was displaced to the right, i.e., the half-maximally effective insulin concentration was 270 +/- 27 microU/ml for the obese compared with 130 +/- 10 microU/ml for controls. In nine of the obese subjects, the dose-response curves were shifted to the right, and maximal glucose disposal rates (at a maximally effective insulin concentration) were markedly decreased, indicating both a receptor and a postreceptor defect. On the other hand, four obese patients had right-shifted dose-response curves but reached normal maximal glucose disposal rates, consistent with decreased insulin receptors as the only abnormality. When the individual data were analyzed, it was found that the lease hyperinsulinemic, least insulin-resistant patients displayed only the receptor defect, whereas those with the greatest hyperinsulinemia exhibited the largest post-receptor defect, suggesting a continuous spectrum of defects as one advances from mild to severe insulin resistance. When insulin's ability to suppress hepatic glucose output was assessed, hyperinsulinemia produced total suppresssion in all subjects. The dose-response curve for the obese subjects was shifted to the right, indicating a defect in insulin receptors. Insulin binding to isolated adipocytes obtained from the obese subjects was decreased, and a highly significant inverse linear relationship was demonstrated between insulin binding and the serum insulin concentration required for halfmaximal stimulation of glucose disposal. In conclusion: (a) decreased cellular insulin receptors contribute to the insulin resistance associated with human obesity in all subjects; (b) in the least hyperinsulinemic, insulin-resistant patients, decreased insulin receptors are the sole defect, whereas in the more hyperinsulinemic, insulin-resistant patients, the insulin resistance is the result of a combination of receptor and postreceptor abnormalities; (c) all obese patients were insensitive to insulin's suppressive effects on hepatic glucose output; this was entirely the result of decreased insulin receptors; no postreceptor defect in this insulin effect was demonstrated.

Authors

O G Kolterman, J Insel, M Saekow, J M Olefsky

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RC Moraes, A Blondet, K Birkenkamp-Demtroeder, J Tirard, TF Orntoft, A Gertler, P Durand, D Naville, M Bégeot
Endocrinology 2003
Troglitazone Ameliorates Abnormal Activity of Protein Tyrosine Phosphatase in Adipose Tissues of Otsuka Long-Evans Tokushima Fatty Rats
S Tagami, T Honda, H Yoshimura, H Homma, K Ohno, H Ide, S Sakaue, Y Kawakami
The Tohoku Journal of Experimental Medicine 2002
Waist-hip ratio and breast cancer risk in urbanized Nigerian women
CA Adebamowo, TO Ogundiran, AA Adenipekun, RA Oyesegun, OB Campbell, EE Akang, CN Rotimi, OI Olopade
Breast Cancer Research 2002
Effects of Hormone Replacement Therapy on Left Ventricular Hypertrophy and Growth-Promoting Factors in Hypertensive Postmenopausal Women
Y MIYA, H SUMINO, S ICHIKAWA, T NAKAMURA, T KANDA, H KUMAKURA, Y TAKAYAMA, H MIZUNUMA, T SAKAMAKI, M KURABAYASHI
Hypertension Research 2002
Decreases in serum uric acid by amelioration of insulin resistance in overweight hypertensive patients: effect of a low-energy diet and an insulin-sensitizing agent
S Tsunoda, K Kamide, J Minami, Y Kawano
American Journal of Hypertension 2002
The Medical Risks of Obesity
FX Pi-Sunyer
Obesity Surgery 2002
Racial Differences in Insulin Resistance and Mid-Thigh Fat Deposition in Postmenopausal Women
AS Ryan, BJ Nicklas, DM Berman
Obesity research 2002
Plasma Leptin Concentrations are Independently Associated with Insulin Sensitivity in Lean and Overweight Cats
DJ Appleton, JS Rand, GD Sunvold
Journal of Feline Medicine & Surgery 2002
Measurements of Interstitial Muscle Glycerol in Normal and Insulin-Resistant Subjects
M Sjöstrand, S Gudbjörnsdottir, A Holmäng, L Strindberg, K Ekberg, P Lönnroth
The Journal of clinical endocrinology and metabolism 2002
Plasma leptin concentrations are independently associated with insulin sensitivity in lean and overweight cats.
Appleton DJ, Rand JS, Sunvold GD
Journal of feline medicine and surgery 2002
Insulin action and skeletal muscle blood flow in patients with Type 1 diabetes and microalbuminuria
M Wiggam
Diabetes Research and Clinical Practice 2001
Insulin Action After Resistive Training in Insulin Resistant Older Men and Women
AS Ryan, DE Hurlbut, ME Lott, FM Ivey, J Fleg, BF Hurley, AP Goldberg
Journal of the American Geriatrics Society 2001
Inevitability of beta cell failure in type 2 diabetes
T Siegmund, KH Usadel
Current Opinion in Endocrinology & Diabetes 2001
Insulin resistance and cardiovascular risk in the pediatric patient
J Steinberger
Progress in Pediatric Cardiology 2001
Hypertension and Type 2 Diabetes Comorbidity in Adults in the United States: Risk of Overall and Regional Adiposity
IS Okosun, KM Chandra, S Choi, J Christman, GE Dever, TE Prewitt
Obesity research 2001
Insulin Sensitivity Decreases with Obesity, and Lean Cats with Low Insulin Sensitivity are at Greatest Risk of Glucose Intolerance with Weight Gain
DJ Appleton, JS Rand, GD Sunvold
Journal of Feline Medicine & Surgery 2001
Obesity, Body Fat Distribution, Insulin Sensitivity and Islet β-Cell Function as Explanations for Metabolic Diversity
SE Kahn, RL Prigeon, RS Schwartz, WY Fujimoto, RH Knopp, JD Brunzell, D Porte
The Journal of nutrition 2001
Genetics of Diabetes Mellitus
WL Lowe
2001
Glycemic index, hyperinsulinemia, and breast cancer risk
TJ Key
Annals of Oncology 2001
The Importance of β-Cell Failure in the Development and Progression of Type 2 Diabetes
SE Kahn
The Journal of clinical endocrinology and metabolism 2001
Insulin sensitivity decreases with obesity, and lean cats with low insulin sensitivity are at greatest risk of glucose intolerance with weight gain.
