To assess the mechanisms of the insulin resistance in human obesity, we have determined, using a modification of the euglycemic glucose clamp technique, the shape of the in vivo insulin-glucose disposal dose-response curves in 7 control and 13 obese human subjects. Each subject had at least three euglycemic studies performed at insulin infusion rates of 15, 40, 120, 240, or 1,200 mU/M2/min. The glucose disposal rate was decreased in all obese subjects compared with controls (101 +/- 16 vs. 186 +/- 16 mg/M2/min) during the 40 mU/M2/min insulin infusion. The mean dose-response curve for the obese subjects was displaced to the right, i.e., the half-maximally effective insulin concentration was 270 +/- 27 microU/ml for the obese compared with 130 +/- 10 microU/ml for controls. In nine of the obese subjects, the dose-response curves were shifted to the right, and maximal glucose disposal rates (at a maximally effective insulin concentration) were markedly decreased, indicating both a receptor and a postreceptor defect. On the other hand, four obese patients had right-shifted dose-response curves but reached normal maximal glucose disposal rates, consistent with decreased insulin receptors as the only abnormality. When the individual data were analyzed, it was found that the lease hyperinsulinemic, least insulin-resistant patients displayed only the receptor defect, whereas those with the greatest hyperinsulinemia exhibited the largest post-receptor defect, suggesting a continuous spectrum of defects as one advances from mild to severe insulin resistance. When insulin's ability to suppress hepatic glucose output was assessed, hyperinsulinemia produced total suppresssion in all subjects. The dose-response curve for the obese subjects was shifted to the right, indicating a defect in insulin receptors. Insulin binding to isolated adipocytes obtained from the obese subjects was decreased, and a highly significant inverse linear relationship was demonstrated between insulin binding and the serum insulin concentration required for halfmaximal stimulation of glucose disposal. In conclusion: (a) decreased cellular insulin receptors contribute to the insulin resistance associated with human obesity in all subjects; (b) in the least hyperinsulinemic, insulin-resistant patients, decreased insulin receptors are the sole defect, whereas in the more hyperinsulinemic, insulin-resistant patients, the insulin resistance is the result of a combination of receptor and postreceptor abnormalities; (c) all obese patients were insensitive to insulin's suppressive effects on hepatic glucose output; this was entirely the result of decreased insulin receptors; no postreceptor defect in this insulin effect was demonstrated.
O G Kolterman, J Insel, M Saekow, J M Olefsky
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Long-term survival in stroke patients: insights into triglyceride-glucose body mass index from ICU data.
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Role of Dietary Macronutrient Composition and Fibre Intake in Development of Double Diabetes in Indian Youth
Oza C, Mandlik R, Khadilkar AV, Gondhalekar KM, Khadilkar VV |
Indian journal of endocrinology and metabolism | 2024 |
Association of triglyceride-glucose index and delirium in patients with sepsis: a retrospective study.
Fang Y, Dou A, Shen Y, Li T, Liu H, Cui Y, Xie K |
Lipids in Health and Disease | 2024 |
PPARβ/δ upregulates the insulin receptor β subunit in skeletal muscle by reducing lysosomal activity and EphB4 levels
Wang JR, Jurado-Aguilar J, Barroso E, Rodríguez-Calvo R, Camins A, Wahli W, Palomer X, Vázquez-Carrera M |
Cell Communication and Signaling : CCS | 2024 |
Insulin Resistance, Hyperinsulinemia and Atherosclerosis: Insights into Pathophysiological Aspects and Future Therapeutic Prospects
Papaetis GS, Sacharidou A, Michaelides IC, Mikellidis KC, Karvounaris SA |
Current Cardiology Reviews | 2024 |
Evaluation of mulberry leaves' hypoglycemic properties and hypoglycemic mechanisms.
Chen S, Xi M, Gao F, Li M, Dong T, Geng Z, Liu C, Huang F, Wang J, Li X, Wei P, Miao F |
Frontiers in pharmacology | 2023 |
Concepts of Lactate Metabolic Clearance Rate and Lactate Clamp for Metabolic Inquiry: A Mini-Review.
Emhoff CW, Messonnier LA |
Nutrients | 2023 |
Determinants and Characteristics of Insulin Dose Requirements in Children and Adolescents with New-Onset Type 1 Diabetes: Insights from the INSENODIAB Study
Beckers M, Polle O, Gallo P, Bernard N, Bugli C, Lysy PA |
Journal of Diabetes Research | 2023 |
Beta-cell function and plasma insulin clearance in people with obesity and different glycemic status
Bettina Mittendorfer, Bruce W. Patterson, Gordon I. Smith, Mihoko Yoshino, Samuel Klein |
Journal of Clinical Investigation | 2022 |
p300 or CBP is required for insulin-stimulated glucose uptake in skeletal muscle and adipocytes
Vitor F Martins, Samuel A. LaBarge, Alexandra Stanley, Kristoffer Svensson, Chao-Wei Hung, Omer Keinan, Theodore Ciaraldi, Dion Banoian, Ji E. Park, Christina Ha, Byron Hetrick, Gretchen A Meyer, Andrew Philp, Larry L. David, Robert Henry, Joseph E Aslan, Alan R. Saltiel, Carrie E. McCurdy, Simon Schenk |
JCI Insight | 2022 |
Insulin Clearance in Obesity and Type 2 Diabetes
H Koh, C Cao, B Mittendorfer |
International journal of molecular sciences | 2022 |
A Longitudinal Retrospective Observational Study on Obesity Indicators and the Risk of Impaired Fasting Glucose in Pre- and Postmenopausal Women
Nam MJ, Kim H, Choi YJ, Cho KH, Kim SM, Roh YK, Han K, Jung JH, Park YG, Park JH, Kim DH |
Journal of Clinical Medicine | 2022 |
The Insulin Centennial—100 years of milestones in biochemistry
AD Attie, QQ Tang, KE Bornfeldt |
The Journal of biological chemistry | 2021 |
The Insulin Centennial—100 years of milestones in biochemistry
AD Attie, QQ Tang, KE Bornfeldt |
Journal of lipid research | 2021 |
The aetiology and molecular landscape of insulin resistance
DE James, J Stöckli, MJ Birnbaum |
Nature Reviews Molecular Cell Biology | 2021 |
Insulin Resistance and Cancer: In Search for a Causal Link
E Chiefari, M Mirabelli, SL Vignera, S Tanyolaç, DP Foti, A Aversa, A Brunetti |
International journal of molecular sciences | 2021 |
Roles of hepatic atypical protein kinase C hyperactivity and hyperinsulinemia in insulin‐resistant forms of obesity and type 2 diabetes mellitus
MP Sajan, BC Hansen, M AcevedoDuncan, MS Kindy, DR Cooper, RV Farese |
2021 | |
Metabolic regulation of T cells in the tumor microenvironment by nutrient availability and diet
S Zhao, RM Peralta, N Avina-Ochoa, GM Delgoffe, SM Kaech |
Seminars in Immunology | 2021 |
Heterogeneity in insulin-stimulated glucose uptake among different muscle groups in healthy lean people and people with obesity
HC Koh, S van Vliet, GA Meyer, R Laforest, RJ Gropler, S Klein, B Mittendorfer |
Diabetologia | 2021 |
Endoplasmic reticulum stress causes insulin resistance by inhibiting delivery of newly synthesized insulin receptors to the cell surface
M Brown, S Dainty, N Strudwick, AD Mihai, JN Watson, R Dendooven, AW Paton, JC Paton, M Schröder, JA Olzmann |
Molecular biology of the cell | 2020 |
Lactation Versus Formula Feeding: Insulin, Glucose, and Fatty Acid Metabolism During the Postpartum Period
MA Ramos-Roman, MM Syed-Abdul, B Adams-Huet, BM Casey, EJ Parks |
Diabetes | 2020 |
Different physiological mechanisms underlie an adverse cardiovascular disease risk profile in men and women
A Fappi, B Mittendorfer |
Proceedings of the Nutrition Society | 2019 |
Sex-specific prevalence, inequality and associated predictors of hypertension, diabetes, and comorbidity among Bangladeshi adults: results from a nationwide cross-sectional demographic and health survey
N Ali, R Akram, N Sheikh, AR Sarker, M Sultana |
BMJ Open | 2019 |
Translational Research Methods in Diabetes, Obesity, and Nonalcoholic Fatty Liver Disease: A Focus on Early Phase Clinical Drug Development
AJ Krentz, C Weyer, M Hompesch |
2019 | |
Predictor Factors of Glycemic Control in Children and Adolescents with Type 1 Diabetes Mellitus Treated at a Referral Service in Rio de Janeiro, Brazil
RF Fortins, EM de Aquino Lacerda, RN Silverio, CN do Carmo, AA Pereira, C Felizardo, BF do Nascimento, JL Luescher, P de Carvalho Padilha |
Diabetes Research and Clinical Practice | 2019 |
Insulin Resistance: Childhood Precursors of Adult Disease
PS Zeitler, KJ Nadeau |
2019 | |
A word of caution against excessive protein intake.
Mittendorfer B, Klein S, Fontana L |
Nature reviews. Endocrinology | 2019 |
Muscle and adipose tissue insulin resistance: malady without mechanism?
