Livers from normal and nephrotic rats were perfused by the nonrecirculating technique. Nephrosis was studied on the 7th d after the injection of puromycin animonucleoside. Amino acid-labeled lipoproteins (d < 1.21) were isolated from the perfusion medium by agarose column chromatography or by sequential density ultracentrifugation. In both groups of animals, in addition to very low density lipoproteins and nascent high density lipoproteins, column chromatography revealed the presence of a peak of 2-3 × 106 daltons. This peak contained lipoproteins of densities corresponding to <1.006, 1.006 < d < 1.02, and 1.02 < d < 1.06, which indicated that rat liver secretes a heterogeneous mixture of triglyceride-rich lipoproteins.
Julian B. Marsh, Charles E. Sparks
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Atherosclerosis | 2000 |
Insulin-treated Zucker diabetic fatty rats retain the hypertriglyceridemia associated with obesity
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Metabolism | 2000 |
Hepatic cholesterol metabolism in experimental nephrotic syndrome
A Al-Shurbaji, E Humble, M Rudling, B Lindenthal, L Berglund |
Lipids | 1998 |
Increased VLDL in nephrotic patients results from a decreased catabolism while increased LDL results from increased synthesis
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Kidney International | 1998 |
Lipoprotein alterations in 10- and 20-week-old Zucker diabetic fatty rats: Hyperinsulinemic versus insulinopenic hyperglycemia
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Metabolism | 1998 |
Viscosity regulates apolipoprotein A-1 gene expression in experimental models of secondary hyperlipidemia and in cultured hepatocytes
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Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism | 1997 |
Suki and Massry’s THERAPY OF RENAL DISEASES AND RELATED DISORDERS
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1997 | |
Lipoprotein Kinetics in Patients With Analbuminemia: Evidence for the Role of Serum Albumin in Controlling Lipoprotein Metabolism
C Maugeais, S Braschi, K Ouguerram, P Maugeais, P Mahot, B Jacotot, D Darmaun, T Magot, M Krempf |
Arteriosclerosis, thrombosis, and vascular biology | 1997 |
The serum lathosterol to cholesterol ratio, an index of cholesterol synthesis, is not elevated in patients with glomerular proteinuria and is not associated with improvement of hyperlipidemia in response to antiproteinuric treatment
RP Dullaart, RT Gansevoort, WJ Sluiter, D Zeeuw, PE de Jong |
Metabolism | 1996 |
Intracellular apoprotein B degradation is suppressed by decreased albumin concentration in Hep G2 cells
T Hirano, S Furukawa, M Kurokawa, T Ebara, JL Dixon, S Nagano |
Kidney International | 1995 |
Plasma triglyceride levels are higher in nephrotic than in analbuminemic rats despite a similar increase in hepatic triglyceride secretion
JA Joles, C Bijleveld, A Tol, MJ Geelen, HA Koomans |
Kidney International | 1995 |
Changes in apoprotein distribution between lipoprotein classes of hypercholesterolemic rats treated with ascorbate
M Santillo, P Mondola, F Santangelo, A Gioielli, S Iossa, A Basilisco, R Mercato |
The International Journal of Biochemistry & Cell Biology | 1995 |
Overexpression of human apolipoprotein A-I in transgenic rats and the hyperlipoproteinemia associated with experimental nephrosis
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Journal of lipid research | 1995 |
Increases in Serum Lipids During Pregnancy in Type 1 Diabetic Women with Nephropathy
G Biesenbach, O Janko, H Stöger, J Zazgornik |
Diabetic Medicine | 1994 |
Liver regrowth and apolipoprotein B secretion by rat hepatocytes following partial hepatectomy
JD Sparks, JP Corsetti, CE Sparks |
Metabolism | 1994 |
Insulin regulation of triacylglycerol-rich lipoprotein synthesis and secretion
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Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism | 1994 |
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Extrarenal Complications of the Nephrotic Syndrome
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American Journal of Kidney Diseases | 1994 |
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American Journal of Kidney Diseases | 1994 |
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MA Thabet, A Challa, JC Chan, WM Pandak, DM Heuman, ZR Vlahčevič |
Kidney International | 1993 |
Hyperlipidemia in childhood nephrotic syndrome
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Pediatric Nephrology | 1993 |
