Citations to this article

Myeloperoxidase-Mediated Platelet Release Reaction
Robert A. Clark
Robert A. Clark
Published February 1, 1979
Citation Information: J Clin Invest. 1979;63(2):177-183. https://doi.org/10.1172/JCI109287.
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Research Article

Myeloperoxidase-Mediated Platelet Release Reaction

Abstract

The ability of the neutrophil myeloperoxidase-hydrogen peroxide-halide system to induce the release of human platelet constituents was examined. Both lytic and nonlytic effects on platelets were assessed by comparison of the simultaneously measured release of a dense-granule marker, [3H]serotonin, and a cytoplasmic marker, [14C]adenine. Incubation of platelets with H2O2 alone (20 μM H2O2 for 10 min) resulted in a small, although significant, release of both serotonin and adenine, suggesting some platelet lysis. Substantial release of these markers was observed only with increased H2O2 concentrations (>0.1 mM) or prolonged incubation (1-2 h).

Authors

Robert A. Clark

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Citations to this article (40)

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HB Dunford, Y Hsuanyu 		Biochemistry and Cell Biology 1999
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N Hsia, J Everse 		Artificial Cells, Blood Substitutes and Biotechnology 1996
Potential Role of the Peroxidase-Dependent Metabolism of Serotonin in Lowering the Polymorphonuclear Leukocyte Bactericidal Function
S Salman-Tabcheh, MC Guérin, J Torreilles 		Free Radical Research 1996
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D Salvemini, R Botting 		Trends in Pharmacological Sciences 1993
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G Rousseau, D Hébert, D Libersan, A Khalil, G St-Jean, JG Latour 		American Heart Journal 1993
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KV Biagas, MW Uhl, JK Schiding, EM Nemoto, PM Kochanek 		Journal of Neurotrauma 1992
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The determination of myeloperoxidase activity in liver
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CD Simone, S Delia, LD Meco, C Mastroianni, C Mastropietro, V Vullo, F Sorice 		Immunological Investigations 1985
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PA Ward, KJ Johnson, GO Till 		Annals of Emergency Medicine 1985
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O Stendahl, BI Coble, C Dahlgren, J Hed, L Molin 		Journal of Clinical Investigation 1984
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SE Fligiel, EC Lee, JP McCoy, KJ Johnson, J Varani 		The American Journal of Pathology 1984
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