DJ Fazakerley, JR Krycer, AL Kearney, SL Hocking, DE James |
Journal of lipid research | 2018 |
Effects of Tempeh Fermentation with Lactobacillus plantarum and Rhizopus oligosporus on Streptozotocin-Induced Type II Diabetes Mellitus in Rats
YC Huang, BH Wu, YL Chu, WC Chang, MC Wu |
Nutrients | 2018 |
Predictors of changing insulin dose requirements and glycaemic control in children, adolescents and young adults with Type 1 diabetes
GH Teló, CE Dougher, LK Volkening, ML Katz, LM Laffel |
Diabetic Medicine | 2018 |
Food intake and energy expenditure in growing cats with and without a predisposition to overweight
V Ghielmetti, B Wichert, S Rüegg, D Frey, A Liesegang |
Journal of Animal Physiology and Animal Nutrition | 2018 |
Airborne PM2.5-Induced Hepatic Insulin Resistance by Nrf2/JNK-Mediated Signaling Pathway
J Xu, W Zhang, Z Lu, F Zhang, W Ding |
International journal of environmental research and public health | 2017 |
Pediatric Hypertension
J Flynn, JR Ingelfinger, K Redwine |
Pediatric Hypertension | 2017 |
Synthesis, Binding Mode, and Antihyperglycemic Activity of Potent and Selective (5-Imidazol-2-yl-4-phenylpyrimidin-2-yl)[2-(2-pyridylamino)ethyl]amine Inhibitors of Glycogen Synthase Kinase 3
AS Wagman, RS Boyce, SP Brown, E Fang, D Goff, JM Jansen, VP Le, BH Levine, SC Ng, ZJ Ni, JM Nuss, KB Pfister, S Ramurthy, PA Renhowe, DB Ring, W Shu, S Subramanian, XA Zhou, CM Shafer, SD Harrison, KW Johnson, DE Bussiere |
Journal of Medicinal Chemistry | 2017 |
Curcumin prevents inflammatory response, oxidative stress and insulin resistance in high fructose fed male Wistar rats: Potential role of serine kinases
N Maithilikarpagaselvi, MG Sridhar, RP Swaminathan, B Zachariah |
Chemico-Biological Interactions | 2016 |
Preventive effect of curcumin on inflammation, oxidative stress and insulin resistance in high-fat fed obese rats
N Maithilikarpagaselvi, MG Sridhar, RP Swaminathan, R Sripradha |
Journal of Complementary and Integrative Medicine | 2016 |
Combination of Vildagliptin and Pioglitazone in Experimental Type 2 Diabetes in Male Rats: COMBINATION OF VILDAGLIPTIN AND PIOGLITAZONE IN DIABETIC RATS
R Refaat, A Sakr, M Salama, AE Sarha |
Drug Development Research | 2016 |
Endocrinology: Adult and Pediatric
M Gurnell, TJ Visser, P Beck-Peccoz, VK Chatterjee |
Endocrinology: Adult and Pediatric | 2016 |
Obesogen effects after perinatal exposure of 4,4′-sulfonyldiphenol (Bisphenol S) in C57BL/6 mice
LI Moral, LL Corre, H Poirier, I Niot, T Truntzer, JF Merlin, P Rouimi, P Besnard, R Rahmani, MC Chagnon |
Toxicology | 2016 |
Clinical Dilemmas in Non-Alcoholic Fatty Liver Disease: Williams/Clinical Dilemmas in Non-Alcoholic Fatty Liver Disease
H Yki-Järvinen |
Clinical Dilemmas in Non-Alcoholic Fatty Liver Disease: Williams/Clinical Dilemmas in Non-Alcoholic Fatty Liver Disease | 2016 |
Endocrinology
C Napier, SH Pearce |
Endocrinology | 2016 |
Glucose uptake saturation explains glucose kinetics profiles measured by different tests
R Bizzotto, A Natali, A Gastaldelli, E Muscelli, M Krssak, A Brehm, M Roden, E Ferrannini, A Mari |
American journal of physiology. Endocrinology and metabolism | 2016 |
Effects of Scutellariae Radix Extract on Lipid Metabolism, Oxidation and Production of Pro-Inflammatory Cytokines in Rats Fed Highly Oxidized Fat
SM Kim, YY Cha |
Journal of Korean Medicine for Obesity Research | 2016 |
Quasi-Steady-State Analysis based on Structural Modules and Timed Petri Net Predict System’s Dynamics: The Life Cycle of the Insulin Receptor
J Scheidel, K Lindauer, J Ackermann, I Koch |
Metabolites | 2015 |
Quantifying insulin sensitivity and entero-insular responsiveness to hyper- and hypoglycemia in ferrets
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PloS one | 2014 |
Comprehensive Physiology
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Comprehensive Physiology | 2014 |
Diet, Exercise, and Chronic Disease: The Biological Basis of Prevention
J Cannizzo |
Diet, Exercise, and Chronic Disease: The Biological Basis of Prevention | 2014 |
Homeostasis model assessment of insulin resistance and the risk of hyperuricemia: A 6-year prospective study in non-diabetic Japanese men
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Diabetes Research and Clinical Practice | 2014 |
Quantifying Insulin Sensitivity and Entero-Insular Responsiveness to Hyper- and Hypoglycemia in Ferrets
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PloS one | 2014 |
Effect of Roux-en-Y gastric bypass and laparoscopic adjustable gastric banding on branched-chain amino acid metabolism
F Magkos, D Bradley, GG Schweitzer, BN Finck, JC Eagon, O Ilkayeva, CB Newgard, S Klein |
Diabetes | 2013 |
Pharmacological approach to cardiovascular risk in metabolic syndrome:
A Bellis, B Trimarco |
Journal of Cardiovascular Medicine | 2013 |
Treating Diabetes with Exercise - Focus on the Microvasculature
C Kolka |
Journal of Diabetes & Metabolism | 2013 |
The Genetics of Obesity
SF Grant |
2013 | |
Hyperandrogenism exerts an anti-inflammatory effect in obese women with polycystic ovary syndrome
F González, CL Sia, FZ Stanczyk, HE Blair, ME Krupa |
Endocrine | 2012 |
Identification of intracellular peptides in rat adipose tissue: Insights into insulin resistance
DA Berti, LC Russo, LM Castro, L Cruz, FC Gozzo, JC Heimann, FB Lima, AC Oliveira, S Andreotti, PO Prada, AS Heimann, ES Ferro |
PROTEOMICS | 2012 |
A fully human, allosteric monoclonal antibody that activates the insulin receptor and improves glycemic control
V Bhaskar, ID Goldfine, DH Bedinger, A Lau, HF Kuan, LM Gross, M Handa, BA Maddux, SR Watson, S Zhu, AJ Narasimha, R Levy, L Webster, SD Wijesuriya, N Liu, X Wu, D Chemla-Vogel, C Tran, SR Lee, S Wong, D Wilcock, ML White, JA Corbin |
Diabetes | 2012 |
Obesity: Epidemiology, Pathophysiology, and Prevention, Second Edition
R Kong |
Obesity: Epidemiology, Pathophysiology, and Prevention, Second Edition | 2012 |
Sodium-retaining effect of insulin in diabetes
MW Brands, MM Manhiani |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2012 |
Hyperandrogenism sensitizes mononuclear cells to promote glucose-induced inflammation in lean reproductive-age women
F González, KS Nair, JK Daniels, E Basal, JM Schimke |
American journal of physiology. Endocrinology and metabolism | 2012 |
Hyperandrogenism sensitizes mononuclear cells to promote glucose-induced inflammation in lean reproductive-age women
F González, KS Nair, JK Daniels, E Basal, JM Schimke |
American journal of physiology. Endocrinology and metabolism | 2011 |
Annual Reports in Medicinal Chemistry
JJ Liu, TW Lee |
Annual Reports in Medicinal Chemistry Volume 46 | 2011 |
Fetal and Neonatal Physiology
LH Johnson, VK Bhutani |
Fetal and Neonatal Physiology | 2011 |
Effects of Ixeris dentata ext. on Lowering Lipid and Anti-oxidation
E Lee |
Korean Journal of Plant Resources | 2011 |
Metabolic effects of obesity: A review
P Singla, A Bardoloi, AA Parkash |
World journal of diabetes | 2010 |
TLR4 and Insulin Resistance
JJ Kim, DD Sears |
Gastroenterology Research and Practice | 2010 |
Models of accelerated sarcopenia: critical pieces for solving the puzzle of age-related muscle atrophy
TW Buford, SD Anton, AR Judge, E Marzetti, SE Wohlgemuth, CS Carter, C Leeuwenburgh, M Pahor, TM Manini |
Ageing Research Reviews | 2010 |
The Association Between C‐Reactive Protein Levels and Insulin Therapy in Obese vs Nonobese Veterans With Type 2 Diabetes Mellitus
Khatana SA, Taveira TH, Dooley AG, Wu W |
The Journal of Clinical Hypertension | 2010 |
Randomized clinical trial to compare the effects of preoperative oral carbohydrateversusplacebo on insulin resistance after colorectal surgery
ZG Wang, Q Wang, WJ Wang, HL Qin |
British Journal of Surgery | 2010 |
The identification of insulin saturation effects during the dynamic insulin sensitivity test
PD Docherty, JG Chase, CE Hann, TF Lotz, J Lin, KA McAuley, GM Shaw |
The open medical informatics journal | 2010 |
The Association Between C-Reactive Protein Levels and Insulin Therapy in Obese vs Nonobese Veterans With Type 2 Diabetes Mellitus
SA Khatana, TH Taveira, AG Dooley, WC Wu |
The Journal of Clinical Hypertension | 2010 |
A three-compartment model of the C-peptide–insulin dynamic during the DIST test
JG Chase, K Mayntzhusen, PD Docherty, S Andreassen, KA McAuley, TF Lotz, CE Hann |
Mathematical Biosciences | 2010 |
Metabolic effects of obesity: A review
P Singla |
World journal of diabetes | 2010 |
The Future of Aging
GM Fahy, MD West, LS Coles, SB Harris |
2010 | |
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
Stevioside and related compounds: Therapeutic benefits beyond sweetness
V Chatsudthipong, C Muanprasat |
Pharmacology & Therapeutics | 2009 |
Obesity and Hypertension
FX Pi-Sunyer |
Obesity Management | 2009 |
Fed-state clamp stimulates cellular mechanisms of muscle protein anabolism and modulates glucose disposal in normal men
OA Adegoke, S Chevalier, JA Morais, R Gougeon, SR Kimball, LS Jefferson, SS Wing, EB Marliss |
American journal of physiology. Endocrinology and metabolism | 2009 |
Metabolic syndrome in sub-Saharan Africa: “smaller twin” of a region’s prostatic diseases?
CE Ejike, LU Ezeanyika |
International Urology and Nephrology | 2008 |
Acquired obesity and poor physical fitness impair expression of genes of mitochondrial oxidative phosphorylation in monozygotic twins discordant for obesity
L Mustelin, KH Pietiläinen, A Rissanen, AR Sovijärvi, P Piirilä, J Naukkarinen, L Peltonen, J Kaprio, H Yki-Järvinen |
American journal of physiology. Endocrinology and metabolism | 2008 |
Fundamental and Clinical Cardiology Series
PD Stein |
Cardiovascular Disease in the Elderly | 2008 |
Fed-state clamp stimulates cellular mechanisms of muscle protein anabolism and modulates glucose disposal in normal men
OA Adegoke, S Chevalier, JA Morais, R Gougeon, SR Kimball, LS Jefferson, SS Wing, EB Marliss |
American journal of physiology. Endocrinology and metabolism | 2008 |
The hypothalamic-pituitary-adrenal-axis in the regulation of energy balance
AG Nieuwenhuizen, F Rutters |
Physiology & Behavior | 2008 |
Adverse effects of obesity on β-cell function in Japanese subjects with normal glucose tolerance
Y Akehi, K Anzai, H Katsuta, R Yoshida, K Ohkubo, T Yamashita, H Kawashima, J Ono |
Obesity Research & Clinical Practice | 2008 |
Development of hyperinsulinemia and insulin resistance during the early stage of weight gain
J Erdmann, B Kallabis, U Oppel, O Sypchenko, S Wagenpfeil, V Schusdziarra |
American journal of physiology. Endocrinology and metabolism | 2008 |
Acquired obesity and poor physical fitness impair expression of genes of mitochondrial oxidative phosphorylation in monozygotic twins discordant for obesity
L Mustelin, KH Pietiläinen, A Rissanen, AR Sovijärvi, P Piirilä, J Naukkarinen, L Peltonen, J Kaprio, H Yki-Järvinen |
American journal of physiology. Endocrinology and metabolism | 2008 |
Enhanced proportion of small adipose cells in insulin-resistant vs insulin-sensitive obese individuals implicates impaired adipogenesis
T McLaughlin, A Sherman, P Tsao, O Gonzalez, G Yee, C Lamendola, GM Reaven, SW Cushman |
Diabetologia | 2007 |
Obesity
CY Chen, J Blumberg |
Obesity | 2007 |
Stress, eating and the reward system
TC Adam, ES Epel |
Physiology & Behavior | 2007 |
Insulin signaling in hypertension
B Trimarco, S Crispo, C Morisco |
International Congress Series | 2007 |
Obesity: Genomics and Postgenomics
A Xu, A Butler, G Barsh |
Obesity: Genomics and Postgenomics | 2007 |
Obesity in adolescence: Implications in orthodontic treatment
WW Neeley, DA Gonzales |
American Journal of Orthodontics and Dentofacial Orthopedics | 2007 |
Contribution of Hepatic and Extrahepatic Insulin Resistance to the Pathogenesis of Impaired Fasting Glucose: Role of Increased Rates of Gluconeogenesis
G Bock, E Chittilapilly, R Basu, G Toffolo, C Cobelli, V Chandramouli, BR Landau, RA Rizza |
Diabetes | 2007 |
Mechanisms of Insulin Action
AR Saltiel, JE Pessin |
2007 | |
Insulin Resistance and Cardiovascular Risk: New Insights From Molecular and Cellular Biology
C Morisco, G Lembo, B Trimarco |
Trends in Cardiovascular Medicine | 2006 |
Molecular Mechanisms of Insulin Resistance: Serine Phosphorylation of Insulin Receptor Substrate-1 and Increased Expression of p85 : The Two Sides of a Coin
B Draznin |
Diabetes | 2006 |
Chronic administration of olanzapine induces metabolic and food intake alterations: a mouse model of the atypical antipsychotic-associated adverse effects
R Coccurello, A Caprioli, O Ghirardi, R Conti, B Ciani, S Daniele, A Bartolomucci, A Moles |
Psychopharmacology | 2006 |
Adipose tissue, hepatic, and skeletal muscle insulin sensitivity in extremely obese subjects with acanthosis nigricans
DN Reeds, CA Stuart, O Perez, S Klein |
Metabolism | 2006 |
IRS-1 Serine Phosphorylation and Insulin Resistance in Skeletal Muscle From Pancreas Transplant Recipients
K Bouzakri, HK Karlsson, H Vestergaard, S Madsbad, E Christiansen, JR Zierath |
Diabetes | 2006 |
Hyperglycemia Alters Tumor Necrosis Factor-α Release from Mononuclear Cells in Women with Polycystic Ovary Syndrome
F González, J Minium, NS Rote, JP Kirwan |
The Journal of clinical endocrinology and metabolism | 2005 |
Changes in blood pressure and plasma catecholamine levels during prolonged hyperinsulinemia
W Kern, A Peters, J Born, HL Fehm, B Schultes |
Metabolism | 2005 |
Body mass index and waist circumference correlate to the same degree with insulin-mediated glucose uptake
HM Farin, F Abbasi, GM Reaven |
Metabolism | 2005 |
Hyperinsulinaemia: A prospective risk factor for lethal clinical prostate cancer
J Hammarsten, B Högstedt |
European Journal of Cancer | 2005 |
Basal plasma insulin and homeostasis model assessment (HOMA) are indicators of insulin sensitivity in cats
DJ Appleton, JS Rand, GD Sunvold |
Journal of Feline Medicine & Surgery | 2005 |
Role of the Adipocyte, Free Fatty Acids, and Ectopic Fat in Pathogenesis of Type 2 Diabetes Mellitus: Peroxisomal Proliferator-Activated Receptor Agonists Provide a Rational Therapeutic Approach
H Bays, L Mandarino, RA DeFronzo |
The Journal of clinical endocrinology and metabolism | 2004 |
Insulin resistance and changes in plasma concentration of TNFalpha, IGF1, and NEFA in dogs during weight gain and obesity
C Gayet, E Bailhache, H Dumon, L Martin, B Siliart, P Nguyen |
Journal of Animal Physiology and Animal Nutrition | 2004 |
Dysfunctional fat cells, lipotoxicity and type 2 diabetes
RA Defronzo |
International Journal of Clinical Practice | 2004 |
Can long-term exposure to chromium improve insulin sensitivity in chromium mine workers?
