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Sex Steroid Modulation of Fatty Acid Utilization and Fatty Acid Binding Protein Concentration in Rat Liver
Robert K. Ockner, … , Scott E. Monroe, David A. Burnett
Robert K. Ockner, … , Scott E. Monroe, David A. Burnett
Published May 1, 1980
Citation Information: J Clin Invest. 1980;65(5):1013-1023. https://doi.org/10.1172/JCI109753.
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Research Article

Sex Steroid Modulation of Fatty Acid Utilization and Fatty Acid Binding Protein Concentration in Rat Liver

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Abstract

The mechanism by which sex steroids influence very low density hepatic lipoprotein triglyceride production has not been fully elucidated. In previous studies we showed that [14C]oleate utilization and incorporation into triglycerides were greater in hepatocyte suspensions from adult female rats than from males. The sex differences were not related to activities of the enzymes of triglyceride biosynthesis, whereas fatty acid binding protein (FABP) concentration in liver cytosol was greater in females. These findings suggested that sex differences in lipoprotein could reflect a sex steroid influence on the availability of fatty acids for hepatocellular triglyceride biosynthesis. In the present studies, sex steroid effects on hepatocyte [14C]oleate utilization and FABP concentration were investigated directly.

Authors

Robert K. Ockner, Nina Lysenko, Joan A. Manning, Scott E. Monroe, David A. Burnett

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