Appleton DJ, Rand JS, Sunvold GD
Journal of feline medicine and surgery 2001
Series Introduction: The molecular and physiological basis of insulin resistance: emerging implications for metabolic and cardiovascular diseases
AR Saltiel
Journal of Clinical Investigation 2000
Glucose Metabolism Rather Than Insulin Is a Main Determinant of Leptin Secretion in Humans
P Wellhoener, B Fruehwald-Schultes, W Kern, D Dantz, W Kerner, J Born, HL Fehm, A Peters
Journal of Clinical Investigation 2000
Exercise, Nutrition and the Older Woman
SN Meydani, T McElreavy, M Meydani
Exercise, Nutrition and the Older Woman 2000
Influence of body mass on glycemic control in a type 2 diabetic population: a 3-year follow-up
P Fumelli
Archives of Gerontology and Geriatrics 2000
Duration of obesity and risk of non-insulin-dependent diabetes mellitus
Y Sakurai
Biomedecine & Pharmacotherapy 2000
Effects of changes in body weight on carbohydrate metabolism, catecholamine excretion, and thyroid function
M Rosenbaum, J Hirsch, E Murphy, RL Leibel
The American journal of clinical nutrition 2000
The Effect of 3-Month Ingestion of Ginkgo biloba Extract on Pancreatic β-Cell Function in Response to Glucose Loading in Normal Glucose Tolerant Individuals
GB Kudolo
The Journal of Clinical Pharmacology 2000
Glucose Metabolism Rather Than Insulin Is a Main Determinant of Leptin Secretion in Humans
P Wellhoener, B Fruehwald-Schultes, W Kern, D Dantz, W Kerner, J Born, HL Fehm, A Peters
The Journal of clinical endocrinology and metabolism 2000
Obesity as a medical problem
PG Kopelman
Nature 2000
Dose-response characteristics of insulin action on glucose metabolism: a non-steady-state approach
A Natali, A Gastaldelli, S Camastra, AM Sironi, E Toschi, A Masoni, E Ferrannini, A Mari
American journal of physiology. Endocrinology and metabolism 2000
Effects of hyperglycaemia and hyperinsulinaemia on plasma amino acid levels in obese subjects with normal glucose tolerance
G Marchesini, G Bianchi, B Rossi, M Muggeo, E Bonora
International Journal of Obesity 2000
Metabolic Changes in Persons After Spinal Cord Injury
WA Bauman, AM Spungen
Physical medicine and rehabilitation clinics of North America 2000
Pathologie der Leber und Gallenwege
H Denk, HP Dienes, J Düllmann, HP Fischer, O Klinge, W Lierse, KH zum Büschenfelde, U Pfeifer, KH Preisegger, G Ramadori, A Tannapfel, C Wittekind, U Wulfhekel, H Zhou
2000
Obesity: Pathology and Therapy
DH Lockwood, TC Heffner
2000
Pathogenesis of non-insulin-dependent (type II) diabetes mellitus (NIDDM) – genetic predisposition and metabolic abnormalities
HS Jun, HY Bae, BR Lee, KS Koh, YS Kim, KW Lee, H Kim, JW Yoon
Advanced Drug Delivery Reviews 1999
Comorbidities of overweight and obesity: current evidence and research issues
FX Pi-Sunyer
Medicine & Science in Sports & Exercise 1999
Lactate and glycerol release from subcutaneous adipose tissue in black and white lean men
MT van der Merwe, PA Jansson, NJ Crowther, IH Boyd, IP Gray, BI Joffe, PN Lönnroth
The Journal of clinical endocrinology and metabolism 1999
Severe hyperlipidemia in apolipoprotein E2 homozygotes due to a combined effect of hyperinsulinemia and an SstI polymorphism
EJ Sijbrands, MJ Hoffer, AE Meinders, LM Havekes, RR Frants, AH Smelt, PD Knijff
Arteriosclerosis, thrombosis, and vascular biology 1999
Ambulatory Blood Pressure and M;etabolic Abnormalities in Hypertensive Subjects With Inappropriately High Left Ventricular Mass
V Palmieri, G de Simone, MJ Roman, JE Schwartz, TG Pickering, RB Devereux
Hypertension 1999
Endotoxin-Induced Inhibition of Growth Hormone Receptor Signaling in Rat Liver in Vivo1
Y Mao, PR Ling, TP Fitzgibbons, KC McCowen, GP Frick, BR Bistrian, RJ Smith
Endocrinology 1999
Effects of 3-month nifedipine treatment on endocrine-metabolic parameters in patients with abdominal obesity and mild hypertension
M Maccario, SE Oleandri, E Avogadri, R Rossetto, S Grottoli, M Procopio, F Camanni, E Ghigo
Journal of Endocrinological Investigation 1998
ACSM Position Stand: Exercise and Physical Activity for Older Adults
RS Mazzeo, P Cavanagh, WJ Evans, M Fiatarone, J Hagberg, E McAuley, J Startzell
Medicine and Science in Sports and Exercise 1998
Insulin Resistance versus Insulin Deficiency in Non-Insulin-Dependent Diabetes Mellitus: Problems and Prospects
E Ferrannini
Endocrine reviews 1998
Insulin Resistance
DC Whitelaw, SG Gilbey
Annals of Clinical Biochemistry 1998
Alterations in skeletal muscle protein-tyrosine phosphatase activity and expression in insulin-resistant human obesity and diabetes
F Ahmad, JL Azevedo, R Cortright, GL Dohm, BJ Goldstein
Journal of Clinical Investigation 1997
Insulin resistance and hypersecretion in obesity. European Group for the Study of Insulin Resistance (EGIR)
E Ferrannini, A Natali, P Bell, P Cavallo-Perin, N Lalic, G Mingrone
Journal of Clinical Investigation 1997
Effect of Weight Gain and Subsequent Weight Loss on Glucose Tolerance and Insulin Response in Healthy Cats
V Biourge, RW Nelson, EC Feldman, NH Willits, JG Morris, QR Rogers
Journal of Veterinary Internal Medicine 1997
Improved sensitivity to insulin in obese subjects following weight loss is accompanied by reduced protein-tyrosine phosphatases in adipose tissue
F Ahmad, RV Considine, TL Bauer, JP Ohannesian, CC Marco, BJ Goldstein
Metabolism 1997
Obesity worsens cardiovascular risk profiles independently of hyperinsulinaemia
E Bonora, G Targher, MB Zenere, F Saggiani, MP Alberiche, P Branzi, M Muggeo
Journal of Internal Medicine 1997
Time course of insulin resistance associated with feeding dogs a high-fat diet
AP Rocchini, P Marker, T Cervenka
American journal of physiology. Endocrinology and metabolism 1997
Effect of obesity on pharmacokinetics and biologic effect of interferon-alpha in hepatitis C
N P Lam, D Pitrak, R Speralakis, A H Lau, T E Wiley, T J Layden
Digestive Diseases and Sciences 1997
The roles of insulin and glucagon in the regulation of hepatic glycogen synthesis and turnover in humans
M Roden, G Perseghin, KF Petersen, JH Hwang, GW Cline, K Gerow, DL Rothman, GI Shulman
Journal of Clinical Investigation 1996
Interactions Between Glucose and FFA Metabolism in Man
C Saloranta, L Groop
Diabetes/Metabolism Reviews 1996
Effects of insulin on glucose turnover rates in vivo: Isotope dilution versus constant specific activity technique
O Hother-Nielsen, JE Henriksen, JJ Holst, H Beck-Nielsen
Metabolism 1996
Increased Plasma Oxidizability in Subjects with Severe Obesity
R Pipek, G Dankner, A Ben-Amotz, M Aviram, Y Levy
Journal of Nutritional and Environmental Medicine 1996
Triacylglycerol lowering properties of the adenosine analog GR 79236 during 5 days of dosing large, old rats: A pilot study
CS Thompson, P Strong, DP Mikhailidis
Nutrition Research 1996
Effects of glucocorticoids on energy metabolism and food intake in humans
PA Tataranni, DE Larson, S Snitker, JB Young, JP Flatt, E Ravussin
American journal of physiology. Endocrinology and metabolism 1996
Microdialysis measurements in skin: evidence for significant lactate release in healthy humans
PA Jansson, AL Krogstad, P Lonnroth
American journal of physiology. Endocrinology and metabolism 1996
CLINICAL DETERMINANTS OF GLUCOSE HOMEOSTASIS AFTER PANCREAS TRANSPLANTATION:
BJ Nankivell, JR Chapman, KJ Bovington, ST Spicer, PJ O'Connell, RD Allen
Transplantation 1996
Metabolic and Hemodynamic Effects of a Graded Intracoronary Insulin Infusion in Normal and Fat Anesthetized Dogs: A Preliminary Study
AP Rocchini, RF Wilson, P Marker, T Cervenka
Hypertension 1996
