A quantitative primate model of arterial thromboembolism has been characterized with respect to mechanism and usefulness in evaluating modifying variables. The model involved the kinetic measurements of 51Cr-platelets and 125I-fibrinogen consumption by femoral arteriovenous cannulae in chaired baboons.
Laurence A. Harker, Stephen R. Hanson, Thomas R. Kirkman
Title and authors | Publication | Year |
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Recent advancements in polymeric heart valves: From basic research to clinical trials
Wang Y, Fu Y, Wang Q, Kong D, Wang Z, Liu J |
Materials Today Bio | 2024 |
Polymeric prosthetic heart valves: A review of current technologies and future directions.
Singh SK, Kachel M, Castillero E, Xue Y, Kalfa D, Ferrari G, George I |
Frontiers in Cardiovascular Medicine | 2023 |
Vascular Grafts: Technology Success/Technology Failure
Ratner B |
2023 | |
Assessment of a Siloxane Poly(urethane‐urea) Elastomer Designed for Implantable Heart Valve Leaflets
C Jenney, P Millson, DW Grainger, R Grubbs, P Gunatillake, SJ McCarthy, J Runt, J Beith |
2020 | |
Antithrombotic Therapy in Patients With Heart Valve Prostheses:
H Hermans, T Vanassche, P Herijgers, B Meuris, MC Herregods, FV de Werf, P Verhamme |
Cardiology in Review | 2013 |
Nonhuman primate models of thrombosis
DD Myers |
Thrombosis Research | 2012 |
Therapeutic Advances in Thrombosis: De Caterina/Therapeutic Advances in Thrombosis
GJ Vlachojannis, V Kunadian, JM Sweeny, R Mehran |
Therapeutic Advances in Thrombosis: De Caterina/Therapeutic Advances in Thrombosis | 2012 |
Interventional Cardiology
G Sangiorgi, A Mauriello, S Trimarchi, E Bonanno, LG Spagnoli |
Interventional Cardiology | 2011 |
Genetic influences on peripheral blood cell counts: a study in baboons
MC Mahaney, C Brugnara, LR Lease, OS Platt |
Blood | 2005 |
Platelet activation, aggregation, and life span in calves implanted with axial flow ventricular assist devices
TA Snyder, MJ Watach, KN Litwak, WR Wagner |
The Annals of Thoracic Surgery | 2002 |
Blood compatibility — a perspective
BD Ratner |
Journal of Biomaterials Science, Polymer Edition | 2000 |
What really is blood compatibility?
M V.Sefton, CH Gemmell, MB Gorbet |
Journal of Biomaterials Science, Polymer Edition | 2000 |
Reduced Thrombus Formation by Hyaluronic Acid Coating of Endovascular Devices
S Verheye, CP Markou, MY Salame, B Wan, SB King, KA Robinson, NA Chronos, SR Hanson |
Arteriosclerosis, thrombosis, and vascular biology | 2000 |
Effects of megakaryocyte growth and development factor on platelet production, platelet life span, and platelet function in healthy human volunteers
LA Harker, LK Roskos, UM Marzec, RA Carter, JK Cherry, B Sundell, EN Cheung, D Terry, W Sheridan |
Blood | 2000 |
Sites of elimination and pharmacokinetics of recombinant [131I]lepirudin in baboons
SM Meiring, MG L�tter, PN Badenhorst, E Bucha, G Nowak, HF Kotz� |
Journal of Pharmaceutical Sciences | 1999 |
Clopidogrel Inhibition of Stent, Graft, and Vascular Thrombogenesis With Antithrombotic Enhancement by Aspirin in Nonhuman Primates
LA Harker, UM Marzec, AB Kelly, NR Chronos, IB Sundell, SR Hanson, JM Herbert |
Circulation | 1998 |
Reduction in Stent and Vascular Graft Thrombosis and Enhancement of Thrombolysis by Recombinant Lys-Plasminogen in Nonhuman Primates
IB Sundell, UM Marzec, AB Kelly, NA Chronos, LC Petersen, SR Hanson, U Hedner, LA Harker |
Circulation | 1997 |
Textbook of Coronary Thrombosis and Thrombolysis
RC Becker |
1997 | |
Endothelial cell seeding of native vascular surfaces
KP Walluscheck, G Steinhoff, A Haverich |
European Journal of Vascular and Endovascular Surgery | 1996 |
Implants, Devices, and Biomaterials
JM Anderson, SA Brown, AS Hoffman, JB Kowalski, K Merritt, RF Morrissey, BD Ratner, FJ Schoen |
1996 | |
Biomaterials Science
