The metabolic clearance rate (MCR) of synthetic human connecting peptide (C-peptide) was measured with a single-dose injection technique in six normal and seven diabetic subjects and with a constant infusion technique in one normal subject. The MCR of C-peptide did not differ in normal subjects (4.4 ml/min per kg; range, 3.7-4.9) and in diabetic subjects (4.7 ml/min per kg; range, 3.7-5.8). Employment of both techniques in one subject gave similar MCR. The average half-life of C-peptide in plasma calculated from the last 1-h period of the single-dose injection studies was longer in the insulin-dependent diabetics (42.5 min; range, 39.4-48.5) than in the normal subjects (33.5 min; range, 24.9-45.3). These results indicate that the beta-cell secretory capacity of normal and insulin-dependent diabetic subjects can be compared by measuring the C-peptide concentration in peripheral venous plasma. The difference in the half-life of C-peptide in plasma between diabetics and normals suggests an altered kinetics of the disappearance of the peptide, while the overall metabolism, as expressed by the MCR, is similar.
O K Faber, C Hagen, C Binder, J Markussen, V K Naithani, P M Blix, H Kuzuya, D L Horwitz, A H Rubenstein, N Rossing
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Suppression of Endogenous Insulin Secretion by Euglycemic Hyperinsulinemia.
Karakaplan ND, Song Y, Laurenti MC, Vella A, Jensen MD |
The Journal of clinical endocrinology and metabolism | 2024 |
High Doses of Exogenous Glucagon Stimulate Insulin Secretion and Reduce Insulin Clearance in Healthy Humans.
Gray SM, Goonatilleke E, Emrick MA, Becker JO, Hoofnagle AN, Stefanovski D, He W, Zhang G, Tong J, Campbell J, D'Alessio DA |
Diabetes | 2024 |
Urinary C-Peptide to Creatinine Ratio (UCPCR) as Indicator for Metabolic Risk in Apparently Healthy Adults-A BioPersMed Cohort Study.
Reintar S, Pöchhacker M, Obermayer A, Eberhard K, Zirlik A, Verheyen N, von Lewinski D, Scherr D, Hutz B, Haudum CW, Pieber TR, Sourij H, Obermayer-Pietsch B |
Nutrients | 2023 |
Quantifying beta cell function in the preclinical stages of type 1 diabetes.
Galderisi A, Carr ALJ, Martino M, Taylor P, Senior P, Dayan C |
Diabetologia | 2023 |
Proinsulin-to-C-Peptide Ratio as a Marker of β-Cell Function in African American and European American Adults.
Couch CA, Piccinini F, Fowler LA, Garvey WT, Gower BA |
Diabetes care | 2023 |
Multiplexed quantification of insulin and C-peptide by LC-MS/MS without the use of antibodies.
Foulon N, Goonatilleke E, MacCoss MJ, Emrick MA, Hoofnagle AN |
2022 | |
The elusive cephalic phase insulin response: triggers, mechanisms, and functions
Langhans W, Watts AG, Spector AC |
Physiological reviews | 2022 |
C-peptide enhances glucagon secretion in response to hyperinsulinemia under euglycemic and hypoglycemic conditions
Mary Courtney Moore, Shana O. Warner, Yufei Dai, Nicole Sheanon, Marta Smith, Ben Farmer, Rebecca L. Cason, Alan D. Cherrington, Jason J. Winnick |
JCI Insight | 2021 |
Combination of disease duration‐to‐age at diagnosis and hemoglobin A1c‐to‐serum C‐peptide reactivity ratios predicts patient response to glucose‐lowering medication in type 2 diabetes: A retrospective cohort study across Japan (JDDM59)
A Kanatsuka, Y Sato, Y Higashi, Y Goto, K Kawai, H Maegawa |
Journal of Diabetes Investigation | 2021 |
Stroke Revisited: Diabetes in Stroke
SH Lee, DW Kang |
2021 | |
Streptozotocin-Induced Diabetes in a Mouse Model (BALB/c) Is Not an Effective Model for Research on Transplantation Procedures in the Treatment of Type 1 Diabetes.