Increased abundance of the receptor-type protein-tyrosine phosphatase LAR accounts for the elevated insulin receptor dephosphorylating activity in adipose tissue of obese human subjects
F Ahmad, RV Considine, BJ Goldstein
Journal of Clinical Investigation 1995
Failure of complete suppression of endogenous glucose production by euglycaemic hyperinsulinaemia in normal humans
RD Neely, R Harper, DP Rooney, CN Ennis, PM Bell, ER Trimble
European Journal of Clinical Investigation 1995
Insulin regulation of muscle glucose metabolism: Role of pre-receptorial mechanisms
B Capaldo, L Saccà
Diabetes / Metabolism Reviews 1995
Advances in Veterinary Science and Comparative Medicine
GM Happ
Veterinary Medical Specialization - Bridging Science and Medicine 1995
Low-carbohydrate diet alters intracellular glucose metabolism but not overall glucose disposal in exercise-trained subjects
DL Cutler, CG Gray, SW Park, MG Hickman, JM Bell, OG Kolterman
Metabolism 1995
Insulin binding in non-insulin-dependent diabetes mellitus (NIDDM) is correlated with glycemic control: Clinical evidence for abnormal receptor regulation in NIDDM
CM Kelly, IG Fantus
Metabolism 1995
Alterations in carbohydrate metabolism during stress: A review of the literature
BA Mizock
The American Journal of Medicine 1995
Transport-induced stress responses in fed and fasted donkeys
AJ Forhead, D Smart, RF Smith, H Dobson
Research in Veterinary Science 1995
The Hypothalamic-Pituitary-Adrenal Axis in Obesity
S Chalew, H Nagel, S Shore
Obesity research 1995
Mathematical formulae for the prediction of the residual beta cell function during the first two years of disease in children and adolescents with insulin-dependent diabetes mellitus
Y Klipper-Aurbach, M Wasserman, N Braunspiegel-Weintrob, D Borstein, S Peleg, S Assa, M Karp, Y Benjamini, Y Hochberg, Z Laron
Medical Hypotheses 1995
Exercise, Nutrition, and Aging
WJ Evans
Clinics in Geriatric Medicine 1995
Insulin and Forearm Vasodilation in Hypertension-Prone Men
UL Hulthén, T Endre, I Mattiasson, G Berglund
Hypertension 1995
Multiple Risk Factors in Cardiovascular Disease
AM Gotto, C Lenfant, AL Catapano, R Paoletti
1995
Metabolic effects of darglitazone, an insulin sensitizer, in NIDDM subjects
RL Chaiken, M Eckert-Norton, R Pasmantier, G Boden, I Ryan, RA Gelfand, HE Lebovitz
Diabetologia 1995
Insulin regulation of glucose turnover and lipid levels in obese children with fasting normoinsulinaemia
LD Monti, P Brambilla, I Stefani, A Caumo, F Magni, R Poma, L Tomasini, G Agostini, M Galli-Kienle, C Cobelli, G Chiumello, G Pozza
Diabetologia 1995
The Effects of Exercise on Growth:
KT Borer
Sports Medicine 1995
Lactate release from the subcutaneous tissue in lean and obese men
PA Jansson, A Larsson, U Smith, P Lönnroth
Journal of Clinical Investigation 1994
Impaired insulin-induced sympathetic neural activation and vasodilation in skeletal muscle in obese humans
P Vollenweider, D Randin, L Tappy, E Jéquier, P Nicod, U Scherrer
Journal of Clinical Investigation 1994
How to measure insulin action in vivo
AJ Scheen, N Paquot, MJ Castillo, PJ Lefèbvre
Diabetes / Metabolism Reviews 1994
Clinical and histologic predictors of response to interferon-α in patients with chronic hepatitis C viral infection
NP Lam, LJ DeGuzman, D Pitrak, TJ Layden
Digestive Diseases and Sciences 1994
Genetic epidemiology of non-insulin-dependent diabetes
P Valsania, P Micossi
Diabetes / Metabolism Reviews 1994
Insulin resistance syndrome as a feature of cardiological syndrome X in non-obese men
JW Swan, C Walton, IF Godsland, D Crook, MF Oliver, JC Stevenson
British heart journal 1994
Augmented effect of short-term pulsatile versus continuous insulin delivery on lipid metabolism but similar effect on whole-body glucose metabolism in obese subjects
O Schmitz, SB Pedersen, A Mengel, N Pørksen, J Bak, N Møller, B Richelsen, KG Alberti, PC Butler, H Ørskov
Metabolism 1994
Hemodynamic actions of insulin
R Aikawa, M Nawano, Y Gu, H Katagiri, T Asano, W Zhu, R Nagai, I Komuro
The American journal of physiology 1994
4 Hormones and obesity
PG Kopelman
Baillière's Clinical Endocrinology and Metabolism 1994
Skeletal muscle blood flow independently modulates insulin-mediated glucose uptake
AD Baron, H Steinberg, G Brechtel, A Johnson
American journal of physiology. Endocrinology and metabolism 1994
Insulin and renal sodium retention in hypertension-prone men
T Endre, I Mattiasson, G Berglund, UL Hulthén
Hypertension 1994
High-fructose feeding elicits insulin resistance, hyperinsulinism, and hypertension in normal mongrel dogs
FJ Martinez, RA Rizza, JC Romero
Hypertension 1994
Additive effects of obesity, hypertension, and type 2 diabetes on insulin resistance
P Maheux, J Jeppesen, WH Sheu, CB Hollenbeck, C Clinkingbeard, MS Greenfield, YD Chen, GM Reaven
Hypertension 1994
Impaired insulin sensitivity and maximal responsiveness in older hypertensive men
DR Dengel, RE Pratley, JM Hagberg, AP Goldberg
Hypertension 1994
Primary, secondary and tertiary prevention of non-insulin-dependent diabetes
A Dornhorst, PK Merrin
Postgraduate medical journal 1994
The Link Between Insulin Resistance and Hypertension: Effects of Antihypertensive and Antihyperlipidaemic Drugs on Insulin Sensitivity
T Baba, S Neugebauer
Drugs 1994
Angiotensin II increases glucose utilization during acute hyperinsulinemia via a hemodynamic mechanism
TA Buchanan, H Thawani, W Kades, JG Modrall, FA Weaver, C Laurel, R Poppiti, A Xiang, W Hsueh
Journal of Clinical Investigation 1993
The effects of single and sequential insulin infusions on glucose disposal in older men
RE Prately, PJ Coon, DC Muller, EM Rogus, AP Goldberg
Experimental Gerontology 1993
Insulin and hypertension: Are they related?
WP Meehan, CH Darwin, NB Maalouf, TA Buchanan, MF Saad
Steroids 1993
Characteristics and mechanisms of tachyphylaxis of cardiac contractile response to insulin
R Sethi, H Rupp, BJ Naimark, J Barwinsky, RE Beamish, NS Dhalla
International Journal of Cardiology 1993
Body fat distribution, blood pressure and blood glucose in Egyptian obese women undergoing a weight control program
SM El-Shebini, ST Tapozada, LM Hanna
Zeitschrift für Ernährungswissenschaft 1993
Insulin differentially regulates systemic and skeletal muscle vascular resistance
AD Baron, G Brechtel
American journal of physiology. Endocrinology and metabolism 1993
Hepatic and extrahepatic insulin action in humans: measurement in the absence of non-steady-state error
H Katz, P Butler, M Homan, A Zerman, A Caumo, C Cobelli, R Rizza
American journal of physiology. Endocrinology and metabolism 1993
From ‘Syndrome X’ to the Thrifty Phenotype: A Reappraisal of the Insulin Resistance Theory of Atherogenesis
JH Pinkney, DK Nagi, JS Yudkin
1993
Skeletal muscle blood flow. A possible link between insulin resistance and blood pressure
AD Baron, G Brechtel-Hook, A Johnson, D Hardin
Hypertension 1993
Insulin resistance is an important determinant of left ventricular mass in the obese
Z Sasson, Y Rasooly, T Bhesania, I Rasooly
Circulation 1993
New Concepts in the Pathogenesis of NIDDM
CG Östenson, S Efendić, M Vranic
1993
Insulin resistance in offspring of hypertensive parents
OL Beatty, R Harper, B Sheridan, AB Atkinson, PM Bell
BMJ : British Medical Journal 1993
Insulin resistance in a case of coexisting insulinoma and type 2 diabetes
G Grunberger
Acta Diabetologica 1993
Insulin sensitivity of protein and glucose metabolism in human forearm skeletal muscle
RJ Louard, DA Fryburg, RA Gelfand, EJ Barrett
Journal of Clinical Investigation 1992
Relation of serum lipoprotein lipids and apolipoproteins to obesity in children: The Bogalusa heart study
DA Kikuchi, SR Srinivasan, DW Harsha, LS Webber, TA Sellers, GS Berenson
