To characterize the cell(s) responsible for the suppressor-cell dysfunction in active systemic lupus erythematosus (SLE), we fractionated blood mononuclear cells into thymus-derived (T), bone marrow-derived (B), and monocyte-depleted populations. Various cell populations from active SLE, inactive SLE, or normals, were activated with Concanavalin A, washed, and then co-cultured with active SLE cells. Soluble immune response suppressor (SIRS) from culture supernates of the activated cells was also used for the possible correction of the suppressor-cell dysfunction. Suppression was tested by enumerating DNA-binding cells by radioautography and by quantitating anti-DNA antibody in culture supernates by radioimmunoassay; and immunoglobulin was tested in cells and supernates by the immunofluorescence and the immunofluor techniques, respectively. Except for the numbers of DNA-binding cells, which were not suppressed, all the other three parameters in co-cultures with cells from active SLE patients were suppressed by Concanavalin A-activated cells (P < 0.001), or by SIRS (P < 0.05) from normals or inactive SLE patients. Concanavalin A-activated autologous or allogeneic active SLE cells and nonactivated cells from active or inactive SLE failed to suppress the various B-cell functions. Nonactivated normal cells suppressed levels of anti-DNA and immunoglobulin in supernates (P < 0.05).
Akira Sagawa, Nabih I. Abdou
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1988 | |
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Clinical Immunology and Immunopathology | 1985 |
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Cellular mechanism of DNA-specific antibody synthesis by lymphocytes from systemic lupus erythematosus patients
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Arthritis & Rheumatism | 1984 |
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Journal of Clinical Investigation | 1983 |
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Clinical & Experimental Immunology | 1983 |
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Clinical & Experimental Immunology | 1983 |
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AN Theofilopoulos, GJ Prud'homme, TM Fieser, FJ Dixon |
Immunology Today | 1983 |
Nucleoside-specific suppression in MRL/MP +/+ mice
BP Giroir, EC Raps, RM Lewis, Y Borel |
Cellular Immunology | 1983 |
Is schizophrenia an immunologic receptor disorder?
HH Fudenberg, HD Whitten, E Merler, O Farmati |
Medical Hypotheses | 1983 |
Immune Mechanisms in Renal Disease
NB Cummings, AF Michael, CB Wilson |
1983 | |
Anti-Ia reactivity in sera from patients with systemic lupus erythematosus
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Studies of immune functions of patients with systemic lupus erythematosus: antibodies to desialized, rather than intact, T cells preferentially bind to and eliminate suppressor effector T cells
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Cellular mechanism of tissue injury and immune derangement in systemic lupus erythematosus
RC Williams |
Arthritis & Rheumatism | 1982 |
Cutaneous and Systemic Manifestations of Auto-Immune Disorders
GV Gordon |
International Journal of Dermatology | 1982 |
In Vitro Immune Response of SLE Lymphocytes
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Scandinavian Journal of Immunology | 1982 |
Suppressor Cell Function Is Preserved in Pemphigus and Pemphigoid
AJ King, SA Schwartz, D Lopatin, JJ Voorhees, LA Diaz |
Journal of Investigative Dermatology | 1982 |
Further Aspects of T Cell Function in Systemic Lupus Erythematosus
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Immunological Investigations | 1982 |
Direct demonstration of the function of T cell subsets reactive with anti-T cell antibodies from SLE sera
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Rheumatology International | 1982 |
Spontaneous plaque forming cells in the peripheral blood of patients with systemic lupus erythematosus
AG Wangel, A Milton, JB Egan |
Clinical & Experimental Immunology | 1982 |
Autoimmune diseases: immunopathology and etiopathogenesis