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European Journal of Clinical Investigation | 1993 |
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American Journal of Kidney Diseases | 1993 |
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Arteriosclerosis Thrombosis and Vascular Biology | 1993 |
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American journal of physiology. Cell physiology | 1992 |
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K Jung, H Mattenheimer, U Burchardt |
1992 | |
Increased concentration of plasma cholesteryl ester transfer protein in nephrotic syndrome: role in dyslipidemia
P Moulin, GB Appel, HN Ginsberg, AR Tall |
Journal of lipid research | 1992 |
Isolation of nascent high-density lipoprotein from rat liver perfusates by immunoaffinity chromatography: Effects of oleic acid infusion
JB Marsh, MR Diffenderfer |
Metabolism | 1991 |
Roles of hypoalbuminemia and lipoprotein lipase on hyperlipoproteinemia in continuous ambulatory peritoneal dialysis
T Shoji, Y Nishizawa, H Nishitani, M Yamakawa, H Morii |
Metabolism | 1991 |
Dyslipoproteinemia in an inbred rat strain with spontaneous chronic progressive nephrotic syndrome
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Journal of lipid research | 1991 |
Effects of thyroid status and fasting on hepatic metabolism of apolipoprotein A-I
HG Wilcox, RA Frank, M Heimberg |
Journal of lipid research | 1991 |
Management of hyperlipidemia of kidney disease
SM Grundy |
Kidney International | 1990 |
Effects of membrane lipid composition on the kinetics of cholesterol exchange between lipoproteins and different species of red blood cells
JC Gold, MC Phillips |
Biochimica et Biophysica Acta (BBA) - Biomembranes | 1990 |
Catabolic defect of triglyceride is associated with abnormal very-low-density lipoprotein in experimental nephrosis
S Furukawa, T Hirano, JC Mamo, S Nagano, T Takahashi |
Metabolism | 1990 |
Low-density lipoprotein metabolism in the nephrotic syndrome
GL Warwick, MJ Caslake, JM Boulton-Jones, M Dagen, CJ Packard, J Shepherd |
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Experimental nephrotic syndrome: removal and tissue distribution of chylomicrons and very-low-density lipoproteins of normal and nephrotic origin
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Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism | 1990 |
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Baillière's Clinical Endocrinology and Metabolism | 1990 |
Transcriptional and posttranscriptional regulation of apolipoprotein E, A-I, and A-II gene expression in normal rat liver and during several pathophysiologic states
A Panduro, YC Lin-Lee, L Chan, DA Shafritz |
Biochemistry | 1990 |
Causes of high blood cholesterol
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Circulation | 1990 |
International Yearbook of Nephrology 1990
VE Andreucci, LG Fine, CM Kjellstrand, N Sugino |
1990 | |
The role of circulating mevalonate in nephrotic hypercholesterolemia in the rat
TA Golper, KR Feingold, MH Fulford, MD Siperstein |
Journal of lipid research | 1990 |
Insulin effects on apolipoprotein B production by normal, diabetic and treated-diabetic rat liver and cultured rat hepatocytes
JD Sparks, CE Sparks, LL Miller |
Biochemical Journal | 1989 |
Chylomicron synthesis in experimental nephrotic syndrome
E Levy, E Ziv, H Bar-On, E Shafrir |
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism | 1989 |
Lovastatin in the Treatment of Multifactorial Hyperlipidemia Associated With Proteinuria
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American Journal of Kidney Diseases | 1989 |
Changes in lipoprotein binding and uptake by hepatocytes during rat liver regeneration
A Trentalance, G Bruscalupi, LC Devirgiliis, S Leoni, MT Mangiantini, L Rossini, S Spagnuolo, SK Erickson |
Bioscience Reports | 1989 |
Measurement of apolipoprotein B synthesis in perfused rat liver using stable isotopes: [15N]hippurate as a measure of the intracellular [15N]glycine precursor enrichment
T Matsushima, DR Cryer, KE Winkler, JB Marsh, JA Cortner |
Journal of lipid research | 1989 |
Characterization of nascent high density lipoprotein subfractions from perfusates of rat liver
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Journal of lipid research | 1989 |
Effects of nonketotic streptozotocin diabetes on apolipoprotein B synthesis and secretion by primary cultures of rat hepatocytes
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Journal of Clinical Investigation | 1988 |