Wszola M, Klak M, Kosowska A, Tymicki G, Berman A, Adamiok-Ostrowska A, Olkowska-Truchanowicz J, Uhrynowska-Tyszkiewicz I, Kaminski A |
Biomedicines | 2021 |
Can chewing gum be another source of preanalytical variability in fasting outpatients?
Ricardas Stonys, Valdas Banys, Dalius Vitkus, Gabriel Lima-Oliveira |
EJIFCC | 2020 |
Novel Formulations of C-Peptide with Long-Acting Therapeutic Potential for Treatment of Diabetic Complications
N Zashikhina, V Sharoyko, M Antipchik, I Tarasenko, Y Anufrikov, A Lavrentieva, T Tennikova, E Korzhikova-Vlakh |
Pharmaceutics | 2019 |
Assessment of Pulsatile Insulin Secretion Derived from Peripheral Plasma C-peptide Concentrations by Nonparametric Stochastic Deconvolution
MC Laurenti, A Vella, RT Varghese, JC Andrews, A Sharma, NE Kittah, RA Rizza, A Matveyenko, G de Nicolao, C Cobelli, CD Man |
American journal of physiology. Endocrinology and metabolism | 2019 |
Lower Insulin-Dose Adjusted A1c (IDAA1c) Is Associated With Less Complications in Individuals With Type 1 Diabetes Treated With Hematopoetic Stem-Cell Transplantation and Conventional Therapy
JG Penaforte-Saboia, CE Couri, VO Fernandes, AP Montenegro, LA Batista, L Zajdenverg, CA Negrato, KC Malmegrim, DA Moraes, JB Dias, MC Oliveira, A Hussain, MB Gomes, RM Montenegro |
Frontiers in Endocrinology | 2019 |
Genomewide association study of C-peptide surfaces key regulatory genes in Indians
K Bandesh, G Prasad, AK Giri, VS Voruganti, NF Butte, SA Cole, AG Comuzzie, N Tandon, D Bharadwaj |
Journal of Genetics | 2019 |
The pharmacokinetics of porcine C-peptide after intraperitoneal injection
N Iizuka, M Nishimura, Y Fujita, O Sawamoto, S Matsumoto |
Xenotransplantation | 2019 |
Transcriptome profiling of four candidate milk genes in milk and tissue samples of temperate and tropical cattle
Olanrewaju B Morenikeji, Mabel O Akinyemi, Mathew Wheto, Olawale J Ogunshola, Adebanjo A Badejo, Clifford A Chineke |
Journal of Genetics | 2019 |
Dissection of hepatic versus extra-hepatic insulin clearance: Ethnic differences in childhood
F Piccinini, DC Polidori, BA Gower, JR Fernandez, RN Bergman |
Diabetes, obesity & metabolism | 2018 |
Impact of First Meal Size during Prolonged Sitting on Postprandial Glycaemia in Individuals with Prediabetes: A Randomised, Crossover Study
E Parr, B Devlin, S Pinto, D Dunstan, J Hawley |
Nutrients | 2018 |
Performance of individually measured vs population-based C-peptide kinetics to assess β-cell function in the presence and absence of acute insulin resistance
RT Varghese, CD Man, MC Laurenti, F Piccinini, A Sharma, M Shah, KR Bailey, RA Rizza, C Cobelli, A Vella |
Diabetes, obesity & metabolism | 2017 |
Characterisation of preproendothelin-1 derived peptides identifies Endothelin-Like Domain Peptide as a modulator of Endothelin-1
J Yuzugulen, JA Douthwaite, EG Wood, IC Villar, NS Patel, J Jegard, H Gaertner, I Rossitto-Borlat, K Rose, O Hartley, PR Cutillas, A Ahluwalia, R Corder |
Scientific Reports | 2017 |
Hepatic but Not Extrahepatic Insulin Clearance Is Lower in African American Than in European American Women
F Piccinini, DC Polidori, BA Gower, RN Bergman |
Diabetes | 2017 |
Unraveling the aggregation propensity of human insulin C-peptide: C-peptide Aggregation Propensity
PL Tsiolaki, NN Louros, AA Zompra, SJ Hamodrakas, VA Iconomidou |
Biopolymers | 2017 |
