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Citations to this article

Prevention of Collagen Deposition Following Pulmonary Oxygen Toxicity in the Rat by Cis-4-Hydroxy-l-Proline
David J. Riley, … , Norman H. Edelman, Darwin J. Prockop
David J. Riley, … , Norman H. Edelman, Darwin J. Prockop
Published March 1, 1980
Citation Information: J Clin Invest. 1980;65(3):643-651. https://doi.org/10.1172/JCI109709.
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Prevention of Collagen Deposition Following Pulmonary Oxygen Toxicity in the Rat by Cis-4-Hydroxy-l-Proline

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Abstract

Exposure of rats to high oxygen tensions causes increased collagen content of lungs and alveolar enlargement in 3-6 wk. We tested whether cis-hydroxyproline, a proline analogue that inhibits collagen synthesis, could prevent the collagen accumulation and alveolar enlargement. Rats were exposed to hyperoxia for 60 h and then to room air and hyperoxia for alternate 24-h periods for 11.5 d. Treated oxygen-exposed rats received 200 mg/kg cis-hydroxyproline twice daily over the 14-d exposure period. Control rats breathed room air. Examination of lungs on day 14 showed collagen content of oxygen-exposed lungs to be 48% greater than control (P < 0.05). The collagen content of the treated oxygen-exposed lungs was −12% of control (NS). Total lung volume was 16% greater than control in oxygen-exposed rats (P < 0.05) and 8% greater than control in treated oxygen-exposed rats (NS). Morphometric studies showed alveolar size was greater than control in oxygen-exposed rats (188±11 [SE] vs. 143±6 μμl [P < 0.05]). Oxygen-exposed, treated rats had a mean alveolar volume of 150±7 μμl. Lung pressure-volume curves were significantly shifted to the left of control in the oxygen-exposed rats, whereas the curves of the oxygen-exposed, treated group were identical to control. These data suggest that cis-hydroxyproline prevented the accumulation of collagen in the lungs in pulmonary oxygen toxicity. In addition, there was apparent protection from airspace dilatation and decreased lung elasticity, suggesting that alveolar enlargement after oxygen toxicity is linked to the deposition in lung tissue of new connective tissue fibers.

Authors

David J. Riley, Richard A. Berg, Norman H. Edelman, Darwin J. Prockop

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Total citations by year

Year: 2019 2016 2015 2013 2012 2010 2008 2007 1999 1994 1993 1992 1991 1990 1989 1988 1987 1986 1985 1984 1983 1982 1981 Total
Citations: 1 1 1 1 3 1 2 1 1 2 2 1 2 6 2 5 1 1 2 3 1 4 2 46
Citation information
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Citations to this article (46)