Preventive Medicine 1992
Assessment of Glucose Turnover Rates in Euglycaemic Clamp Studies using Primed-constant [3-3H]-glucose Infusion and Labelled or Unlabelled Glucose Infusates
O Hother-Nielsen, A Møngel, J Møller, O Rasmussen, O Schmitz, H Beck-Nielsen
Diabetic Medicine 1992
Relationship of insulin clearance and secretion to insulin sensitivity in non-diabetic Mexican Americans
SM Haffner, MP Stern, RM Watanabe, RN Bergman
European Journal of Clinical Investigation 1992
The glucoregulatory and antilipolytic actions of insulin in abdominal obesity with normal or impaired glucose tolerance: an in vivo and in vitro study
P Cavallo-Perin, A Bruno, M Cassader, L Cesco, G Gruden, G Pagano
European Journal of Clinical Investigation 1992
Effects of morbid obesity on insulin clearance and insulin sensitivity in several aspects of metabolism as assessed by low-dose insulin infusion
DA Robertson, BM Singh, PJ Hale, M Nattrass
Metabolism 1992
Insulin and lipogenesis in rat adipocytes. I. Effect of insulin incubation on lipid synthesis by isolated rat adipocytes
LM Morales, G Campos, E Ryder, A Casanova
Biochemical and Biophysical Research Communications 1992
Autosomal dominant insulin resistance syndrome due to a postbinding defect
E Seemanová, HW Rüdiger, M Dreyer
American Journal of Medical Genetics 1992
Time course of plasma free fatty acid concentration in response to insulin: Effect of obesity and physical fitness
PJ Coon, EM Rogus, AP Goldberg
Metabolism 1992
Influence of sympatho-adrenal system on insulin sensitivity using the euglycemic clamp technique
M Kusunoki, Y Oshida, A Iguchi, T Iida, T Suga, T Funado, Y Sato, K Kato, N Sakamoto
Diabetes Research and Clinical Practice 1992
Exploration de l'insulinosensibilité périphérique des obèses diabétiques ou non
H Puy, F Boitte, JM Marcelli, X Debussche, O Vincent, G Desmet, J Quichaud
Nutrition Clinique et Métabolisme 1992
Lipoprotein metabolism following gastroplasty in obese women
HV Schenck, L Wallentin, C Lennmarken, J Larsson
Scandinavian Journal of Clinical & Laboratory Investigation 1992
Effects of epinephrine on insulin-mediated glucose uptake in whole body and leg muscle in humans: role of blood flow
M Laakso, SV Edelman, G Brechtel, AD Baron
American journal of physiology. Endocrinology and metabolism 1992
Effect of insulin on oxidative and nonoxidative pathways of free fatty acid metabolism in human obesity
LC Groop, RC Bonadonna, DC Simonson, AS Petrides, M Shank, RA DeFronzo
American journal of physiology. Endocrinology and metabolism 1992
Possible Epidemiological Factors Associated with Rupture of the Posterior Tibial Tendon
GB Holmes, RA Mann
1992
Use of [3-3H]glucose and [6-14C]glucose to measure glucose turnover and glucose metabolism in humans
H Katz, M Homan, P Butler, R Rizza
American journal of physiology. Endocrinology and metabolism 1992
Insulin resistance in werner's syndrome
M Okamoto, M Okamoto, K Yamada, Y Yoshimasa, A Kosaki, S Kono, Inoue, I Maeda, M Kubota, T Hayashi, S Kato, H Kuzuya, H Imura
Mechanisms of Ageing and Development 1992
Short-term regulation of insulin-mediated glucose utilization in four-day fasted human volunteers: role of amino acid availability
PJ Flakoll, LS Wentzel, DE Rice, JO Hill, NN Abumrad
Diabetologia 1992
Diabetes and Atherosclerosis
RW Stout
1992
Reduced glycogen synthase activity in skeletal muscle from obese patients with and without Type 2 (non-insulin-dependent) diabetes mellitus
C Bogardus, S Lillioja, K Stone, D Mott
Journal of Clinical Investigation 1991
Differences in insulin action as a function of original anatomical site of newly differentiated adipocytes obtained in primary culture
C Sztalryd, S Azhar, GM Reaven
Journal of Clinical Investigation 1991
Acute C-Peptide, Insulin and Branched Chain Amino Acid Response to Feeding in Formula and Breast Fed Infants
M Wallensteen, BS Lindblad, R Zetterström, B Persson
Acta Paediatrica 1991
Urinary C-peptide Excretion in Obese and Anorectic Children
M Wallensteen, BE Ginsburg, B Persson, G Dahlquist
Acta Paediatrica 1991
Understanding “insulin resistance”: Both glucose resistance and insulin resistance are required to model human diabetes
AS Rudenski, DR Matthews, JC Levy, RC Turner
Metabolism 1991
The effects of euglycemic hyperinsulinemia and amino acid infusion on regional and whole body glucose disposal in man
PW Pisters, NP Restifo, E Cersosimo, MF Brennan
Metabolism 1991
Differential effects of insulin resistance on leucine and glucose kinetics in obesity
B Caballero, RJ Wurtman
Metabolism 1991
Altered plasma free amino acid levels in obese traumatized man
M Jeevanandam, L Ramias, WR Schiller
Metabolism 1991
A mathematical model and computer simulation study of insulin receptor regulation
MJ Quon, LA Campfield
Journal of Theoretical Biology 1991
Effects of ciglitazone on endogenous plasma islet amyloid polypeptide and insulin sensitivity in obese-diabetic viable yellow mice
AM Gill, TT Yen
Life Sciences 1991
Insulin resistance and action in hypertriglyceridemia
S Zuniga-Guarjardo, G Steiner, S Shumak, B Zinman
Diabetes Research and Clinical Practice 1991
International Review of Cytology
RA Miller
International Review of Cytology 1991
Essential hypertension, metabolic disorders, and insulin resistance
E Ferrannini, A Natali
American Heart Journal 1991
A two-step model for development of non-insulin-dependent diabetes
MF Saad, WC Knowler, DJ Pettitt, RG Nelson, MA Charles, PH Bennett
The American Journal of Medicine 1991
Glucose tolerance and insulin release in adolescent female
L Benassi, G Tridenti, N Orlandi, A Pezzarossa
Journal of Endocrinological Investigation 1991
Amino Acids Enhance Insulin Resistance to Exogenous Glucose Infusion in Overnight-Fasted Humans
PJ Flakoll, M Kulaylat, M Frexes-Steed, JO Hill, NN Abumrad
JPEN. Journal of parenteral and enteral nutrition 1991
Hyperinsulinaemia: the key feature of a cardiovascular and metabolic syndrome
E Ferrannini, SM Haffner, BD Mitchell, MP Stern
Diabetologia 1991
Insulin resistance and diabetes due to different mutations in the tyrosine kinase domain of both insulin receptor gene alleles
J Kusari, Y Takata, E Hatada, G Freidenberg, O Kolterman, JM Olefsky
The Journal of biological chemistry 1991
Hepatic protein phosphotyrosine phosphatase. Dephosphorylation of insulin and epidermal growth factor receptors in normal and alloxan diabetic rats
PA Gruppuso, JM Boylan, BI Posner, R Faure, DL Brautigan
Journal of Clinical Investigation 1990
Decreased effect of insulin to stimulate skeletal muscle blood flow in obese man. A novel mechanism for insulin resistance
M Laakso, SV Edelman, G Brechtel, AD Baron
Journal of Clinical Investigation 1990
Insulin Insensitivity in Offspring of Parents with Type 2 Diabetes Mellitus
LT Ho, ZY Chang, JT Wang, SH Li, YF Liu, YD Chen, GM Reaven
Diabetic Medicine 1990
Diabetes mellitus in the pima indians: Incidence, risk factors and pathogenesis
WC Knowler, DJ Pettitt, MF Saad, PH Bennett
Diabetes / Metabolism Reviews 1990
Lack of effect of tenoxicam on dynamic responses to concurrent oral doses of glucose and glibenclamide
D Hartmann, A Korn, M Komjati, G Heinz, P Haefelfinger, R Defoin, WK Waldhäusl
British Journal of Clinical Pharmacology 1990
Obesity and insulin resistance in humans: A dose-response study
RC Bonadonna, G Leif, N Kraemer, E Ferrannini, SD Prato, RA DeFronzo
Metabolism 1990
The assessment of hepatic and peripheral insulin sensitivity in hypertriglyceridemia
WR McKane, AB Stevens, R Woods, WJ Andrews, RW Henry, PM Bell
Metabolism 1990
Does fasting interval affect the glucose challenge test?
