In an individual homozygous for G gamma-delta beta-thalassemia, a physical alteration in gamma-globin gene organization was detected by restriction enzyme mapping. The data indicated that the absence of A gamma-globin chains resulted from extension of the DNA deletion from the delta beta-globin gene region into the gamma-globin gene region rather than a functional disturbance of gamma-gene expression.
S H Orkin, B P Alter, C Altay
Title and authors | Publication | Year |
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The Emerging Complexity of Genetic Control of Persistent Fetal Hemoglobin Biosynthesis in Adults
SH Boyer |
Annals of the New York Academy of Sciences | 1989 |