Long-Acting C-Peptide and Neuropathy in Type 1 Diabetes: A 12-Month Clinical Trial
J Wahren, H Foyt, M Daniels, JC Arezzo |
Diabetes care | 2016 |
Utility of C-peptide for a reliable estimate of insulin secretion in children with growth hormone deficiency
A Ciresi, F Cicciò, S Radellini, C Giordano |
Growth Hormone & IGF Research | 2016 |
Lean Seafood Intake Reduces Postprandial C-peptide and Lactate Concentrations in Healthy Adults in a Randomized Controlled Trial with a Crossover Design
EK Aadland, IE Graff, C Lavigne, Ø Eng, M Paquette, A Holthe, G Mellgren, L Madsen, H Jacques, B Liaset |
The Journal of nutrition | 2016 |
Age-dependent impairment of glucose tolerance in the 3xTg-AD mouse model of Alzheimer's disease
M Vandal, PJ White, G Chevrier, C Tremblay, I St.-Amour, E Planel, A Marette, F Calon |
The FASEB Journal | 2015 |
Efficacy of a long-acting C-peptide analogue against peripheral neuropathy in streptozotocin-diabetic mice
CG Jolivalt, M Rodriguez, J Wahren, NA Calcutt |
Diabetes Obesity and Metabolism | 2015 |
C-peptide as a Therapy for Kidney Disease: A Systematic Review and Meta-Analysis
JA Shaw, P Shetty, KD Burns, D Fergusson, GA Knoll, EA Burdmann |
PloS one | 2015 |
C-peptide: New Findings and Therapeutic Possibilities
J Wahren, C Larsson |
Diabetes Research and Clinical Practice | 2015 |
Short-term glucagon stimulation test of C-peptide effect on glucose utilization in patients with type 1 diabetes mellitus
V Mojto, Z Rausova, J Chrenova, L Dedik |
Medical & Biological Engineering & Computing | 2015 |
Clinical Advances in Diabetes Mellitus
T Forst, C Kaptiza |
Clinical Advances in Diabetes Mellitus | 2015 |
Physiological effects and therapeutic potential of proinsulin C-peptide
GL Yosten, C Maric-Bilkan, P Luppi, J Wahren |
American journal of physiology. Endocrinology and metabolism | 2014 |
Glucose homeostasis and the enteroinsular axis in the horse: A possible role in equine metabolic syndrome
E Graaf-Roelfsema |
The Veterinary Journal | 2014 |
Disproportionately elevated proinsulinemia is observed at modestly elevated glucose levels within the normoglycemic range
C Lorenzo, AJ Hanley, MJ Rewers, SM Haffner |
Acta Diabetologica | 2014 |
Residual C-peptide in type 1 diabetes: what do we really know?: Residual C-peptide in T1D
DE VanBuecken, CJ Greenbaum |
Pediatric Diabetes | 2014 |
Moderate diet-induced weight loss is associated with improved insulin sensitivity in middle-aged healthy obese Korean women
HO Lee, JE Yim, YS Kim, R Choue |
Nutrition Research and Practice | 2014 |
Pancreatic secretion, hepatic extraction, and plasma clearance of insulin from steady-state insulin and C-peptide measurements in critically ill patients
U Pielmeier, ML Rousing, S Andreassen |
IFAC Proceedings Volumes | 2014 |
Cereal Processing Influences Postprandial Glucose Metabolism as Well as the GI Effect
S Vinoy, S Normand, A Meynier, M Sothier, C Louche-Pelissier, J Peyrat, C Maitrepierre, JA Nazare, J Brand-Miller, M Laville |
Journal of the American College of Nutrition | 2013 |
Impact of Short Term Consumption of Diets High in Either Non-Starch Polysaccharides or Resistant Starch in Comparison with Moderate Weight Loss on Indices of Insulin Sensitivity in Subjects with Metabolic Syndrome
G Lobley, G Holtrop, D Bremner, A Calder, E Milne, A Johnstone |
Nutrients | 2013 |
Persistent C-peptide: what does it mean?
