Citations to this article

Iron uptake from rat plasma transferrin by rat reticulocytes.
H Huebers, … , E Csiba, C A Finch
H Huebers, … , E Csiba, C A Finch
Published November 1, 1978
Citation Information: J Clin Invest. 1978;62(5):944-951. https://doi.org/10.1172/JCI109223.
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Research Article

Iron uptake from rat plasma transferrin by rat reticulocytes.

Abstract

Fast and slow rat transferrins were isolated by isoelectric focusing and prepared in their di- and monoferric forms. A comparison of the rates of iron release between fast and slow monoferric transferrins when incubated with reticulocytes or injected in vivo showed no significant difference in the behavior of the two isotransferrin species. Reticulocyte uptake of diferric transferrin resulted in the removal of both iron atoms from the transferrin molecule. A twofold greater iron uptake was observed from diferric as compared with monoferric iron, provided reticulocyte receptors were saturated. It is concluded that the two species of transferrin and their individual sites function similarly in their release of iron to tissue receptors.

Authors

H Huebers, E Huebers, E Csiba, C A Finch

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Citations to this article (31)

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Y Ohkubo, S Takasu, M Itakura, S Katoh, A Sasayama, H Kohno, A Kubodera 		Annals of Nuclear Medicine 1992
Biochemical Pharmacology of Blood and Bloodforming Organs
JW Fisher 		1992
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T Intragumtornchai, HA Huebers, CA Finch 		Blut Zeitschrift für die Gesamte Blutforschung 1990
Endothelial Mediation Is Necessary for Subsequent Hepatocyte Uptake of Transferrin
R Soda, CL Hardy, M Kataoka, M Tavassoli 		The American Journal of the Medical Sciences 1989
The behavior of asialotransferrin-iron in the rat
Y Beguin, G Bergamaschi, HA Huebers, CA Finch 		American Journal of Hematology 1988
Liver endothelium mediates the uptake of iron-transferrin complex by hepatocytes
M Tavassoli, T Kishimoto, R Soda, M Kataoka, K Harjes 		Experimental Cell Research 1986
Uptake and subcellular processing of 59Fe-125I-labelled transferrin by rat liver
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Metalloproteins
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Occupancy of the iron binding sites of human transferrin
HA Huebers, B Josephson, E Huebers, E Csiba, CA Finch 		Proceedings of the National Academy of Sciences 1984
Quantitative determination of transferrins in serum of different species
RG Werner, AM Erne, A Stecher, H Goeth 		FEMS Microbiology Letters 1983
Competitive advantage of diferric transferrin in delivering iron to reticulocytes
HA Huebers, E Csiba, E Huebers, CA Finch 		Proceedings of the National Academy of Sciences 1983
Binding of transferrin-iron to the plasma membrane of a lactating rabbit mammary gland cell
DA Moutafchiev, AC Shisheva, LM Sirakov 		International Journal of Biochemistry 1983
Studies on the forms of iron-transferrin released from rabbit reticulocytes
TT Loh 		Life Sciences 1983
Basis of plasma iron exchange in the rabbit
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Uptake and release of iron from human transferrin
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Interaction of human diferric transferrin with reticulocytes
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Studies on the mechanism of transferrin iron uptake by rat reticulocytes
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Transferrin acquisition of catabolized erythrocyte iron in the rat
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The kinetics of iron release from human transferrin by EDTA. Effect of salts and detergents
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Biochemistry of Nonheme Iron
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Protides of the Biological Fluids
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