HS Borovetz, JF Burke, TM Chang, A Colas, AN Cranin, J Curtis, CH Gemmell, BP Griffith, NJ Hallab, J Heller, AS Hoffman, JJ Jacobs, R Ideker, JL Katz, J Kennedy, JE Lemons, PS Malchesky, JR Morgan, RE Padera, AS Patel, MF Reffojo, MS Roby, TE Rohr, FJ Schoen, MV Sefton, RT Sheridan, DC Smith, FA Spelman, PJ Tarcha, RG Tomapkins, R Venugopalan, WR Wagner, P Yager, ML Yarmush |
Biomaterials Science | 1996 |
Enhanced In Vivo Antithrombotic Effects of Endothelial Cells Expressing Recombinant Plasminogen Activators Transduced With Retroviral Vectors
DA Dichek, J Anderson, AB Kelly, SR Hanson, LA Harker |
Circulation | 1996 |
Enhanced Thrombolytic and Antithrombotic Potency of a Fibrin-Targeted Plasminogen Activator in Baboons
MS Runge, LA Harker, C Bode, J Ruef, AB Kelly, UM Marzec, E Allen, R Caban, SY Shaw, E Haber, SR Hanson |
Circulation | 1996 |
Comparative Hemostasis in Vertebrates
JH Lewis |
1996 | |
Advances in the analysis of surfaces of biomedical interest
BD Ratner |
Surface and Interface Analysis | 1995 |
In vitro and in vivo evaluation of the site-specific administration of d-phenylalanyl-l-prolyl-l-arginyl chloromethyl ketone (PPACK): a powerful thrombin inhibitor
N Vyavahare, NA Scott, SR Hanson, J Kohn |
Journal of Controlled Release | 1993 |
Interruption of vascular thrombus formation and vascular lesion formation by dietary n-3 fatty acids in fish oil in nonhuman primates
LA Harker, AB Kelly, SR Hanson, W Krupski, A Bass, B Osterud, GA FitzGerald, SH Goodnight, WE Connor |
Circulation | 1993 |
Dermatan sulfate inhibition of fibrin-rich thrombus formation in nonhuman primates
Y Cadroy, SR Hanson, LA Harker |
Arteriosclerosis Thrombosis and Vascular Biology | 1993 |
The Design of Synthetic Inhibitors of Thrombin
G Claeson, MF Scully, VV Kakkar, J Deadman |
1993 | |
Nuclear Imaging in Drug Discovery, Development, and Approval
HD Burns, RE Gibson, RF Dannals, PK Siegl |
1993 | |
Exteriorized chronic aorto‐caval arteriovenous access shunts in the baboon ( Papio cynocephalus )
A Bass, WC Krupski, SR Hanson, T Dodson, A Lumsden, D White, LA Harker, AB Kelly |
Journal of Medical Primatology | 1993 |
Antithrombotic effects of synthetic peptides targeting various functional domains of thrombin
AB Kelly, JM Maraganore, P Bourdon, SR Hanson, LA Harker |
Proceedings of the National Academy of Sciences | 1992 |
Noninvasive arterial thrombus imaging with 99mTc monoclonal antifibrin antibody
MD Cerqueira, JR Stratton, R Vracko, TF Schaible, JL Ritchie |
Circulation | 1992 |
Induction of transient neurological dysfunction in baboons by platelet microemboli
C Kessler, AB Kelly, WD Suggs, JD Weissman, CM Epstein, SR Hanson, LA Harker |
Stroke; a journal of cerebral circulation | 1992 |
Platelet consumption by polyvinyl alcohol coated tubing in canines
WF Ip, MV Sefton |
Journal of Biomedical Materials Research | 1991 |
Physical and blood contacting characteristics of propyl sulphonate grafted Biomer
AZ Okkema, XH Yu, SL Cooper |
Biomaterials | 1991 |
Platelet adhesion and consumption
W Zingg, AW Neumann |
Biofouling | 1991 |
Reduction in thrombus formation by placement of endovascular stents at endarterectomy sites in baboon carotid arteries
WC Krupski, A Bass, AB Kelly, SR Hanson, LA Harker |
Circulation | 1991 |
Plasma Deposition, Treatment, and Etching of Polymers
BD Ratner, A Chilkoti, GP Lopez |
Plasma Deposition, Treatment, and Etching of Polymers | 1990 |
Analysis of indium-111 platelet kinetics and imaging in patients with aortic grafts and abdominal aortic aneurysms
SR Hanson, HF Kotzé, H Pieters, AD Heyns |
Arteriosclerosis (Dallas, Tex.) | 1990 |
Heparin-resistant thrombus formation by endovascular stents in baboons. Interruption by a synthetic antithrombin
WC Krpski, A Bass, AB Kelly, UM Marzec, SR Hanson, LA Harker |
Circulation | 1990 |
Prevention of platelet-rich arterial thrombosis by selective thrombin inhibition
IK Jang, HK Gold, AA Ziskind, RC Leinbach, JT Fallon, D Collen |
Circulation | 1990 |
Platelets and Atherosclerosis
C Kessler |
1990 | |
