We have shown that levels of circulating immune complexes are closely associated with the presence of precipitating antibodies to bovine milk proteins in individuals with selective immunoglobin (Ig)A deficiency. To test whether milk proteins are involved in immune complex formation, sera of seven IgA-deficient individuals were studied for the appearance of complexes after milk ingestion. In three of the seven, an initial fall in the level of complexes was followed by an increasing value, which peaked at 120-150 min. In another three, there was a tendency toward the formation of two peaks of complexes, the first at 30-60 min and the second at 120-150 min after drinking milk. One subject, who had had recent treatment for two separate neoplasms, had a steady level of complexes that did not change during the course of this test. After drinking milk, the molecular weight of the complexes found in the sera of one individual at the start of the milk test fell from >19S to 7-11S, and in vitro additions of progressively increasing amounts of a mixture of milk proteins or bovine gamma globulin, to sera that contained complexes produced a progressive reduction in the level of complexes detectable. We conclude that the circulating immune complexes found in some patients who lack IgA contain bovine milk proteins and that periodic fluctuation of the molecular weight of such complexes, depending upon antigen ingestion, appears likely. It remains uncertain what effect the chronic circulation of complexes has upon the clinical state of this group of patients.
Charlotte Cunningham-Rundles, Werner E. Brandeis, Robert A. Good, Noorbibi K. Day
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Primary Immunodeficiency Diseases
AR Gennery, L Marodi, JB Ziegler, T Español, B Grimbacher |
Primary Immunodeficiency Diseases | 2017 |
Reference Module in Biomedical Sciences
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Advances in Food and Nutrition Research
N Siriwardhana, NS Kalupahana, N Moustaid-Moussa |
Marine Medicinal Foods - Implications and Applications - Animals and Microbes | 2012 |
Complement C1q formation of immune complexes with milk caseins and wheat glutens in schizophrenia
EG Severance, KL Gressitt, M Halling, CR Stallings, AE Origoni, C Vaughan, S Khushalani, A Alaedini, D Dupont, FB Dickerson, RH Yolken |
Neurobiology of Disease | 2012 |
Dietary antigens, epitope recognition, and immune complex formation in recent onset psychosis and long-term schizophrenia
EG Severance, J Lin, HA Sampson, G Gimenez, FB Dickerson, M Halling, K Gressitt, L Haile, CR Stallings, AE Origoni, D Dupont, RH Yolken |
Schizophrenia Research | 2011 |
Selective IgA Deficiency in Children in Israel
V Shkalim, Y Monselize, N Segal, I Zan-Bar, V Hoffer, BZ Garty |
Journal of Clinical Immunology | 2010 |
Comprehensive Toxicology
JM Sands, JW Verlander |
Comprehensive Toxicology | 2010 |
Cross-reactive antibodies induced by xenogeneic IgA can cause selective IgA deficiency
A Klartag, CC Chen, JP Dougherty, Y Ron |
Autoimmunity | 2009 |
Familial aggregation of IgAD and autoimmunity
GH Jorgensen, I Thorsteinsdottir, S Gudmundsson, L Hammarstrom, BR Ludviksson |
Clinical Immunology | 2009 |
Middleton's Allergy: Principles and Practice
RP Schleimer |
Middleton's Allergy: Principles and Practice | 2009 |
Novartis Foundation Symposia
EJ Campbell |
Ciba Foundation Symposium 44 - Research and Medical Practice: Their Interaction | 2008 |
IgG antibodies against bovine serum albumin in humans—their prevalence and response to exposure to bovine serum albumin