A Tuzcu, M Bahcec?, M Dursun, Y Parmaks?z, M Ertem, A Dalg?c, C Turgut, E Kale |
The Journal of Trace Elements in Experimental Medicine | 2004 |
Type 2 Diabetes and Disease Management: Exploring the Connections
KR Segal |
Disease Management | 2004 |
Myosin heavy chain profiles and body composition are different in old versus young Standardbred mares
RA Lehnhard, KH McKeever, CF Kearns, MD Beekley |
The Veterinary Journal | 2004 |
Insulin secretion, peripheral insulin sensitivity and insulin-receptor binding in subjects with different degrees of obesity
AM Borissova, TI Tankova, DJ Koev |
Diabetes & Metabolism | 2004 |
Dietary carbohydrate source affects glucose concentrations, insulin secretion, and food intake in overweight cats
DJ Appleton, JS Rand, J Priest, GD Sunvold, JR Vickers |
Nutrition Research | 2004 |
Clinical, haemodynamic, anthropometric, metabolic and insulin profile of men with high‐stage and high‐grade clinical prostate cancer
J Hammarsten, B Högstedt |
Blood Pressure | 2004 |
Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sex
M Cnop, PJ Havel, KM Utzschneider, DB Carr, MK Sinha, EJ Boyko, BM Retzlaff, RH Knopp, JD Brunzell, SE Kahn |
Diabetologia | 2003 |
International Textbook of Diabetes Mellitus
RA DeFronzo, L Mandarino, E Ferrannini |
International Textbook of Diabetes Mellitus | 2003 |
An insulin-resistant hypertriglyceridaemic normotensive obese dog model: assessment of insulin resistance by the euglycaemic hyperinsulinaemic clamp in combination with the stable isotope technique
E Bailhache, K Ouguerram, C Gayet, M Krempf, B Siliart, T Magot, P Nguyen |
Journal of Animal Physiology and Animal Nutrition | 2003 |
Pancreatic beta-cell loss and preservation in type 2 diabetes
TA Buchanan |
Clinical Therapeutics | 2003 |
Prevention of type 2 diabetes in young people: a theoretical perspective
TT Huang, MI Goran |
Pediatric Diabetes | 2003 |
Obesity and type 2 diabetes
CA Maggio, FX Pi-Sunyer |
Endocrinology & Metabolism Clinics of North America | 2003 |
A mitochondrial DNA variant associated with left ventricular hypertrophy in diabetes
Y Momiyama, M Furutani, Y Suzuki, R Ohmori, S Imamura, A Mokubo, T Asahina, C Murata, K Kato, S Anazawa, K Hosokawa, Y Atsumi, K Matsuoka, M Kimura, H Kasanuki, F Ohsuzu, R Matsuoka |
Biochemical and Biophysical Research Communications | 2003 |
Hepatic glucose metabolism in humans—its role in health and disease
M Roden, E Bernroider |
Best Practice & Research Clinical Endocrinology & Metabolism | 2003 |
The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes
SE Kahn |
Diabetologia | 2003 |
Study of the Alteration of Gene Expression in Adipose Tissue of Diet-Induced Obese Mice by Microarray and Reverse Transcription-Polymerase Chain Reaction Analyses
RC Moraes, A Blondet, K Birkenkamp-Demtroeder, J Tirard, TF Orntoft, A Gertler, P Durand, D Naville, M Bégeot |
Endocrinology | 2003 |
Troglitazone Ameliorates Abnormal Activity of Protein Tyrosine Phosphatase in Adipose Tissues of Otsuka Long-Evans Tokushima Fatty Rats
S Tagami, T Honda, H Yoshimura, H Homma, K Ohno, H Ide, S Sakaue, Y Kawakami |
The Tohoku Journal of Experimental Medicine | 2002 |
Waist-hip ratio and breast cancer risk in urbanized Nigerian women
CA Adebamowo, TO Ogundiran, AA Adenipekun, RA Oyesegun, OB Campbell, EE Akang, CN Rotimi, OI Olopade |
Breast Cancer Research | 2002 |
Effects of Hormone Replacement Therapy on Left Ventricular Hypertrophy and Growth-Promoting Factors in Hypertensive Postmenopausal Women
Y MIYA, H SUMINO, S ICHIKAWA, T NAKAMURA, T KANDA, H KUMAKURA, Y TAKAYAMA, H MIZUNUMA, T SAKAMAKI, M KURABAYASHI |
Hypertension Research | 2002 |
Decreases in serum uric acid by amelioration of insulin resistance in overweight hypertensive patients: effect of a low-energy diet and an insulin-sensitizing agent
S Tsunoda, K Kamide, J Minami, Y Kawano |
American Journal of Hypertension | 2002 |
The Medical Risks of Obesity
FX Pi-Sunyer |
Obesity Surgery | 2002 |
Racial Differences in Insulin Resistance and Mid-Thigh Fat Deposition in Postmenopausal Women
AS Ryan, BJ Nicklas, DM Berman |
Obesity research | 2002 |
Plasma Leptin Concentrations are Independently Associated with Insulin Sensitivity in Lean and Overweight Cats
DJ Appleton, JS Rand, GD Sunvold |
Journal of Feline Medicine & Surgery | 2002 |
Measurements of Interstitial Muscle Glycerol in Normal and Insulin-Resistant Subjects
M Sjöstrand, S Gudbjörnsdottir, A Holmäng, L Strindberg, K Ekberg, P Lönnroth |
The Journal of clinical endocrinology and metabolism | 2002 |
Plasma leptin concentrations are independently associated with insulin sensitivity in lean and overweight cats.
Appleton DJ, Rand JS, Sunvold GD |
Journal of feline medicine and surgery | 2002 |
Insulin action and skeletal muscle blood flow in patients with Type 1 diabetes and microalbuminuria
M Wiggam |
Diabetes Research and Clinical Practice | 2001 |
Insulin Action After Resistive Training in Insulin Resistant Older Men and Women
AS Ryan, DE Hurlbut, ME Lott, FM Ivey, J Fleg, BF Hurley, AP Goldberg |
Journal of the American Geriatrics Society | 2001 |
Inevitability of beta cell failure in type 2 diabetes
T Siegmund, KH Usadel |
Current Opinion in Endocrinology & Diabetes | 2001 |
Insulin resistance and cardiovascular risk in the pediatric patient
J Steinberger |
Progress in Pediatric Cardiology | 2001 |
Hypertension and Type 2 Diabetes Comorbidity in Adults in the United States: Risk of Overall and Regional Adiposity
IS Okosun, KM Chandra, S Choi, J Christman, GE Dever, TE Prewitt |
Obesity research | 2001 |
Insulin Sensitivity Decreases with Obesity, and Lean Cats with Low Insulin Sensitivity are at Greatest Risk of Glucose Intolerance with Weight Gain
DJ Appleton, JS Rand, GD Sunvold |
Journal of Feline Medicine & Surgery | 2001 |
Obesity, Body Fat Distribution, Insulin Sensitivity and Islet β-Cell Function as Explanations for Metabolic Diversity
SE Kahn, RL Prigeon, RS Schwartz, WY Fujimoto, RH Knopp, JD Brunzell, D Porte |
The Journal of nutrition | 2001 |
Genetics of Diabetes Mellitus
WL Lowe |
2001 | |
Glycemic index, hyperinsulinemia, and breast cancer risk
TJ Key |
Annals of Oncology | 2001 |
The Importance of β-Cell Failure in the Development and Progression of Type 2 Diabetes
SE Kahn |
The Journal of clinical endocrinology and metabolism | 2001 |
Insulin sensitivity decreases with obesity, and lean cats with low insulin sensitivity are at greatest risk of glucose intolerance with weight gain.
