Citations to this article

Dietary Modification of Thyroxine Deiodination in Rat Liver is Not Mediated by Hepatic Sulfhydryls
Laurence A. Gavin, … , Francis A. McMahon, M. Moeller
Laurence A. Gavin, … , Francis A. McMahon, M. Moeller
Published April 1, 1980
Citation Information: J Clin Invest. 1980;65(4):943-946. https://doi.org/10.1172/JCI109751.
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Dietary Modification of Thyroxine Deiodination in Rat Liver is Not Mediated by Hepatic Sulfhydryls

Abstract

The enzymatic deiodination of thyroxine (T4) is thiol dependent. Fasting (72 h) depresses hepatic T4 deiodination and lowers the hepatic content of nonprotein sulfhydryls (NP-SH) and reduced glutathione (GSH). It has been proposed that the fasting effect may be mediated through these alterations in hepatic sulfhydryls. To test the importance of tissue (hepatic) thiol content in the modification of T4 deiodination consequent to dietary manipulation, we examined the sequential deiodination of T4 to 3,5,3′-triiodothyronine (T3) (5′-deiodination) and 3,3′,5-triiodothyronine (reverse T3, rT3) (5-deiodination) in liver homogenates without added thiol from groups of rats fed Purina lab chow (P) (a protein-rich diet), glucose alone (G), or glucose plus cysteine (Gc) for 72 h or fasted (F) for the same period. The initial rate of each reaction was compared to the tissue concentrations of NP-SH and GSH.

Authors

Laurence A. Gavin, Francis A. McMahon, M. Moeller

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Year: 2012 1997 1995 1990 1989 1986 1985 1984 1983 1982 1981 Total
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Citations to this article (18)

Title and authors Publication Year
Contribution of Nutritional Deficit to the Pathogenesis of the Nonthyroidal Illness Syndrome in Critical Illness: A Rabbit Model Study
L Mebis, A Eerdekens, F Güiza, L Princen, S Derde, YM Vanwijngaerden, I Vanhorebeek, VM Darras, GV den Berghe, L Langouche 		Endocrinology 2012
Methods in Enzymology
JD Stone, AS Chervin, DH Aggen, DM Kranz 		Protein Engineering for Therapeutics Part B 2012
A role for thyroid hormones in the regulation of diet-induced thermogenesis in birds
JF Gabarrou, C Duchamp, J Williams, PA Géraert 		British Journal of Nutrition 1997
THYROID HORMONES IN NON-INSULIN-DEPENDENT DIABETES BEFORE AND AFTER THERAPY
JS SAINI, S NAQVI, OP DUTT 		Medical Journal Armed Forces India 1995
Thyroid Function & Disease
JH Oppenheimer 		Thyroid Function & Disease 1990
Rat hepatic and renal 5′-deiodination of rT3 during fasting: Supportive role of intermediate Mr cytosolic non-glutathione thiol cofactor and NADPH
K Iwase, BC Hummel, PG Walfish 		Metabolism 1989
NADPH-dependent generation of a cytosolic dithiol which activates hepatic iodothyronine 5'-deiodinase. Demonstration by alkylation with iodoacetamide
AK Das, BC Hummel, PG Walfish 		Biochemical Journal 1986
Properties of cytosolic components activating rat hepatic 5' [corrected]-deiodination in the presence of NADPH
K Sawada, BC Hummel, PG Walfish 		Biochemical Journal 1986
Frontiers in Thyroidology
G Medeiros-Neto, E Gaitan 		1986
Contemporary Endocrinology
SH Ingbar 		1985
Purification and characterization of a cytosolic protein enhancing GSH-dependent microsomal iodothyronine 5'-monodeiodination
A Goswami, IN Rosenberg 		The Journal of biological chemistry 1985
Ethanol feeding and thyroid hormone monodeiodination
ML Shank, SP Singh, BB Blivaiss, MA Kabir, K Williams, BN Premachandra 		Metabolism 1984
Somatostatin inhibits rat hepatic T4-5'-deiodinase. The effect is independent of the associated hypoinsulinemia
LA Gavin, M Moeller 		Journal of Clinical Investigation 1983
The mechanism of recovery of hepatic T4-5′-deiodinase during glucose-refeeding: Role of glucagon and insulin
LA Gavin, M Moeller 		Metabolism 1983
Differing thyrotropin responses to increased serum triiodothyronine concentrations produced by overfeeding and by triiodothyronine administration
RD Utiger 		Metabolism 1982
Alterations in hepatic monodeiodination of iodothyronines in the diabetic rat
IJ Chopra, W Wiersinga, H Frank 		Life Sciences 1981
Effects of dietary manipulation on the generation of 3,5,3'-triiodothyronine from thyroxine in rat liver preparations
A Balsam, F Sexton, SH Ingbar 		Life Sciences 1981
The effects of diabetes mellitus on the 3,5,3′-triiodothyronine production
CS Pittman, RH Lindsay, O Senga, JB Chambers, JB Hill 		Life Sciences 1981

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