T Mogues, J Li, J Coburn, DJ Kuter |
Journal of Immunological Methods | 2005 |
Mucosal Immunology
WR Brown |
Mucosal Immunology | 2005 |
Immunodeficiency and Mucosal Immunity
Cunningham-Rundles C |
Mucosal Immunology | 2005 |
Physiology of IgA and IgA deficiency
C Cunningham-Rundles |
Journal of Clinical Immunology | 2001 |
Joint Pain and Severe Asthma in a 10-Year-Old Boy
ST McGEADY, E Glasofer, I Spitzer |
Pediatric Asthma, Allergy & Immunology | 2000 |
DIETS, DIETARY SUPPLEMENTS, AND NUTRITIONAL THERAPIES IN RHEUMATIC DISEASES
CJ Henderson, RS Panush |
Rheumatic Disease Clinics of North America | 1999 |
Nutritional dermatology
AM Dattner |
Clinics in Dermatology | 1999 |
Transfusion management of an IgA deficient patient with anti-IgA and incidental correction of IgA deficiency after allogeneic bone marrow transplantation
RL Rogers, TA Javed, RE Ross, G Virella, RK Stuart, D Frei-Lahr |
American Journal of Hematology | 1998 |
INTERACTION OF ANTIGENS AND ANTIBODIES AT MUCOSAL SURFACES
ME Lamm |
Annual Review of Microbiology | 1997 |
Gut Permeability to Human α-Lactalbumin, β-Lactoglobulin, Mannitol, and Lactulose in Celiac Disease
M Kuitunen, E Savilahti |
Journal of Pediatric Gastroenterology & Nutrition | 1996 |
DEVELOPMENT OF IMMUNE FUNCTION IN THE INTESTINE AND ITS ROLE IN NEONATAL DISEASES
RM Insoft, IR Sanderson, WA Walker |
Pediatric Clinics of North America | 1996 |
DNA TYPING OF DQ AND DR ALLELES IN IgA-DEFICIENT SUBJECTS
M Fiore, C Pera, L Delfino, I Scotese, GB Ferrara, C Pignata |
European Journal of Immunogenetics | 1995 |
Multireactive pattern of serum autoantibodies in asymptomatic individuals with immunoglobulin A deficiency
N Barka, GQ Shen, Y Shoenfeld, IJ Alosachie, ME Gershwin, H Reyes, JB Peter |
Clinical and diagnostic laboratory immunology | 1995 |
Immunohistochemical findings in jejunal specimens from patients with IgA deficiency
T Klemola, E Savilahti, A Arato, T Ormala, J Partanen, C Eland, S Koskimies |
Gut | 1995 |
Human ?-lactalbumin and bovine ?-lactoglobulin absorption in infants
M Kuitunen, E Savilahti, A Sarnesto |
Allergy | 1994 |
Handbook of Mucosal Immunology
D Nadal, CP Braegger, P Knoflach, B Albini |
Handbook of Mucosal Immunology | 1994 |
Symposium in Immunology III
MM Eibl, C Huber, HH Peter, U Wahn |
1994 | |
Mécanismes physiopathologiques de l'allergie alimentaire
C Dupont |
Revue Française d'Allergologie et d'Immunologie Clinique | 1993 |
Biological activities of polyethylene-glycol immunoglobulin conjugates resistance to enzymatic degradation
C Cunningham-Rundles, Z Zhuo, B Griffith, J Keenan |
Journal of Immunological Methods | 1992 |
IgG subclass antibodies to dietary antigens in IgA deficiency quantification and correlation with serum IgG subclass levels
S Husby, VA Oxelius, SE Svehag |
Clinical Immunology and Immunopathology | 1992 |
Genetically Engineered Vaccines
JE Ciardi, JR McGhee, JM Keith |
1992 | |
Relationship between naturally occurring human antibodies to casein and autologous antiidiotypic antibodies: Implications for the network theory
C Cunningham-Rundles, ZK Feng, Z Zhou, KR Woods |
Journal of Clinical Immunology | 1991 |
Fc receptor function and circulating immune complexes in gluten sensitive enteropathy--possible significance of serum IgA
B Lavo, B Nilsson, L Loof, UR Nilsson, KN Ekdahl |
Gut | 1991 |
Ontogeny of the Mucosal Immune System and IgA Deficiency
P Brandtzaeg, DE Nihsen, TO Rognum, PS Thrane |
Gastroenterology Clinics of North America | 1991 |
Does Food Cause or Cure Arthritis?
