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Citations to this article

The effect of acute and chronic ethanol intake on hepatic glycerolipid biosynthesis in the hamster.
R G Lamb, … , C K Wood, H J Fallon
R G Lamb, … , C K Wood, H J Fallon
Published January 1, 1979
Citation Information: J Clin Invest. 1979;63(1):14-20. https://doi.org/10.1172/JCI109268.
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Research Article

The effect of acute and chronic ethanol intake on hepatic glycerolipid biosynthesis in the hamster.

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Abstract

The effect of acute and chronic ethanol intake on hepatic glycerolipid biosynthesis in the hamster was studied by in vivo and in vitro techniques. The results were compared with those from control hamsters receiving isocaloric amounts of glucose. Both chronic and acute ethanol intake elevated serum and hepatic triglyceride concentrations and induced a rapid rise in the capacity of neutral glycerolipid formation from sn[1,3-14C]glycerol-3-phosphate by hamster liver homogenate and microsomal fractions. Ethanol intake also produced a corresponding increase in the incorporation of [1,3-14C]glycerol into hepatic neutral glycerolipids by the intact animal. The ethanol-induced rise in the capacity of neutral glycerolipid production by liver as measured in vivo and in vitro correlated well with an increase in hepatic phosphatidate phosphohydrolase activity. Therefore, the rise in hepatic and serum triglyceride levels associated with ethanol intake may be explained in part by an increase in the activity of the enzyme.

Authors

R G Lamb, C K Wood, H J Fallon

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Total citations by year

Year: 2017 2014 2004 1994 1993 1992 1991 1989 1988 1987 1985 1984 1983 1982 1981 1980 1979 Total
Citations: 1 1 1 4 2 2 2 2 1 2 3 5 3 3 6 1 3 42
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article (42)

