Citations to this article

Detection of Antilymphocyte Antibody with Two-Color Method in Systemic Lupus Erythematosus and Its Heterogeneous Specificities against Human T-Cell Subsets
Kunio Okudaira, … , Yoshihiko Horiuchi, Takeo Juji
Kunio Okudaira, … , Yoshihiko Horiuchi, Takeo Juji
Published November 1, 1979
Citation Information: J Clin Invest. 1979;64(5):1213-1220. https://doi.org/10.1172/JCI109575.
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Research Article

Detection of Antilymphocyte Antibody with Two-Color Method in Systemic Lupus Erythematosus and Its Heterogeneous Specificities against Human T-Cell Subsets

Abstract

The two-color method originally described by Van Rood et al. (Van Rood, J. J., A. Van Leeuwen, and J. S. Ploen. 1976. Simultaneous detection of two cell populations by two-color fluorescence and application to the recognition of B-cell determinants. Nature (Lond.). 262: 795-797) for the typing of homologous leukocytic antibodies, D-region was used for the detection of antilymphocyte antibody (ALA) in systemic lupus erythematosus. In this method, surface immunoglobulin-bearing cells were identified with fluorescein isothiocyanate-labeled anti-immunoglobulin and nuclei of killed cells were stained with ethidium bromide. Therefore, cell type (T or B) of the target cells can be identified without fractionating them. ALA was detected in 87% of lupus sera and had a preferential reactivity with T cells. Its major immunoglobulin class was shown to be immunoglobulin (Ig)M.

Authors

Kunio Okudaira, Hidenori Nakai, Tetsuo Hayakawa, Takamichi Kashiwado, Kiyoaki Tanimoto, Yoshihiko Horiuchi, Takeo Juji

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Year: 2019 2014 2006 1993 1992 1989 1988 1986 1985 1984 1983 1982 1981 1980 1960 Total
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Citations to this article (37)

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Theophylline-Resistant and Theophylline-Sensitive "Active" and "Total" E Rosette-Forming Lymphocytes in Patients with Systemic Scleroderma
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