Appleton DJ, Rand JS, Sunvold GD |
Journal of feline medicine and surgery | 2001 |
Series Introduction: The molecular and physiological basis of insulin resistance: emerging implications for metabolic and cardiovascular diseases
AR Saltiel |
Journal of Clinical Investigation | 2000 |
Glucose Metabolism Rather Than Insulin Is a Main Determinant of Leptin Secretion in Humans
P Wellhoener, B Fruehwald-Schultes, W Kern, D Dantz, W Kerner, J Born, HL Fehm, A Peters |
Journal of Clinical Investigation | 2000 |
Exercise, Nutrition and the Older Woman
SN Meydani, T McElreavy, M Meydani |
Exercise, Nutrition and the Older Woman | 2000 |
Influence of body mass on glycemic control in a type 2 diabetic population: a 3-year follow-up
P Fumelli |
Archives of Gerontology and Geriatrics | 2000 |
Duration of obesity and risk of non-insulin-dependent diabetes mellitus
Y Sakurai |
Biomedecine & Pharmacotherapy | 2000 |
Effects of changes in body weight on carbohydrate metabolism, catecholamine excretion, and thyroid function
M Rosenbaum, J Hirsch, E Murphy, RL Leibel |
The American journal of clinical nutrition | 2000 |
The Effect of 3-Month Ingestion of Ginkgo biloba Extract on Pancreatic β-Cell Function in Response to Glucose Loading in Normal Glucose Tolerant Individuals
GB Kudolo |
The Journal of Clinical Pharmacology | 2000 |
Glucose Metabolism Rather Than Insulin Is a Main Determinant of Leptin Secretion in Humans
P Wellhoener, B Fruehwald-Schultes, W Kern, D Dantz, W Kerner, J Born, HL Fehm, A Peters |
The Journal of clinical endocrinology and metabolism | 2000 |
Obesity as a medical problem
PG Kopelman |
Nature | 2000 |
Dose-response characteristics of insulin action on glucose metabolism: a non-steady-state approach
A Natali, A Gastaldelli, S Camastra, AM Sironi, E Toschi, A Masoni, E Ferrannini, A Mari |
American journal of physiology. Endocrinology and metabolism | 2000 |
Effects of hyperglycaemia and hyperinsulinaemia on plasma amino acid levels in obese subjects with normal glucose tolerance
G Marchesini, G Bianchi, B Rossi, M Muggeo, E Bonora |
International Journal of Obesity | 2000 |
Metabolic Changes in Persons After Spinal Cord Injury
WA Bauman, AM Spungen |
Physical medicine and rehabilitation clinics of North America | 2000 |
Pathologie der Leber und Gallenwege
H Denk, HP Dienes, J Düllmann, HP Fischer, O Klinge, W Lierse, KH zum Büschenfelde, U Pfeifer, KH Preisegger, G Ramadori, A Tannapfel, C Wittekind, U Wulfhekel, H Zhou |
2000 | |
Obesity: Pathology and Therapy
DH Lockwood, TC Heffner |
2000 | |
Pathogenesis of non-insulin-dependent (type II) diabetes mellitus (NIDDM) – genetic predisposition and metabolic abnormalities
HS Jun, HY Bae, BR Lee, KS Koh, YS Kim, KW Lee, H Kim, JW Yoon |
Advanced Drug Delivery Reviews | 1999 |
Comorbidities of overweight and obesity: current evidence and research issues
FX Pi-Sunyer |
Medicine & Science in Sports & Exercise | 1999 |
Lactate and glycerol release from subcutaneous adipose tissue in black and white lean men
MT van der Merwe, PA Jansson, NJ Crowther, IH Boyd, IP Gray, BI Joffe, PN Lönnroth |
The Journal of clinical endocrinology and metabolism | 1999 |
Severe hyperlipidemia in apolipoprotein E2 homozygotes due to a combined effect of hyperinsulinemia and an SstI polymorphism
EJ Sijbrands, MJ Hoffer, AE Meinders, LM Havekes, RR Frants, AH Smelt, PD Knijff |
Arteriosclerosis, thrombosis, and vascular biology | 1999 |
Ambulatory Blood Pressure and M;etabolic Abnormalities in Hypertensive Subjects With Inappropriately High Left Ventricular Mass
V Palmieri, G de Simone, MJ Roman, JE Schwartz, TG Pickering, RB Devereux |
Hypertension | 1999 |
Endotoxin-Induced Inhibition of Growth Hormone Receptor Signaling in Rat Liver in Vivo1
Y Mao, PR Ling, TP Fitzgibbons, KC McCowen, GP Frick, BR Bistrian, RJ Smith |
Endocrinology | 1999 |
Effects of 3-month nifedipine treatment on endocrine-metabolic parameters in patients with abdominal obesity and mild hypertension
M Maccario, SE Oleandri, E Avogadri, R Rossetto, S Grottoli, M Procopio, F Camanni, E Ghigo |
Journal of Endocrinological Investigation | 1998 |
ACSM Position Stand: Exercise and Physical Activity for Older Adults
RS Mazzeo, P Cavanagh, WJ Evans, M Fiatarone, J Hagberg, E McAuley, J Startzell |
Medicine and Science in Sports and Exercise | 1998 |
Insulin Resistance versus Insulin Deficiency in Non-Insulin-Dependent Diabetes Mellitus: Problems and Prospects
E Ferrannini |
Endocrine reviews | 1998 |
Insulin Resistance
DC Whitelaw, SG Gilbey |
Annals of Clinical Biochemistry | 1998 |
Alterations in skeletal muscle protein-tyrosine phosphatase activity and expression in insulin-resistant human obesity and diabetes
F Ahmad, JL Azevedo, R Cortright, GL Dohm, BJ Goldstein |
Journal of Clinical Investigation | 1997 |
Insulin resistance and hypersecretion in obesity. European Group for the Study of Insulin Resistance (EGIR)
E Ferrannini, A Natali, P Bell, P Cavallo-Perin, N Lalic, G Mingrone |
Journal of Clinical Investigation | 1997 |
Effect of Weight Gain and Subsequent Weight Loss on Glucose Tolerance and Insulin Response in Healthy Cats
V Biourge, RW Nelson, EC Feldman, NH Willits, JG Morris, QR Rogers |
Journal of Veterinary Internal Medicine | 1997 |
Improved sensitivity to insulin in obese subjects following weight loss is accompanied by reduced protein-tyrosine phosphatases in adipose tissue
F Ahmad, RV Considine, TL Bauer, JP Ohannesian, CC Marco, BJ Goldstein |
Metabolism | 1997 |
Obesity worsens cardiovascular risk profiles independently of hyperinsulinaemia
E Bonora, G Targher, MB Zenere, F Saggiani, MP Alberiche, P Branzi, M Muggeo |
Journal of Internal Medicine | 1997 |
Time course of insulin resistance associated with feeding dogs a high-fat diet
AP Rocchini, P Marker, T Cervenka |
American journal of physiology. Endocrinology and metabolism | 1997 |
Effect of obesity on pharmacokinetics and biologic effect of interferon-alpha in hepatitis C
N P Lam, D Pitrak, R Speralakis, A H Lau, T E Wiley, T J Layden |
Digestive Diseases and Sciences | 1997 |
The roles of insulin and glucagon in the regulation of hepatic glycogen synthesis and turnover in humans
M Roden, G Perseghin, KF Petersen, JH Hwang, GW Cline, K Gerow, DL Rothman, GI Shulman |
Journal of Clinical Investigation | 1996 |
Interactions Between Glucose and FFA Metabolism in Man
C Saloranta, L Groop |
Diabetes/Metabolism Reviews | 1996 |
Effects of insulin on glucose turnover rates in vivo: Isotope dilution versus constant specific activity technique
O Hother-Nielsen, JE Henriksen, JJ Holst, H Beck-Nielsen |
Metabolism | 1996 |
Increased Plasma Oxidizability in Subjects with Severe Obesity
R Pipek, G Dankner, A Ben-Amotz, M Aviram, Y Levy |
Journal of Nutritional and Environmental Medicine | 1996 |
Triacylglycerol lowering properties of the adenosine analog GR 79236 during 5 days of dosing large, old rats: A pilot study
CS Thompson, P Strong, DP Mikhailidis |
Nutrition Research | 1996 |
Effects of glucocorticoids on energy metabolism and food intake in humans
PA Tataranni, DE Larson, S Snitker, JB Young, JP Flatt, E Ravussin |
American journal of physiology. Endocrinology and metabolism | 1996 |
Microdialysis measurements in skin: evidence for significant lactate release in healthy humans
PA Jansson, AL Krogstad, P Lonnroth |
American journal of physiology. Endocrinology and metabolism | 1996 |
CLINICAL DETERMINANTS OF GLUCOSE HOMEOSTASIS AFTER PANCREAS TRANSPLANTATION:
BJ Nankivell, JR Chapman, KJ Bovington, ST Spicer, PJ O'Connell, RD Allen |
Transplantation | 1996 |
Metabolic and Hemodynamic Effects of a Graded Intracoronary Insulin Infusion in Normal and Fat Anesthetized Dogs: A Preliminary Study
AP Rocchini, RF Wilson, P Marker, T Cervenka |
Hypertension | 1996 |
Increased abundance of the receptor-type protein-tyrosine phosphatase LAR accounts for the elevated insulin receptor dephosphorylating activity in adipose tissue of obese human subjects
F Ahmad, RV Considine, BJ Goldstein |
Journal of Clinical Investigation | 1995 |
Failure of complete suppression of endogenous glucose production by euglycaemic hyperinsulinaemia in normal humans
RD Neely, R Harper, DP Rooney, CN Ennis, PM Bell, ER Trimble |
European Journal of Clinical Investigation | 1995 |
Insulin regulation of muscle glucose metabolism: Role of pre-receptorial mechanisms
B Capaldo, L Saccà |
Diabetes / Metabolism Reviews | 1995 |
Advances in Veterinary Science and Comparative Medicine
GM Happ |
Veterinary Medical Specialization - Bridging Science and Medicine | 1995 |
Low-carbohydrate diet alters intracellular glucose metabolism but not overall glucose disposal in exercise-trained subjects
DL Cutler, CG Gray, SW Park, MG Hickman, JM Bell, OG Kolterman |
Metabolism | 1995 |
Insulin binding in non-insulin-dependent diabetes mellitus (NIDDM) is correlated with glycemic control: Clinical evidence for abnormal receptor regulation in NIDDM
CM Kelly, IG Fantus |
Metabolism | 1995 |
Alterations in carbohydrate metabolism during stress: A review of the literature
BA Mizock |
The American Journal of Medicine | 1995 |
Transport-induced stress responses in fed and fasted donkeys
AJ Forhead, D Smart, RF Smith, H Dobson |
Research in Veterinary Science | 1995 |
The Hypothalamic-Pituitary-Adrenal Axis in Obesity
S Chalew, H Nagel, S Shore |
Obesity research | 1995 |
Mathematical formulae for the prediction of the residual beta cell function during the first two years of disease in children and adolescents with insulin-dependent diabetes mellitus
Y Klipper-Aurbach, M Wasserman, N Braunspiegel-Weintrob, D Borstein, S Peleg, S Assa, M Karp, Y Benjamini, Y Hochberg, Z Laron |
Medical Hypotheses | 1995 |
Exercise, Nutrition, and Aging
WJ Evans |
Clinics in Geriatric Medicine | 1995 |
Insulin and Forearm Vasodilation in Hypertension-Prone Men
UL Hulthén, T Endre, I Mattiasson, G Berglund |
Hypertension | 1995 |
Multiple Risk Factors in Cardiovascular Disease
AM Gotto, C Lenfant, AL Catapano, R Paoletti |
1995 | |
Metabolic effects of darglitazone, an insulin sensitizer, in NIDDM subjects
RL Chaiken, M Eckert-Norton, R Pasmantier, G Boden, I Ryan, RA Gelfand, HE Lebovitz |
Diabetologia | 1995 |
Insulin regulation of glucose turnover and lipid levels in obese children with fasting normoinsulinaemia
LD Monti, P Brambilla, I Stefani, A Caumo, F Magni, R Poma, L Tomasini, G Agostini, M Galli-Kienle, C Cobelli, G Chiumello, G Pozza |
Diabetologia | 1995 |
The Effects of Exercise on Growth:
KT Borer |
Sports Medicine | 1995 |
Lactate release from the subcutaneous tissue in lean and obese men
PA Jansson, A Larsson, U Smith, P Lönnroth |
Journal of Clinical Investigation | 1994 |
Impaired insulin-induced sympathetic neural activation and vasodilation in skeletal muscle in obese humans
P Vollenweider, D Randin, L Tappy, E Jéquier, P Nicod, U Scherrer |
Journal of Clinical Investigation | 1994 |
How to measure insulin action in vivo
AJ Scheen, N Paquot, MJ Castillo, PJ Lefèbvre |
Diabetes / Metabolism Reviews | 1994 |
Clinical and histologic predictors of response to interferon-α in patients with chronic hepatitis C viral infection
NP Lam, LJ DeGuzman, D Pitrak, TJ Layden |
Digestive Diseases and Sciences | 1994 |
Genetic epidemiology of non-insulin-dependent diabetes
P Valsania, P Micossi |
Diabetes / Metabolism Reviews | 1994 |
Insulin resistance syndrome as a feature of cardiological syndrome X in non-obese men
JW Swan, C Walton, IF Godsland, D Crook, MF Oliver, JC Stevenson |
British heart journal | 1994 |
Augmented effect of short-term pulsatile versus continuous insulin delivery on lipid metabolism but similar effect on whole-body glucose metabolism in obese subjects
O Schmitz, SB Pedersen, A Mengel, N Pørksen, J Bak, N Møller, B Richelsen, KG Alberti, PC Butler, H Ørskov |
Metabolism | 1994 |
Hemodynamic actions of insulin
R Aikawa, M Nawano, Y Gu, H Katagiri, T Asano, W Zhu, R Nagai, I Komuro |
The American journal of physiology | 1994 |
4 Hormones and obesity
PG Kopelman |
Baillière's Clinical Endocrinology and Metabolism | 1994 |
Skeletal muscle blood flow independently modulates insulin-mediated glucose uptake
AD Baron, H Steinberg, G Brechtel, A Johnson |
American journal of physiology. Endocrinology and metabolism | 1994 |
Insulin and renal sodium retention in hypertension-prone men
T Endre, I Mattiasson, G Berglund, UL Hulthén |
Hypertension | 1994 |
High-fructose feeding elicits insulin resistance, hyperinsulinism, and hypertension in normal mongrel dogs
FJ Martinez, RA Rizza, JC Romero |
Hypertension | 1994 |
Additive effects of obesity, hypertension, and type 2 diabetes on insulin resistance
P Maheux, J Jeppesen, WH Sheu, CB Hollenbeck, C Clinkingbeard, MS Greenfield, YD Chen, GM Reaven |
Hypertension | 1994 |
Impaired insulin sensitivity and maximal responsiveness in older hypertensive men
DR Dengel, RE Pratley, JM Hagberg, AP Goldberg |
Hypertension | 1994 |
Primary, secondary and tertiary prevention of non-insulin-dependent diabetes
A Dornhorst, PK Merrin |
Postgraduate medical journal | 1994 |
The Link Between Insulin Resistance and Hypertension: Effects of Antihypertensive and Antihyperlipidaemic Drugs on Insulin Sensitivity
T Baba, S Neugebauer |
Drugs | 1994 |
Angiotensin II increases glucose utilization during acute hyperinsulinemia via a hemodynamic mechanism
TA Buchanan, H Thawani, W Kades, JG Modrall, FA Weaver, C Laurel, R Poppiti, A Xiang, W Hsueh |
Journal of Clinical Investigation | 1993 |
The effects of single and sequential insulin infusions on glucose disposal in older men
RE Prately, PJ Coon, DC Muller, EM Rogus, AP Goldberg |
Experimental Gerontology | 1993 |
Insulin and hypertension: Are they related?