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Kidney International | 1988 |
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SK Erickson, G Bruscalupi, LC Devirgiliis, S Leoni, MT Mangiantini, S Spagnuolo, A Trentalance |
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism | 1988 |
Ascites fluid lipoproteins in experimental nephrotic syndrome
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Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism | 1988 |
Modulation of the synthesis of apolipoproteins in rat hepatoma cells
A Pietrangelo, R Tiozzo, M Ghisellini, MR Cingi, L Albertazzi, E Ventura, S Calandra |
Journal of Hepatology | 1988 |
Secretion of high and low molecular weight phosphorylated apolipoprotein B by hepatocytes from control and diabetic rats. Phosphorylation of APO BH and APO BL
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The Journal of biological chemistry | 1988 |
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R Hay, R Fleming, W O'Connell, J Kirschner, W Oppliger |
Journal of lipid research | 1988 |
A 13C NMR characterization of lysine residues in apolipoprotein B and their role in binding to the low density lipoprotein receptor
S Lund-Katz, JA Ibdah, JY Letizia, MT Thomas, MC Phillips |
The Journal of biological chemistry | 1988 |
Albumin synthesis, albuminuria and hyperlipemia in nephrotic patients
GA Kaysen, J Gambertoglio, J Felts, FN Hutchison |
Kidney International | 1987 |
Identification and partial characterization of discrete apolipoprotein B containing lipoprotein particles produced by human hepatoma cell line HepG2
N Dashti, P Alaupovic, C Knight-Gibson, E Koren |
Biochemistry | 1987 |
Coronary heart disease in young Type 1 (insulin-dependent) diabetic patients with and without diabetic nephropathy: incidence and risk factors
T Jensen, K Borch-Johnsen, A Kofoed-Enevoldsen, T Deckert |
Diabetologia | 1987 |
Secretion of lipids, apolipoproteins, and lipoproteins by human hepatoma cell line, HepG2: effects of oleic acid and insulin
N Dashti, G Wolfbauer |
Journal of lipid research | 1987 |
Cholesterol flux between cells and high density lipoprotein. Lack of relationship to specific binding of the lipoprotein to the cell surface
JB Karlin, WJ Johnson, CR Benedict, GK Chacko, MC Phillips, GH Rothblat |
The Journal of biological chemistry | 1987 |
Serum and urinary high density lipoproteins in glomerular disease with proteinuria
CD Short, PN Durrington, NP Mallick, LP Hunt, L Tetlow, M Ishola |
Kidney International | 1986 |
Insulin effects on apolipoprotein B lipoprotein synthesis and secretion by primary cultures of rat hepatocytes
CE Sparks, JD Sparks, M Bolognino, A Salhanick, PS Strumph, JM Amatruda |
Metabolism | 1986 |
Changes in apolipoprotein A-I mRNA level in the liver of rats with experimental nephrotic syndrome
P Tarugi, S Calandra, L Chan |
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression | 1986 |
Enzymes of Lipid Metabolism II
L Freysz, H Dreyfus, R Massarelli, S Gatt |
1986 | |
The bidirectional flux of cholesterol between cells and lipoproteins. Effects of phospholipid depletion of high density lipoprotein
WJ Johnson, MJ Bamberger, RA Latta, PE Rapp, MC Phillips, GH Rothblat |
The Journal of biological chemistry | 1986 |
Lipoprotein distribution and composition in the human nephrotic syndrom
E Muls, M Rosseneu, R Daneels, M Schurgers, J Boelaert |
Atherosclerosis | 1985 |
The Hyperlipidemia of the Nephrotic Syndrome: Relation to Plasma Albumin Concentration, Oncotic Pressure, and Viscosity
GB Appel, CB Blum, S Chien, CL Kunis, AS Appel |
New England Journal of Medicine | 1985 |
Regulation of plasma lipid levels by plasma viscosity in nephrotic rats
S Yedgar, O Eilam, E Shafrir |
American journal of physiology. Endocrinology and metabolism | 1985 |
Hyperlipidemic Effects of Adriamycin in Rats
M KUNITOMO, Y YAMAGUCHI, K MATSUSHIMA, Y FUTAGAWA, Y BANDO |
The Japanese Journal of Pharmacology | 1985 |
Regulated biosynthesis and divergent metabolism of three forms of hepatic apolipoprotein B in the rat
HG Windmueller, AE Spaeth |
Journal of lipid research | 1985 |
Catabolism of very low density lipoproteins in experimental nephrosis
DW Garber, BA Gottlieb, JB Marsh, CE Sparks |
Journal of Clinical Investigation | 1984 |
Lipid metabolism in nephrotic rats induced by daunomycin injection
N Morisaki, N Matsuoka, Y Saito, A Kumagai |
Metabolism | 1984 |
Therapy of Renal Diseases and Related Disorders
WN Suki, SG Massry |
1984 | |
Lipoprotein metabolism in experimental nephrosis
JB Marsh |
Journal of lipid research | 1984 |
