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Citations to this article

Regulation of cytoplasmic dihydrotestosterone binding in dog prostate by 17 beta-estradiol.
R J Moore, … , J M Gazak, J D Wilson
R J Moore, … , J M Gazak, J D Wilson
Published March 1, 1979
Citation Information: J Clin Invest. 1979;63(3):351-357. https://doi.org/10.1172/JCI109310.
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Regulation of cytoplasmic dihydrotestosterone binding in dog prostate by 17 beta-estradiol.

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Abstract

17 beta-estradiol enchances androgen-induced prostate growth in the castrate dog to a degree comparable to that seen in spontaneous prostatic hypertrophy. To investigate the mechanism of this synergism, cytosol androgen binding was measured by a density gradient technique in prostates of control and 17 beta-estradiol-treated castrate dogs. [3H]Dihydrotestosterone was bound principally to a moiety that averaged 8.6S in size. Approximately twofold enhancement of this binding by 17 beta-estradiol was demonstrable after 1 wk of treatment with 750 microgram/wk and after 3 wk with 75 microgram/wk. Under conditions in which binding in the 8S region was demonstrable with dihydrotestosterone and testosterone no binding of 3 alpha-androstanediol or progesterone was detectable. Thus, enhancement by 17 beta-estradiol of a prostate cytosol androgen-binding protein occurs under circumstances in which 17 beta-estradiol enhances androgen-mediated prostatic growth.

Authors

R J Moore, J M Gazak, J D Wilson

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Total citations by year

Year: 2013 2011 2010 2008 2006 2005 2004 2003 2002 2001 2000 1999 1998 1996 1995 1994 1993 1992 1991 1990 1989 1988 1987 1986 1985 1984 1983 1982 1981 1980 1979 Total
Citations: 1 1 1 1 4 4 4 4 3 3 3 2 1 3 4 3 1 5 2 5 2 8 6 2 3 6 5 6 5 4 3 105
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