Citations to this article

A common uptake system for serotonin and dopamine in human platelets.
G S Omenn, L T Smith
G S Omenn, L T Smith
Published August 1, 1978
Citation Information: J Clin Invest. 1978;62(2):235-240. https://doi.org/10.1172/JCI109121.
View: Text | PDF
Research Article

A common uptake system for serotonin and dopamine in human platelets.

Abstract

Kinetic and pharmacologic properties of uptake of serotonin and dopamine by normal human platelets have been investigated to test whether platelets can be employed as a model system for the reuptake of serotonin and dopamine in brain. Uptake of serotonin into platelets closely resembles reuptake of serotonin into serotonergic neurons. In contrast, uptake of dopamine into platelets appears to be mediated inefficiently via the specific serotonin uptake mechanism, based upon several lines of evidence. Serotonin and dopamine compete with each other, Antidepressant drugs, which are competitive inhibitors of uptake of both of these neurotransmitters, act at the same concentration of drug despite large differences in the Km values. Serotonin antagonists inhibit both serotonin and dopamine uptake. Finally, a serotonin-specific uptake inhibitor (fluoxetine) blocks dopamine, as well as serotonin, uptake.

Authors

G S Omenn, L T Smith

×

Total citations by year

Year: 2022 2019 2016 2010 2006 2004 1997 1995 1994 1993 1992 1990 1989 1987 1986 1985 1984 1983 1981 1980 Total
Citations: 1 1 1 2 2 1 1 1 1 1 5 3 2 3 1 3 3 1 5 4 42
Citation information

Citations to this article (42)