RS Panush |
Rheumatic diseases clinics of North America | 1991 |
Dietary Antigens and Immunologic Disease in Humans
C Cunningham-Rundles |
Rheumatic diseases clinics of North America | 1991 |
Bovine Albumin-Like Protein in Commercial Human Albumin for Clinical Use
T Murozuka, M Moriwaka, H Ito, S Sekiguchi, M Naiki, K Tanaka, T Aoyama, K Komuro |
Vox Sanguinis | 1990 |
Selective IgA deficiency and spondyloarthropathy: a distinct disease?
G Herrero-Beaumont, JB Armas, J Elswood, RK Will, A Calin |
Annals of the rheumatic diseases | 1990 |
Non-opportunistic causes of diarrhoea in HIV infection
EO Riecken, M Zeitz, R Ullrich |
Bailliere's Clinical Gastroenterology | 1990 |
Advances in Human Genetics
H Harris, K Hirschhorn |
1990 | |
Jejunal bacterial overgrowth and intestinal permeability in children with immunodeficiency syndromes
C Pignata, G Budillon, G Monaco, E Nani, R Cuomo, G Parrilli, F Ciccimarra |
Gut | 1990 |
Macromolecular Absorption in Preterm and Term Infants
I Axelsson, I Jakobsson, T Lindberg, S Polberger, B Benediktsson, N Räihä |
Acta Paediatrica | 1989 |
Follow-Up of Anti-IgA Antibodies in Primary Immunodeficient Patients Treated with γ-Globulin
A Ferreira, MC Rodriguez, G Fontán |
Vox Sanguinis | 1989 |
Production of a Monoclonal Antibody to Bovinek-Casein
ZK Feng, C Cunningham-Rundles |
Hybridoma | 1989 |
Food Allergy: Facts and Fiction
RA Schreiber, WA Walker |
Mayo Clinic Proceedings | 1989 |
Measurement of circulating IgG and IgE food-immune complexes
AL Sheffer, PL Lieberman, DW Aaronson, JA Anderson, AP Kaplan, WE Pierson, EF Ellis, LM Lichtenstein, RF Lockey, JE Salvaggio, B Zweiman, B Zimmerman |
Journal of Allergy and Clinical Immunology | 1988 |
Immunologic outcome of enteric administration of ovalbumin to neonatal rats is anatomic-site specific
RJ Hall, E Lee, WR Brown |
Journal of Pediatric Surgery | 1988 |
Host Defense Development in Gut and Related Disorders
EJ Israel, WA Walker |
Pediatric Clinics of North America | 1988 |
Digestive Disease Pathology
S Watanabe, M Wolff, SC Sommers |
1988 | |
Inadequacy of musocal IgM antibodies in selective IgA deficiency: Excretion of attenuated polio viruses is prolonged
E Savilahti, T Klemola, B Carlsson, L Mellander, M Stenvik, T Hovi |
Journal of Clinical Immunology | 1988 |
Diagnostic tests for food allergy
S L Bahna |
Clinical Reviews in Allergy | 1988 |
IgE immune complexes in food allergy: significance, pathogenicity and clinical considerations
C Carini |
Clinical & Experimental Allergy | 1987 |
Failure of oral tolerance in (NZB × NZW)F1 mice is antigen specific and appears to parallel antibody patterns in human systemic lupus erythematosus (SLE)
RI Carr, D Tilley, S Forsyth, P Etheridge, D Sadi |
Clinical Immunology and Immunopathology | 1987 |
Intestinal plasma cell alterations in acquired immunodeficiency syndrome
DP Kotler, JV Scholes, AR Tierney |
Digestive Diseases and Sciences | 1987 |
Passage of dietary antigens into the blood of children with coeliac disease. Quantification and size distribution of absorbed antigens
S Husby, N Foged, A Host, SE Svehag |
Gut | 1987 |
Dietary bovine antigens and immune complex formation after intravenous immunoglobulin in common varied immunodeficiency
C Cunningham-Rundles, RI Carr |
Journal of Clinical Immunology | 1986 |
