Citations to this article

Bone marrow-derived lymphoid cell lines from patients with agammaglobulinemia.
J Schwaber, … , H Lazarus, F S Rosen
J Schwaber, … , H Lazarus, F S Rosen
Published August 1, 1978
Citation Information: J Clin Invest. 1978;62(2):302-310. https://doi.org/10.1172/JCI109130.
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Research Article

Bone marrow-derived lymphoid cell lines from patients with agammaglobulinemia.

Abstract

In vitro infection with Epstein-Barr virus of bone marrow-derived (B) lymphocytes from blood of patients with X-linked or common varied agammaglobulinemia resulted in the establishment of long-term B-lymphoid cell lines (LCL). LCL were established only with B lymphocytes from patients whose B cells failed to respond to in vitro mitogenic stimulation. In contrast, lymphocytes from patients without small B lymphocytes or with B cells that synthesized but failed to secrete Ig failed uniformly to establish LCL. Analysis of the "nonsecretory" B lymphocytes demonstrated the presence of receptors for C3b and C3d as well as surface Ig, but absence of detectable receptors for Epstein-Barr virus. All of the six cell lines that were established formed rosettes with EAC3 but not with sheep erythrocytes. Four of the six LCL were principally surface IgD bearing and did not synthesize detectable Ig for secretion. Two of the cell lines were indistinguishable from cell lines from normal individuals: they had surface IgG, A, M, and D and synthesized and secreted Ig.

Authors

J Schwaber, H Lazarus, F S Rosen

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Year: 2008 1997 1995 1990 1989 1988 1985 1984 1983 1982 1981 1980 1978 Total
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Citations to this article (27)

Title and authors Publication Year
The capacity of interleukin-4 to induce in vitro IgE synthesis by B cells of patients with common variable immunodeficiency
G Pastorelli, MG Roncarolo, C Peronne, PA Tovo, JE Vries 		Clinical & Experimental Immunology 2008
Transcription of germline VH gene elements by normal human fetal liver
N Koenig, B Malone, S Hoch, J Schwaber 		Molecular Immunology 1997
The Primary Immunodeficiencies
FS Rosen, MD Cooper, RJ Wedgwood 		New England Journal of Medicine 1995
The capacity of interleukin-4 to induce in vitro IgE synthesis by B cells of patients with common variable immunodeficiency.
Pastorelli G, Roncarolo MG, Peronne C, Tovo PA, de Vries JE 		Clinical & Experimental Immunology 1990
Interleukin-4 suppresses immunoglobulin production by peripheral blood lymphocytes of patients with common variable immunodeficiency (CVI) induced by supernatants of T cell clones
G Pastorelli, MG Roncarolo, JL Touraine, F Rousset, J Pene, JE de Vries 		Clinical & Experimental Immunology 1989
HLA-DR molecules on all cells are electrophoretically unique
JM Pesando, P Hoffman, MA Stucki 		Leukemia Research 1989
Regulation of the production of secretory and membrane immunoglobulin during lymphocyte development
SL Brown, SL Morrison 		Clinical Immunology and Immunopathology 1989
B lymphocytes from X-linked agammaglobulinemia. Delayed expression of light chain and demonstration of Lyonization in carriers
J Schwaber, J Payne, R Chen 		Journal of Clinical Investigation 1988
Bone Marrow Findings in Immunodeficiency Syndromes
MJ Duggan, DD Weisenburger, NC Sun, DT Purtilo 		Hematology/Oncology Clinics of North America 1988
Human Hybridomas and Monoclonal Antibodies
EG Engleman, SK Foung, JW Larrick, AA Raubitschek 		1985
Human-human hybrids secreting pneumococcal antibodies
JF Schwaber, MR Posner, SF Schlossman, H Lazarus 		Human Immunology 1984
Epstein-Barr virus-induced lymphoblastoid cell lines derived from the peripheral blood of patients with X-linked agammaglobulinemia can secrete IgM
D Levitt, H Ochs, RJ Wedgwood 		Journal of Clinical Immunology 1984
Early pre-B cells from normal and X-linked agammaglobulinaemia produce Cμ without an attached VH region
J Schwaber, H Molgaard, SH Orkin, HJ Gould, FS Rosen 		Nature 1983
Frequency of anti-DNA antibody producing cells from normals and patients with systemic lupus erythematosus
S Hoch, PH Schur, J Schwaber 		Clinical Immunology and Immunopathology 1983
Comparison of a rabbit heteroantiserum and a murine monoclonal antibody raised against a human epithelial ovarian carcinoma cell line
R Berkowitz, S Kabawat, H Lazarus, R Colvin, R Knapp, RC Bast 		American Journal of Obstetrics and Gynecology 1983
Epstein-Barr virus-induced immunoglobulin synthesis by B cells from individuals with late-onset panhypogammaglobulinemia
PL Haber, H Kubagawa, MD Cooper 		Journal of Clinical Immunology 1983
Immature B cells in fetal development and immunodeficiency: Studies of IgM, IgG, IgA and IgD production in vitro using epstein-Barr virus activation
S Pereira, D Webster, T Platts-Mills 		European Journal of Immunology 1982
Isotypes of surface immunoglobulin on B lymphocytes from patients with immune deficiency
JF Schwaber, FS Rosen 		Journal of Clinical Immunology 1982
Reactivity of a monoclonal antibody with human ovarian carcinoma
RC Bast, M Feeney, H Lazarus, LM Nadler, RB Colvin, RC Knapp 		Journal of Clinical Investigation 1981
Deficiency of T Helper Cells in Transient Hypogammaglobulinemia of Infancy
RL Siegel, T Issekutz, J Schwaber, FS Rosen, RS Geha 		New England Journal of Medicine 1981
IgM-restricted production of immunoglobulin by lymphoid cell lines from patients with immunodeficiency with hyper IgM (dysgammaglobulinemia)
JF Schwaber, H Lazarus, FS Rosen 		Clinical Immunology and Immunopathology 1981
Human cell lines express multiple populations of Ia-like molecules
JM Pesando, LM Nadler, H Lazarus, KJ Tomaselli, P Stashenko, J Ritz, H Levine, EJ Yunis, SF Schlossman 		Human Immunology 1981
Epstein-Barr Virus-induced Lymphoblastoid Cell Lines from Patients with Primary Immunodeficiency Diseases
S Tsuchiya, T Konno, K Tada, Y Ono 		Scandinavian Journal of Immunology 1980
Pre-B cells and other possible precursor lymphoid cell lines derived from patients with X-linked agammaglobulinemia
SM Fu, JN Hurley, JM McCune, HG Kunkel, RA Good 		Journal of Experimental Medicine 1980
Functional 'immaturity' of isolated B cells from patients with hypogammaglobulinaemia
GC de Gast, SR Wilkins, AD Webster, A Rickinson, TA Platts-Mills 		Clinical & Experimental Immunology 1980
Predominance of B-lymphocyte function after cultured thymus fragment therapy in severe combined immunodeficiency disease
JF Jones, OF Sieber, VA Fulginiti, H Ochs, H Schulte-Wisserman, R Hong 		Clinical Immunology and Immunopathology 1980
Induction of human immunoglobulin synthesis and secretion in somatic cell hybrids of mouse myeloma and human B lymphocytes from patients with agammaglobulinemia
JF Schwaber, FS Rosen 		Journal of Experimental Medicine 1978

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