MD Berkus, MP Stern, BD Mitchell, ER Newton, O Langer
American Journal of Obstetrics and Gynecology 1990
Relationships between glucose levels and insulin secretio during a glucose challenge test
MD Berkus, MP Stern, BD Mitchell, A Abashawl, O Langer
American Journal of Obstetrics and Gynecology 1990
Use of a variable tracer infusion method to determine glucose turnover in humans
JM Molina, AD Baron, SV Edelman, G Brechtel, P Wallace, JM Olefsky
American journal of physiology. Endocrinology and metabolism 1990
Insulin resistance is associated with lipid and lipoprotein abnormalities in subjects with varying degrees of glucose tolerance
M Laakso, H Sarlund, L Mykkänen
Arteriosclerosis (Dallas, Tex.) 1990
Insulin resistance and blood pressure in young black men
B Falkner, S Hulman, J Tannenbaum, H Kushner
Hypertension 1990
Insulin administration alters gonadal steroid metabolism independent of changes in gonadotropin secretion in insulin-resistant women with the polycystic ovary syndrome
A Dunaif, M Graf
Journal of Clinical Investigation 1989
Insulin transport across capillaries is rate limiting for insulin action in dogs
YJ Yang, ID Hope, M Ader, RN Bergman
Journal of Clinical Investigation 1989
Hepatic glucose production in insulin-resistant states
E Ferrannini, LC Groop
Diabetes / Metabolism Reviews 1989
Assessment of insulin sensitivity in vivo: A critical review
RN Bergman, ID Hope, YJ Yang, RM Watanabe, MA Meador, JH Youn, M Ader
Diabetes / Metabolism Reviews 1989
The impact of obesity on the pathogenesis of non-insulin-dependent diabetes mellitus: A review of current hypotheses
O Pedersen
Diabetes / Metabolism Reviews 1989
The Insulin Receptor: Structure and Functio
Y Zick
Critical Reviews in Biochemistry and Molecular Biology 1989
Essential hypertension and insulin resistance in non-insulin-dependent diabetes
M Laakso, H Sarlund, L Mykkänen
European Journal of Clinical Investigation 1989
SEQUENTIAL CHANGES IN SERUM INSULIN CONCENTRATION DURING DEVELOPMENT OF NON-INSULIN-DEPENDENT DIABETES
MF Saad, DJ Pettitt, DM Mott, WC Knowler, RG Nelson, PH Bennett
The Lancet 1989
Insulin resistance in skeletal muscles of patients with diabetes mellitus
H Beck-Nielsen
Diabetes / Metabolism Reviews 1989
Insulin transport across capillaries is rate limiting for insulin action in dogs
YJ Yang, ID Hope, M Ader, RN Bergman
New England Journal of Medicine 1989
Insulin Secretion in Childhood Obesity
T Yoshizumi, H Masuda, T Fujiwara, Y Uchida, H Kamiya, H Hirota, M Kubo, C Haibara, M Sakurai
Pediatrics International 1989
Disopyramide induces insulin secretion and plasma glucose diminution: Studies using the in situ canine pancreas
H Nakabayashi, T Ito, T Igawa, Y Hiraiwa, T Imamura, T Seta, M Kawato, N Usukura, R Takeda
Metabolism 1989
Insulin resistance in porphyria cutanea tarda
F Calcinaro, G Basta, P Lisi, C Cruciani, M Pietropaolo, F Santeusanio, A Falorni, R Calafiore
Journal of Endocrinological Investigation 1989
Low Levels of High-Affinity Growth Hormone-Binding Protein in African Pygmies
G Baumann, MA Shaw, TJ Merimee
New England Journal of Medicine 1989
Endocrine Aspects of Obesity
AR Glass
Medical Clinics of North America 1989
Reproductive endocrinologic alterations in female asymptomatic obesity
EE Wallach, R Azziz
Fertility and Sterility 1989
Insulin sensitivity and responsiveness during lactation and dry period in goats
E Debras, J Grizard, E Aina, S Tesseraud, C Champredon, M Arnal
American journal of physiology. Endocrinology and metabolism 1989
Effects of obesity on insulin sensitivity and responsiveness in sheep
EN Bergman, SS Reulein, RE Corlett
American journal of physiology. Endocrinology and metabolism 1989
Insulin and renal sodium retention in obese adolescents
AP Rocchini, V Katch, D Kveselis, C Moorehead, M Martin, R Lampman, M Gregory
Hypertension 1989
Pathogenesis of weight-related changes in blood pressure in dogs
AP Rocchini, CP Moorehead, S DeRemer, D Bondie
Hypertension 1989
Nutrition, Aging, and the Elderly
HN Munro, DE Danford
1989
Handbook of Research Methods in Cardiovascular Behavioral Medicine
N Schneiderman, SM Weiss, PG Kaufmann
1989
The Reduction of Peripheral Insulin Concentrations in Obese Subjects following a Hypocaloric Diet: Reduced Pancreatic Secretion or Increased Hepatic Extraction?
R Gama, V Marks
Annals of Clinical Biochemistry 1989
Recovery of maximal insulin responsiveness and insulin sensitivity after induction of insulin resistance in primary cultured adipocytes
RR Traxinger, S Marshall
The Journal of biological chemistry 1989
Role of glucose transporters in the cellular insulin resistance of type II non-insulin-dependent diabetes mellitus
WT Garvey, TP Huecksteadt, S Matthaei, JM Olefsky
Journal of Clinical Investigation 1988
Mild type II diabetes markedly increases glucose cycling in the postabsorptive state and during glucose infusion irrespective of obesity
S Efendic, S Karlander, M Vranic
Journal of Clinical Investigation 1988
An in vitro human muscle preparation suitable for metabolic studies. Decreased insulin stimulation of glucose transport in muscle from morbidly obese and diabetic subjects
GL Dohm, EB Tapscott, WJ Pories, DJ Dabbs, EG Flickinger, D Meelheim, T Fushiki, SM Atkinson, CW Elton, JF Caro
Journal of Clinical Investigation 1988
Reversibility of defective adipocyte insulin receptor kinase activity in non-insulin-dependent diabetes mellitus. Effect of weight loss
GR Freidenberg, D Reichart, JM Olefsky, RR Henry
Journal of Clinical Investigation 1988
Metabolic basis of obesity and noninsulin-dependent diabetes mellitus
A Golay, JP Felber, E Jequier, RA DeFronzo, E Ferrannini
Diabetes / Metabolism Reviews 1988
Correlation of in vivo and in vitro actions of insulin in obesity and noninsulin-dependent diabetes mellitus: Role of the glucose transport system
WT Garvey, OG Kolterman
Diabetes / Metabolism Reviews 1988
Die Beziehung zwischen Körperfettverteilung, Insulinspiegeln und Glukosetoleranz bei übergewichtigen Frauen
H Hauner, EF Pfeiffer
Klinische Wochenschrift 1988
Insulin sensitivity in anorexia nervosa: A mirror image of obesity?
