John Mendelsohn, Judith Nordberg
Citation Information: J Clin Invest. 1979;63(6):1124-1132. https://doi.org/10.1172/JCI109405.
John Mendelsohn, Judith Nordberg
Published June 1, 1979
Citation Information: J Clin Invest. 1979;63(6):1124-1132. https://doi.org/10.1172/JCI109405.
Abstract
Lymphocytes were purified from peripheral blood of normal donors and patients with chronic lymphocytic leukemia (CLL) by Ficoll-Hypaque centrifugation. Adenylate cyclase activity, expressed as picomoles [32P]cyclic AMP generated per milligram protein per minute, was 57±4 in normals and 26±4 in CLL patients. Enzyme activity, expressed as picomoles [32P]cyclic AMP generated per 106 lymphocytes per minute, was 2.09±0.19 for normal lymphocytes and 1.10±0.16 for CLL lymphocytes. The differences between normal and CLL peripheral lymphocytes are highly significant (P < 0.001) with either method of calculating activity.
Authors
John Mendelsohn, Judith Nordberg
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