M Pietropaolo |
Current opinion in endocrinology, diabetes, and obesity | 2013 |
Obesity-related markers and breast cancer in CPS-II Nutrition Cohort
MM Gaudet, AV Patel, LR Teras, J Sun, PT Campbell, VL Stevens, EJ Jacobs, SM Gapstur |
International journal of molecular epidemiology and genetics | 2013 |
C-Peptide Versus Insulin: Relationships with Risk Biomarkers of Cardiovascular Disease in Metabolic Syndrome in Young Arab Females
A Abdullah, H Hasan, V Raigangar, W Bani-Issa |
International Journal of Endocrinology | 2012 |
Correlations between Glucagon Stimulated C-peptide Levels and Microvascular Complications in Type 2 Diabetes Patients
HJ Yoon, YZ Cho, JY Kim, BJ Kim, KY Park, GP Koh, DH Lee, DM Lim |
Diabetes & Metabolism Journal | 2012 |
Significance of plasma C-peptide in obese African American adolescents
Gregory V Williams, Kanwal K Gambhir, Gail Nunlee-Bland, Cynthia K Abrams, Vijaya Ganta, Wolali Odonkor |
Journal of the National Medical Association | 2012 |
Williams Textbook of Endocrinology
DW Cooke, SA Divall, S Radovick |
Williams Textbook of Endocrinology | 2011 |
Significance of Plasma C-peptide in Obese African American Adolescents
GV Williams, KK Gambhir, G Nunlee-Bland, CK Abrams, V Ganta, W Odonkor |
Journal of the National Medical Association | 2011 |
Measurement of C-peptide concentrations and responses to somatostatin, glucose infusion, and insulin resistance in horses
F Tóth, N Frank, T Martin-Jiménez, SB Elliott, RJ Geor, RC Boston |
Equine Veterinary Journal | 2010 |
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
Variation of Fasting Serum C-Peptide Level After Admission in Japanese Patients with Type 2 Diabetes Mellitus
Y Tajiri, M Kimura, K Mimura, F Umeda |
Diabetes Technology & Therapeutics | 2009 |
A numerical deconvolution method to estimate C-peptide secretion in humans after an intravenous glucose tolerance test
RC Boston, D Pei, PJ Moate |
Metabolism | 2009 |
Anti-inflammatory properties of C-Peptide
J Haidet, V Cifarelli, M Trucco, P Luppi |
The review of diabetic studies : RDS | 2009 |
A minimal C-peptide sampling method to capture peak and total prehepatic insulin secretion in model-based experimental insulin sensitivity studies
T Lotz, U Göltenbott, JG Chase, P Docherty, CE Hann |
Journal of diabetes science and technology | 2009 |
Murder by insulin: suspected, purported and proven-a review
V Marks |
Drug Testing and Analysis | 2009 |
Ethnic and gender differences regarding the insulin–blood pressure relationship
IM Palmer, AE Schutte, HW Huisman |
Diabetes Research and Clinical Practice | 2009 |
Reduced postprandial proinsulinaemia and 32–33 split proinsulinaemia after a mixed meal in type 2 diabetic patients following sensitization to insulin with pioglitazone
MB Cooper, KA Majali, CJ Bailey, DJ Betteridge |
Clinical Endocrinology | 2008 |
Urinary C-peptide of insulin as a non-invasive marker of energy balance in wild orangutans
ME Thompson, CD Knott |
Hormones and Behavior | 2008 |
Measures of β-Cell Function during the Oral Glucose Tolerance Test, Liquid Mixed-Meal Test, and Hyperglycemic Clamp Test
F Bacha, N Gungor, SA Arslanian |
The Journal of Pediatrics | 2008 |
The effect of exercise on the absorption of inhaled human insulin in healthy volunteers
AH Petersen, G Köhler, S Korsatko, A Wutte, M Wonisch, A Mautner, BB Rønn, P Clauson, T Laursen, P Wollmer, TR Pieber |
British Journal of Clinical Pharmacology | 2008 |
Targeting vesicular monoamine transporter Type 2 for noninvasive PET-based β-cell mass measurements
A Maffei, PE Harris |
Expert Review of Endocrinology & Metabolism | 2007 |
Effect of liver fat on insulin clearance
A Kotronen, S Vehkavaara, A Seppälä-Lindroos, R Bergholm, H Yki-Järvinen |
American journal of physiology. Endocrinology and metabolism | 2007 |