WP Meehan, CH Darwin, NB Maalouf, TA Buchanan, MF Saad |
Steroids | 1993 |
Characteristics and mechanisms of tachyphylaxis of cardiac contractile response to insulin
R Sethi, H Rupp, BJ Naimark, J Barwinsky, RE Beamish, NS Dhalla |
International Journal of Cardiology | 1993 |
Body fat distribution, blood pressure and blood glucose in Egyptian obese women undergoing a weight control program
SM El-Shebini, ST Tapozada, LM Hanna |
Zeitschrift für Ernährungswissenschaft | 1993 |
Insulin differentially regulates systemic and skeletal muscle vascular resistance
AD Baron, G Brechtel |
American journal of physiology. Endocrinology and metabolism | 1993 |
Hepatic and extrahepatic insulin action in humans: measurement in the absence of non-steady-state error
H Katz, P Butler, M Homan, A Zerman, A Caumo, C Cobelli, R Rizza |
American journal of physiology. Endocrinology and metabolism | 1993 |
From ‘Syndrome X’ to the Thrifty Phenotype: A Reappraisal of the Insulin Resistance Theory of Atherogenesis
JH Pinkney, DK Nagi, JS Yudkin |
1993 | |
Skeletal muscle blood flow. A possible link between insulin resistance and blood pressure
AD Baron, G Brechtel-Hook, A Johnson, D Hardin |
Hypertension | 1993 |
Insulin resistance is an important determinant of left ventricular mass in the obese
Z Sasson, Y Rasooly, T Bhesania, I Rasooly |
Circulation | 1993 |
New Concepts in the Pathogenesis of NIDDM
CG Östenson, S Efendić, M Vranic |
1993 | |
Insulin resistance in offspring of hypertensive parents
OL Beatty, R Harper, B Sheridan, AB Atkinson, PM Bell |
BMJ : British Medical Journal | 1993 |
Insulin resistance in a case of coexisting insulinoma and type 2 diabetes
G Grunberger |
Acta Diabetologica | 1993 |
Insulin sensitivity of protein and glucose metabolism in human forearm skeletal muscle
RJ Louard, DA Fryburg, RA Gelfand, EJ Barrett |
Journal of Clinical Investigation | 1992 |
Relation of serum lipoprotein lipids and apolipoproteins to obesity in children: The Bogalusa heart study
DA Kikuchi, SR Srinivasan, DW Harsha, LS Webber, TA Sellers, GS Berenson |
Preventive Medicine | 1992 |
Assessment of Glucose Turnover Rates in Euglycaemic Clamp Studies using Primed-constant [3-3H]-glucose Infusion and Labelled or Unlabelled Glucose Infusates
O Hother-Nielsen, A Møngel, J Møller, O Rasmussen, O Schmitz, H Beck-Nielsen |
Diabetic Medicine | 1992 |
Relationship of insulin clearance and secretion to insulin sensitivity in non-diabetic Mexican Americans
SM Haffner, MP Stern, RM Watanabe, RN Bergman |
European Journal of Clinical Investigation | 1992 |
The glucoregulatory and antilipolytic actions of insulin in abdominal obesity with normal or impaired glucose tolerance: an in vivo and in vitro study
P Cavallo-Perin, A Bruno, M Cassader, L Cesco, G Gruden, G Pagano |
European Journal of Clinical Investigation | 1992 |
Effects of morbid obesity on insulin clearance and insulin sensitivity in several aspects of metabolism as assessed by low-dose insulin infusion
DA Robertson, BM Singh, PJ Hale, M Nattrass |
Metabolism | 1992 |
Insulin and lipogenesis in rat adipocytes. I. Effect of insulin incubation on lipid synthesis by isolated rat adipocytes
LM Morales, G Campos, E Ryder, A Casanova |
Biochemical and Biophysical Research Communications | 1992 |
Autosomal dominant insulin resistance syndrome due to a postbinding defect
E Seemanová, HW Rüdiger, M Dreyer |
American Journal of Medical Genetics | 1992 |
Time course of plasma free fatty acid concentration in response to insulin: Effect of obesity and physical fitness
PJ Coon, EM Rogus, AP Goldberg |
Metabolism | 1992 |
Influence of sympatho-adrenal system on insulin sensitivity using the euglycemic clamp technique
M Kusunoki, Y Oshida, A Iguchi, T Iida, T Suga, T Funado, Y Sato, K Kato, N Sakamoto |
Diabetes Research and Clinical Practice | 1992 |
Exploration de l'insulinosensibilité périphérique des obèses diabétiques ou non
H Puy, F Boitte, JM Marcelli, X Debussche, O Vincent, G Desmet, J Quichaud |
Nutrition Clinique et Métabolisme | 1992 |
Lipoprotein metabolism following gastroplasty in obese women
HV Schenck, L Wallentin, C Lennmarken, J Larsson |
Scandinavian Journal of Clinical & Laboratory Investigation | 1992 |
Effects of epinephrine on insulin-mediated glucose uptake in whole body and leg muscle in humans: role of blood flow
M Laakso, SV Edelman, G Brechtel, AD Baron |
American journal of physiology. Endocrinology and metabolism | 1992 |
Effect of insulin on oxidative and nonoxidative pathways of free fatty acid metabolism in human obesity
LC Groop, RC Bonadonna, DC Simonson, AS Petrides, M Shank, RA DeFronzo |
American journal of physiology. Endocrinology and metabolism | 1992 |
Possible Epidemiological Factors Associated with Rupture of the Posterior Tibial Tendon
GB Holmes, RA Mann |
1992 | |
Use of [3-3H]glucose and [6-14C]glucose to measure glucose turnover and glucose metabolism in humans
H Katz, M Homan, P Butler, R Rizza |
American journal of physiology. Endocrinology and metabolism | 1992 |
Insulin resistance in werner's syndrome
M Okamoto, M Okamoto, K Yamada, Y Yoshimasa, A Kosaki, S Kono, Inoue, I Maeda, M Kubota, T Hayashi, S Kato, H Kuzuya, H Imura |
Mechanisms of Ageing and Development | 1992 |
Short-term regulation of insulin-mediated glucose utilization in four-day fasted human volunteers: role of amino acid availability
PJ Flakoll, LS Wentzel, DE Rice, JO Hill, NN Abumrad |
Diabetologia | 1992 |
Diabetes and Atherosclerosis
RW Stout |
1992 | |
Reduced glycogen synthase activity in skeletal muscle from obese patients with and without Type 2 (non-insulin-dependent) diabetes mellitus
C Bogardus, S Lillioja, K Stone, D Mott |
Journal of Clinical Investigation | 1991 |
Differences in insulin action as a function of original anatomical site of newly differentiated adipocytes obtained in primary culture
C Sztalryd, S Azhar, GM Reaven |
Journal of Clinical Investigation | 1991 |
Acute C-Peptide, Insulin and Branched Chain Amino Acid Response to Feeding in Formula and Breast Fed Infants
M Wallensteen, BS Lindblad, R Zetterström, B Persson |
Acta Paediatrica | 1991 |
Urinary C-peptide Excretion in Obese and Anorectic Children
M Wallensteen, BE Ginsburg, B Persson, G Dahlquist |
Acta Paediatrica | 1991 |
Understanding “insulin resistance”: Both glucose resistance and insulin resistance are required to model human diabetes
AS Rudenski, DR Matthews, JC Levy, RC Turner |
Metabolism | 1991 |
The effects of euglycemic hyperinsulinemia and amino acid infusion on regional and whole body glucose disposal in man
PW Pisters, NP Restifo, E Cersosimo, MF Brennan |
Metabolism | 1991 |
Differential effects of insulin resistance on leucine and glucose kinetics in obesity
B Caballero, RJ Wurtman |
Metabolism | 1991 |
Altered plasma free amino acid levels in obese traumatized man
M Jeevanandam, L Ramias, WR Schiller |
Metabolism | 1991 |
A mathematical model and computer simulation study of insulin receptor regulation
MJ Quon, LA Campfield |
Journal of Theoretical Biology | 1991 |
Effects of ciglitazone on endogenous plasma islet amyloid polypeptide and insulin sensitivity in obese-diabetic viable yellow mice
AM Gill, TT Yen |
Life Sciences | 1991 |
Insulin resistance and action in hypertriglyceridemia
S Zuniga-Guarjardo, G Steiner, S Shumak, B Zinman |
Diabetes Research and Clinical Practice | 1991 |
International Review of Cytology
RA Miller |
International Review of Cytology | 1991 |
Essential hypertension, metabolic disorders, and insulin resistance
E Ferrannini, A Natali |
American Heart Journal | 1991 |
A two-step model for development of non-insulin-dependent diabetes
MF Saad, WC Knowler, DJ Pettitt, RG Nelson, MA Charles, PH Bennett |
The American Journal of Medicine | 1991 |
Glucose tolerance and insulin release in adolescent female
L Benassi, G Tridenti, N Orlandi, A Pezzarossa |
Journal of Endocrinological Investigation | 1991 |
Amino Acids Enhance Insulin Resistance to Exogenous Glucose Infusion in Overnight-Fasted Humans
PJ Flakoll, M Kulaylat, M Frexes-Steed, JO Hill, NN Abumrad |
JPEN. Journal of parenteral and enteral nutrition | 1991 |
Hyperinsulinaemia: the key feature of a cardiovascular and metabolic syndrome
E Ferrannini, SM Haffner, BD Mitchell, MP Stern |
Diabetologia | 1991 |
Insulin resistance and diabetes due to different mutations in the tyrosine kinase domain of both insulin receptor gene alleles
J Kusari, Y Takata, E Hatada, G Freidenberg, O Kolterman, JM Olefsky |
The Journal of biological chemistry | 1991 |
Hepatic protein phosphotyrosine phosphatase. Dephosphorylation of insulin and epidermal growth factor receptors in normal and alloxan diabetic rats
PA Gruppuso, JM Boylan, BI Posner, R Faure, DL Brautigan |
Journal of Clinical Investigation | 1990 |
Decreased effect of insulin to stimulate skeletal muscle blood flow in obese man. A novel mechanism for insulin resistance
M Laakso, SV Edelman, G Brechtel, AD Baron |
Journal of Clinical Investigation | 1990 |
Insulin Insensitivity in Offspring of Parents with Type 2 Diabetes Mellitus
LT Ho, ZY Chang, JT Wang, SH Li, YF Liu, YD Chen, GM Reaven |
Diabetic Medicine | 1990 |
Diabetes mellitus in the pima indians: Incidence, risk factors and pathogenesis
WC Knowler, DJ Pettitt, MF Saad, PH Bennett |
Diabetes / Metabolism Reviews | 1990 |
Lack of effect of tenoxicam on dynamic responses to concurrent oral doses of glucose and glibenclamide
D Hartmann, A Korn, M Komjati, G Heinz, P Haefelfinger, R Defoin, WK Waldhäusl |
British Journal of Clinical Pharmacology | 1990 |
Obesity and insulin resistance in humans: A dose-response study
RC Bonadonna, G Leif, N Kraemer, E Ferrannini, SD Prato, RA DeFronzo |
Metabolism | 1990 |
The assessment of hepatic and peripheral insulin sensitivity in hypertriglyceridemia
WR McKane, AB Stevens, R Woods, WJ Andrews, RW Henry, PM Bell |
Metabolism | 1990 |
Does fasting interval affect the glucose challenge test?
