Citations to this article

In vitro idiotypic suppression of chronic lymphocytic leukemia lymphocytes secreting monoclonal immunoglobulin M anti-sheep erythrocyte antibody.
C A Bona, A S Fauci
C A Bona, A S Fauci
Published March 1, 1980
Citation Information: J Clin Invest. 1980;65(3):761-767. https://doi.org/10.1172/JCI109724.
View: Text | PDF
Research Article

In vitro idiotypic suppression of chronic lymphocytic leukemia lymphocytes secreting monoclonal immunoglobulin M anti-sheep erythrocyte antibody.

Abstract

A patient with chronic lymphocytic leukemia was found to have B cells with surface immunoglobulin (Ig)M manifesting anti-sheep erythrocyte (SRBC) specificity together with a high titer serum monoclonal anti-SRBC IgM antibody. By immunizing a sheep with the monoclonal IgM antibody, followed by multiple absorptions against normal human IgM, an anti-idiotype (Id) antibody was obtained. The serum IgM anti-SRBC antibody was then demonstrated to share the same idiotypic determinants with the surface IgM with anti-SRBC specificity on the patient's B cells. The anti-Id antibody suppressed the spontaneous secretion of anti-SRBC antibody as well as the pokeweed mitogen-induced anti-SRBC antibody production as measured by a hemolysis-in-gel plaque-forming cell assay. In contrast, pokeweed mitogen-induced anti-SRBC plaque-forming cell responses of normal individuals were not suppressed by the anti-Id antibody. Thus, this study demonstrates in vitro suppression of human B-cell function by anti-Id antibody.

Authors

C A Bona, A S Fauci

×

Total citations by year

Year: 1989 1988 1987 1986 1985 1984 1983 1982 1981 1980 Total
Citations: 1 1 3 2 4 2 4 2 2 1 22
Citation information

Citations to this article (22)

Title and authors Publication Year
Anti-idiotype modulation of the in vitro immune response to hepatitis B surface antigen (HBsAg) following remote infection by hepatitis B virus in man
TR Cupps, SA Haas-Smith, JL Gerin, L Tibbles, RC Kennedy 		Cellular Immunology 1989
Human immune response to group A streptococcal carbohydrate (A-CHO) III. Comparison of the efficiencies of anti-idiotopic antibody and of nominal antigen in the induction of IgM anti-A-CHO-producing B cells
AC Bloem, R Jürgens, K Eichmann, F Emmrich 		European Journal of Immunology 1988
Inhibition of spontaneous proliferation of human leukemic B cells from patients with chronic lymphocytic leukemia by anti-μ antibodies
J Steinberg, MA Moore, CA Bona, WR Benjamin, JJ Farrar, PC Familletti, CD Platsoucas 		Clinical Immunology and Immunopathology 1987
White cells and platelets in blood transfusion
CT Sibinga, PC Das, CP Engelfriet 		1987
Essential Oncology of the Lymphocyte
IJ Forbes, AS Leong 		1987
Idiotypes
DS Pisetsky, MA O'Donnell 		Idiotypes 1986
Effects of anti-IgM on mitogen-induced proliferation of human B-lymphocyte malignancies
TR Baeker, TL Rothstein 		Clinical Immunology and Immunopathology 1986
Establishment of the amsalem T-cell line from a patient with acute lymphoblastic leukemia. Expression of E-receptor-associated antigens in cells incapable of forming E-rosettes
HB Bassat, R Rabinowitz, A Polliack, R Hadar, M Schlesinger 		International Journal of Cancer 1985
Neuropathy and anti-myelin-associated glycoprotein IgM M proteins: T cell regulation of M protein secretion in vitro
N Latov, M Godfrey, Y Thomas, E Nobile-Orazio, L Spatz, J Abraham, G Perman, L Freddo, L Chess 		Annals of Neurology 1985
Phenotypic and functional analysis of lymphocytes in myasthenia gravis
AI Levinson, RP Lisak, B Zweiman, M Kornstein 		Springer Seminars in Immunopathology 1985
Monoclonal Antibodies in Cancer
S Sell, RA Reisfeld 		1985
Consumption of monoclonal anti-idiotypic antibody by neoplastic B lymphocytes: a guide for immunotherapy
FK Stevenson, MJ Glennie, DM Johnston, AL Tutt, GT Stevenson 		British Journal of Cancer 1984
Lymphocyte markers in health and disease
J Laurence 		Disease-a-Month 1984
Regulation of immunoglobulin E antibody synthesis in man by antiidiotypic antibodies
RS Geha, M Comunale 		Journal of Clinical Investigation 1983
Suppression of in vitro monoclonal human rheumatoid factor synthesis by antiidiotypic antibody. Target cells and molecular requirements
WJ Koopman, RE Schrohenloher, JC Barton, EC Greenleaf 		Journal of Clinical Investigation 1983
A new method for the preparation of anti-idiotypic antibodies against six different human cold agglutinins
W Römer, D Roelcke, EW Rauterberg 		Immunobiology 1983
Expression of a receptor for sheep erythrocytes by B lymphocytes from a chronic lymphocytic leukemia patient
R Sitia, L Sciariada, A Zicca, A Leprini, R Ghio, M Ferrarini 		Clinical Immunology and Immunopathology 1983
Cellular localization of rheumatoid factor idiotypes
VR Bonagura, HG Kunkel, B Pernis 		Journal of Clinical Investigation 1982
Spontaneous in vitro differentiation of antigen-specific lymphocytes from a patient with immunoglobulin M gammopathy
J Halper, EA Kabat, EF Osserman, P Tonda, B Pernis 		Journal of Clinical Investigation 1982
Paraproteinaemia: use of idiotypic determinants as specific markers for tumour activity
MA King, J Vivianwells 		Clinical & Experimental Immunology 1981
Cells from a chronic lymphocytic leukemia patient display surface immunoglobulins specific for Forssman antigen
J Bertoglio, M Robert, B Noel, J Portoukalian, JF Doré 		Clinical Immunology and Immunopathology 1981
Clinical applications of monoclonal antibodies
AJ McMichael, JM Bastin 		Immunology Today 1980

Advertisement