Allergen absorption in the intestine: Implication for food allergy in infants
WA Walker |
Journal of Allergy and Clinical Immunology | 1986 |
Passage of Undegraded Dietary Antigen into the Blood of Healthy Adults Further Characterization of the Kinetics of Uptake and the Size Distribution of the Antigen
S Husby, JC Jensenius, SE Svehag |
Scandinavian Journal of Immunology | 1986 |
Cross-Reactive Idiotypes in IgA-Deficient Sera
C Cunningham-Rundles, MK Cheung, J Koistinen |
Annals of the New York Academy of Sciences | 1986 |
Immune complex glomerulopathy in a child with food hypersensitivity
WW McCrory, CG Becker, C Cunningham–Rundles, RF Klein, J Mouradian, L Reisman |
Kidney International | 1986 |
Effect of fetal and adult bovine albumins on human lymphocyte proliferation in vitro
ML Gallango, P Maiuri-Ranauro, A Soyano |
Comparative Biochemistry and Physiology Part A: Physiology | 1986 |
IgA-associated renal diseases: Antibodies to environmental antigens in sera and deposition of immunoglobulins and antigens in glomeruli
MW Russell, J Mestecky, BA Julian, JH Galla |
Journal of Clinical Immunology | 1986 |
Antigen Handling by the Small Intestine
WA Walker |
1986 | |
Cross-reactive idiotypes in immunoglobulin A-deficient sera
MK Cheung, C Cunningham-Rundles, J Koistinen |
Journal of Clinical Investigation | 1985 |
Passage of Undegraded Dietary Antigen into the Blood of Healthy Adults
S Husby, JC Jensenius, SE Svehag |
Scandinavian Journal of Immunology | 1985 |
Food Allergies and Other Adverse Reactions to Foods
RS Panush, EM Webster |
Medical Clinics of North America | 1985 |
Food Allergy and Intolerance
M Stern, WA Walker |
Pediatric Clinics of North America | 1985 |
Systemic antibody deficiency in patients without serum immunoglobulin deficiency or with selective IgA deficiency
MA French, G Harrison |
Clinical & Experimental Immunology | 1984 |
Dietary protein antigenemia in humoral immunodeficiency
C Cunningham-Rundles, RI Carr, RA Good |
The American Journal of Medicine | 1984 |
Recent Advances in Immunology
AÜ Müftüoğlu, N Barlas |
1984 | |
Interactions of food antigens, antibodies, and antigen-antibody complexes in health and disease
R Paganelli, P M Matricardi, F Aiuti |
Clinical Reviews in Allergy | 1984 |
Dietary Gluten Challenge Does Not Influence the Levels of Circulating Immune Complexes in Patients with Dermatitis Herpetiformis
KB Yancey, JC Cason, RP Hall, TJ Lawley |
Journal of Investigative Dermatology | 1983 |
ISOLATION AND ANALYSIS OF ANTI-IDIOTYPIC ANTIBODIES FROM IgA-DEFICIENT SERA
C Cunningham-Rundles |
Annals of the New York Academy of Sciences | 1983 |
Diet therapy for rheumatoid arthritis
RS Panush, RL Carter, P Katz, B Kowsari, S Longley, S Finnie |
Arthritis & Rheumatism | 1983 |
Immune complexes in IgA nephropathy: presence of antibodies against diet antigens and delayed clearance of specific polymeric IgA immune complexes
J Sancho, J Egido, F Rivera, L Hernando |
Clinical & Experimental Immunology | 1983 |
Antibodies to Mi-1 in SLE: relationship to other precipitins and reaction with bovine immunoglobulin
IN Targoff, G Raghu, M Reichlin |
Clinical & Experimental Immunology | 1983 |
Do food antigens play a role in the pathogenesis of some cases of human glomerulonephritis?
