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Citations to this article

Cyclic hematopoiesis. Effects of endotoxin on colony-forming cells and colony-stimulating activity in grey collie dogs.
W P Hammond, … , E R Engelking, D C Dale
W P Hammond, … , E R Engelking, D C Dale
Published April 1, 1979
Citation Information: J Clin Invest. 1979;63(4):785-792. https://doi.org/10.1172/JCI109363.
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Research Article

Cyclic hematopoiesis. Effects of endotoxin on colony-forming cells and colony-stimulating activity in grey collie dogs.

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Abstract

Cyclic changes in blood neutrophil counts of grey collie dogs with cyclic hematopoiesis can be eliminated by daily endotoxin injections. Studies were performed to determine the mechanism whereby endotoxin alters this disease. Bone marrow granulocyte-macrophage progenitor cells (colony-forming cells [CFUc]) showed cyclic variation in the untreated grey collie, which was eliminated by chronic endotoxin treatment (Salmonella typhosa lipopolysaccharide W, 5 microgram/kg per day). Similar cyclic variation in blood CFUc was eliminated by this treatment. Tritiated thymidine suicide of the marrow colony-forming cells failed to show cyclic changes to explain the marked swing in CFUc numbers in untreated grey collies. The thymidine suicide rates were not significantly changed by chronic endotoxin treatment. Similarly, serum colony-stimulating activity did not show cyclic variation with the cyclic neutrophil counts in untreated grey collies and was not altered by chronic endotoxin treatment. We suggest that endotoxin eliminates neutrophil cycling in cyclic hematopoiesis by a direct effect on the flux of pluripotent stem cells into the committed stem cell compartment and that this occurs independent of changes in serum colony-stimulating activity.

Authors

W P Hammond, E R Engelking, D C Dale

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Total citations by year

Year: 1991 1990 1985 1983 1982 1981 1980 Total
Citations: 1 1 1 3 1 1 1 9
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article (9)

Title and authors Publication Year
Chronic neutropenia. A new canine model induced by human granulocyte colony-stimulating factor
WP Hammond, E Csiba, A Canin, H Hockman, LM Souza, JE Layton, DC Dale
Journal of Clinical Investigation 1991
Synchrony of bone marrow proliferation and maturation as the origin of cyclic haemopoiesis
S Schmitz, M Loeffler, JB Jones, RD Lange, HE Wichmann
Cell Proliferation 1990
Myelopoiesis and Marrow Adherent Cells in Estradiol-Treated Mice
SD Gaunt, KR Pierce
Veterinary pathology 1985
Canine cyclic hematopoiesis is associated with abnormal purine and pyrimidine metabolism
WR Osborne, WP Hammond, DC Dale
Journal of Clinical Investigation 1983
Mechanism of canine cyclic hematopoiesis: The role of prostaglandin E in feedback regulation
WP Hammond, RP Robertson, DC Dale
American Journal of Hematology 1983
Clinical and pathologic features of cyclic hematopoiesis in grey collie dogs
RF DiGiacomo, WP Hammond, LL Kunz, PA Cox
The American Journal of Pathology 1983
Canine cyclic haematopoiesis: the effect of endotoxin on erythropoiesis
WP Hammond, JW Adamson, DC Dale, E Rodger, C Wise
British Journal of Haematology 1982
Immunologic Defects in Laboratory Animals 1
ME Gershwin, B Merchant
1981
The role of colony-stimulating factor in granulopoiesis
RK Shadduck, G Pigoli, A Waheed, F Boegel
Journal of Supramolecular Structure 1980

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