Title and authors Publication Year
Implications of glycerol metabolism for lipid production
LL Xue, HH Chen, JG Jiang
Progress in Lipid Research 2017
The role of glycerol-3-phosphate dehydrogenase 1 in the progression of fatty liver after acute ethanol administration in mice
T Sato, A Morita, N Mori, S Miura
Biochemical and Biophysical Research Communications 2014
Some novel insights into the pathogenesis of alcoholic steatosis
MR Lakshman
Alcohol 2004
Effect of alcohol on the activity and subcellular distribution of phosphatidate phosphohydrolase in rat liver
KJ Simpson, S Venkatesan, A Martin, DN Brindley, TJ Peters
Biochimica et Biophysica Acta (BBA) - General Subjects 1994
Anin vitro model of ethanol-dependent liver cell injury
RG Lamb, JC Koch, JW Snyder, SM Huband, SR Bush
Hepatology 1994
Effect of morphine and stadol on lipid content in liver of rat
ES el Daly
Life Sciences 1994
The biochemistry of alcohol-induced fatty liver
CP Day, SJ Yeaman
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1994
The activity of the metabolic form of hepatic phosphatidate phosphohydrolase correlates with the severity of alcoholic fatty liver in human beings
CP Day, OF James, AS Brown, MK Bennett, IN Fleming, SJ Yeaman
Hepatology 1993
Animal models of alcoholic liver disease
KJ Simpson, TJ Peters
Bailliere's Clinical Gastroenterology 1993
Physical evidence for the presence of two forms of phosphatidate phosphohydrolase in rat liver
CP Day, SJ Yeaman
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1992
Chronic ethanol intake inhibits both the vasoactive intestinal peptide binding and the associated cyclic AMP production in rat enterocytes
J Jimenez, JR Calvo, P Molinero, R Goberna, JM Guerrero
General Pharmacology: The Vascular System 1992
Time-course effects of ethanol pretreatment on hepatic necrosis and fat accumulation induced by aflatoxin B1 in the rat
C Toskulkao, P Lohakachonpan, T Glinsukon
Toxicology Letters 1991
Liver Pathology and Alcohol
RR Watson
1991
Microsomal induction, alcohol, and lipoprotein metabolism: Is there a three-way relationship?
DM Goldberg, JG Parkes, S Hahn
Clinical Biochemistry 1989
Effect of chronic intake of ethanol on the binding of vasoactive intestinal peptide to rat spleen lymphoid cells
J Jimenez, R Goberna, JC Mesa, MF Morales, JR Calvo
General Pharmacology: The Vascular System 1989
Effects of ethanol feeding on hepatic lipid synthesis
LB Tijburg, A MaQuedano, C Bijleveld, M Guzmán, MJ Geelen
Archives of Biochemistry and Biophysics 1988
Stimulation by acetoacetate of hepatic triacylglycerol synthesis
OA Oredipe, VK Murthy, JC Shipp
Diabetes Research and Clinical Practice 1987
Recent Developments in Alcoholism
M Galanter
1987
Alcohol and the Liver: Metabolism of Ethanol, Metabolic Effects and Pathogenesis of Injury
CS Lieber
Acta Medica Scandinavica 1985
Ethanol and Membrane Lipids
GY Sun, AY Sun
Alcoholism, clinical and experimental research 1985
Alcohol Related Diseases in Gastroenterology
HK Seitz, B Kommerell
1985
Ethanol and Lipids
CS Lieber, M Savolainen
Alcoholism, clinical and experimental research 1984
Relationship of Endocrine Status on the Stimulatory Effect of Ethanol on Hepatic Very Low Density Lipoprotein Synthesis
MR Lakshmanan, ME Felver, M Ezekiel
Alcoholism, clinical and experimental research 1984
Intracellular translocation of phosphatidate phosphohydrolase and its possible role in the control of glycerolipid synthesis
DN Brindley
Progress in Lipid Research 1984
Metabolism and Metabolic Effects of Alcohol
CS Lieber
Medical Clinics of North America 1984
Hepatic triacylglycerol synthesizing activity during progression of alcoholic liver injury in the baboon
MJ Savolainen, E Baraona, P Pikkarainen, CS Lieber
Journal of lipid research 1984
Effect of ethanol on nucleolar structure: A cytological indication of change in RNA/protein synthesis
CR Dunmire, FW Lavelle
The Anatomical Record 1983
New Comprehensive Biochemistry
S Yamamoto
New Comprehensive Biochemistry 1983
The effect of fatty acid exposure on the biosynthesis of glycerolipids by cultured hepatocytes
RG Lamb, SB McCue
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1983
The effects of bromobenzene and Carbon tetrachloride exposure in vitro on the phospholipase C activity of rat liver cells
RG Lamb, DW Schwertz
Toxicology and Applied Pharmacology 1982
Nutritional Toxicology
DM Kuhn, W Lovenberg
Nutritional Toxicology 1982
Effects of chronic insulin and glucagon exposure on the biosynthesis of glycerolipids by cultured hepatocytes
RG Lamb, SJ Bow, TO Wright
The Journal of biological chemistry 1982
Regulation of hepatic triglyceride synthesis in diabetic rats
VK Murthy, JC Shipp
Journal of Clinical Investigation 1981
Triacylglycerol metabolism in the phenobarbital-treated rat
DM Goldberg, MW Roomi, A Yu, DA Roncari
Biochemical Journal 1981
Effects of chronic modification of dietary fat and carbohydrate on the insulin, corticosterone and metabolic responses of rats fed acutely with glucose, fructose or ethanol
DN Brindley, J Cooling, HP Glenny, SL Burditt, IS McKechnie
Biochemical Journal 1981
The acute effects of streptozotocin-induced diabetes on rat liver glycerolipid biosynthesis
JA Woods, TE Knauer, RG Lamb
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1981
Separation and characterization of the membrane-bound and aqueously dispersed phosphatidate phosphatidic acid phosphohydrolase activities in rat lung
PG Casola, F Possmayer
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1981
Research Advances in Alcohol and Drug Problems
Y Israel, FB Glaser, H Kalant, RE Popham, W Schmidt, RG Smart
1981
Effects of phenobarbital upon triacylglycerol metabolism in the rabbit
DM Goldberg, MW Roomi, A Yu, DA Roncari
Biochemical Journal 1980
The involvement of glucocorticoids in regulating the activity of phosphatidate phosphohydrolase and the synthesis of triacylglycerols in the liver. Effects of feeding rats with glucose, sorbitol, fructose, glycerol and ethanol
DN Brindley, J Cooling, SL Burditt, PH Pritchard, S Pawson, RG Sturton
Biochemical Journal 1979
Can the alterations in serum glucocorticoid concentrations explain the effects of ethanol and benfluorex on the synthesis of hepatic triacylglycerols?
PH Pritchard, J Cooling, SL Burditt, DN Brindley
Journal of Pharmacy and Pharmacology 1979
Effect of hydrazine exposure on hepatic triacylglycerol biosynthesis
RG Lamb, WL Banks
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1979

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