Effect of heparin-pva hydrogel on platelets in a chronic canine arterio-venous shunt
CH Cholakis, W Zingg, MV Sefton |
Journal of Biomedical Materials Research | 1989 |
In vitro andex vivo platelet interactions with hydrophilic-hydrophobic poly(ethylene oxide)-polystyrene multiblock copolymers
DW Grainger, C Nojiri, T Okano, SW Kim |
Journal of Biomedical Materials Research | 1989 |
Thromboembolic potential of synthetic vascular grafts in baboons
PA Schneider, HF Kotzé, AP Heyns, SR Hanson |
Journal of Vascular Surgery | 1989 |
Abolition of in vivo platelet thrombus formation in primates with monoclonal antibodies to the platelet GPIIb/IIIa receptor. Correlation with bleeding time, platelet aggregation, and blockade of GPIIb/IIIa receptors
BS Coller, JD Folts, SR Smith, LE Scudder, R Jordan |
Circulation | 1989 |
Selective decrease in platelet dense granule adenine nucleotides during recovery from acute experimental thrombocytopenia and ensuing thrombocytosis in baboons
B Savage, SR Hanson, LA Harker |
British Journal of Haematology | 1988 |
Preliminary in vivo studies on the platelet aggregation inhibitory activity of α,α′-bis[3-(N,N-diethylcarbamoyl)piperidino]-p-xylene dihydrobromide in beagle dogs
WH Lawrence, R Gollamudi, EO Dillingham, G Carter-Burks, PA Tisdelle, A Lasslo |
Journal of Pharmaceutical Sciences | 1988 |
Interruption of acute platelet-dependent thrombosis by the synthetic antithrombin D-phenylalanyl-L-prolyl-L-arginyl chloromethyl ketone
SR Hanson, LA Harker |
Proceedings of the National Academy of Sciences | 1988 |
Vascular Graft Thrombus Formation
SR Hanson, LA Harker |
Annals of the New York Academy of Sciences | 1987 |
Effective antiplatelet drug concentrations in experimental arterial thromboembolism
TD Bjomsson, SR Hanson, LA Harker |
Thrombosis Research | 1987 |
Platelet-inhibitor drugs' role in coronary artery disease
V Fuster, PC Adams, JJ Badimon, JH Chesebro |
Progress in Cardiovascular Diseases | 1987 |
Pharmacology of platelet inhibitors
LA Harker, V Fuster |
Journal of the American College of Cardiology | 1986 |
The kinetics of baboon fibrinogen adsorption to polymers:In vitro andin vivo studies
TA Horbett, CM Cheng, BD Ratner, AS Hoffman, SR Hanson |
Journal of Biomedical Materials Research | 1986 |
Endothelial regeneration. VI. Chronic nondenuding injury in baboon vascular grafts
MA Reidy, SS Chao, TR Kirkman, AW Clowes |
The American Journal of Pathology | 1986 |
Experimental acute thrombotic stroke in baboons
GJ Zoppo, BR Copeland, LA Harker, TA Waltz, J Zyroff, SR Hanson, E Battenberg |
Stroke; a journal of cerebral circulation | 1986 |
Reduction of indium-111 platelet deposition on Dacron vascular grafts in humans by aspirin plus dipyridamole
JR Stratton, JL Ritchie |
Circulation | 1986 |
Iliac artery mural thrombus formation. Effect of antiplatelet therapy on 111In-platelet deposition in baboons
SR Hanson, LD Paxton, LA Harker |
Arteriosclerosis (Dallas, Tex.) | 1986 |
Polymers in Medicine II
E Chiellini, P Giusti, C Migliaresi, L Nicolais |
1986 | |
Effects of platelet-modifying drugs on arterial thromboembolism in baboons. Aspirin potentiates the antithrombotic actions of dipyridamole and sulfinpyrazone by mechanism(s) independent of platelet cyclooxygenase inhibition
SR Hanson, LA Harker, TD Bjornsson |
Journal of Clinical Investigation | 1985 |
COMBINING ANTIPLATELET AGENTS: POTENTIATION BETWEEN ASPIRIN AND DIPYRIDAMOLE
P Gresele, J Arnout, H Deckmyn, J Vermylen |
The Lancet | 1985 |
Factors Controlling Thrombus Formation on Arterial Lesions
H Baumgartner, K Sakariassen |
Annals of the New York Academy of Sciences | 1985 |
Evaluation of arterial prostheses in a baboon ex vivo shunt: The effect of graft material and flow on platelet deposition
J Eldrup-Jorgensen, WC Mackey, RJ Connolly, JL McCullough, K Ramberg, V Gavris, TF O'Donnell, AD Callow |
The American Journal of Surgery | 1985 |
The Platelets
SM Stahl |
The Platelets | 1985 |
