Usage Information

Changes in Sedimentation of Surfactant in Ventilated Excised Rat Lungs: PHYSICAL ALTERATIONS IN SURFACTANT ASSOCIATED WITH THE DEVELOPMENT AND REVERSAL OF ATELECTASIS
Lyn Aung Thet, Linda Clerch, Gloria D. Massaro, Donald Massaro
Lyn Aung Thet, Linda Clerch, Gloria D. Massaro, Donald Massaro
View: Text | PDF

Changes in Sedimentation of Surfactant in Ventilated Excised Rat Lungs: PHYSICAL ALTERATIONS IN SURFACTANT ASSOCIATED WITH THE DEVELOPMENT AND REVERSAL OF ATELECTASIS

Abstract

We ventilated excised rat lungs at a constant tidal volume (CTV); they developed areas of atelectasis which could be reversed by a large inflation (CTV + I) or prevented by the addition of positive end-expiratory pressure to the CTV. To explore the possibility that these modes of ventilation led to changes in surfactant, we lavaged the lungs and centrifuged the returns at 500 g; we measured the amount of disaturated phosphatidylcholine (DSPC) in the resultant pellet and supernatant fluid as a marker for surfactant. We found 16.9±1.5 (mean±SE), 38.0±2.4, 18.3±1.6, and 21.7±2.3% of the total lavage DSPC, in the pellet from freshly excised, CTV, CTV + I, and positive end-expiratory pressure to the CTV lungs, respectively. The total amount of lavage DSPC was the same in all groups.

Authors

Lyn Aung Thet, Linda Clerch, Gloria D. Massaro, Donald Massaro

×

Usage data is cumulative from November 2025 through November 2026.

Usage JCI PMC
Text version 338 6
PDF 219 4
Scanned page 906 0
Citation downloads 265 0
Totals 1,728 10
Total Views 1,738
(Click and drag on plot area to zoom in. Click legend items above to toggle)

Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

Various methods are used to distinguish robotic usage. For example, Google automatically scans articles to add to its search index and identifies itself as robotic; other services might not clearly identify themselves as robotic, or they are new or unknown as robotic. Because this activity can be misinterpreted as human readership, data may be re-processed periodically to reflect an improved understanding of robotic activity. Because of these factors, readers should consider usage information illustrative but subject to change.

Advertisement