17 beta-estradiol enchances androgen-induced prostate growth in the castrate dog to a degree comparable to that seen in spontaneous prostatic hypertrophy. To investigate the mechanism of this synergism, cytosol androgen binding was measured by a density gradient technique in prostates of control and 17 beta-estradiol-treated castrate dogs. [3H]Dihydrotestosterone was bound principally to a moiety that averaged 8.6S in size. Approximately twofold enhancement of this binding by 17 beta-estradiol was demonstrable after 1 wk of treatment with 750 microgram/wk and after 3 wk with 75 microgram/wk. Under conditions in which binding in the 8S region was demonstrable with dihydrotestosterone and testosterone no binding of 3 alpha-androstanediol or progesterone was detectable. Thus, enhancement by 17 beta-estradiol of a prostate cytosol androgen-binding protein occurs under circumstances in which 17 beta-estradiol enhances androgen-mediated prostatic growth.
R J Moore, J M Gazak, J D Wilson
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A Vermeulen, JM Kaufman, S Goemaere, IV Pottelberg |
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Annals of Medicine | 2000 |
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Endocrine reviews | 2000 |
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Biology of reproduction | 1999 |
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International Journal of Andrology | 1998 |
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Mori T, Cui L, Kato K, Takahashi S, Imaida K, Iwasaki S, Ito N, Shirai T |
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International Urology and Nephrology | 1995 |
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G Srinivasan, E Campbell, N Bashirelahi |
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Geriatric Nephrology and Urology | 1992 |
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RE Hall, WD Tilley, MJ McPhaul, RL Sutherland |
International Journal of Cancer | 1992 |
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New England Journal of Medicine | 1992 |
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The Journal of Steroid Biochemistry and Molecular Biology | 1992 |
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Endocrinology and metabolism clinics of North America | 1991 |
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British Journal of Urology | 1990 |
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LC Krey, MY Mcginnis |
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American journal of physiology. Endocrinology and metabolism | 1990 |
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Journal of Steroid Biochemistry | 1988 |
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The Journal of Urology | 1988 |
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Urological Research | 1988 |
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Journal of Clinical Investigation | 1987 |
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Cancer and Metastasis Reviews | 1987 |
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1987 | |
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Clinics in Endocrinology and Metabolism | 1986 |
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The Prostate | 1985 |
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1985 | |
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Annals of the New York Academy of Sciences | 1984 |
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British Journal of Cancer | 1984 |
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Journal of Steroid Biochemistry | 1984 |
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R Horton |
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1984 | |
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Journal of Steroid Biochemistry | 1983 |
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The Journal of Urology | 1983 |
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The Journal of Urology | 1983 |
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1983 | |
Acute therapy with megestrol acetate decreases nuclear and cytosol androgen receptors in human BPH tissue
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The Prostate | 1982 |
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1982 | |
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1981 | |
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