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Citations to this article

Cholesterol reduces the effects of dihydroxy bile acids and fatty acids on water and solute transport in the human jejunum.
S L Broor, … , T Slota, H V Ammon
S L Broor, … , T Slota, H V Ammon
Published April 1, 1980
Citation Information: J Clin Invest. 1980;65(4):920-925. https://doi.org/10.1172/JCI109746.
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Research Article

Cholesterol reduces the effects of dihydroxy bile acids and fatty acids on water and solute transport in the human jejunum.

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Abstract

Jejunal perfusion studies were performed in 16 healthy volunteers to test the hypothesis that intraluminal cholesterol can mitigate the fluid secretion induced by dihydroxy bile acids and fatty acids. Fluid secretion in the presence of 5 mM taurodeoxycholate was somewhat reduced by 4 mM mono-olein which was used for the solubilization of cholesterol. Addition of 0.8 mM cholesterol reduced fluid secretion further (P less than 0.05). Fluid secretion induced by 4 mM oleic acid was changed to net absorption in a linear fashion with increasing cholesterol concentration in the perfusion solutions. 1 mM cholesterol reduced fluid secretion induced by 6 mM oleic acid (P less than 0.005), but had no effect on fluid secretion induced by 6 mM linolenic acid. Glucose absorption was generally affected in a similar manner as water transport. In vitro, 1 mM cholesterol reduced monomer activity of 6 mM oleic acid to 72.3 +/- 0.9% of control and that of linolenic acid to 81.1 +/- 1.7% of control. Although statistically significant (P less than 0.001), the difference in the effects of cholesterol on monomer activities of the two fatty acids was rather small and it is unlikely that changes in monomer concentration of fatty acids and bile acids account for the protective effect of cholesterol. The in vivo observations point to a new physiological role for biliary cholesterol: the modification of the response of the small intestine to the effects of dihydroxy bile acids and fatty acids.

Authors

S L Broor, T Slota, H V Ammon

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Total citations by year

Year: 2014 2008 1998 1994 1985 1983 1982 1981 Total
Citations: 1 1 1 1 1 3 1 3 12
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article (12)

Title and authors Publication Year
Intestinal Secretory Mechanisms in Irritable Bowel Syndrome–Diarrhea
M Camilleri
Clinical Gastroenterology and Hepatology 2014
Dualistic acidic and neutral glucose fermentation balance in small intestine: Simulation in vitro
E Hakalehto, T Humppi, H Paakkanen
Pathophysiology 2008
Hepatic cholestasis during the post-embryonic development of fish larvae
JP Diaz, L Mani-Ponset, E Guyot, R Connes
The Journal of Experimental Zoology 1998
Protective role of biliary cholesterol and phospholipid lamellae against bile acid-induced cell damage
L Puglielli, L Amigo, M Arrese, L Núñez, A Rigotti, J Garrido, S González, G Mingrone, AV Greco, L Accatino, F Nervi
Gastroenterology 1994
Protection by Dietary Proteins Against the Effects of Bile Acids on Rat Jejunum and Stomach
JF Kruidenier, HV Ammon, UK Charaf, LG Walter
Gastroenterology 1985
Hepatic Free Fatty Acids in Alcoholic Liver Disease and Morbid Obesity
PG Mavrelis, HV Ammon, JJ Gleysteen, RA Komorowski, UK Charaf
Hepatology 1983
Effects of lysophosphatidylcholine on jejunal water and solute transport in the rat in vivo
HV Ammon, RE Loeffler, LA Luedtke
Lipids 1983
Comparison of cholesterol and beta-sitosterol: effects on jejunal fluid secretion induced by oleate, and absorption from mixed micellar solutions.
Slota T, Kozlov NA, Ammon HV
Gut 1983
Bile Acid-Dependent Secretion of Alkaline Phosphatase in Rat Bile
DE Hatoff, WG Hardison
Hepatology 1982
Regulation of 3-hydroxy-3-methylglutaryl CoA reductase by analogs of cholesterol and bile acids in cultured intestinal mucosa
EF Stange, A Schneider, G Preclik, M Alavi, H Ditschuneit
Lipids 1981
Bile acid induced interconversion of 3-hydroxy-3-methylglutaryl coenzyme a reductase in cultured intestine
EF Stange, A Schneider, G Preclik, H Ditschuneit
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1981
Effect of glucose on jejunal water and solute absorption in the presence of glycodeoxycholate and oleate in man.
Brown BD, Ammon HV
Digestive Diseases and Sciences 1981

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