When serum complement is activated by either the classical or alternative pathways, a factor with an apparent 80,000 mol wt is generated that is chemotactic for human dermal fibroblasts. The origin of this serum-derived chemotactic factor (SDCF) is not known; however, it may be a cleavage product from C5 because it is inactivated by monospecific antiserum to human C5, and it is not generated when the complement system is activated in human serum deficient in C5. SDCF is not chemotactic for human neutrophils or monocytes. Because SDCF is generated when serum complement is activated, it may function in vivo to attract connective tissue fibroblasts to sites of inflammatory reactions in which the complement system participates.
A E Postlethwaite, R Snyderman, A H Kang
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Allergology International | 1998 |
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1994 | |
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Research in Experimental Medicine | 1993 |
Effects of high calcium concentration on the functions and interactions of osteoblastic cells and monocytes and on the formation of osteoclast-like cells
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Journal of Bone and Mineral Research | 1993 |
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Research in Experimental Medicine | 1993 |
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Dermatologic Clinics | 1993 |
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GW Kalmus, JE Poulos, CW O'Rear |
General Pharmacology: The Vascular System | 1992 |
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R van Furth |
1992 | |
The Peritoneum
GS diZerega, KE Rodgers |
1992 | |
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AE Postlethwaite, JM Seyer |
Journal of Clinical Investigation | 1991 |
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Kidney International | 1991 |
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M Kuwahara, M Kuwahara, KE Bijwaard, DM Gersten, CA Diglio, E Kagan |
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Interleukin-1 enhances the response of osteoblasts to platelet-derived growth factor through the alpha receptor-specific up-regulation
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The Journal of biological chemistry | 1991 |
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Bronchial Epithelial Cells Produce Lung Fibroblast Chemotactic Factor: Fibronectin
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American journal of respiratory cell and molecular biology | 1989 |
Studies in fetal wound healing: II. A fetal environment accelerates fibroblast migration in vitro
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Journal of Pediatric Surgery | 1989 |
Transforming Growth Factors in the Regulation of Malignant Cell Growth and Invasion
J Keski-Oja, AE Postlethwaite, HL Moses |
Cancer Investigation | 1988 |
Decline of Fibroblast Chemotaxis with Age of Donor and Cell Passage Number
A Albini, B Pontz, M Pulz, G Allavena, H Mensing, PK Müller |
Collagen and Related Research | 1988 |
The Molecular and Cellular Biology of Wound Repair
RA Clark, PM Henson |
1988 | |
Identification of a Protein in Sera of Normal Humans That Inhibits Fibroblast Chemotactic and Random Migration In Vitro
ME Ochs, AE Postlethwaite, AH Kang |
Journal of Investigative Dermatology | 1987 |
Conformational studies of synthetic tripeptide chemoattractants
G Vertuani, S Spisani, M Boggian, S Traniello, A Scatturin |
International Journal of Peptide and Protein Research | 1987 |
Normal rabbit aqueous humour, fibronectin, and fibroblast conditioned medium are chemoattractant to Tenon's capsule fibroblasts
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Eye | 1987 |
Effects of fibrinogen derivatives upon the inflammatory response. Studies with human fibrinopeptide B
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Journal of Clinical Investigation | 1986 |
Generation and characterization of a neutrophil-derived inhibitor of fibroblast chemotaxis
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Archives of Dermatological Research | 1986 |
Bedeutung der Fibroblasten-Chemotaxis für Wundheilung und Tumorzellevasion
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Klinische Wochenschrift | 1985 |
SV40 transformed fibroblasts recognize the same 140 kD fibronectin chemotactic fragment as non-transformed cells
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Macrophage chemotaxis in experimental tooth movement in the rat
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Archives of Oral Biology | 1985 |
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Wound Healing 1985: An Update
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The Journal of Dermatologic Surgery and Oncology | 1985 |
Immunology of Rheumatic Diseases
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1985 | |
Induction of fibroblast proliferation by interleukin-1 derived from human monocytic leukemia cells
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Arthritis & Rheumatism | 1984 |
Alteration of the chemotactic response of NIH/3T3 cells to PDGF by growth factors, transformation, and tumor promoters
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Cell | 1984 |
Cellular and molecular mechanisms in wound healing: Selected concepts
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Clinics in Dermatology | 1984 |
Keratophakia and Keratomileusis
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Ophthalmology | 1984 |
In vitro lessons for wound healing
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Clinics in Dermatology | 1984 |
Migration by haptotaxis of a Schwann cell tumor line to the basement membrane glycoprotein laminin
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The Journal of Cell Biology | 1983 |
Fibronectin mediates cell attachment to C1q: a mechanism for the localization of fibrosis in inflammatory disease
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Clinical & Experimental Immunology | 1983 |
Chemotactic activity of platelet alpha granule proteins for fibroblasts
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The Journal of Cell Biology | 1983 |
A quantitative in vitro study of fibroblast and endothelial cell migration in response to serum and wound fluid
SU Orredson, DR Knighton, H Scheuenstuhl, TK Hunt |
Journal of Surgical Research | 1983 |
Leukocyte Locomotion and Chemotaxis
HU Keller, GO Till |
1983 | |
Chemotactic responses of fibroblasts to tropoelastin and elastin-derived peptides
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Journal of Clinical Investigation | 1982 |
Platelet-derived growth factor is a chemoattractant for vascular smooth muscle cells
GR Grotendorst, T Chang, HE Sepp�, HK Kleinman, GR Martin |
Journal of Cellular Physiology | 1982 |
Inflammatory myopathy: A review of etiologic and pathogenetic factors
JN Whitaker |
Muscle & Nerve | 1982 |
Tumor Invasion and Metastasis
LA Liotta, IR Hart |
1982 | |
Themotaxis of metastatic tumor cells
J Varani |
Cancer and Metastasis Reviews | 1982 |
Comparison of the chemotactic responsiveness of two fibrosarcoma subpopulations of differing malignancy
FW Orr, J Varani, J Delikatny, N Jain, PA Ward |
The American Journal of Pathology | 1981 |
Attachment of smooth muscle cells to collagen and their migration toward platelet-derived growth factor
GR Grotendorst, HE Seppä, HK Kleinman, GR Martin |
Proceedings of the National Academy of Sciences | 1981 |
Induction of fibroblast chemotaxis by fibronectin. Localization of the chemotactic region to a 140,000-molecular weight non-gelatin-binding fragment
AE Postlethwaite, J Keski-Oja, G Balian, AH Kang |
Journal of Experimental Medicine | 1981 |
Responses of normal and malignant cells to collagen, collagen-derived peptides and the C5-related tumor cell chemotactic peptide
JA Wass, J Varani, GE Piontek, PA Ward, FW Orr |
Cell Differentiation | 1981 |