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The American Journal of Pathology | 1982 |
Cell-mediated immune functions and immunoregulatory cells in Behçet's syndrome
RM Victorino, P Ryan, GR Hughes, HJ Hodgson |
Clinical & Experimental Immunology | 1982 |
Hydrocortisone reverses the suppression of immunoglobulin synthesis by concanavalin A-activated spleen cell supernatants
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Clinical & Experimental Immunology | 1982 |
Abnormal adenosine-induced immunosuppression and cAMP metabolism in T lymphocytes of patients with systemic lupus erythematosus
R Mandler, RE Birch, SH Polmar, GM Kammer, SA Rudolph |
Proceedings of the National Academy of Sciences | 1982 |
Familial progressive systemic sclerosis (scleroderma): immunological analysis of two patients and six siblings from a single kindred
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Clinical & Experimental Immunology | 1982 |
Normal Suppressor-Cell Activity in Systemic Lupus Erythematosus. ASstudy on 26 Cases
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Immunobiology | 1982 |
Mycobacterium fortuitum infection: Evidence of bactericidal defect due to hyperactive antigen-specific suppressor cells
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The American Journal of Medicine | 1982 |
Special characteristics of cellular immune function in normal individuals of the HLA-DR3 type
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Clinical Immunology and Immunopathology | 1982 |
Transglutaminase may mediate certain physiological effects of endogenous amines and of amine-containing therapeutic agents
DH Russell, JR Womble |
Life Sciences | 1982 |
The correlation between inducer/suppressor ratios, generation of concanavalin A-activated suppressor cells, and mitogen-stimulated proliferation of peripheral blood lymphocytes in patients with alopecia areata and normal controls
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Clinical Immunology and Immunopathology | 1982 |
Etude quantitative des sous-populations lymphocytaires régulatrices par anticorps monoclonaux au cours du syndrome de Gougerot-Sjögren
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La Revue de Médecine Interne | 1982 |
Case Report Disseminated Sporotrichosis Presenting as Sarcoidosis: Electron Microscopic and Immunologic Studies
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The American Journal of the Medical Sciences | 1982 |
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1982 | |
Effect of indomethacin on phytohemagglutinin-stimulated peripheral blood lymphocytes in thyroid autoimmune diseases
F Pacini, P Fragu, S Mariotti, LJ DeGroot |
Journal of Clinical Immunology | 1982 |
Lymphocyte-reactive Antibodies in SLE
RP Arles, RA WILLIAMS |
Clinics in rheumatic diseases | 1982 |
Antibodies to T cells in patients with systemic lupus erythematosus can induce antibody-dependent cell-mediated cytotoxicity against human T cells
S Kumagai, AD Steinberg, I Green |
Journal of Clinical Investigation | 1981 |
Autoantibody to an Immunoregulatory Inducer Population in Patients with Juvenile Rheumatoid Arthritis
C Morimoto, EL Reinherz, Y Borel, E Mantzouranis, AD Steinberg, SF Schlossman |
Journal of Clinical Investigation | 1981 |
Network theory in autoimmunity. In vitro suppression of serum anti-DNA antibody binding to DNA by anti-idiotypic antibody in systemic lupus erythematosus
NI Abdou, H Wall, HB Lindsley, JF Halsey, T Suzuki |
Journal of Clinical Investigation | 1981 |
Genetic and Immune Aspects of Systemic Lupus Erythematosus
JD Taurog, AD Steinberg |
International Journal of Dermatology | 1981 |
Maturation of B-Cell Differentiation Ability and T-Cell Regulatory Function in Infancy and Childhood
T Miyawaki, N Moriya, T Nagaoki, N Taniguchi |
Immunological Reviews | 1981 |
Human T Lymphocyte Antigens as Defined by Monoclonal Antibodies
BF Haynes |
Immunological Reviews | 1981 |
COMPARATIVE IMMUNOGLOBULIN SYNTHESIS BY BLOOD LYMPHOCYTES OF MYASTHENICS AND NORMALS
AI Levinson, A Dziarski, RP Lisak, B Zweiman, A Moskovitz, T Brenner, O Abramsky |
Annals of the New York Academy of Sciences | 1981 |