AJ Scheen, M Castillo, PJ Lefèbvre
Diabetes / Metabolism Reviews 1988
Glucose-induced insulin resistance of skeletal-muscle glucose transport and uptake
EA Richter, BF Hansen, SA Hansen
Biochemical Journal 1988
Relationship between lipoprotein levels and in vivo insulin action in normal young white men
A Garg, JH Helderman, M Koffler, R Ayuso, J Rosenstock, P Raskin
Metabolism 1988
Following weight loss in massively obese patients correction of the insulin resistance of fat metabolism is delayed relative to the improvement in carbohydrate metabolism
PJ Hale, BM Singh, J Crase, RM Baddeley, M Nattrass
Metabolism 1988
Obesity is associated with impaired insulin-mediated potassium uptake
RA DeFronzo
Metabolism 1988
Plasma acetate levels in response to intravenous fat or infusions in diabetic and non-diabetic subjects
AO Akanji, L Ng, S Humphreys
Clinica Chimica Acta 1988
Impaired insulin action in adipocytes of New Zealand Obese mice: A role for postbinding defects in pyruvate dehydrogenase and insulin mediator activity
SL Macaulay, RG Larkins
Metabolism 1988
Bed-rest-induced insulin resistance occurs primarily in muscle
CA Stuart, RE Shangraw, MJ Prince, EJ Peters, RR Wolfe
Metabolism 1988
2 Role of insulin resistance in the pathogenesis of Type 2 (non-insulin-dependent) diabetes mellitus
JE Gerich
Baillière's Clinical Endocrinology and Metabolism 1988
Obesity and insulin resistance: lessons learned from the Pima Indians
S Lillioja, C Bogardus
Diabetes/Metabolism Reviews 1988
Antecedent chronic hyperglycaemia blocks phlorizin-induced insulin resistance in the dog
M Koffler, T Imamura, F Santeusanio, JH Helderman
Diabetologia 1988
Insulin: Either Alone or Combined with Oral Hypoglycemic Agents
RG Firth
Primary care 1988
Decreased kinase activity of insulin receptors from adipocytes of non-insulin-dependent diabetic subjects
GR Freidenberg, RR Henry, HH Klein, DR Reichart, JM Olefsky
Journal of Clinical Investigation 1987
Equivalence of the insulin sensitivity index in man derived by the minimal model method and the euglycemic glucose clamp
RN Bergman, R Prager, A Volund, JM Olefsky
Journal of Clinical Investigation 1987
Mechanism for enhanced glucose transport response to insulin in adipose cells from chronically hyperinsulinemic rats. Increased translocation of glucose transporters from an enlarged intracellular pool
BB Kahn, ES Horton, SW Cushman
Journal of Clinical Investigation 1987
Effects of insulin infusion on human skeletal muscle pyruvate dehydrogenase, phosphofructokinase, and glycogen synthase. Evidence for their role in oxidative and nonoxidative glucose metabolism
LJ Mandarino, KS Wright, LS Verity, J Nichols, JM Bell, OG Kolterman, H Beck-Nielsen
Journal of Clinical Investigation 1987
Weight reduction increases adipose tissue lipoprotein lipase responsiveness in obese women
RH Eckel, TJ Yost
Journal of Clinical Investigation 1987
Factors regulating the disposal of an oral glucose load in normal, diabetic, and obese subjects
WK Waldhäusl, P Bratusch-Marrain
Diabetes / Metabolism Reviews 1987
Insulin resistance in patients with colorectal cancer
GP Copeland, SJ Leinster, JC Davis, LJ Hipkin
British Journal of Surgery 1987
Insulin binding to erythrocytes in hyperinsulinemic patients with precirrhotic hemochromatosis and cirrhosis
AS Petrides, W Paßlack, H Reinauer, W Stremmel, G Strohmeyer
Klinische Wochenschrift 1987
Diet composition and lipoprotein lipase (EC 3.1.1.34) activity in human obesity
LA Smolin, MB Grosvenor, DJ Handelsman, JA Brasel
British Journal of Nutrition 1987
Regulation of hepatic glucose metabolism in humans
RA DeFronzo, E Ferrannini
Diabetes / Metabolism Reviews 1987
Beta cell function in the preclinical period of insulin-dependent diabetes
DK McCulloch, JP Palmer, EA Benson
Diabetes / Metabolism Reviews 1987
Insulin Resistance and Ammo Acid Metabolism in Obesity
B Caballero
Annals of the New York Academy of Sciences 1987
Potential Role of Adipose Tissue for the Development of Insulin Resistance in Obesity
P Lönnroth
Acta Medica Scandinavica 1987
Insulin Action-Biochemical and Clinical Aspects
U Smith
Acta Medica Scandinavica 1987
Defective glucose utilization in patients with functioning beta-cell tumors persists after tumor excision
GS McGee, MM Kulaylat, NN Abumrad
Annals of Surgery 1987
Insulin action in non-insulin-dependent diabetes mellitus: The relationship between hepatic and extrahepatic insulin resistance and obesity
R Firth, P Bell, R Rizza
Metabolism 1987
Protein–energy malnutrition in pregnant rats improves the adaptation of the endocrine pancreas in malnourished offspring and induces insulin resistance after rehabilitation
JM Dollet, B Beck, JP Max, G Debry
British Journal of Nutrition 1987
Importance of substrate competition in the mechanism of insulin resistance in man
D Vouillamoz, E Temler, E Jéquier, JP Felber
Metabolism 1987
Aging and diabetes mellitus as risk factors for vascular disease
KL Minaker
The American Journal of Medicine 1987
6 Insulin sensitivity in the intact organism
M Ader, RN Bergman
Baillière's Clinical Endocrinology and Metabolism 1987
Theory of the etiology of human toxemia of pregnancy: Fetal hyperinsulinemia as a compensatory response to decreased uterine blood flow
DR Bonds, LO Crosby
Medical Hypotheses 1987
Puberty decreases insulin sensitivity
CA Bloch, P Clemons, MA Sperling
The Journal of Pediatrics 1987
Insulin Resistance and the Use of U-500 Insulin: A Case Report
JA Fain
The Diabetes Educator 1987
Dissociation of in vitro sensitivities of glucose transport and antilipolysis to insulin in NIDDM
H Yki-Jarvinen, K Kubo, J Zawadzki, S Lillioja, A Young, W Abbott, JE Foley
American journal of physiology. Endocrinology and metabolism 1987
Chronic administration of theophylline to rats induces a post-insulin binding defect in adipocyte glucose transport
A Green
Diabetologia 1987
Modifications of cellular lipids induce insulin resistance in cultured hepatoma cells
C Bruneau, P Hubert, A Waksman, JP Beck, C Staedel-Flaig
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1987
Endocrine Abnormalities in Morbid Obesity
A Peiris, A Kissebah
Gastroenterology Clinics of North America 1987
Glucose and insulin co-regulate the glucose transport system in primary cultured adipocytes. A new mechanism of insulin resistance
WT Garvey, JM Olefsky, S Matthaei, S Marshall
The Journal of biological chemistry 1987
Adenosine receptor down-regulation and insulin resistance following prolonged incubation of adipocytes with an A1 adenosine receptor agonist
A Green
The Journal of biological chemistry 1987
Insulin. Its role in the thermic effect of glucose
L Christin, CA Nacht, O Vernet, E Ravussin, E Jéquier, KJ Acheson
Journal of Clinical Investigation 1986
In vivo kinetics of insulin action on peripheral glucose disposal and hepatic glucose output in normal and obese subjects
R Prager, P Wallace, JM Olefsky
Journal of Clinical Investigation 1986
Glucoregulation in acute liver failure
H Vilstrup, J Iversen, N Tygstrup
European Journal of Clinical Investigation 1986
Physical training and insulin sensitivity
VA Koivisto, H Yki-Järvinen, RA DeFronzo
Diabetes / Metabolism Reviews 1986
Exercise and physical training: Effects on insulin sensitivity and glucose metabolism
ES Horton
Diabetes / Metabolism Reviews 1986
The effect of liver microsomal enzyme inducing and inhibiting drugs on insulin mediated glucose metabolism in man
JT Lahtela, B Gachalyi, S Eksymä, A Hämäläinen, EA Sotaniemi
British Journal of Clinical Pharmacology 1986
Overnutrition induced decrease in insulin action for glucose storage: In vivo and in vitro in man
DM Mott, S Lillioja, C Bogardus
Metabolism 1986
Insulin resistance with acanthosis nigricans: The roles of obesity and androgen excess
CA Stuart, EJ Peters, MJ Prince, G Richards, A Cavallo, WJ Meyer
Metabolism 1986
Effects of massive obesity on insulin sensitivity and insulin clearance and the metabolic response to insulin as assessed by the euglycemic clamp technique
S Zuniga-Guajardo, J Jimenez, A Angel, B Zinman
Metabolism 1986