MD Berkus, MP Stern, BD Mitchell, ER Newton, O Langer |
American Journal of Obstetrics and Gynecology | 1990 |
Relationships between glucose levels and insulin secretio during a glucose challenge test
MD Berkus, MP Stern, BD Mitchell, A Abashawl, O Langer |
American Journal of Obstetrics and Gynecology | 1990 |
Use of a variable tracer infusion method to determine glucose turnover in humans
JM Molina, AD Baron, SV Edelman, G Brechtel, P Wallace, JM Olefsky |
American journal of physiology. Endocrinology and metabolism | 1990 |
Insulin resistance is associated with lipid and lipoprotein abnormalities in subjects with varying degrees of glucose tolerance
M Laakso, H Sarlund, L Mykkänen |
Arteriosclerosis (Dallas, Tex.) | 1990 |
Insulin resistance and blood pressure in young black men
B Falkner, S Hulman, J Tannenbaum, H Kushner |
Hypertension | 1990 |
Insulin administration alters gonadal steroid metabolism independent of changes in gonadotropin secretion in insulin-resistant women with the polycystic ovary syndrome
A Dunaif, M Graf |
Journal of Clinical Investigation | 1989 |
Insulin transport across capillaries is rate limiting for insulin action in dogs
YJ Yang, ID Hope, M Ader, RN Bergman |
Journal of Clinical Investigation | 1989 |
Hepatic glucose production in insulin-resistant states
E Ferrannini, LC Groop |
Diabetes / Metabolism Reviews | 1989 |
Assessment of insulin sensitivity in vivo: A critical review
RN Bergman, ID Hope, YJ Yang, RM Watanabe, MA Meador, JH Youn, M Ader |
Diabetes / Metabolism Reviews | 1989 |
The impact of obesity on the pathogenesis of non-insulin-dependent diabetes mellitus: A review of current hypotheses
O Pedersen |
Diabetes / Metabolism Reviews | 1989 |
The Insulin Receptor: Structure and Functio
Y Zick |
Critical Reviews in Biochemistry and Molecular Biology | 1989 |
Essential hypertension and insulin resistance in non-insulin-dependent diabetes
M Laakso, H Sarlund, L Mykkänen |
European Journal of Clinical Investigation | 1989 |
SEQUENTIAL CHANGES IN SERUM INSULIN CONCENTRATION DURING DEVELOPMENT OF NON-INSULIN-DEPENDENT DIABETES
MF Saad, DJ Pettitt, DM Mott, WC Knowler, RG Nelson, PH Bennett |
The Lancet | 1989 |
Insulin resistance in skeletal muscles of patients with diabetes mellitus
H Beck-Nielsen |
Diabetes / Metabolism Reviews | 1989 |
Insulin transport across capillaries is rate limiting for insulin action in dogs
YJ Yang, ID Hope, M Ader, RN Bergman |
New England Journal of Medicine | 1989 |
Insulin Secretion in Childhood Obesity
T Yoshizumi, H Masuda, T Fujiwara, Y Uchida, H Kamiya, H Hirota, M Kubo, C Haibara, M Sakurai |
Pediatrics International | 1989 |
Disopyramide induces insulin secretion and plasma glucose diminution: Studies using the in situ canine pancreas
H Nakabayashi, T Ito, T Igawa, Y Hiraiwa, T Imamura, T Seta, M Kawato, N Usukura, R Takeda |
Metabolism | 1989 |
Insulin resistance in porphyria cutanea tarda
F Calcinaro, G Basta, P Lisi, C Cruciani, M Pietropaolo, F Santeusanio, A Falorni, R Calafiore |
Journal of Endocrinological Investigation | 1989 |
Low Levels of High-Affinity Growth Hormone-Binding Protein in African Pygmies
G Baumann, MA Shaw, TJ Merimee |
New England Journal of Medicine | 1989 |
Endocrine Aspects of Obesity
AR Glass |
Medical Clinics of North America | 1989 |
Reproductive endocrinologic alterations in female asymptomatic obesity
EE Wallach, R Azziz |
Fertility and Sterility | 1989 |
Insulin sensitivity and responsiveness during lactation and dry period in goats
E Debras, J Grizard, E Aina, S Tesseraud, C Champredon, M Arnal |
American journal of physiology. Endocrinology and metabolism | 1989 |
Effects of obesity on insulin sensitivity and responsiveness in sheep
EN Bergman, SS Reulein, RE Corlett |
American journal of physiology. Endocrinology and metabolism | 1989 |
Insulin and renal sodium retention in obese adolescents
AP Rocchini, V Katch, D Kveselis, C Moorehead, M Martin, R Lampman, M Gregory |
Hypertension | 1989 |
Pathogenesis of weight-related changes in blood pressure in dogs
AP Rocchini, CP Moorehead, S DeRemer, D Bondie |
Hypertension | 1989 |
Nutrition, Aging, and the Elderly
HN Munro, DE Danford |
1989 | |
Handbook of Research Methods in Cardiovascular Behavioral Medicine
N Schneiderman, SM Weiss, PG Kaufmann |
1989 | |
The Reduction of Peripheral Insulin Concentrations in Obese Subjects following a Hypocaloric Diet: Reduced Pancreatic Secretion or Increased Hepatic Extraction?
R Gama, V Marks |
Annals of Clinical Biochemistry | 1989 |
Recovery of maximal insulin responsiveness and insulin sensitivity after induction of insulin resistance in primary cultured adipocytes
RR Traxinger, S Marshall |
The Journal of biological chemistry | 1989 |
Role of glucose transporters in the cellular insulin resistance of type II non-insulin-dependent diabetes mellitus
WT Garvey, TP Huecksteadt, S Matthaei, JM Olefsky |
Journal of Clinical Investigation | 1988 |
Mild type II diabetes markedly increases glucose cycling in the postabsorptive state and during glucose infusion irrespective of obesity
S Efendic, S Karlander, M Vranic |
Journal of Clinical Investigation | 1988 |
An in vitro human muscle preparation suitable for metabolic studies. Decreased insulin stimulation of glucose transport in muscle from morbidly obese and diabetic subjects
GL Dohm, EB Tapscott, WJ Pories, DJ Dabbs, EG Flickinger, D Meelheim, T Fushiki, SM Atkinson, CW Elton, JF Caro |
Journal of Clinical Investigation | 1988 |
Reversibility of defective adipocyte insulin receptor kinase activity in non-insulin-dependent diabetes mellitus. Effect of weight loss
GR Freidenberg, D Reichart, JM Olefsky, RR Henry |
Journal of Clinical Investigation | 1988 |
Metabolic basis of obesity and noninsulin-dependent diabetes mellitus
A Golay, JP Felber, E Jequier, RA DeFronzo, E Ferrannini |
Diabetes / Metabolism Reviews | 1988 |
Correlation of in vivo and in vitro actions of insulin in obesity and noninsulin-dependent diabetes mellitus: Role of the glucose transport system
WT Garvey, OG Kolterman |
Diabetes / Metabolism Reviews | 1988 |
Die Beziehung zwischen Körperfettverteilung, Insulinspiegeln und Glukosetoleranz bei übergewichtigen Frauen
H Hauner, EF Pfeiffer |
Klinische Wochenschrift | 1988 |
Insulin sensitivity in anorexia nervosa: A mirror image of obesity?
AJ Scheen, M Castillo, PJ Lefèbvre |
Diabetes / Metabolism Reviews | 1988 |
Glucose-induced insulin resistance of skeletal-muscle glucose transport and uptake
EA Richter, BF Hansen, SA Hansen |
Biochemical Journal | 1988 |
Relationship between lipoprotein levels and in vivo insulin action in normal young white men
A Garg, JH Helderman, M Koffler, R Ayuso, J Rosenstock, P Raskin |
Metabolism | 1988 |
Following weight loss in massively obese patients correction of the insulin resistance of fat metabolism is delayed relative to the improvement in carbohydrate metabolism
PJ Hale, BM Singh, J Crase, RM Baddeley, M Nattrass |
Metabolism | 1988 |
Obesity is associated with impaired insulin-mediated potassium uptake
RA DeFronzo |
Metabolism | 1988 |
Plasma acetate levels in response to intravenous fat or infusions in diabetic and non-diabetic subjects
AO Akanji, L Ng, S Humphreys |
Clinica Chimica Acta | 1988 |
Impaired insulin action in adipocytes of New Zealand Obese mice: A role for postbinding defects in pyruvate dehydrogenase and insulin mediator activity
SL Macaulay, RG Larkins |
Metabolism | 1988 |
Bed-rest-induced insulin resistance occurs primarily in muscle
CA Stuart, RE Shangraw, MJ Prince, EJ Peters, RR Wolfe |
Metabolism | 1988 |
2 Role of insulin resistance in the pathogenesis of Type 2 (non-insulin-dependent) diabetes mellitus
JE Gerich |
Baillière's Clinical Endocrinology and Metabolism | 1988 |
Obesity and insulin resistance: lessons learned from the Pima Indians
S Lillioja, C Bogardus |
Diabetes/Metabolism Reviews | 1988 |
Antecedent chronic hyperglycaemia blocks phlorizin-induced insulin resistance in the dog
M Koffler, T Imamura, F Santeusanio, JH Helderman |
Diabetologia | 1988 |
Insulin: Either Alone or Combined with Oral Hypoglycemic Agents
RG Firth |
Primary care | 1988 |
Decreased kinase activity of insulin receptors from adipocytes of non-insulin-dependent diabetic subjects
GR Freidenberg, RR Henry, HH Klein, DR Reichart, JM Olefsky |
Journal of Clinical Investigation | 1987 |
Equivalence of the insulin sensitivity index in man derived by the minimal model method and the euglycemic glucose clamp
RN Bergman, R Prager, A Volund, JM Olefsky |
Journal of Clinical Investigation | 1987 |
Mechanism for enhanced glucose transport response to insulin in adipose cells from chronically hyperinsulinemic rats. Increased translocation of glucose transporters from an enlarged intracellular pool
BB Kahn, ES Horton, SW Cushman |
Journal of Clinical Investigation | 1987 |
Effects of insulin infusion on human skeletal muscle pyruvate dehydrogenase, phosphofructokinase, and glycogen synthase. Evidence for their role in oxidative and nonoxidative glucose metabolism
LJ Mandarino, KS Wright, LS Verity, J Nichols, JM Bell, OG Kolterman, H Beck-Nielsen |
Journal of Clinical Investigation | 1987 |
Weight reduction increases adipose tissue lipoprotein lipase responsiveness in obese women
RH Eckel, TJ Yost |
Journal of Clinical Investigation | 1987 |
Factors regulating the disposal of an oral glucose load in normal, diabetic, and obese subjects
WK Waldhäusl, P Bratusch-Marrain |
Diabetes / Metabolism Reviews | 1987 |
Insulin resistance in patients with colorectal cancer
GP Copeland, SJ Leinster, JC Davis, LJ Hipkin |
British Journal of Surgery | 1987 |
Insulin binding to erythrocytes in hyperinsulinemic patients with precirrhotic hemochromatosis and cirrhosis
AS Petrides, W Paßlack, H Reinauer, W Stremmel, G Strohmeyer |
Klinische Wochenschrift | 1987 |
Diet composition and lipoprotein lipase (EC 3.1.1.34) activity in human obesity
LA Smolin, MB Grosvenor, DJ Handelsman, JA Brasel |
British Journal of Nutrition | 1987 |
Regulation of hepatic glucose metabolism in humans
RA DeFronzo, E Ferrannini |
Diabetes / Metabolism Reviews | 1987 |
Beta cell function in the preclinical period of insulin-dependent diabetes
DK McCulloch, JP Palmer, EA Benson |
Diabetes / Metabolism Reviews | 1987 |
Insulin Resistance and Ammo Acid Metabolism in Obesity
B Caballero |
Annals of the New York Academy of Sciences | 1987 |
Potential Role of Adipose Tissue for the Development of Insulin Resistance in Obesity
