Citations to this article

Serum Inhibitor of C5 Fragment-Mediated Polymorphonuclear Leukocyte Chemotaxis Associated with Chronic Hemodialysis
Simeon E. Goldblum, … , Dennis E. Van Epps, William P. Reed
Simeon E. Goldblum, … , Dennis E. Van Epps, William P. Reed
Published July 1, 1979
Citation Information: J Clin Invest. 1979;64(1):255-264. https://doi.org/10.1172/JCI109446.
View: Text | PDF
Research Article

Serum Inhibitor of C5 Fragment-Mediated Polymorphonuclear Leukocyte Chemotaxis Associated with Chronic Hemodialysis

Abstract

Abnormal granulocyte chemotaxis has been described in chronic hemodialysis patients. In this study, sera from 53 hemodialysis patients were tested for chemotactic inhibitory activity by a modified Boyden technique. Chemotactic inhibitory activity, defined as >20% inhibition of normal granulocyte chemotaxis, was found in 45% of patients. Only sera from patients having undergone >3 mo hemodialysis displayed chemotactic inhibitory activity and retained this inhibitory activity when retested 9 mo later. Four of five patients who had initially undergone <3 mo hemodialysis and lacked serum chemotactic inhibitory activity developed inhibitory activity when tested 9 mo later. Clinical evaluation of patients with serum chemotactic inhibitory activity showed that these patients did not have a significantly increased incidence of infection, although a trend toward decreased mortality during the time of study was observed (P = 0.0721).

Authors

Simeon E. Goldblum, Dennis E. Van Epps, William P. Reed

×

Total citations by year

Year: 2012 2003 2001 1994 1993 1991 1990 1989 1987 1986 1985 1984 1983 1982 1981 1980 1979 Total
Citations: 1 1 1 3 1 1 1 2 3 1 1 1 1 3 1 1 1 24
Citation information

Citations to this article (24)

Title and authors Publication Year
Bacillus anthracis-derived edema toxin (ET) counter-regulates movement of neutrophils and macromolecules through the endothelial paracellular pathway
C Nguyen, C Feng, M Zhan, AS Cross, SE Goldblum 		BMC Microbiology 2012
Protein tyrosine phosphatase activity regulates endothelial cell-cell interactions, the paracellular pathway, and capillary tube stability
BA Young, X Sui, TD Kiser, SW Hyun, P Wang, S Sakarya, DJ Angelini, KL Schaphorst, JD Hasday, AS Cross, LH Romer, A Passaniti, SE Goldblum 		American journal of physiology. Lung cellular and molecular physiology 2003
Exposure to febrile temperature modifies endothelial cell response to tumor necrosis factor-α
JD Hasday, D Bannerman, S Sakarya, AS Cross, IS Singh, D Howard, BE Drysdale, SE Goldblum 		Journal of applied physiology 2001
A Rare Complication in Elective Repair of an Abdominal Aortic Aneurysm: Multiple Transmural Colonic Infarcts Secondary to Atheroemboli
S Bayne, D Donovan, W Henthorne 		Annals of Vascular Surgery 1994
Risk Factors for Infection and Immunoglobulin Replacement Therapy in Adult Nephrotic Syndrome
M Ogi, H Yokoyama, N Tomosugi, Y Hisada, S Ohta, M Takaeda, T Wada, T Naito, K Ikeda, S Goshima, K Takasawa, K Kobayashi 		American Journal of Kidney Diseases 1994
Impact of Continuous Ambulatory Peritoneal Dialysis Solutions and Clearance of Macromolecules on Polymorphonuclear Neutrophils
M Haag-Weber, WH Hörl 		Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis 1994
Lymphocyte subsets in hemodialysis patients treated with recombinant human erythropoietin
Y Ueki, M Nagata, S Miyake, Y Tominaga 		Journal of Clinical Immunology 1993
New Aspects of Human Polymorphonuclear Leukocytes
WH Hörl, PJ Schollmeyer 		1991
Impaired Function of Macrophage Fc<sub>γ</sub> Receptors in End-Stage Renal Disease
P Ruiz, F Gomez, AD Schreiber 		New England Journal of Medicine 1990
New Actions of Parathyroid Hormone
SG Massry, T Fujita 		1989
The immune status of uraemic children/adolescents with chronic renal failure and renal replacement therapy
R Drachman, M Schlesinger, H Shapira, A Drukker 		Pediatric Nephrology 1989
Leukocyte C5a receptor modulation during hemodialysis
SL Lewis, DE van Epps, DE Chenoweth 		Kidney International 1987
Identification of a Protein in Sera of Normal Humans That Inhibits Fibroblast Chemotactic and Random Migration In Vitro
ME Ochs, AE Postlethwaite, AH Kang 		Journal of Investigative Dermatology 1987
Hematologic Abnormalities in Patients with Renal Diseases
WG Hocking 		Hematology/Oncology Clinics of North America 1987
Impaired cellular immune responses in chronic renal failure: Evidence for a T cell defect
P Kurz, H Köhler, S Meuer, T Hütteroth, KH Büschenfelde 		Kidney International 1986
Immunology of Rheumatic Diseases
S Gupta, N Talal 		1985
Biologically active complement (C5)-derived peptides and their relevance to disease
HD Perez 		Critical Reviews in Oncology/Hematology 1984
Polymorphonuclear leukocytes: Dedicated professional phagocytes
BH Wade, GL Mandell 		The American Journal of Medicine 1983
Lymphocyte and granulocyte function in zinc-treated and zinc-deficient hemodialysis patients
WA Briggs, MM Pedersen, SK Mahajan, DH Sillix, AS Prasad, FD McDonald 		Kidney International 1982
Alterations in activities of anaphylatoxin inactivator and chemotactic factor inactivator during hemodialysis
JR McCormick, DL Kreutzer, HJ Keating, J Hupp, A Despins, M Moore 		The American Journal of Pathology 1982
Gram-positive bacteria-induced granulocytopenia and pulmonary leukostasis in rabbits
SE Goldblum, WP Reed 		Infection and immunity 1982
Reversal of hemodialysis granulocytopenia and pulmonary leukostasis: A clinical manifestation of selective down-regulation of granulocyte responses to C5adesarg
KM Skubitz, PR Craddock 		Journal of Clinical Investigation 1981
IgA paraprotein inhibition of human neutrophil chemotaxis reduced activity following treatment with IgA-specific protease fromNeisseria gonorrhoeae
DE Epps, A Plaut, GM Bernier, RC Williams 		Inflammation 1980
Replacement of Renal Function by Dialysis
W Drukker, FM Parsons, JF Maher 		1979

Advertisement