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Citations to this article

Selective Depression of the Xenogeneic Cell-Mediated Lympholysis in Systemic Lupus Erythematosus
B. Charpentier, … , C. Carnaud, J. F. Bach
B. Charpentier, … , C. Carnaud, J. F. Bach
Published August 1, 1979
Citation Information: J Clin Invest. 1979;64(2):351-360. https://doi.org/10.1172/JCI109469.
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Research Article

Selective Depression of the Xenogeneic Cell-Mediated Lympholysis in Systemic Lupus Erythematosus

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Abstract

The immunological responsiveness of a panel of 17 patients with systemic lupus erythematosus (SLE) was studied in an in vitro model of xenogeneic sensitization against mouse lymphoid cells. Generation of cytotoxic thymus-derived (T) cells evaluated by a chromium release assay against labeled target cells was found to be drastically impaired in these lupus patients. Such depression was independent of drug therapy at the time of the study, clinical status, and other immunological parameters such as antibodies against native DNA, complement levels, cryoglobulinemia, circulating immune complexes, or T- and bone marrow-derived (B)-cell numbers. In contrast to the cytotoxic response, the proliferative responses to phytohemagglutinin, to allogeneic lymphocytes, and to xenogeneic lymphocytes were not significantly different from those of normal individuals. The latter response was shown to be H-2 restricted with the primed lymphocyte test. These results suggest the presence of a selective defect in the generation or in the expression of killer cells rather than a deficiency in antigen recognition by T cells. The role of serum factor(s) was examined by educating the lymphocytes of normal subjects in the presence of serum from SLE patients. Such manipulation affected both the generation of killer cells and the proliferative response. Finally our observations indicate that depression of cell-mediated immunity in SLE patients may be associated with several mechanisms including a cellular one, specifically affecting the generation of killer T cells, and a humoral one possibly as a result of antilymphocytic antibodies and(or) immune complexes.

Authors

B. Charpentier, C. Carnaud, J. F. Bach

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Total citations by year

Year: 2019 2018 2017 2009 2006 1994 1992 1991 1989 1988 1987 1986 1985 1983 1982 1981 Total
Citations: 1 1 1 1 2 1 1 1 1 1 1 2 4 2 5 3 28
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article (28)

Title and authors Publication Year
Strong Selection of a Few Dominant CD8 Clones in a TLR7-Dependent Autoimmune Mouse Model.
Morawski PA, Bolland S
ImmunoHorizons 2019
Both perforin and FasL are required for optimal CD8 T cell control of autoreactive B cells and autoantibody production in parent-into-F1 lupus mice
K Soloviova, M Puliaiev, R Puliaev, I Puliaeva, CS Via
Clinical Immunology 2018
Lupus
WA Khan
Lupus 2017
Lupus and T Cells
AL Cava
Lupus 2009
Systemic Lupus Erythematosus
M Petri
JCR: Journal of Clinical Rheumatology 2006
The Autoimmune Diseases
I Kang, J Craft
The Autoimmune Diseases 2006
Cytokine Gene Profile in Circulating Blood Mononuclear Cells from Patients with Systemic Lupus Erythematosus: Increased Interleukin-2 but not Interleukin-4 mRNA
DA Horwitz, H Wang, JD Gray
Lupus 1994
Impaired generation of polyclonal T cell-mediated cytolytic activity despite normal polyclonal T cell proliferation in systemic lupus erythematosus
W Stohl
Clinical Immunology and Immunopathology 1992
Human CD8+ lymphocytes stimulated in the absence of CD4+ cells enhance IgG production by antibody-secreting B cells
T Takahashi, JD Gray, DA Horwitz
Clinical Immunology and Immunopathology 1991
Deficient interleukin-2-activated killer cell cytotoxicity in patients with systemic lupus erythematosus
CJ Froelich, S Guiffaut, M Sosenko, K Muth
Clinical Immunology and Immunopathology 1989
The decrease in peripheral blood CD4+ T cells following thermal injury in humans can be accounted for by a concomitant decrease in suppressor-inducer CD4+ T cells as assessed using anti-CD45R
SE Calvano, HF deRiesthal, MA Marano, AC Antonacci
Clinical Immunology and Immunopathology 1988
Interleukin-1-production by monocytes from patients with systemic lupus erythematosus
S Sierakowski, EJ Kucharz, RW Lightfoot, JS Goodwin
Clinical Rheumatology 1987
Cell-mediated immunity in rheumatic disease
SJ Padula, RB Clark, JH Korn
Human Pathology 1986
Deficient γ-interferon production in patients with systemic lupus erythematosus
GC Tsokos, DT Boumpas, PL Smith, JY Djeu, JE Balow, AH Rook
Arthritis & Rheumatism 1986
Interleukin-2
PF Mühlradt
Nachrichten aus Chemie, Technik und Laboratorium 1985
Interleukin-2 restores the depressed allogeneic cell-mediated lympholysis and natural killer cell activity in patients with systemic lupus erythematosus
GC Tsokos, PL Smith, CB Christian, RN Lipnick, JE Balow, JY Djeu
Clinical Immunology and Immunopathology 1985
Modulation of the sodium periodate (NaIO4) response in systemic lupus erythematosus (SLE): Effect of Interleukin-1 (IL-1), Interleukin-2 (IL-2), phorbol myristate acetate (PMA), and indomethacin
R Phillips, R Lomnitzer, AR Rabson
Clinical Immunology and Immunopathology 1985
Immunology of Rheumatic Diseases
S Gupta, N Talal
1985
Impaired T cell capping and receptor regeneration in active systemic lupus erythematosus. Evidence for a disorder intrinsic to the T lymphocyte
GM Kammer
Journal of Clinical Investigation 1983
Phenotypes of T lymphocytes in systemic lupus erythematosus: Decreased cytotoxic/suppressor subpopulation is associated with deficient allogeneic cytotoxic responses rather than with concanavalin A-induced suppressor cells
GC Tsokos, JE Balow
Clinical Immunology and Immunopathology 1983
Cellular mechanism of tissue injury and immune derangement in systemic lupus erythematosus
RC Williams
Arthritis & Rheumatism 1982
Depressed Natural and Lectin-Dependent Cell-Mediated Cytotoxicity Against Adherent Hep-2 Cells in Patients with Systemic Lupus Erythematosus
A Perl, R Gonzalez-Cabello, I Láng, P Gergely
Immunological Investigations 1982
Natural killer augmentation in systemic lupus erythematosus via a soluble mediator derived from human lymphocytes
DB Kaufman
Arthritis & Rheumatism 1982
Natural killer cells and interferon responses in patients with systemic lupus erythematosus
GC Tsokos, AH Rook, JY Djeu, JE Balow
Clinical & Experimental Immunology 1982
Defect in the generation of cytotoxic T cells in lepromatous leprosy
JL Stach, M Strobel, F Fumoux, JF Bach
Clinical & Experimental Immunology 1982
Cytotoxic responses to alloantigens in systemic lupus erythematosus
GC Tsokos, JE Balow
Journal of Clinical Immunology 1981
The use of monoclonal anti-T cell antibodies to study T cell imbalances in human diseases
MA Bach, JF Bach
Clinical & Experimental Immunology 1981
Studies on T cell subsets and functions in leprosy
MA Bach, L Chatenoud, D Wallach, FP Tuy, F Cottenot
Clinical & Experimental Immunology 1981

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