Title and authors Publication Year
Functional reorganization of monoamine transport systems during villous trophoblast differentiation: evidence of distinct differences between primary human trophoblasts and BeWo cells.
Vachalova V, Karahoda R, Ottaviani M, Anandam KY, Abad C, Albrecht C, Staud F 		Reproductive biology and endocrinology : RB&E 2022
Engineered human platelet-derived microparticles as natural vectors for targeted drug delivery.
Kailashiya J, Gupta V, Dash D 		Oncotarget 2019
Are the changes in the peripheral brain-derived neurotrophic factor levels due to platelet activation?
M Serra-Millàs 		World Journal of Psychiatry 2016
Data Mining in Proteomics
M Hamacher, M Eisenacher, C Stephan 		2010
Encyclopedia of Psychopharmacology
IP Stolerman, LH Price 		2010
HUPO Brain Proteome Project: Summary of the pilot phase and introduction of a comprehensive data reprocessing strategy
M Hamacher, R Apweiler, G Arnold, A Becker, M Blüggel, O Carrette, C Colvis, MJ Dunn, T Fröhlich, M Fountoulakis, A Hall, F Herberg, J Ji, H Kretzschmar, P Lewczuk, G Lubec, K Marcus, L Martens, NP Bustamante, YM Park, SR Pennington, J Robben, K Stühler, KA Reidegeld, P Riederer, J Rossier, JC Sanchez, M Schrader, C Stephan, D Tagle, H Thiele, J Wang, J Wiltfang, JS Yoo, C Zhang, J Klose, HE Meyer 		PROTEOMICS 2006
Increased cortisol in women with intimate partner violence-related posttraumatic stress disorder☆☆Research was conduited at the University of Pittsburgh. First author is now at the Department of Veterans Affairs, San Francisco and at the University of California, san Francisco. Portions of this data were presented at the new york Academy of Sciences Meeting; Psychobiology of Post-Traumatic stress Disorder: A Decade of this progress, New York (September 11-13, 2005). An extended abstract of this presentation is in press in the Annals of the york Academy of Sciences
SS Inslicht, CR Marmar, TC Neylan, TJ Metzler, SL Hart, C Otte, SE McCaslin, GL Larkin, KB Hyman, A Baum 		Psychoneuroendocrinology 2006
Effects of 5-HT2A receptor antagonist on blood flow in chronically compressed nerve roots
M Sekiguchi, S Konno, S Kikuchi 		Journal of the Peripheral Nervous System 2004
Current Update in Psychoimmunology
G Wieselmann 		1997
Decreased dopamine uptake into platelet storage granules in Gilles de la Tourette disease
JM Rabey, Z Oberman, E Graff, AD Korczyn 		Biological Psychiatry 1995
Fluoxetine at anorectic doses does not have properties of a dopamine uptake inhibitor
RW Fuller, SK Hemrick-Luecke, HD Snoddy 		Journal of Neural Transmission 1994
[3H] dopamine uptake by platelet storage granules in Parkinson's disease
JM Rabey, H Shabtai, E Graff, Z Oberman 		Life Sciences 1993
Evidence for various tryptamines and related compounds acting as substrates of the platelet 5-hydroxytryptamine transporter
R W�lfel, KH Graefe 		Naunyn-Schmiedeberg's Archives of Pharmacology 1992
Anorectic Activity of Fluoxetine and Norfluoxetine in Rats: Relationship Between Brain Concentrations and In-vitro Potencies on Monoaminergic Mechanisms
S Caccia, A Bizzi, G Coltro, C Fracasso, E Frittoli, T Mennini, S Garattini 		Journal of Pharmacy and Pharmacology 1992
An assay to measure the simultaneous uptake of [3H]dopamine and [14C]serotonin by the human platelet reveals an imipramine-insensitive [3H]dopamine uptake mechanism
B Dean, DL Copolov 		Life Sciences 1992
[3H] Dopamine uptake by platelet storage granules in schizophrenia
JM Rabey, A Lerner, M Sigal, E Graff, Z Oberman 		Life Sciences 1992
Evidence for various tryptamines and related compounds acting as substrates of the platelet 5-hydroxytryptamine transporter
R Wlfel, KH Graefe 		Naunyn-Schmiedeberg's Archives of Pharmacology 1992
Validation of a method to measure the uptake of [3H]dopamine by human platelets
B Dean, J Kulkarni, DL Copolov 		Clinica Chimica Acta 1990
Platelet catecholamine contents are cumulative indexes of sympathoadrenal activity
KG Chamberlain, RG Pestell, JD Best 		American journal of physiology. Endocrinology and metabolism 1990
Current Aspects of the Neurosciences
NN Osborne 		1990
Dopamine uptake by platelets is selective, temperature dependent and not influenced by the dopamine-D1 or dopamine-D2 receptor
B Dean, DL Copolov 		Life Sciences 1989
Dopamine uptake by the human platelet: effects of dopamine receptor agonists
B Dean, DL Copolov 		European Journal of Pharmacology 1989
Catecholamines metabolism in infantile autism: A controlled study of 22 autistic children
JM Launay, C Bursztejn, P Ferrari, C Dreux, A Braconnier, E Zarifian, S Lancrenon, J Fermanian 		Journal of Autism and Developmental Disorders 1987
3H-spiroperidol binding sites in blood platelets
AS Khanna, AK Agrawal, PK Seth 		Biochemical and Biophysical Research Communications 1987
Catecholamines metabolism in infantile autism: A controlled study of 22 autistic children
, C Bursztejn, P Ferrari, C Dreux, A Braconnier, E Zarifian, S Lancrenon, J Fermanian 		Journal of Autism and Developmental Disorders 1987
Neurotransmitter receptors, endocrine responses and the biological substrates of depression: A review
BE Leonard 		Human Psychopharmacology: Clinical and Experimental 1986
Approaches to the study of cerebral dopamine metabolism in certain extrapyramidal diseases
VP Barkhatova, I Kandel', EG Demina 		Neuroscience and Behavioral Physiology 1985
Uptake of gamma-aminobutyric acid by human blood platelets: Comparison with CNS uptake
JW Hambley, GA Johnston 		Life Sciences 1985
Approaches to the study of cerebral dopamine metabolism in certain extrapyramidal diseases
VP Barkhatova, , EG Demina 		Neuroscience and Behavioral Physiology 1985
The Impact of Protein Chemistry on the Biomedical Sciences
M Vaughan 		The Impact of Protein Chemistry on the Biomedical Sciences 1984
Time-dependent inhibition of platelet aggregation by dopamine and 3-methoxytyramine
H Kodaira, M Ishikawa, Y Komoda, T Nakajima 		Biochemical Pharmacology 1984
Platelets and biogenic amines: I. Platelets are poor investigative models for dopamine re-uptake
R Malingren 		Psychopharmacology 1984
Assessment of blood platelets as a model for CNS response: Comparative effects of caffeine on 5-HT uptake and release mechanisms in rat platelets and rat brain serotonin neurons
DT Chou, H Cuzzone, KR Hirsh 		Life Sciences 1983
Dopamine uptake in platelets: Two different low-affinity, saturable mechanisms
O Lingjærde, O Kildemo 		Agents and Actions 1981
The effect of tryptolines (1, 2, 3, 4-tetrahydro-β-carbolines) on monoamine metabolism and the platelet aggregation response in human platelets
MB Youdim, B Oppenheim 		Neuroscience 1981
The uptake and release of an 125I-labelled analogue of chloroquine (IQ3) by rat blood platelets
MN Eakins, S Somaia 		International Journal of Nuclear Medicine and Biology 1981
The uptake of tyramine by rat platelets
L Bianchi, L Stella, G Dagnino, GD Gaetano, EC Rossi 		Biochemical Pharmacology 1981
Methods in Clinical Pharmacology—Central Nervous System
MH Lader, A Richens 		1981
A study of gamma-aminobutyric acid uptake in normal and Down's syndrome platelets
L Enns, EE McCoy 		British Journal of Pharmacology 1980
Biochemical assessment of antidepressive drugs
K Ghose 		British Journal of Clinical Pharmacology 1980
A STUDY OF γ-AMINOBUTYRIC ACID UPTAKE IN NORMAL AND DOWN'S SYNDROME PLATELETS
L Enns, EE McCOY 		British Journal of Pharmacology 1980
Platelet dopamine uptake in autistic and other psychotic children. Inhibition by imipramine
GA Szekely, R Caplan, A Rotman 		Progress in Neuro-Psychopharmacology 1980

Advertisement