P Lönnroth |
Acta Medica Scandinavica | 1987 |
Insulin Action-Biochemical and Clinical Aspects
U Smith |
Acta Medica Scandinavica | 1987 |
Defective glucose utilization in patients with functioning beta-cell tumors persists after tumor excision
GS McGee, MM Kulaylat, NN Abumrad |
Annals of Surgery | 1987 |
Insulin action in non-insulin-dependent diabetes mellitus: The relationship between hepatic and extrahepatic insulin resistance and obesity
R Firth, P Bell, R Rizza |
Metabolism | 1987 |
Protein–energy malnutrition in pregnant rats improves the adaptation of the endocrine pancreas in malnourished offspring and induces insulin resistance after rehabilitation
JM Dollet, B Beck, JP Max, G Debry |
British Journal of Nutrition | 1987 |
Importance of substrate competition in the mechanism of insulin resistance in man
D Vouillamoz, E Temler, E Jéquier, JP Felber |
Metabolism | 1987 |
Aging and diabetes mellitus as risk factors for vascular disease
KL Minaker |
The American Journal of Medicine | 1987 |
6 Insulin sensitivity in the intact organism
M Ader, RN Bergman |
Baillière's Clinical Endocrinology and Metabolism | 1987 |
Theory of the etiology of human toxemia of pregnancy: Fetal hyperinsulinemia as a compensatory response to decreased uterine blood flow
DR Bonds, LO Crosby |
Medical Hypotheses | 1987 |
Puberty decreases insulin sensitivity
CA Bloch, P Clemons, MA Sperling |
The Journal of Pediatrics | 1987 |
Insulin Resistance and the Use of U-500 Insulin: A Case Report
JA Fain |
The Diabetes Educator | 1987 |
Dissociation of in vitro sensitivities of glucose transport and antilipolysis to insulin in NIDDM
H Yki-Jarvinen, K Kubo, J Zawadzki, S Lillioja, A Young, W Abbott, JE Foley |
American journal of physiology. Endocrinology and metabolism | 1987 |
Chronic administration of theophylline to rats induces a post-insulin binding defect in adipocyte glucose transport
A Green |
Diabetologia | 1987 |
Modifications of cellular lipids induce insulin resistance in cultured hepatoma cells
C Bruneau, P Hubert, A Waksman, JP Beck, C Staedel-Flaig |
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 1987 |
Endocrine Abnormalities in Morbid Obesity
A Peiris, A Kissebah |
Gastroenterology Clinics of North America | 1987 |
Glucose and insulin co-regulate the glucose transport system in primary cultured adipocytes. A new mechanism of insulin resistance
WT Garvey, JM Olefsky, S Matthaei, S Marshall |
The Journal of biological chemistry | 1987 |
Adenosine receptor down-regulation and insulin resistance following prolonged incubation of adipocytes with an A1 adenosine receptor agonist
A Green |
The Journal of biological chemistry | 1987 |
Insulin. Its role in the thermic effect of glucose
L Christin, CA Nacht, O Vernet, E Ravussin, E Jéquier, KJ Acheson |
Journal of Clinical Investigation | 1986 |
In vivo kinetics of insulin action on peripheral glucose disposal and hepatic glucose output in normal and obese subjects
R Prager, P Wallace, JM Olefsky |
Journal of Clinical Investigation | 1986 |
Glucoregulation in acute liver failure
H Vilstrup, J Iversen, N Tygstrup |
European Journal of Clinical Investigation | 1986 |
Physical training and insulin sensitivity
VA Koivisto, H Yki-Järvinen, RA DeFronzo |
Diabetes / Metabolism Reviews | 1986 |
Exercise and physical training: Effects on insulin sensitivity and glucose metabolism
ES Horton |
Diabetes / Metabolism Reviews | 1986 |
The effect of liver microsomal enzyme inducing and inhibiting drugs on insulin mediated glucose metabolism in man
JT Lahtela, B Gachalyi, S Eksymä, A Hämäläinen, EA Sotaniemi |
British Journal of Clinical Pharmacology | 1986 |
Overnutrition induced decrease in insulin action for glucose storage: In vivo and in vitro in man
DM Mott, S Lillioja, C Bogardus |
Metabolism | 1986 |
Insulin resistance with acanthosis nigricans: The roles of obesity and androgen excess
CA Stuart, EJ Peters, MJ Prince, G Richards, A Cavallo, WJ Meyer |
Metabolism | 1986 |
Effects of massive obesity on insulin sensitivity and insulin clearance and the metabolic response to insulin as assessed by the euglycemic clamp technique
S Zuniga-Guajardo, J Jimenez, A Angel, B Zinman |
Metabolism | 1986 |
Effects of caloric restriction and exercise of insulin receptors in obesity: Association with changes in membrane lipids
ND Neufeld, C Ezrin, L Corbo, D Long, MA Bush |
Metabolism | 1986 |
Studies on overnight insulin requirements and metabolic clearance rate of insulin in normal and diabetic man: relevance to the pathogenesis of the dawn phenomenon
P Feo, G Perriello, MM Ventura, F Calcinaro, G Basta, C Lolli, C Cruciani, A Dell'Olio, F Santeusanio, P Brunetti, GB Bolli |
Diabetologia | 1986 |
Hypertension and diabetes in obesity: A review and new ideas on the contributing role of ions
RS El-Mallakh |
Medical Hypotheses | 1986 |
Subclinical abnormalities of glucose metabolism in subjects with previous gestational diabetes
PM Catalano, IM Bernstein, RR Wolfe, S Srikanta, E Tyzbir, EA Sims |
American Journal of Obstetrics and Gynecology | 1986 |
Natural Course of Insulin Resistance in Type I Diabetes
H Yki-Järvinen, VA Koivisto |
New England Journal of Medicine | 1986 |
The Receptors
RG Rosenfeld, RL Hintz |
The Receptors | 1986 |
The Effects of Diet and Exercise in the Treatment of Non-Insulin Dependent Diabetes Mellitus
HM Kim, SK Lim, KR Kim, HC Lee, KB Huh, HS Park |
The Korean Journal of Internal Medicine | 1986 |
Review: Pathogenesis of Type 2 Diabetes Mellitus: An Interpretation of Current Data
MB Davidson |
The American Journal of the Medical Sciences | 1986 |
Insulin resistance in acromegaly: defects in both hepatic and extrahepatic insulin action
I Hansen, E Tsalikian, B Beaufrere, J Gerich, M Haymond, R Rizza |
American journal of physiology. Endocrinology and metabolism | 1986 |
Body fat distribution and hyperinsulinemia as risk factors for diabetes and cardiovascular disease
MP Stern, SM Haffner |
Arteriosclerosis (Dallas, Tex.) | 1986 |
Pathogenesis and Treatment of Diabetes Mellitus
JK Radder, HH Lemkes, HM Krans |
1986 | |
Biological and Psychological Factors in Cardiovascular Disease
TH Schmidt, TM Dembroski, G Blümchen |
1986 | |
Insulin receptors and the clinician
R Taylor |
BMJ : British Medical Journal | 1986 |
Studies on overnight insulin requirements and metabolic clearance rate of insulin in normal and diabetic man: relevance to the pathogenesis of the dawn phenomenon
PD Feo, G Perriello, MM Ventura, F Calcinaro, G Basta, C Lolli, C Cruciani, A Dell'Olio, F Santeusanio, P Brunetti, GB Bolli |
Diabetologia | 1986 |
Insulin receptor down-regulation is linked to an insulin-induced postreceptor defect in the glucose transport system in rat adipocytes
WT Garvey, JM Olefsky, S Marshall |
Journal of Clinical Investigation | 1985 |
Effect of insulin on the distribution and disposition of glucose in man
E Ferrannini, JD Smith, C Cobelli, G Toffolo, A Pilo, RA DeFronzo |
Journal of Clinical Investigation | 1985 |
Evidence that insulin resistance is responsible for the decreased thermic effect of glucose in human obesity
E Ravussin, KJ Acheson, O Vernet, E Danforth, E Jéquier |
Journal of Clinical Investigation | 1985 |
Kinetic Models for Plasma Disappearance of Insulin in Normal Subjects
B Thorsteinsson, S Fugleberg, B Feldt-Rasmussen, C Binder |
Acta Pharmacologica et Toxicologica | 1985 |
Cellular mechanisms in selected states of insulin resistance: Human obesity, glucocorticoid excess, and chronic renal failure
JM Amatruda, JN Livingston, DH Lockwood |
Diabetes / Metabolism Reviews | 1985 |
Insulin action and glucose metabolism in sheep fed on dried-grass or ground, maize-based diets
AN Janes, TE Weekes, DG Armstrong |
British Journal of Nutrition | 1985 |
Pathogenesis of impaired glucose tolerance and type II diabetes mellitus--current status
MB Davidson |
The Western journal of medicine | 1985 |
Suppression of basal, but not of glucose-stimulated insulin secretion by human insulin in healthy and obese hyperinsulinemic subjects
PR Bratusch-Marrain, WK Waldhäusl |
Metabolism | 1985 |
Hepatic and peripheral insulin resistance following streptozotocin-induced insulin deficiency in the dog
S Bevilacqua, EJ Barrett, D Smith, DC Simonson, M Olsson, P Bratusch-Marrain, E Ferrannini, RA DeFronzo |
Metabolism | 1985 |
Control of erythrocyte membrane microviscosity by insulin
AK Dutta-Roy, TK Ray, AK Sinha |
Biochimica et Biophysica Acta (BBA) - Biomembranes | 1985 |
The metabolic response to the eugylcemic insulin clamp in type I diabetes and normal humans
S Zuniga-Guajardo, B Zinman |
Metabolism | 1985 |
Insulin resistance: Receptor and post-binding defects in human obesity and non-insulin-dependent diabetes mellitus
JA Truglia, JN Livingston, DH Lockwood |
The American Journal of Medicine | 1985 |
Insulin receptor — and nonreceptor — controlled cellular substrate processing.: A review of clinical studies in the isolated human adipocyte model
O Pedersen |
Journal of Endocrinological Investigation | 1985 |
Insulin receptors and insulin sensitivity in normo and hyperinsulinemic obese patients
AC Artenisio, F Ragonese, F Forte, G Saitta, G Perrone, G Lettina, R Campisi, F Consolo |
Journal of Endocrinological Investigation | 1985 |
Effect of Intravenously Infused Porcine Gip on Serum Insulin in Obese and Lean Subjects Studied with the Hyperglycemic Clamp Technique
PF Amland, R Jorde, P Burhol, KE Giercksky |
Scandinavian Journal of Gastroenterology | 1985 |
Effect of thyroid hormone excess on action, secretion, and metabolism of insulin in humans
G Dimitriadis, B Baker, H Marsh, L Mandarino, R Rizza, R Bergman, M Haymond, J Gerich |
American journal of physiology. Endocrinology and metabolism | 1985 |
The Second Generation Sulfonylureas: Glipizide and Glyburide
DE Baker, RK Campbell |
The Diabetes Educator | 1985 |
Relationship between degree of obesity and in vivo insulin action in man
C Bogardus, S Lillioja, DM Mott, C Hollenbeck, G Reaven |
American journal of physiology. Endocrinology and metabolism | 1985 |
Comparison of Type I and Type II Diabetes
M Vranic, CH Hollenberg, G Steiner |
1985 | |
Mechanisms of Receptor Regulation
G Poste, ST Crooke |
1985 | |
Gene for Human Insulin Receptor: Localization to Site on Chromosome 19 Involved in Pre-B-Cell Leukemia
TL Yang-Feng, U Francke, A Ullrich |
Science | 1985 |
Insulin binding in differentiating rat preadipocytes in culture
