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Citations to this article

Hepatic Secretion of Lipoproteins in the Rat and the Effect of Experimental Nephrosis
Julian B. Marsh, Charles E. Sparks
Julian B. Marsh, Charles E. Sparks
Published November 1, 1979
Citation Information: J Clin Invest. 1979;64(5):1229-1237. https://doi.org/10.1172/JCI109577.
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Research Article

Hepatic Secretion of Lipoproteins in the Rat and the Effect of Experimental Nephrosis

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Abstract

Livers from normal and nephrotic rats were perfused by the nonrecirculating technique. Nephrosis was studied on the 7th d after the injection of puromycin animonucleoside. Amino acid-labeled lipoproteins (d < 1.21) were isolated from the perfusion medium by agarose column chromatography or by sequential density ultracentrifugation. In both groups of animals, in addition to very low density lipoproteins and nascent high density lipoproteins, column chromatography revealed the presence of a peak of 2-3 × 106 daltons. This peak contained lipoproteins of densities corresponding to <1.006, 1.006 < d < 1.02, and 1.02 < d < 1.06, which indicated that rat liver secretes a heterogeneous mixture of triglyceride-rich lipoproteins.

Authors

Julian B. Marsh, Charles E. Sparks

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Year: 2016 2012 2011 2008 2005 2004 2002 2000 1998 1997 1996 1995 1994 1993 1992 1991 1990 1989 1988 1987 1986 1985 1984 1983 1982 1981 1980 1958 Total
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