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Citations to this article

Glucose Disposal during Insulinopenia in Somatostatin-Treated Dogs: THE ROLES OF GLUCOSE AND GLUCAGON
Gerald I. Shulman, … , William W. Lacy, Alan D. Cherrington
Gerald I. Shulman, … , William W. Lacy, Alan D. Cherrington
Published August 1, 1978
Citation Information: J Clin Invest. 1978;62(2):487-491. https://doi.org/10.1172/JCI109150.
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Glucose Disposal during Insulinopenia in Somatostatin-Treated Dogs: THE ROLES OF GLUCOSE AND GLUCAGON

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Abstract

The first aim of this study was to determine whether the plasma glucose level can regulate hepatic glucose balance in vivo independent of its effects on insulin and glucagon secretion. To accomplish this, glucose was infused into conscious dogs whose basal insulin and glucagon secretion had been replaced by exogenous intraportal insulin and glucagon infusion after somatostatin inhibition of endogenous pancreatic hormone release. The acute induction of hyperglycemia (mean increment of 121 mg/dl) in the presence of basal levels of insulin (7±1 μU/ml) and glucagon (76±3 pg/ml) resulted in a 56% decrease in net hepatic glucose production but did not cause net hepatic glucose uptake.

Authors

Gerald I. Shulman, John E. Liljenquist, Phillip E. Williams, William W. Lacy, Alan D. Cherrington