Title and authors Publication Year
N-Vanillylnonanamide, a natural product from capsicum oleoresin, as potential inhibitor of collagen fibrillation
M Visalatchi, B Madhan, G Shanmugam
International Journal of Biological Macromolecules 2019
Collagen VI deficiency reduces muscle pathology, but does not improve muscle function, in the γ-sarcoglycan-null mouse
JC de Greef, R Hamlyn, BS Jensen, RO Landa, JR Levy, K Kobuke, KP Campbell
Human Molecular Genetics 2016
Collagen Inhibitory Peptide R1R2 Mediates Vascular Remodeling by Decreasing Inflammation and Smooth Muscle Cell Activation
TH Lee, J Sottile, HY Chiang, AP Gadeau
PloS one 2015
Properties, metabolisms, and applications of l-proline analogues
TM Bach, H Takagi
Applied Microbiology and Biotechnology 2013
Production of N-acetyl cis-4-hydroxy-l-proline by the yeast N-acetyltransferase Mpr1
BT Hoa, T Hibi, R Nasuno, G Matsuo, Y Sasano, H Takagi
Journal of Bioscience and Bioengineering 2012
Microbial production of N-acetyl cis-4-hydroxy-l-proline by coexpression of the Rhizobium l-proline cis-4-hydroxylase and the yeast N-acetyltransferase Mpr1
TM Bach, R Hara, K Kino, I Ohtsu, N Yoshida, H Takagi
Applied Microbiology and Biotechnology 2012
Inhibition of collagen fibril formation
A Steplewski, A Fertala
Fibrogenesis & Tissue Repair 2012
Oxygen distribution in the human eye: relevance to the etiology of open-angle glaucoma after vitrectomy
CJ Siegfried, YB Shui, NM Holekamp, F Bai, DC Beebe
Investigative ophthalmology & visual science 2010
Effects of long-term low-dose oxygen supplementation on the epithelial function, collagen metabolism and interstitial fibrogenesis in the guinea pig lung
T Aoki, F Yamasawa, T Kawashiro, T Shibata, A Ishizaka, T Urano, Y Okada
Respiratory Research 2008
Collagen Fibril Formation: A NEW TARGET TO LIMIT FIBROSIS
HJ Chung, A Steplewski, KY Chung, J Uitto, A Fertala
The Journal of biological chemistry 2008
A kampo medicine, Yin-Chiao-san, Prevents bleomycin-induced pulmonary injury in rats
FL Yen, TH Wu, CW Liao, CC Lin
Phytotherapy Research 2007
Chronic Lung Disease in Early Infancy
D Riley
Chronic Lung Disease in Early Infancy 1999
Pitfalls in Antiprotease Therapy of Emphysema
GL Snider, EC Lucey, PJ Stone
American journal of respiratory and critical care medicine 1994
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GJ Poiani, DJ Riley, JD Fox, JE Kemnitzer, KF Gean, J Kohn
Bioconjugate Chemistry 1994
Effects of cis-4-hydroxy-L-proline on the androgen-lnduced growth of the prostate of the prepubertally castrated guinea pig
YC Wong, FL Chan
The Prostate 1993
Antifibrotic effect of a proline analogue delivered in liposomes to cells in culture
G J Poiani, K F Gean, J D Fox, J Kohn, D J Riley
Amino Acids 1993
Emphysema: The First Two Centuries-and Beyond: A Historical Overview, with Suggestions for Future Research: Part
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American journal of respiratory and critical care medicine 1992
Putative Role of Neutrophil Elastase in the Pathogenesis of Emphysema
GL Snider, DE Ciccolella, SM Morris, PJ Stone, EC Lucey
Annals of the New York Academy of Sciences 1991
Synthesis and characterization of magnetically responsive albumin microspheres containingcis-hydroxyproline for scar inhibition
JP Iannotti, TC Baradet, M Tobin, A Alavi, M Staum
Journal of Orthopaedic Research 1991
Strain specific respiratory air space enlargement in aged rats
JS Kerr, SY Yu, DJ Riley
Experimental Gerontology 1990
Exacerbation of doxorubicin cardiotoxicity by digoxin administration in an experimental rabbit model
WC Reeves, JW Griffith, MA Wood, L Whitesell
International Journal of Cancer 1990
Organization and Assembly of Plant and Animal Extracellular Matrix
NA Guzman, GC Fuller, JE Dixon
Organization and Assembly of Plant and Animal Extracellular Matrix 1990
El pulmón como órgano diana del estrés oxidativo. radicales libres y especies activas del oxígeno
DR Alvira, AS Ariño, FC Lambán, MM Villacampa, MP Martin
Archivos de Bronconeumología 1990
Amino Acids
G Lubec, GA Rosenthal
Amino Acids 1990
Molecular, Pharmacologic, and Clinical Aspects of Oxygen-Induced Lung Injury
RM Jackson
Clinics in Chest Medicine 1990
Pulmonary Strategies of Antioxidant Defense
JE Heffner, JE Repine
American journal of respiratory and critical care medicine 1989
Long-term Pulmonary Sequelae after Legionella pneumophila Infection in the Hamster
CM Parenti, SW Richards, JR Hoidal, DE Niewoehner
American journal of respiratory and critical care medicine 1989
Effects of cis-4-hydroxy-l-proline, an inhibitor of Schwann cell differentiation, on the secretion of collagenous and noncollagenous proteins by Schwann cells
CF Eldridge, RP Bunge, MB Bunge
Experimental Cell Research 1988
Treatment of experimental silicosis with antifibrotic agents
LS Geismar, JS Kerr, RL Trelstad, DJ Riley
Toxicology 1988
Cadmium-Chloride-induced Air-Space Enlargement with Interstitial Pulmonary Fibrosis Is Not Associated with Destruction of Lung Elastin: Implications for the Pathogenesis of Human Emphysema
GL Snider, EC Lucey, B Faris, Y Jung-Legg, PJ Stone, C Franzblau
American journal of respiratory and critical care medicine 1988
Colchicine Suppresses the Release of Fibroblast Growth Factors from Alveolar Macrophages In Vitro : The Basis of a Possible Therapeutic Approach to the Fibrotic Disorders
SI Rennard, PB Bitterman, T Ozaki, WN Rom, RG Crystal
American journal of respiratory and critical care medicine 1988
Elastase/Antielastase Systems in Pulmonary Diseases
S Umeki, Y Niki, R Soejima
The American Journal of the Medical Sciences 1988
Repair of chronic hyperoxic lung injury: Changes in lung ultrastructure and matrix
RA Durr, BA Dubaybo, LA Thet
Experimental and Molecular Pathology 1987
Sequential changes in lung morphology during the repair of acute oxygen-induced lung injury in adult rats
L A Thet, S C Parra, J D Shelburne
Experimental Lung Research 1986
Oxidant injury of the extracellular matrix: Potential role in the pathogenesis of pulmonary emphysema
DJ Riley, JS Kerr
Lung 1985
Biochemical and cellular aspects of pulmonary oxygen toxicity
B A.Freeman, AK Tanswell
Advances in Free Radical Biology & Medicine 1985
Effect of proline analogs on oxygen toxicity-induced pulmonary fibrosis in the rat
DJ Riley, JS Kerr, SY Yu
Toxicology and Applied Pharmacology 1984
Incorporation of modified amino acids into proteins in vivo
MJ Wilson, DL Hatfield
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1984
Variability in Lung Collagen Amounts After Prolonged Support of Acute Respiratory Failure
JF Collins, JD Smith, JJ Coalson, WG Johanson
Chest 1984
Pulmonary Oxygen Toxicity Connective Tissue Changes during Injury and Repair
DJ Riley, JS Kerr, SY Yu, RA Berg, NH Edelman
Chest 1983
A stereochemical concept for the catalytic mechanism of prolylhydroxylase
HM Hanauske-Abel, V Günzler
Journal of Theoretical Biology 1982
Adult Respiratory-Distress Syndrome: Changing Concepts of Lung Injury and Repair
JE Rinaldo, RM Rogers
New England Journal of Medicine 1982
Cellular Biology of the Lung
G Cumming, G Bonsignore
1982
Lung Fibrosis and Emphysema: Divergent Responses to a Common Injury?
DE Niewoehner, JR Hoidal
Science 1982
The effect of indomethacin, prednisolone and Cis-4-hydroxyproline on pulmonary fibrosis produced by butylated hydroxytoluene and oxygen
JP Kehrer, H Witschi
Toxicology 1981
Effect of Cis-4-Hydroxy-L-Proline on Lung Mechanics and Collagen Content of Bleomycin-Treated H amsters
DJ Riley, JS Kerr, RA Berg, B Ianni, NH Edelman, DJ Prockop
Chest 1981

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