Effects of caloric restriction and exercise of insulin receptors in obesity: Association with changes in membrane lipids
ND Neufeld, C Ezrin, L Corbo, D Long, MA Bush
Metabolism 1986
Studies on overnight insulin requirements and metabolic clearance rate of insulin in normal and diabetic man: relevance to the pathogenesis of the dawn phenomenon
P Feo, G Perriello, MM Ventura, F Calcinaro, G Basta, C Lolli, C Cruciani, A Dell'Olio, F Santeusanio, P Brunetti, GB Bolli
Diabetologia 1986
Hypertension and diabetes in obesity: A review and new ideas on the contributing role of ions
RS El-Mallakh
Medical Hypotheses 1986
Subclinical abnormalities of glucose metabolism in subjects with previous gestational diabetes
PM Catalano, IM Bernstein, RR Wolfe, S Srikanta, E Tyzbir, EA Sims
American Journal of Obstetrics and Gynecology 1986
Natural Course of Insulin Resistance in Type I Diabetes
H Yki-Järvinen, VA Koivisto
New England Journal of Medicine 1986
The Receptors
RG Rosenfeld, RL Hintz
The Receptors 1986
The Effects of Diet and Exercise in the Treatment of Non-Insulin Dependent Diabetes Mellitus
HM Kim, SK Lim, KR Kim, HC Lee, KB Huh, HS Park
The Korean Journal of Internal Medicine 1986
Review: Pathogenesis of Type 2 Diabetes Mellitus: An Interpretation of Current Data
MB Davidson
The American Journal of the Medical Sciences 1986
Insulin resistance in acromegaly: defects in both hepatic and extrahepatic insulin action
I Hansen, E Tsalikian, B Beaufrere, J Gerich, M Haymond, R Rizza
American journal of physiology. Endocrinology and metabolism 1986
Body fat distribution and hyperinsulinemia as risk factors for diabetes and cardiovascular disease
MP Stern, SM Haffner
Arteriosclerosis (Dallas, Tex.) 1986
Pathogenesis and Treatment of Diabetes Mellitus
JK Radder, HH Lemkes, HM Krans
1986
Biological and Psychological Factors in Cardiovascular Disease
TH Schmidt, TM Dembroski, G Blümchen
1986
Insulin receptors and the clinician
R Taylor
BMJ : British Medical Journal 1986
Studies on overnight insulin requirements and metabolic clearance rate of insulin in normal and diabetic man: relevance to the pathogenesis of the dawn phenomenon
PD Feo, G Perriello, MM Ventura, F Calcinaro, G Basta, C Lolli, C Cruciani, A Dell'Olio, F Santeusanio, P Brunetti, GB Bolli
Diabetologia 1986
Insulin receptor down-regulation is linked to an insulin-induced postreceptor defect in the glucose transport system in rat adipocytes
WT Garvey, JM Olefsky, S Marshall
Journal of Clinical Investigation 1985
Effect of insulin on the distribution and disposition of glucose in man
E Ferrannini, JD Smith, C Cobelli, G Toffolo, A Pilo, RA DeFronzo
Journal of Clinical Investigation 1985
Evidence that insulin resistance is responsible for the decreased thermic effect of glucose in human obesity
E Ravussin, KJ Acheson, O Vernet, E Danforth, E Jéquier
Journal of Clinical Investigation 1985
Kinetic Models for Plasma Disappearance of Insulin in Normal Subjects
B Thorsteinsson, S Fugleberg, B Feldt-Rasmussen, C Binder
Acta Pharmacologica et Toxicologica 1985
Cellular mechanisms in selected states of insulin resistance: Human obesity, glucocorticoid excess, and chronic renal failure
JM Amatruda, JN Livingston, DH Lockwood
Diabetes / Metabolism Reviews 1985
Insulin action and glucose metabolism in sheep fed on dried-grass or ground, maize-based diets
AN Janes, TE Weekes, DG Armstrong
British Journal of Nutrition 1985
Pathogenesis of impaired glucose tolerance and type II diabetes mellitus--current status
MB Davidson
The Western journal of medicine 1985
Suppression of basal, but not of glucose-stimulated insulin secretion by human insulin in healthy and obese hyperinsulinemic subjects
PR Bratusch-Marrain, WK Waldhäusl
Metabolism 1985
Hepatic and peripheral insulin resistance following streptozotocin-induced insulin deficiency in the dog
S Bevilacqua, EJ Barrett, D Smith, DC Simonson, M Olsson, P Bratusch-Marrain, E Ferrannini, RA DeFronzo
Metabolism 1985
Control of erythrocyte membrane microviscosity by insulin
AK Dutta-Roy, TK Ray, AK Sinha
Biochimica et Biophysica Acta (BBA) - Biomembranes 1985
The metabolic response to the eugylcemic insulin clamp in type I diabetes and normal humans
S Zuniga-Guajardo, B Zinman
Metabolism 1985
Insulin resistance: Receptor and post-binding defects in human obesity and non-insulin-dependent diabetes mellitus
JA Truglia, JN Livingston, DH Lockwood
The American Journal of Medicine 1985
Insulin receptor — and nonreceptor — controlled cellular substrate processing.: A review of clinical studies in the isolated human adipocyte model
O Pedersen
Journal of Endocrinological Investigation 1985
Insulin receptors and insulin sensitivity in normo and hyperinsulinemic obese patients
AC Artenisio, F Ragonese, F Forte, G Saitta, G Perrone, G Lettina, R Campisi, F Consolo
Journal of Endocrinological Investigation 1985
Effect of Intravenously Infused Porcine Gip on Serum Insulin in Obese and Lean Subjects Studied with the Hyperglycemic Clamp Technique
PF Amland, R Jorde, P Burhol, KE Giercksky
Scandinavian Journal of Gastroenterology 1985
Effect of thyroid hormone excess on action, secretion, and metabolism of insulin in humans
G Dimitriadis, B Baker, H Marsh, L Mandarino, R Rizza, R Bergman, M Haymond, J Gerich
American journal of physiology. Endocrinology and metabolism 1985
The Second Generation Sulfonylureas: Glipizide and Glyburide
DE Baker, RK Campbell
The Diabetes Educator 1985
Relationship between degree of obesity and in vivo insulin action in man
C Bogardus, S Lillioja, DM Mott, C Hollenbeck, G Reaven
American journal of physiology. Endocrinology and metabolism 1985
Comparison of Type I and Type II Diabetes
M Vranic, CH Hollenberg, G Steiner
1985
Mechanisms of Receptor Regulation
G Poste, ST Crooke
1985
Gene for Human Insulin Receptor: Localization to Site on Chromosome 19 Involved in Pre-B-Cell Leukemia
TL Yang-Feng, U Francke, A Ullrich
Science 1985
Insulin binding in differentiating rat preadipocytes in culture
P Pettersson, RL Van, P Lönnroth, P Björntorp, U Smith
Journal of lipid research 1985
Production of insulin resistance by hyperinsulinaemia in man
R A Rizza, L J Mandarino, J Genest, B A Baker, J E Gerich
Diabetologia 1985
Influence of hyperglycemia on insulin's in vivo effects in type II diabetes
RR Revers, R Fink, J Griffin, JM Olefsky, OG Kolterman
Journal of Clinical Investigation 1984
Relationship between obesity and maximal insulin-stimulated glucose uptake in vivo and in vitro in Pima Indians
C Bogardus, S Lillioja, D Mott, GR Reaven, A Kashiwagi, JE Foley
Journal of Clinical Investigation 1984
Relationship between skeletal muscle insulin resistance, insulin-mediated glucose disposal, and insulin binding. Effects of obesity and body fat topography
DJ Evans, R Murray, AH Kissebah
Journal of Clinical Investigation 1984
Thermic effect of glucose in man. Obligatory and facultative thermogenesis
KJ Acheson, E Ravussin, J Wahren, E Jéquier
Journal of Clinical Investigation 1984
Binding of tyrosine-A-14(125I)-monoiodoinsulin to human erythrocytes
K Pettersson, T Koivula, E Kokko
Scandinavian Journal of Clinical & Laboratory Investigation 1984
Insulin Receptor Assays-Clinical Application and Limitations
R Taylor
Diabetic Medicine 1984
Induction of insulin resistance in normal adipose tissue by uremic human serum
ML McCaleb, R Mevorach, RB Freeman, MS Izzo, DH Lockwood
Kidney International 1984
The short term effects of bezafibrate on the hypertriglyceridaemia of moderate to severe uraemia
AJ Williams, F Baker, J Walls
British Journal of Clinical Pharmacology 1984
Binding and molecular weight properties of the insulin receptor from omental and subcutaneous adipocytes in human obesity
JN Livingston, KM Lerea, J Bolinder, L Kager, L Backman, P Arner
Diabetologia 1984
In vitro insensitivity of glucose transport and antilipolysis to insulin due to receptor and postreceptor abnormalities in obese Pima Indians with normal glucose tolerance
A Kashiwagi, C Bogardus, S Lillioja, TP Huecksteadt, D Brady, MA Verso, JE Foley
Metabolism 1984