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Year: 2024 2022 2020 2019 2017 2015 2014 2012 2011 2010 2009 2007 2006 2003 2001 2000 1999 1998 1997 1996 1995 1994 1993 1992 1991 1990 1989 1988 1987 1986 1985 1984 1983 1982 1981 1980 1979 1964 Total
Citations: 1 1 1 1 1 1 2 1 1 1 2 1 1 2 1 2 3 3 2 1 2 1 1 5 6 1 5 4 9 3 4 4 5 6 6 2 4 1 98
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S Dufour, V Lebon, GI Shulman, KF Petersen
American journal of physiology. Endocrinology and metabolism 2009
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International Textbook of Diabetes Mellitus 2003
Regulation of hepatic and peripheral glucose disposal
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Clinical Nutrition 2000
Banting Lecture 1997. Control of glucose uptake and release by the liver in vivo
L Rossetti, A Giaccari, N Barzilai, K Howard, G Sebel, M Hu
Journal of Clinical Investigation 1999
Autoregulation of glucose production in health and disease
L Tappy, R Chioléro, M Berger
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Banting Lecture 1997. Control of glucose uptake and release by the liver in vivo
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Regulation of endogenous glucose production by glucose per se is impaired in type 2 diabetes mellitus
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Carbon Flux via the Pentose Phosphate Pathway Regulates the Hepatic Expression of the Glucose-6-phosphatase and Phosphoenolpyruvate Carboxykinase Genes in Conscious Rats
D Massillon, W Chen, N Barzilai, D Prus-Wertheimer, M Hawkins, R Liu, R Taub, L Rossetti
The Journal of biological chemistry 1998
Physiological changes in circulating glucagon alter hepatic glucose disposition during portal glucose delivery
LC Holste, CC Connolly, MC Moore, DW Neal, AD Cherrington
American journal of physiology. Endocrinology and metabolism 1997
Abnormal regulation of HGP by hyperglycemia in mice with a disrupted glucokinase allele
L Rossetti, W Chen, M Hu, M Hawkins, N Barzilai, S Efrat
American journal of physiology. Endocrinology and metabolism 1997
The roles of insulin and glucagon in the regulation of hepatic glycogen synthesis and turnover in humans
M Roden, G Perseghin, KF Petersen, JH Hwang, GW Cline, K Gerow, DL Rothman, GI Shulman
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Impact of infection on hepatic disposal of a peripheral glucose infusion in the conscious dog
OP McGuinness, J Jacobs, C Moran, B Lacy
American journal of physiology. Endocrinology and metabolism 1995
Quantitation of hepatic glucose fluxes and pathways of hepatic glycogen synthesis in conscious mice
D Massillon, W Chen, M Hawkins, R Liu, N Barzilai, L Rossetti
American journal of physiology. Endocrinology and metabolism 1995
Pulsatility does not alter the response to a physiological increment in glucagon in the conscious dog
RL Dobbins, SN Davis, DW Neal, C Cobelli, AD Cherrington
American journal of physiology. Endocrinology and metabolism 1994
Effect of hepatic nerves on disposition of an intraduodenal glucose load
MC Moore, GI Shulman, A Giaccari, MJ Pagliassotti, G Cline, D Neal, L Rossetti, AD Cherrington
American journal of physiology. Endocrinology and metabolism 1993
Surgical alterations of the pancreas and insulin-independent glucose disposal
DA Krusch, TL Pruett, G Cornett, JB Hanks
Journal of Surgical Research 1992
BASREP: a method for maintaining euglycemia during somatostatin suppression of pancreatic secretion
G Pacini, M Ader, RN Bergman
Computer Methods and Programs in Biomedicine 1992
Role of hepatic nerves in response of liver to intraportal glucose delivery in dogs
B Adkins-Marshall, MJ Pagliassotti, JR Asher, CC Connolly, DW Neal, PE Williams, SR Myers, GK Hendrick, RB Adkins, AD Cherrington
American journal of physiology. Endocrinology and metabolism 1992
Restoration of stable metabolic conditions during islet suppression in dogs
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Short-term regulation of insulin-mediated glucose utilization in four-day fasted human volunteers: role of amino acid availability
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Intraportal glucose delivery alters the relationship between net hepatic glucose uptake and the insulin concentration
SR Myers, OP McGuinness, DW Neal, AD Cherrington
Journal of Clinical Investigation 1991
Intraportal glucose delivery enhances the effects of hepatic glucose load on net hepatic glucose uptake in vivo
SR Myers, DW Biggers, DW Neal, AD Cherrington
Journal of Clinical Investigation 1991
Effects of small changes in glucagon on glucose production during a euglycemic, hyperinsulinemic clamp
SR Myers, MP Diamond, BA Adkins-Marshall, PE Williams, R Stinsen, AD Cherrington
Metabolism 1991
Mechanism of growth hormone-induced postprandial carbohydrate intolerance in humans
P Butler, E Kryshak, R Rizza
American journal of physiology. Endocrinology and metabolism 1991
Amino Acids Enhance Insulin Resistance to Exogenous Glucose Infusion in Overnight-Fasted Humans
PJ Flakoll, M Kulaylat, M Frexes-Steed, JO Hill, NN Abumrad
JPEN. Journal of parenteral and enteral nutrition 1991
Fuel Homeostasis and the Nervous System
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1991
Evidence that hyperglycaemia per se does not inhibit hepatic glucose production in man
MJ Mller, KJ Acheson, AG Burger, E Jequier
European Journal of Applied Physiology and Occupational Physiology 1990
Intravenous and subcutaneous administration of a long-acting somatostatin analogue: effects on glucose metabolism and splanchnic haemodynamics in healthy subjects
LS Eriksson, J Wahren
European Journal of Clinical Investigation 1989
Influence of the route of glucose administration on hepatic glycogen repletion
GI Shulman, L Rossetti
American journal of physiology. Endocrinology and metabolism 1989
Escape of hepatic glucose production during hyperglycemic clamp
D Elahi, GS Meneilly, KL Minaker, DK Andersen, JW Rowe
American journal of physiology. Endocrinology and metabolism 1989
Review: Parenteral Nutrition in Patients with Diabetes Mellitus: Theoretical and Practical Considerations
M Mcmahon, N Manji, DF Driscoll, BR Bistrian
JPEN. Journal of parenteral and enteral nutrition 1989
Regulation of Carbohydrate Metabolism and Response to Hypoglycemia
PC Butler, RA Rizza
Endocrinology and metabolism clinics of North America 1989
