The effect of acute and chronic ethanol intake on hepatic glycerolipid biosynthesis in the hamster was studied by in vivo and in vitro techniques. The results were compared with those from control hamsters receiving isocaloric amounts of glucose. Both chronic and acute ethanol intake elevated serum and hepatic triglyceride concentrations and induced a rapid rise in the capacity of neutral glycerolipid formation from sn[1,3-14C]glycerol-3-phosphate by hamster liver homogenate and microsomal fractions. Ethanol intake also produced a corresponding increase in the incorporation of [1,3-14C]glycerol into hepatic neutral glycerolipids by the intact animal. The ethanol-induced rise in the capacity of neutral glycerolipid production by liver as measured in vivo and in vitro correlated well with an increase in hepatic phosphatidate phosphohydrolase activity. Therefore, the rise in hepatic and serum triglyceride levels associated with ethanol intake may be explained in part by an increase in the activity of the enzyme.
R G Lamb, C K Wood, H J Fallon
Title and authors | Publication | Year |
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Implications of glycerol metabolism for lipid production
LL Xue, HH Chen, JG Jiang |
Progress in Lipid Research | 2017 |
The role of glycerol-3-phosphate dehydrogenase 1 in the progression of fatty liver after acute ethanol administration in mice
T Sato, A Morita, N Mori, S Miura |
Biochemical and Biophysical Research Communications | 2014 |
Some novel insights into the pathogenesis of alcoholic steatosis
MR Lakshman |
Alcohol | 2004 |
Effect of alcohol on the activity and subcellular distribution of phosphatidate phosphohydrolase in rat liver
KJ Simpson, S Venkatesan, A Martin, DN Brindley, TJ Peters |
Biochimica et Biophysica Acta (BBA) - General Subjects | 1994 |
Anin vitro model of ethanol-dependent liver cell injury
RG Lamb, JC Koch, JW Snyder, SM Huband, SR Bush |
Hepatology | 1994 |
Effect of morphine and stadol on lipid content in liver of rat
ES el Daly |
Life Sciences | 1994 |
The biochemistry of alcohol-induced fatty liver
CP Day, SJ Yeaman |
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism | 1994 |
The activity of the metabolic form of hepatic phosphatidate phosphohydrolase correlates with the severity of alcoholic fatty liver in human beings
CP Day, OF James, AS Brown, MK Bennett, IN Fleming, SJ Yeaman |
Hepatology | 1993 |
Animal models of alcoholic liver disease
KJ Simpson, TJ Peters |
Bailliere's Clinical Gastroenterology | 1993 |
Physical evidence for the presence of two forms of phosphatidate phosphohydrolase in rat liver
CP Day, SJ Yeaman |
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism | 1992 |
Chronic ethanol intake inhibits both the vasoactive intestinal peptide binding and the associated cyclic AMP production in rat enterocytes
J Jimenez, JR Calvo, P Molinero, R Goberna, JM Guerrero |
General Pharmacology: The Vascular System | 1992 |
Time-course effects of ethanol pretreatment on hepatic necrosis and fat accumulation induced by aflatoxin B1 in the rat
C Toskulkao, P Lohakachonpan, T Glinsukon |
Toxicology Letters | 1991 |
Liver Pathology and Alcohol
RR Watson |
1991 | |
Microsomal induction, alcohol, and lipoprotein metabolism: Is there a three-way relationship?
