Usage Information

Concentrations of Insulin and of Insulin Receptors in the Brain are Independent of Peripheral Insulin Levels: STUDIES OF OBESE AND STREPTOZOTOCIN-TREATED RODENTS
Jana Havrankova, Jesse Roth
Jana Havrankova, Jesse Roth
Published August 1, 1979
Citation Information: J Clin Invest. 1979;64(2):636-642. https://doi.org/10.1172/JCI109504.
View: Text | PDF

Concentrations of Insulin and of Insulin Receptors in the Brain are Independent of Peripheral Insulin Levels: STUDIES OF OBESE AND STREPTOZOTOCIN-TREATED RODENTS

Abstract

In view of the potent influences of the central nervous system on glucose metabolism and on its hormonal regulators, and our recent finding of insulin and insulin receptors throughout the central nervous systsem, we have examined extreme conditions of hyperinsulinemia (obese mice) and hypoinsulinemia (streptozotocin-treated rats) with respect to changes in brain insulin and receptor content. Sprague-Dawley rats given streptozotocin (100 mg/kg body wt) developed severe diabetes and by 48 h showed no change in brain insulin. Rats given 65 mg/kg streptozotocin also had severe diabetes, but survived longer. Both at 7 d and at 30 d after streptozotocin treatment there was no significant change in brain insulin or in brain content of insulin receptors, despite the fact that peripheral hepatic receptors were elevated and pancreatic insulin was markedly depleted.

Authors

Jana Havrankova, Jesse Roth

×

Usage data is cumulative from June 2024 through June 2025.

Usage JCI PMC
Text version 402 19
PDF 96 17
Scanned page 296 7
Citation downloads 96 0
Totals 890 43
Total Views 933
(Click and drag on plot area to zoom in. Click legend items above to toggle)

Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

Various methods are used to distinguish robotic usage. For example, Google automatically scans articles to add to its search index and identifies itself as robotic; other services might not clearly identify themselves as robotic, or they are new or unknown as robotic. Because this activity can be misinterpreted as human readership, data may be re-processed periodically to reflect an improved understanding of robotic activity. Because of these factors, readers should consider usage information illustrative but subject to change.

Advertisement