Platelet interactions with Dacron vascular grafts. A model of acute thrombosis in baboons
SR Hanson, HF Kotze, B Savage, LA Harker |
Arteriosclerosis (Dallas, Tex.) | 1985 |
Improved graft patency in patients treated with platelet-inhibiting therapy after coronary bypass surgery
BG Brown, RA Cukingnan, T DeRouen, LV Goede, M Wong, HJ Fee, JA Roth, JS Carey |
Circulation | 1985 |
The Small Diameter Vascular Graft - A Challenging Biomaterials Problem
AS Hoffman, BD Ratner, A Garfinkle, TA Horbett, LO Reynolds, SR Hanson |
Materials Research Society symposia proceedings. Materials Research Society | 1985 |
On the multiplicity of platelet prostaglandin receptors
SS Tynan, NH Andersen, MT Wills, LA Harker, SR Hanson |
Prostaglandins | 1984 |
EX VIVO AND IN VIVO EVALUATION OF DRUGS THAT INHIBIT PLATELET FUNCTION
SR Hanson, LA Harker |
Annals of the New York Academy of Sciences | 1983 |
Effect of dazoxiben on arterial graft thrombosis in the baboon
SR Hanson, LA Harker |
British Journal of Clinical Pharmacology | 1983 |
Mechanism of action of dipyridamole
LA Harker, RA Kadatz |
Thrombosis Research | 1983 |
Myocardial Infarction and Cardiac Death
WH Frishman, EH Sonnenblick |
Myocardial Infarction and Cardiac Death | 1983 |
Application of radiation-grafted hydrogels as blood-contacting biomaterials
AS Hoffman, D Cohn, SR Hanson, LA Harker, TA Horbett, BD Ratner, LO Reynolds |
Radiation Physics and Chemistry (1977) | 1983 |
Vessel injury, platelet adherence, and platelet survival
RL Kinlough-Rathbone, MA Packham, JF Mustard |
Arteriosclerosis (Dallas, Tex.) | 1983 |
Effect of sulfinpyrazone on homocysteine-induced endothelial injury and arteriosclerosis in baboons
LA Harker, JM Harlan, R Ross |
Circulation research | 1983 |
Antiplatelet Agents: Rationale and Results
JG Kelton |
Clinics in Haematology | 1983 |
ANTIPLATELET AGENTS: THEIR ROLE IN THE PREVENTION OF SUDDEN DEATH
J Hirsh |
Annals of the New York Academy of Sciences | 1982 |
Platelet deposition on Dacron aortic bifurcation grafts in man: quantitation with indium-111 platelet imaging
JR Stratton, BL Thiele, JL Ritchie |
Circulation | 1982 |
Thrombosis: its role and prevention in cardiovascular events--Part I. Concepts of thrombogenesis and its prevention
LA Harker |
The Western journal of medicine | 1981 |
Disorders of platelet function: mechanisms, diagnosis and management
LB Huebsch, LA Harker |
The Western journal of medicine | 1981 |
Survival of baboon platelets labeled with diazotized (125-1)-iodosulfanilic acid: No effect of drugs that modify platelet behavior
SR Hanson, LA Harker |
Thrombosis Research | 1981 |
Indium-111 platelet imaging for detection of platelet deposition in abdominal aneurysms and prosthetic arterial grafts
JL Ritchie, JR Stratton, B Thiele, GW Hamilton, LN Warrick, TW Huang, LA Harker |
The American Journal of Cardiology | 1981 |
Methyl ethers of prostaglandins F2α and I2
NH Andersen, N Subramanian, B De, DA McCrae, SS Tynan, CV Rao |
Prostaglandins and Medicine | 1981 |
The Plasma Fibrinogen Level and Vascular Diseases
GD Lowe, CD Forbes |
Scottish Medical Journal | 1981 |
Human Factor IX in Animals: Kinetics from Isolated, Radiolabelled Protein and Platelet Destruction following Crude Concentrate Infusions
AR Thompson, AW Forrey, PA Gentry, KJ Smith, LA Harker |
British Journal of Haematology | 1980 |
Characterization of graft polymers for biomedical applications
BD Ratner |
Journal of Biomedical Materials Research | 1980 |
Analysis of platelet survival curves in an arterial thrombosis model in rats
DG Meuleman, GM Vogel, SM Stulemeyer, HC Moelker |
Thrombosis Research | 1980 |
Platelet serotonin changes in dogs with prosthetic aortic grafts
GP Clagett, M Russo, H Hufnagel, GJ Collins, NM Rich |
Journal of Surgical Research | 1980 |
Factors influencing platelet consumption by polyacrylamide hydrogels
SR Hanson, LA Harker, BD Ratner, AS Hoffman |
Annals of Biomedical Engineering | 1979 |