Plasma glucagon suppressibility after oral glucose in obese subjects with normal and impaired glucose tolerance
VC Borghi, BL Wajchenberg, FP Cesar
Metabolism 1984
Infusion of insulin impairs human adipocyte glucose metabolism in vitro without decreasing adipocyte insulin receptor binding
L Mandarino, B Baker, R Rizza, J Genest, J Gerich
Diabetologia 1984
Structure of Membranes and Receptors
TC Cheng
1984
Evaluation and Treatment of Obesity
J Storlie, HA Jordan
1984
Kinetics of Glucose Metabolism in Relation to Insulin Concentrations in Patients With Alcoholic Cirrhosis and in Healthy Persons
J Iversen, H Vilstrup, N Tygstrup
Gastroenterology 1984
Mechanisms of insulin resistance in aging
RI Fink, OG Kolterman, J Griffin, JM Olefsky
Journal of Clinical Investigation 1983
Characterization of the insulin resistance of aging
JW Rowe, KL Minaker, JA Pallotta, JS Flier
Journal of Clinical Investigation 1983
Thermic effect of infused glucose and insulin in man. Decreased response with increased insulin resistance in obesity and noninsulin-dependent diabetes mellitus
E Ravussin, C Bogardus, RS Schwartz, DC Robbins, RR Wolfe, ES Horton, E Danforth, EA Sims
Journal of Clinical Investigation 1983
In vitro insulin resistance of human adipocytes isolated from subjects with noninsulin-dependent diabetes mellitus
A Kashiwagi, MA Verso, J Andrews, B Vasquez, G Reaven, JE Foley
Journal of Clinical Investigation 1983
Studies of liver insulin receptors in non-obese and obese human subjects
P Arner, K Einarsson, L Backman, K Nilsell, KM Lerea, JN Livingston
Journal of Clinical Investigation 1983
Effect of fatty acids on glucose production and utilization in man
E Ferrannini, EJ Barrett, S Bevilacqua, RA DeFronzo
Journal of Clinical Investigation 1983
Insulin receptors in isolated human adipocytes. Characterization by photoaffinity labeling and evidence for internalization and cellular processing
P Berhanu, OG Kolterman, A Baron, P Tsai, JM Olefsky, D Brandenburg
Journal of Clinical Investigation 1983
Insulin Sensitivity and Responsiveness in Vitro and in Vivo
I Lager, P LÖnnroth
Acta Medica Scandinavica 1983
INFLUENCE OF OBESITY ON BASAL GLUCAGON LEVELS IN NON-DIABETIC AND DIABETIC NAURUANS
FP Alford, P Zimmet, DJ Chisholm, S Whitehouse
Clinical Endocrinology 1983
Influence of ambient glucose and insulin concentrations on adipocyte insulin binding
P Lönnroth, M DiGirolamo, U Smith
Metabolism 1983
New concepts in the pathogenesis and treatment of noninsulin-dependent diabetes mellitus
RA Defronzo, E Ferrannini, V Koivisto
The American Journal of Medicine 1983
Cellular alterations responsible for insulin resistance in obesity and type II diabetes mellitus
DH Lockwood, JM Amatruda
The American Journal of Medicine 1983
Insulin receptors and action in clinical disorders of carbohydrate tolerance
RJ Pollet
The American Journal of Medicine 1983
Insulin resistance in noninsulin-dependent diabetes mellitus: Impact of sulfonylurea agents in vivo and in vitro
OG Kolterman, MJ Prince, JM Olefsky
The American Journal of Medicine 1983
11 Insulin receptors in normal and disease states
G Grunberger, SI Taylor, RF Dons, P Gorden
Clinics in Endocrinology and Metabolism 1983
Enhanced responsiveness to insulin in sheep exposed to cold
TE Weekes, Y Sasaki, T Tsuda
American journal of physiology. Endocrinology and metabolism 1983
Estimation and kinetic analysis of insulin-independent glucose uptake in human subjects
I Gottesman, L Mandarino, J Gerich
American journal of physiology. Endocrinology and metabolism 1983
Reversal of insulin resistance in type I diabetes after treatment with continuous subcutaneous insulin infusion
I Lager, P Lonnroth, H von Schenck, U Smith
BMJ : British Medical Journal 1983
Effect of somatostatin-induced insulinopenia on glucose oxidation in man
JP Felber, D Thibaud, E Maeder, E Jquier, R Hendler, RA DeFronzo
Diabetologia 1983
Insulin Sensitivity and Glucose Uptake in the Course of Surgical Treatment for Valvular Aortic Stenosis
R Ekroth, F Nilsson, H Berggren, K Feddersen, G Holm, J Holm, I Milocco, T Scherstén, G William-Olsson
Scandinavian Cardiovascular Journal 1982
Insulin resistance in uremia mediated by postbinding defects
D Smith, RA DeFronzo
Kidney International 1982
Mechanisms of insulin resistance following injury
PR Black, DC Brooks, PQ Bessey, RR Wolfe, DW Wilmore
Annals of Surgery 1982
Insulin receptor binding and insulin action in human fat cells: Effects of obesity and fasting
O Pedersen, E Hjøllund, NS Sørensen
Metabolism 1982
Familial partial lipodystrophy: Complications of obesity in the non-obese?
DC Robbins, ES Horton, O Tulp, EA Sims
Metabolism 1982
Validation of a practical in vivo insulin dose-response curve in man
J Proietto, M Harewood, P Aitken, A Nankervis, G Caruso, F Alford
Metabolism 1982
Effect of long chain triglyceride infusion on glucose metabolism in man
D Thiébaud, RA DeFronzo, E Jacot, A Golay, K Acheson, E Maeder, E Jéquier, JP Felber
Metabolism 1982
Integrated concentrations of growth hormone, insulin, C-peptide and prolactin in human obesity
MT Meistas, GV Foster, S Margolis, AA Kowarski
Metabolism 1982
Internalization and intracellular processing of insulin and insulin receptors in adipocytes
JM Olefsky, S Marshall, P Berhanu, M Saekow, K Heidenreich, A Green
Metabolism 1982
Thermogenic response to insulin and glucose infusions in man: A model to evaluate the different components of the thermic effect of carbohydrate
E Ravussin, C Bogardus
Life Sciences 1982
4 Insulin resistance in non-insulindependent, type II diabetes mellitus
OG Kolterman, JA Scarlett, JM Olefsky
Clinics in Endocrinology and Metabolism 1982
2 The effects of insulin on carbohydrate metabolism in vivo
AD Cherrington, KE Steiner
Clinics in Endocrinology and Metabolism 1982
Insulin Resistance and Insulin Receptors in Hepatic Cirrhosis
AT Blei, DC Robbins, E Drobny, G Baumann, AH Rubenstein
Gastroenterology 1982
Insulin Resistance in Humans
JM Olefsky
Gastroenterology 1982
Mechanism of the postreceptor defect in insulin action in human obesity. Decrease in glucose transport system activity
TP Ciaraldi, OG Kolterman, JM Olefsky
Journal of Clinical Investigation 1981
Receptor and postreceptor defects contribute to the insulin resistance in noninsulin-dependent diabetes mellitus
OG Kolterman, RS Gray, J Griffin, P Burstein, J Insel, JA Scarlett, JM Olefsky
Journal of Clinical Investigation 1981
The antilipolytic effect of insulin in human adipose tissue in obesity, diabetes mellitus, hyperinsulinemia, and starvation
P Arner, J Bolinder, P Engfeldt, J Östman
Metabolism 1981
Mechanisms of insulin resistance in obesity and noninsulin-dependent (type II) diabetes
JM Olefsky, OG Kolterman
The American Journal of Medicine 1981
Mechanisms of insulin resistance in man
RA Rizza, LJ Mandarino, JE Gerich
The American Journal of Medicine 1981
Adaptation to increasing loads of total parenteral nutrition: Metabolic, endocrine, and insulin receptor responses
WJ Byrne, BM Lippe, CT Strobel, SR Levin, ME Ament, SA Kaplan
Gastroenterology 1981
Polymorphism in the 5′-Flanking Region of the Human Insulin Gene and Its Possible Relation to Type 2 Diabetes
P Rotwein, R Chyn, J Chirgwin, B Cordell, HM Goodman, MA Permut
Science 1981
Clinical Pharmacology of Sulphonylurea Hypoglycaemic Agents: Part 2
JE Jackson, R Bressler
Drugs 1981
The relationship between the hyperplastic pancreatic islet and insulin insensitivity in obesity
RJ Mahler
Acta Diabetologica 1981
Effects of insulin incubation on insulin binding, glucose transport, and insulin degradation by isolated rat adipocytes. Evidence for hormone-induced desensitization at the receptor and postreceptor level
S Marshall, JM Olefsky
Journal of Clinical Investigation 1980
Diabetic ketoacidosis: Reassessment of therapeutic “truths”
AL Taylor
Postgraduate Medicine 1980
Contemporary Metabolism
N Freinkel
1979
Verhandlungen der Deutschen Gesellschaft für Innere Medizin
B Schlegel
1962
Insulin Resistance
A Voll, J Kloster
Acta Medica Scandinavica 1957

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