DM Goldberg, JG Parkes, S Hahn |
Clinical Biochemistry | 1989 |
Effect of chronic intake of ethanol on the binding of vasoactive intestinal peptide to rat spleen lymphoid cells
J Jimenez, R Goberna, JC Mesa, MF Morales, JR Calvo |
General Pharmacology: The Vascular System | 1989 |
Effects of ethanol feeding on hepatic lipid synthesis
LB Tijburg, A MaQuedano, C Bijleveld, M Guzmán, MJ Geelen |
Archives of Biochemistry and Biophysics | 1988 |
Stimulation by acetoacetate of hepatic triacylglycerol synthesis
OA Oredipe, VK Murthy, JC Shipp |
Diabetes Research and Clinical Practice | 1987 |
Recent Developments in Alcoholism
M Galanter |
1987 | |
Alcohol and the Liver: Metabolism of Ethanol, Metabolic Effects and Pathogenesis of Injury
CS Lieber |
Acta Medica Scandinavica | 1985 |
Ethanol and Membrane Lipids
GY Sun, AY Sun |
Alcoholism, clinical and experimental research | 1985 |
Alcohol Related Diseases in Gastroenterology
HK Seitz, B Kommerell |
1985 | |
Ethanol and Lipids
CS Lieber, M Savolainen |
Alcoholism, clinical and experimental research | 1984 |
Relationship of Endocrine Status on the Stimulatory Effect of Ethanol on Hepatic Very Low Density Lipoprotein Synthesis
MR Lakshmanan, ME Felver, M Ezekiel |
Alcoholism, clinical and experimental research | 1984 |
Intracellular translocation of phosphatidate phosphohydrolase and its possible role in the control of glycerolipid synthesis
DN Brindley |
Progress in Lipid Research | 1984 |
Metabolism and Metabolic Effects of Alcohol
CS Lieber |
Medical Clinics of North America | 1984 |
Hepatic triacylglycerol synthesizing activity during progression of alcoholic liver injury in the baboon
MJ Savolainen, E Baraona, P Pikkarainen, CS Lieber |
Journal of lipid research | 1984 |
Effect of ethanol on nucleolar structure: A cytological indication of change in RNA/protein synthesis
CR Dunmire, FW Lavelle |
The Anatomical Record | 1983 |
New Comprehensive Biochemistry
S Yamamoto |
New Comprehensive Biochemistry | 1983 |
The effect of fatty acid exposure on the biosynthesis of glycerolipids by cultured hepatocytes
RG Lamb, SB McCue |
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism | 1983 |
The effects of bromobenzene and Carbon tetrachloride exposure in vitro on the phospholipase C activity of rat liver cells
RG Lamb, DW Schwertz |
Toxicology and Applied Pharmacology | 1982 |
Nutritional Toxicology
DM Kuhn, W Lovenberg |
Nutritional Toxicology | 1982 |
Effects of chronic insulin and glucagon exposure on the biosynthesis of glycerolipids by cultured hepatocytes
RG Lamb, SJ Bow, TO Wright |
The Journal of biological chemistry | 1982 |
Regulation of hepatic triglyceride synthesis in diabetic rats
VK Murthy, JC Shipp |
Journal of Clinical Investigation | 1981 |
Triacylglycerol metabolism in the phenobarbital-treated rat
DM Goldberg, MW Roomi, A Yu, DA Roncari |
Biochemical Journal | 1981 |
Effects of chronic modification of dietary fat and carbohydrate on the insulin, corticosterone and metabolic responses of rats fed acutely with glucose, fructose or ethanol
DN Brindley, J Cooling, HP Glenny, SL Burditt, IS McKechnie |
Biochemical Journal | 1981 |
The acute effects of streptozotocin-induced diabetes on rat liver glycerolipid biosynthesis
JA Woods, TE Knauer, RG Lamb |
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism | 1981 |
Separation and characterization of the membrane-bound and aqueously dispersed phosphatidate phosphatidic acid phosphohydrolase activities in rat lung
PG Casola, F Possmayer |
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism | 1981 |
Research Advances in Alcohol and Drug Problems
Y Israel, FB Glaser, H Kalant, RE Popham, W Schmidt, RG Smart |
1981 | |
Effects of phenobarbital upon triacylglycerol metabolism in the rabbit
DM Goldberg, MW Roomi, A Yu, DA Roncari |
Biochemical Journal | 1980 |
The involvement of glucocorticoids in regulating the activity of phosphatidate phosphohydrolase and the synthesis of triacylglycerols in the liver. Effects of feeding rats with glucose, sorbitol, fructose, glycerol and ethanol
DN Brindley, J Cooling, SL Burditt, PH Pritchard, S Pawson, RG Sturton |
Biochemical Journal | 1979 |
Can the alterations in serum glucocorticoid concentrations explain the effects of ethanol and benfluorex on the synthesis of hepatic triacylglycerols?
PH Pritchard, J Cooling, SL Burditt, DN Brindley |
Journal of Pharmacy and Pharmacology | 1979 |
Effect of hydrazine exposure on hepatic triacylglycerol biosynthesis
RG Lamb, WL Banks |
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism | 1979 |