Effect of chronic intracerebroventricular morphine to feeding responses in male rats
RK Dhatt, AK Rattan, HK Mangat
Physiology & Behavior 1988
Regulation of hepatic glucose output by glucose in vivo
MJ Müller, J Möring, HJ Seitz
Metabolism 1988
Effect of alanine concentration independent of changes in insulin and glucagon on alanine and glucose homeostasis in the conscious dog
MP Diamond, RC Rollings, KE Steiner, PE Williams, WW Lacy, AD Cherrington
Metabolism 1988
Drugs, Athletes, and Physical Performance
JA Thomas
1988
Importance of the route of intravenous glucose delivery to hepatic glucose balance in the conscious dog
BA Adkins, SR Myers, GK Hendrick, RW Stevenson, PE Williams, AD Cherrington
Journal of Clinical Investigation 1987
Role of counterregulatory hormones in the regulation of hepatic glucose metabolism
L Saccà
Diabetes / Metabolism Reviews 1987
Insulin, glucagon, and glucose as regulators of hepatic glucose uptake and production in vivo
AD Cherrington, RW Stevenson, KE Steiner, MA Davis, SR Myers, BA Adkins, NN Abumrad, PE Williams
Diabetes / Metabolism Reviews 1987
Lack of effect of somatostatin on epinephrine-stimulated glucose production in the dog
RW Stevenson, KE Steiner, PE Williams, AD Cherrington
Metabolism 1987
Hepatic response to insulin in control of glucose kinetics in the neonatal lamb
RM Cowett, D Tenenbaum
Metabolism 1987
Basal glucose homeostasis with and without fixed concentrations of glucagon and insulin
RA Jackson, JB Hamling, BM Sim, PM Blix, JB Jaspan, S Markanday, JD Nabarro
Metabolism 1987
Net hepatic lactate balance following mixed meal feeding in the four-day fasted conscious dog
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Metabolism 1987
Effect of somatostatin on glucose homeostasis in conscious long-fasted dogs
RW Stevenson, KE Steiner, GK Hendrick, AD Cherrington
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Selective suppression of hepatic glucose output by human proinsulin in the dog
M Lavelle-Jones, MH Scott, O Kolterman, AH Rubenstein, JM Olefsky, AR Moossa
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Effects of alpha and beta adrenergic blockade on hepatic glucose balance before and after oral glucose. Role of insulin and glucagon
Z Chap, T Ishida, J Chou, L Michael, C Hartley, M Entman, JB Field
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Metabolism 1986
Role of hepatic autoregulation in defense against hypoglycemia in humans
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1985
Effects of morphine on glucose homeostasis in the conscious dog
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Extrapancreatic effect of somatostatin infusion to increase glucose clearance
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Catecholamine responses and their interactions with other glucoregulatory hormones
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Roles of glucagon and epinephrine in hypoglycemic and nonhypoglycemic glucose counterregulation in humans
PE Cryer, TF Tse, WE Clutter, SD Shah
American journal of physiology. Endocrinology and metabolism 1984
Neuroendocrine responses to glucose ingestion in man. Specificity, temporal relationships, and quantitative aspects
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Journal of Clinical Investigation 1983
Effects of insulin and glucose on the production and utilization of glucose in sheep (Ovis aries)
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The effect of hyperglycaemia on the rates of appearance and metabolic clearance of glucose in sheep (Ovis aries)
RP Brockman
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Glucagon I
PJ Lefèbvre
1983
Studies on the mechanism by which exogenous glucose is converted into liver glycogen in the rat. A direct or an indirect pathway?
CB Newgard, LJ Hirsch, DW Foster, JD McGarry
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Differential effects of insulin on splanchnic and peripheral glucose disposal after an intravenous glucose load in man
L Saccà, M Cicala, B Trimarco, B Ungaro, C Vigorito
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Insulin increases the maximum velocity for glucose uptake without altering the Michaelis constant in man. Evidence that insulin increases glucose uptake merely by providing additional transport sites
I Gottesman, L Mandarino, C Verdonk, R Rizza, J Gerich
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2 The effects of insulin on carbohydrate metabolism in vivo
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L Saccà, C Vigorito, M Cicala, B Ungaro, R S Sherwin
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Mechanisms of Epinephrine-induced Glucose Intolerance in Normal Humans
L Saccà, C Vigorito, M Cicala, B Ungaro, RS Sherwin
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Cyclic Nucleotides
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1982
Influence of abdominal surgical trauma and intraoperative infusion of glucose on splanchnic glucose metabolism in man
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Autoregulation by glucose of hepatic glucose balance: Permissive effect of insulin
MB Davidson
Metabolism 1981
The glucoregulatory response to intravenous glucose infusion in normal man: Roles of insulin and glucose
L Saccà, D Vitale, M Cicala, B Trimarco, B Ungaro
Metabolism 1981
Glucagon and the a Cell: Physiology and Pathophysiology(First of Two Parts)
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Glucoregulatory and metabolic response to exercise in obese noninsulin-dependent diabetes
HL Minuk, M Vranic, EB Marliss, AK Hanna, AM Albisser, B Zinman
American journal of physiology. Endocrinology and metabolism 1981
Effect of counterregulatory hormones on kinetic response to ingested glucose in dogs
L Sacca, M Cicala, G Corso, B Ungaro, RS Sherwin
American journal of physiology. Endocrinology and metabolism 1981
Effect of glucose, independent of changes in insulin and glucagon secretion, on alanine metabolism in the conscious dog
GI Shulman, WW Lacy, JE Liljenquist, U Keller, PE Williams, AD Cherrington
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1980
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Contemporary Metabolism
N Freinkel
1979
Advances in Metabolic Disorders
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