High density lipoprotein metabolism
S Eisenberg |
Journal of lipid research | 1984 |
Adriamycin causes hyperlipemia as a consequence of nephrotoxicity
A Bizzi, L Ceriani, M Gerundino, A Spina, MT Tacconi, E Veneroni |
Toxicology Letters | 1983 |
Plasma and urine lipoproteins during the development of nephrotic syndrome induced in the rat by adriamycin
S Calandra, P Tarugi, M Ghisellini, E Gherardi |
Experimental and Molecular Pathology | 1983 |
New Comprehensive Biochemistry
S Yamamoto |
New Comprehensive Biochemistry | 1983 |
A comparison of the surface activities of rat plasma apolipoproteins C-II, C-III-0, C-III-3
KE Krebs, MC Phillips, CE Sparks |
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism | 1983 |
Isolation and characterization of lipoprotein of density less than 1.006 g/ml from rat hepatic lymph
P Tso, JB Ragland, SM Sabesin |
Journal of lipid research | 1983 |
Surface-to-core and interparticle equilibrium distributions of triglyceride-rich lipoprotein lipids
KW Miller, DM Small |
The Journal of biological chemistry | 1983 |
Metabolism of two forms of apolipoprotein B of VLDL by rat liver
CE Sparks, DJ Rader, JB Marsh |
Journal of lipid research | 1983 |
Fettstoffwechselstörungen bei Nierenkrankheiten — Pathogenetische Mechanismen
WH Hörl, M Hörl, A Heidland |
Klinische Wochenschrift | 1982 |
Serum and urinary lipoproteins in the human nephrotic syndrome: Evidence for renal catabolism of lipoproteins
VG Shore, T Forte, H Licht, SB Lewis |
Metabolism | 1982 |
Plasma and urinary lipids and lipoproteins during the development of nephrotic syndrome induced in the rat by puromycin aminonucleoside
E Gherardi, S Calandra |
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism | 1982 |
Properties of Lipoproteins in Blood Plasma and Liver Perfusates of Rats With Cholestasis
TE Felker, RL Hamilton, JL Vigne, RJ Havel |
Gastroenterology | 1982 |
Viscosity of culture medium as a regulator of synthesis and secretion of very low density lipoproteins by cultured hepatocytes
S Yedgar, DB Weinstein, W Patsch, G Schonfeld, FE Casanada, D Steinberg |
The Journal of biological chemistry | 1982 |
Secretion of nascent lipoproteins and apolipoproteins by perfused livers of normal and cholesterol-fed guinea pigs
LS Guo, RL Hamilton, R Ostwald, RJ Havel |
Journal of lipid research | 1982 |
Tissue lipoprotein lipase, serum, and urinary lipids and lipoproteins in experimental glomerulonephritis of rats (Heymann's nephritis)
DV Zoeren, LE Adams, BA Hynd, EV Hess, ML Kashyap |
Biochemical Medicine | 1981 |
Lipid and apolipoprotein levels in patients with nephrotic syndrome
O Takao, M Ichito |
Clinica Chimica Acta | 1981 |
Catabolism of apoprotein A-1 of HDL in normal and nephrotic rats
CE Sparks, SD Tennenberg, JB Marsh |
Metabolism | 1981 |
Lipoprotein apolipoprotein synthesis by human hepatoma cells in culture
JM Rash, GH Rothblat, CE Sparks |
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism | 1981 |
Time-related changes in the synthesis and secretion of very low density, low density and high density lipoproteins by cultured rat hepatocytes
J Bell-Quint, T Forte |
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism | 1981 |
Hormones, Lipoproteins and Atherosclerosis
L Winkler, B Schlag, R Dargel, G Stein, R Fünfstück |
Hormones, Lipoproteins and Atherosclerosis | 1981 |
Secretion of lipoproteins, apolipoprotein A-I and apolipoprotein E by isolated and perfused liver of rat with experimental nephrotic syndrome
S Calandra, E Gherardi, M Fainaru, A Guaitani, I Bartosek |
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism | 1981 |
Increased secretion of very low density lipoprotein triglyceride following inhibition of long chain fatty acid oxidation in isolated rat liver
T Ide, JA Ontko |
The Journal of biological chemistry | 1981 |
Mesenteric lymph apolipoproteins in control and ethinyl estradiol-treated rats: a model for studying apolipoproteins of intestinal origin
BR Krause, CH Sloop, CK Castle, PS Roheim |
Journal of lipid research | 1981 |
Metabolic heterogeneity of apolipoprotein B in the rat
CE Sparks, JB Marsh |
Journal of lipid research | 1981 |
Analysis of lipoprotein apoproteins by SDS-gel filtration column chromatography
CE Sparks, JB Marsh |
Journal of lipid research | 1981 |
Experimental nephrotic syndrome in the rat induced by puromycin aminonucleoside: Hepatic synthesis of lipoproteins and apolipoproteins
E Gherardi, M Messori, R Rozzi, S Calandra |
Lipids | 1980 |
Nephrotic syndrome in children
SP Ghosal, JN Chaudhuri |
The Indian Journal of Pediatrics | 1958 |