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AL Goldstein, MM Zatz, TL Low, R Jacobs |
Annals of the New York Academy of Sciences | 1981 |
Increased incidence of cervical atypia in women with systemic lupus erythematosus treated with chemotherapy
G Nyberg, O Eriksson, NG Westberg |
Arthritis & Rheumatism | 1981 |
Generation of a soluble immune response suppressor factor (IRSF) by unstimulated leukocytes of healthy subjects
MM Lederman, JJ Ellner, HM Rodman |
Clinical & Experimental Immunology | 1981 |
Concanavalin A-induced suppressor cell activity and in vitro immunoglobulin secretion in rheumatoid arthritis: Correlation with clinical and immunological parameters
JS Smolen, G Lanzer, O Scherak, EJ Menzel, WR Mayr, C Steffen, W Knapp |
Rheumatology International | 1981 |
Spontaneous and ConA-Induced Suppressor Lymphocytes: A Comparative Study
C Gattringer, H Huber, G Michlmayr, H Braunsteiner |
Immunobiology | 1981 |
In vitro anti-DNA antibody synthesis by peripheral blood lymphocytes in patients with systemic lupus erythematosus
M Kiyotaki, T Toguchi, T Abe, T Takeuchi, C Morimoto, M Homma |
Clinical Immunology and Immunopathology | 1981 |
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NI Abdou, HB Lindsley, A Pollock, DJ Stechschulte, G Wood |
Clinical Immunology and Immunopathology | 1981 |
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K Okudaira, K Tanimoto, Y Horiuchi |
Clinical Immunology and Immunopathology | 1981 |
Impaired immunoglobulin M synthesis by peripheral blood lymphocytes in systemic lupus erythematosus: A primary B-cell defect
KM Nies, RH Stevens, JS Louie |
Clinical Immunology and Immunopathology | 1981 |
Serum thymic hormone activity with systemic lupus erythematosus
VM Lewis, JJ Twomey, AD Steinberg, G Goldstein |
Clinical Immunology and Immunopathology | 1981 |
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AR Ahmed |
The Journal of Dermatology | 1981 |
The network theory in autoimmunity: In vitro modulation of DNA-binding cells by antiidiotypic antibody present in inactive lupus sera
NI Abdou, H Wall, J Clancy |
Journal of Clinical Immunology | 1981 |
Immunoregulatory T-cell dysfunction in polyclonal gammopathy
RA Robinson, NL Abdou, NI Abdou |
Journal of Clinical Immunology | 1981 |
Lymphocyte studies in pemphigus
AR Ahmed |
Archives of Dermatological Research | 1981 |
Immunological Aspects of Rheumatology
WC Dick |
1981 | |
Covert suppressor T cells in Crohn's disease
CO Elson, AS Graeff, SP James, W Strober |
Gastroenterology | 1981 |
Immunoregulation in Sjögren's Syndrome INFLUENCE OF SERUM FACTORS ON T-CELL SUBPOPULATIONS
HM Moutsopoulos, AS Fauci |
Journal of Clinical Investigation | 1980 |
Alterations in immunoregulatory T cell subsets in active systemic lupus erythematosus
C Morimoto, EL Reinherz, SF Schlossman, PH Schur, JA Mills, AD Steinberg |
Journal of Clinical Investigation | 1980 |
Natural cell mediated cytotoxicity in systemic lupus erythematosus
M Goto, K Tanimoto, Y Horiuchi |
Arthritis & Rheumatism | 1980 |
Suppressor factors: Potential for immunotherapy
RS Krakauer, JD Clough |
Immunopharmacology | 1980 |
Deficiency of T cell mediated regulation of anti-dna production in systemic lupus erythematosus
JD Clough, SA Frank, LH Calabrese |
Arthritis & Rheumatism | 1980 |
Studies of immune functions of patients with systemic lupus erythematosus
T Sakane, AD Steinberg, I Green |
Arthritis & Rheumatism | 1980 |
Heterogeneity of the spontaneously expanded and mitogen-induced generation of suppressor cell function of t cells on b cells in systemic lupus erythematosus
A Ruiz-Arguelles, D Alarcón-Segovia, L Llorente, JO Guidice-Knipping |
Arthritis & Rheumatism | 1980 |
Depressed T cell colony growth in systemic lupus erythematosus
ML Bernstein, A Winkelstein, SA Dobson |
Arthritis & Rheumatism | 1980 |
Developmental Maturations of B Cell Differentiation Ability and T Cell Regulatory Function in Man
T Miyawaki, N Moriya, T Nagaoka, A Yachie, N Taniguchi |
Pediatrics International | 1980 |
Defective immunoreguktion in multiple sclerosis
JM Goust, PM Hoffman, J Pryjma, EL Hogan, HH Fudenberg |
Annals of Neurology | 1980 |
Suppressor cell defect in SLE: relationship to native DNA binding