FJ van der Woude, PJ Hoedemaeker, M der Giessen, PA de Graeff, J Monchy, TH The, GK van der Hem |
Clinical & Experimental Immunology | 1983 |
Food sensitivity: Keys to diagnosis
EP McCarty, OL Frick |
The Journal of Pediatrics | 1983 |
Effects of phenytoin on man's immunity
EJ Bardana, JD Gabourel, GH Davies, S Craig |
The American Journal of Medicine | 1983 |
Induction of IgA Circulating Immune Complexes after Wheat Feeding in Dermatitis Herpetiformis Patients
JJ Zone, BA LaSalle, TT Provost |
Journal of Investigative Dermatology | 1982 |
The Liver: An Integral Part of the Enteric Mucosal Immune System
RE Kleinman, PR Harmatz, WA Walker |
Hepatology | 1982 |
Circulating immune complexes in cardiac disease
PJ Gallagher, DB Jones, CR Casey, GP Sharratt |
Atherosclerosis | 1982 |
Hepatobiliary Clearance of IgA Immune Complexes Formed in the Circulation
PR Harmatz, RE Kleinman, BW Bunnell, KJ Bloch, WA Walker |
Hepatology | 1982 |
IMMUNOLOGIC CONSEQUENCES OF FEEDING INFANTS WITH COW MILK AND SOY PRODUCTS
CD May, SJ Fomon, L Remigio |
Acta Paediatrica | 1982 |
Naturally occurring autologous anti-idiotypic antibodies. Participation in immune complex formation in selective IgA deficiency
C Cunningham-Rundles |
Journal of Experimental Medicine | 1982 |
A quantitative assay for IgA rheumatoid factor
WJ Koopman, RE Schrohenloher, A Solomon |
Journal of Immunological Methods | 1982 |
Nutritional Toxicology
DM Kuhn, W Lovenberg |
Nutritional Toxicology | 1982 |
Immune complexes in primary biliary cirrhosis contain mitochondrial antigens
E Penner, H Goldenberg, B Albini, MM Weiser, F Milgrom |
Clinical Immunology and Immunopathology | 1982 |
The identification of specific antigens in circulating immune complexes by an enzyme-linked immunosorbent assay: detection of bovine x-casein IgG complexes in human sera
C Cunningham-Rundles |
European Journal of Immunology | 1981 |
Allergy and atopic eczema I
D Atherton |
Clinical and Experimental Dermatology | 1981 |
Autoimmunity in selective IgA deficiency: relationship to anti-bovine protein antibodies, circulating immune complexes and clinical disease
C Cunningham-Rundles, WE Brandeis, DJ Pudifin, NK Day, RA Good |
Clinical & Experimental Immunology | 1981 |
The effect of a protein meal on three fluid-phase assays for circulating immune complexes
KB Elkon, JG Lanham, AC Dash, GR Hughes |
Clinical & Experimental Immunology | 1981 |
A Conceptual Approach to Immunodeficiency
EJ Bardana |
Medical Clinics of North America | 1981 |
Usefulness of Measurement of Antibodies in Serum in Diagnosis of Sensitivity to Cow Milk and Soy Proteins in Early Childhood
CD May, L Remigio, SA Bock |
Allergy | 1980 |
Immune complexes in human diseases: a review
AN Theofilopoulos, FJ Dixon |
The American Journal of Pathology | 1980 |
Immune complexes and antibodies to BCG in sera from patients with mycobacterial infections
RI Carr, AK Chakraborty, MJ Brunda, PT Davidson, PB Damle, MA Hardtke, KJ Gilbride, P Minden |
Clinical & Experimental Immunology | 1980 |
The Role of Immune Complexes in the Pathogenesis of Necrotizing Vasculitides
UE Nydegger, PH Lambert |
Clinics in rheumatic diseases | 1980 |
Selective IgA deficiency and circulating immune complexes containing bovine proteins in a child with chronic graft versus host disease
C Cunningham-Rundles, WE Brandeis, B Safai, R O'reilly, NK Day, RA Good |
The American Journal of Medicine | 1979 |