P Pettersson, RL Van, P Lönnroth, P Björntorp, U Smith |
Journal of lipid research | 1985 |
Production of insulin resistance by hyperinsulinaemia in man
R A Rizza, L J Mandarino, J Genest, B A Baker, J E Gerich |
Diabetologia | 1985 |
Influence of hyperglycemia on insulin's in vivo effects in type II diabetes
RR Revers, R Fink, J Griffin, JM Olefsky, OG Kolterman |
Journal of Clinical Investigation | 1984 |
Relationship between obesity and maximal insulin-stimulated glucose uptake in vivo and in vitro in Pima Indians
C Bogardus, S Lillioja, D Mott, GR Reaven, A Kashiwagi, JE Foley |
Journal of Clinical Investigation | 1984 |
Relationship between skeletal muscle insulin resistance, insulin-mediated glucose disposal, and insulin binding. Effects of obesity and body fat topography
DJ Evans, R Murray, AH Kissebah |
Journal of Clinical Investigation | 1984 |
Thermic effect of glucose in man. Obligatory and facultative thermogenesis
KJ Acheson, E Ravussin, J Wahren, E Jéquier |
Journal of Clinical Investigation | 1984 |
Binding of tyrosine-A-14(125I)-monoiodoinsulin to human erythrocytes
K Pettersson, T Koivula, E Kokko |
Scandinavian Journal of Clinical & Laboratory Investigation | 1984 |
Insulin Receptor Assays-Clinical Application and Limitations
R Taylor |
Diabetic Medicine | 1984 |
Induction of insulin resistance in normal adipose tissue by uremic human serum
ML McCaleb, R Mevorach, RB Freeman, MS Izzo, DH Lockwood |
Kidney International | 1984 |
The short term effects of bezafibrate on the hypertriglyceridaemia of moderate to severe uraemia
AJ Williams, F Baker, J Walls |
British Journal of Clinical Pharmacology | 1984 |
Binding and molecular weight properties of the insulin receptor from omental and subcutaneous adipocytes in human obesity
JN Livingston, KM Lerea, J Bolinder, L Kager, L Backman, P Arner |
Diabetologia | 1984 |
In vitro insensitivity of glucose transport and antilipolysis to insulin due to receptor and postreceptor abnormalities in obese Pima Indians with normal glucose tolerance
A Kashiwagi, C Bogardus, S Lillioja, TP Huecksteadt, D Brady, MA Verso, JE Foley |
Metabolism | 1984 |
Plasma glucagon suppressibility after oral glucose in obese subjects with normal and impaired glucose tolerance
VC Borghi, BL Wajchenberg, FP Cesar |
Metabolism | 1984 |
Infusion of insulin impairs human adipocyte glucose metabolism in vitro without decreasing adipocyte insulin receptor binding
L Mandarino, B Baker, R Rizza, J Genest, J Gerich |
Diabetologia | 1984 |
Structure of Membranes and Receptors
TC Cheng |
1984 | |
Evaluation and Treatment of Obesity
J Storlie, HA Jordan |
1984 | |
Kinetics of Glucose Metabolism in Relation to Insulin Concentrations in Patients With Alcoholic Cirrhosis and in Healthy Persons
J Iversen, H Vilstrup, N Tygstrup |
Gastroenterology | 1984 |
Mechanisms of insulin resistance in aging
RI Fink, OG Kolterman, J Griffin, JM Olefsky |
Journal of Clinical Investigation | 1983 |
Characterization of the insulin resistance of aging
JW Rowe, KL Minaker, JA Pallotta, JS Flier |
Journal of Clinical Investigation | 1983 |
Thermic effect of infused glucose and insulin in man. Decreased response with increased insulin resistance in obesity and noninsulin-dependent diabetes mellitus
E Ravussin, C Bogardus, RS Schwartz, DC Robbins, RR Wolfe, ES Horton, E Danforth, EA Sims |
Journal of Clinical Investigation | 1983 |
In vitro insulin resistance of human adipocytes isolated from subjects with noninsulin-dependent diabetes mellitus
A Kashiwagi, MA Verso, J Andrews, B Vasquez, G Reaven, JE Foley |
Journal of Clinical Investigation | 1983 |
Studies of liver insulin receptors in non-obese and obese human subjects
P Arner, K Einarsson, L Backman, K Nilsell, KM Lerea, JN Livingston |
Journal of Clinical Investigation | 1983 |
Effect of fatty acids on glucose production and utilization in man
E Ferrannini, EJ Barrett, S Bevilacqua, RA DeFronzo |
Journal of Clinical Investigation | 1983 |
Insulin receptors in isolated human adipocytes. Characterization by photoaffinity labeling and evidence for internalization and cellular processing
P Berhanu, OG Kolterman, A Baron, P Tsai, JM Olefsky, D Brandenburg |
Journal of Clinical Investigation | 1983 |
Insulin Sensitivity and Responsiveness in Vitro and in Vivo
I Lager, P LÖnnroth |
Acta Medica Scandinavica | 1983 |
INFLUENCE OF OBESITY ON BASAL GLUCAGON LEVELS IN NON-DIABETIC AND DIABETIC NAURUANS
FP Alford, P Zimmet, DJ Chisholm, S Whitehouse |
Clinical Endocrinology | 1983 |
Influence of ambient glucose and insulin concentrations on adipocyte insulin binding
P Lönnroth, M DiGirolamo, U Smith |
Metabolism | 1983 |
New concepts in the pathogenesis and treatment of noninsulin-dependent diabetes mellitus
RA Defronzo, E Ferrannini, V Koivisto |
The American Journal of Medicine | 1983 |
Cellular alterations responsible for insulin resistance in obesity and type II diabetes mellitus
DH Lockwood, JM Amatruda |
The American Journal of Medicine | 1983 |
Insulin receptors and action in clinical disorders of carbohydrate tolerance
RJ Pollet |
The American Journal of Medicine | 1983 |
Insulin resistance in noninsulin-dependent diabetes mellitus: Impact of sulfonylurea agents in vivo and in vitro
OG Kolterman, MJ Prince, JM Olefsky |
The American Journal of Medicine | 1983 |
11 Insulin receptors in normal and disease states
G Grunberger, SI Taylor, RF Dons, P Gorden |
Clinics in Endocrinology and Metabolism | 1983 |
Enhanced responsiveness to insulin in sheep exposed to cold
TE Weekes, Y Sasaki, T Tsuda |
American journal of physiology. Endocrinology and metabolism | 1983 |
Estimation and kinetic analysis of insulin-independent glucose uptake in human subjects
I Gottesman, L Mandarino, J Gerich |
American journal of physiology. Endocrinology and metabolism | 1983 |
Reversal of insulin resistance in type I diabetes after treatment with continuous subcutaneous insulin infusion
I Lager, P Lonnroth, H von Schenck, U Smith |
BMJ : British Medical Journal | 1983 |
Effect of somatostatin-induced insulinopenia on glucose oxidation in man
JP Felber, D Thibaud, E Maeder, E Jquier, R Hendler, RA DeFronzo |
Diabetologia | 1983 |
Insulin Sensitivity and Glucose Uptake in the Course of Surgical Treatment for Valvular Aortic Stenosis
R Ekroth, F Nilsson, H Berggren, K Feddersen, G Holm, J Holm, I Milocco, T Scherstén, G William-Olsson |
Scandinavian Cardiovascular Journal | 1982 |
Insulin resistance in uremia mediated by postbinding defects
D Smith, RA DeFronzo |
Kidney International | 1982 |
Mechanisms of insulin resistance following injury
PR Black, DC Brooks, PQ Bessey, RR Wolfe, DW Wilmore |
Annals of Surgery | 1982 |
Insulin receptor binding and insulin action in human fat cells: Effects of obesity and fasting
O Pedersen, E Hjøllund, NS Sørensen |
Metabolism | 1982 |
Familial partial lipodystrophy: Complications of obesity in the non-obese?
DC Robbins, ES Horton, O Tulp, EA Sims |
Metabolism | 1982 |
Validation of a practical in vivo insulin dose-response curve in man
J Proietto, M Harewood, P Aitken, A Nankervis, G Caruso, F Alford |
Metabolism | 1982 |
Effect of long chain triglyceride infusion on glucose metabolism in man
D Thiébaud, RA DeFronzo, E Jacot, A Golay, K Acheson, E Maeder, E Jéquier, JP Felber |
Metabolism | 1982 |
Integrated concentrations of growth hormone, insulin, C-peptide and prolactin in human obesity
MT Meistas, GV Foster, S Margolis, AA Kowarski |
Metabolism | 1982 |
Internalization and intracellular processing of insulin and insulin receptors in adipocytes
JM Olefsky, S Marshall, P Berhanu, M Saekow, K Heidenreich, A Green |
Metabolism | 1982 |
Thermogenic response to insulin and glucose infusions in man: A model to evaluate the different components of the thermic effect of carbohydrate
E Ravussin, C Bogardus |
Life Sciences | 1982 |
4 Insulin resistance in non-insulindependent, type II diabetes mellitus
OG Kolterman, JA Scarlett, JM Olefsky |
Clinics in Endocrinology and Metabolism | 1982 |
2 The effects of insulin on carbohydrate metabolism in vivo
AD Cherrington, KE Steiner |
Clinics in Endocrinology and Metabolism | 1982 |
Insulin Resistance and Insulin Receptors in Hepatic Cirrhosis
AT Blei, DC Robbins, E Drobny, G Baumann, AH Rubenstein |
Gastroenterology | 1982 |
Insulin Resistance in Humans
JM Olefsky |
Gastroenterology | 1982 |
Mechanism of the postreceptor defect in insulin action in human obesity. Decrease in glucose transport system activity
TP Ciaraldi, OG Kolterman, JM Olefsky |
Journal of Clinical Investigation | 1981 |
Receptor and postreceptor defects contribute to the insulin resistance in noninsulin-dependent diabetes mellitus
OG Kolterman, RS Gray, J Griffin, P Burstein, J Insel, JA Scarlett, JM Olefsky |
Journal of Clinical Investigation | 1981 |
The antilipolytic effect of insulin in human adipose tissue in obesity, diabetes mellitus, hyperinsulinemia, and starvation
P Arner, J Bolinder, P Engfeldt, J Östman |
Metabolism | 1981 |
Mechanisms of insulin resistance in obesity and noninsulin-dependent (type II) diabetes
JM Olefsky, OG Kolterman |
The American Journal of Medicine | 1981 |
Mechanisms of insulin resistance in man
RA Rizza, LJ Mandarino, JE Gerich |
The American Journal of Medicine | 1981 |
Adaptation to increasing loads of total parenteral nutrition: Metabolic, endocrine, and insulin receptor responses
WJ Byrne, BM Lippe, CT Strobel, SR Levin, ME Ament, SA Kaplan |
Gastroenterology | 1981 |
Polymorphism in the 5′-Flanking Region of the Human Insulin Gene and Its Possible Relation to Type 2 Diabetes
P Rotwein, R Chyn, J Chirgwin, B Cordell, HM Goodman, MA Permut |
Science | 1981 |
Clinical Pharmacology of Sulphonylurea Hypoglycaemic Agents: Part 2
JE Jackson, R Bressler |
Drugs | 1981 |
The relationship between the hyperplastic pancreatic islet and insulin insensitivity in obesity
RJ Mahler |
Acta Diabetologica | 1981 |
Effects of insulin incubation on insulin binding, glucose transport, and insulin degradation by isolated rat adipocytes. Evidence for hormone-induced desensitization at the receptor and postreceptor level
S Marshall, JM Olefsky |
Journal of Clinical Investigation | 1980 |
Diabetic ketoacidosis: Reassessment of therapeutic “truths”
AL Taylor |
Postgraduate Medicine | 1980 |
Contemporary Metabolism
N Freinkel |
1979 | |
Verhandlungen der Deutschen Gesellschaft für Innere Medizin
B Schlegel |
1962 | |
Insulin Resistance
A Voll, J Kloster |
Acta Medica Scandinavica | 1957 |