RS Krakauer, JD Clough, T Alexander, J Sundeen, DN Sauder |
Clinical & Experimental Immunology | 1980 |
Relationship between T cell subpopulations and the mitogen responsiveness and suppressor cell function of peripheral blood mononuclear cells in normal individuals
RM Victorino, HJ Hodgson |
Clinical & Experimental Immunology | 1980 |
Immune regulation in inflammatory bowel disease: absence of a serum inhibitor of suppressor cell function
BJ Kemler, E Alpert |
Clinical & Experimental Immunology | 1980 |
Impaired antigen-specific suppressor cell activity in patients with systemic lupus erythematosus
D Gladman, E Keystone, M Urowitz, D Cane, L Poplonski |
Clinical & Experimental Immunology | 1980 |
Myasthenia gravis with a monoclonal gammopathy
M Galli, G Landi, DL Restelli, G Scarlato |
Journal of the Neurological Sciences | 1980 |
Increased immunoglobulin-secreting cells in the blood of patients with active systemic lupus erythematosus
RM Blaese, J Grayson, AD Steinberg |
The American Journal of Medicine | 1980 |
Production of human antithyroglobulin in vitro
GN Beall, SR Kruger |
Clinical Immunology and Immunopathology | 1980 |
Characteristics of anti-T-cell antibodies in systemic lupus erythematosus: Evidence for selective reactivity with normal suppressor cells defined by monoclonal antibodies
C Morimoto, EL Reinherz, T Abe, M Homma, SF Schlossman |
Clinical Immunology and Immunopathology | 1980 |
Suppressor cell-mediated leukopenia and T-cell dysfunction in Nezelof's syndrome
SD Smith, CB Lindsley, NI Abdou |
Clinical Immunology and Immunopathology | 1980 |
Augmentation of immunoglobulin production in connective tissue disorders
IJ Russell, DL Conn, CH McKenna, JD Stobo |
Clinical Immunology and Immunopathology | 1980 |
Multiple concurrent immunoregulatory defects in cancer patients with depressed PHA-induced lymphocyte DNA synthesis
DP Braun, MA Cobleigh, JE Harris |
Clinical Immunology and Immunopathology | 1980 |
Spontaneously enhanced in vitro immunoglobulin synthesis by B cells in systemic lupus erythematosus
K Okudaira, K Tanimoto, T Nakamura, Y Horiuchi |
Clinical Immunology and Immunopathology | 1980 |
Modulation of conconavalin-A-induced suppressor cell activation by prostaglandin E2
JS Goodwin |
Cellular Immunology | 1980 |
Suppression of immunoglobulin synthesis of systemic lupus erythematosus patients by concanavalin A-activated normal human spleen cell supernatants
DN Ilfeld, RS Krakauer |
Clinical Immunology and Immunopathology | 1980 |
Biochemistry of Schizophrenia and Addiction
G Hemmings |
1980 | |
Abnormal regulation of immunoglobulin synthesis in vitro in primary biliary cirrhosis
SP James, CO Elson, EA Jones, W Strober |
Gastroenterology | 1980 |
Suppressor-Cell Antibody in Systemic Lupus Erythematosus POSSIBLE MECHANISM FOR SUPPRESSOR-CELL DYSFUNCTION
A Sagawa, NI Abdou |
Journal of Clinical Investigation | 1979 |
Detection of Antilymphocyte Antibody with Two-Color Method in Systemic Lupus Erythematosus and Its Heterogeneous Specificities against Human T-Cell Subsets
K Okudaira, H Nakai, T Hayakawa, T Kashiwado, K Tanimoto, Y Horiuchi, T Juji |
Journal of Clinical Investigation | 1979 |
Studies of immune functions of patients with systemic lupus erythematosus. T-cell subsets and antibodies to T-cell subsets
T Sakane, AD Steinberg, JP Reeves, I Green |
Journal of Clinical Investigation | 1979 |
Angioimmunoblastic lymphadenopathy with dysproteinemia
AZ Bluming, HG Cohen, A Saxon |
The American Journal of Medicine | 1979 |
Suppressor cell function defect in idiopathic systemic lupus erythematosus
RS Krakauer, JD Clough, S Frank, JT Sundeen |
Clinical Immunology and Immunopathology | 1979 |
Suppression of immunoglobulin synthesis by monocytes in health and in patients with systemic lupus erythematosus
AH Laughter, MD Lidsky, JJ Twomey |
Clinical Immunology and Immunopathology | 1979 |
The Antigens
PJ Lachmann |
The Antigens | 1979 |
Suppressor activity of peripheral blood mononuclear cells in patients with chronic discoid lupus erythematosus
J Hunyadi, A Dobozy, S Husz, AS Kenderessy, G Szegedi, N Simon |
Archives of Dermatological Research | 1979 |