Acute effects of C-peptide on gastric emptying in longstanding type 1 diabetes
JE Stevens, A Russo, CA Delaney, PJ Collins, M Horowitz, KL Jones |
Clinical Autonomic Research | 2006 |
Effects of weight loss in obese subjects with normal fasting plasma glucose or impaired glucose tolerance on insulin release and insulin resistance according to a minimal model analysis
Y Yoshida, N Hashimoto, Y Tokuyama, H Kitagawa, K Takahashi, K Yagui, A Kanatsuka, H Bujo, M Higurashi, S Miyazawa, S Yoshida, Y Saito |
Metabolism | 2004 |
Use of the Gottingen Minipig as a Model of Diabetes, with Special Focus on Type 1 Diabetes Research
MO Larsen, B Rolin |
ILAR journal / National Research Council, Institute of Laboratory Animal Resources | 2004 |
Potent activation of multiple signalling pathways by C-peptide in opossum kidney proximal tubular cells
NM Al-Rasheed, F Meakin, EL Royal, AJ Lewington, J Brown, GB Willars, NJ Brunskill |
Diabetologia | 2004 |
International Textbook of Diabetes Mellitus
RA DeFronzo, L Mandarino, E Ferrannini |
International Textbook of Diabetes Mellitus | 2003 |
Metabolic and molecular basis of insulin resistance
M Bajaj |
Journal of Nuclear Cardiology | 2003 |
Proinsulin C-peptide activates cAMP response element-binding proteins through the p38 mitogen-activated protein kinase pathway in mouse lung capillary endothelial cells
T Kitamura, K Kimura, BD Jung, K Makondo, N Sakane, T Yoshida, M Saito |
Biochemical Journal | 2002 |
In vivo biodistribution and pharmacokinetics of 18F-labeled human C-peptide: evaluation in monkeys using positron emission tomography
A Fredriksson, K Ekberg, M Ingvar, BL Johansson, J Wahren, S Stone-Elander |
Life Sciences | 2002 |
Proinsulin C-peptide rapidly stimulates mitogen-activated protein kinases in Swiss 3T3 fibroblasts: requirement of protein kinase C, phosphoinositide 3-kinase and pertussis toxin-sensitive G-protein
T Kitamura, K Kimura, BD Jung, K Makondo, S Okamoto, X Cañas, N Sakane, T Yoshida, M Saito |
Biochemical Journal | 2001 |
Labeling of human C-peptide by conjugation withN-succinimidyl-4-[18F]fluorobenzoate
A Fredriksson, P Johnstr�m, S Stone-Elander, P Jonasson, P Nygren, K Ekberg, BL Johansson, J Wahren |
Journal of Labelled Compounds and Radiopharmaceuticals | 2001 |
Evidence for insulin resistance in black women from South Africa
MT der Merwe, NJ Crowther, GP Schlaphoff, IP Gray, BI Joffe, PN Lönnroth |
International Journal of Obesity | 2000 |
Insulin sensitivity, insulin secretion, and metabolic and hormonal parameters in healthy women and women with polycystic ovarian syndrome
LC Morin-Papunen, I Vauhkonen, RM Koivunen, A Ruokonen, JS Tapanainen |
Human Reproduction | 2000 |
Automated chemiluminescent assay for C-peptide
R W Hardy, M Cohn, R J Konrad |
Journal of Clinical Laboratory Analysis | 2000 |
Automated chemiluminescent assay for C‐peptide
Hardy RW, Cohn M, Konrad RJ |
Journal of Clinical Laboratory Analysis | 2000 |
The physiological impact of proinsulin C-peptide
T Kunt, T Forst, A Pfützner, J Beyer, J Wahren |
Pathophysiology | 1999 |
Assays for Insulin, Proinsulin(S) and C-Peptide
PM Clark |
Annals of Clinical Biochemistry | 1999 |
Impulse response model in reconstruction of insulin secretion by deconvolution: Role of input design in the identification experiment
G Sparacino, C Cobelli |
Annals of Biomedical Engineering | 1997 |
Eicosanoids and other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury 3
KV Honn, LJ Marnett, S Nigam, RL Jones, PY Wong |
1997 | |
A stochastic deconvolution method to reconstruct insulin secretion rate after a glucose stimulus
G Sparacino, C Cobelli |
IEEE Transactions on Biomedical Engineering | 1996 |
Paradoxical inhibition of insulin secretion by glucose in non-insulin-dependent diabetic patients
M Linstow, KJ Mikines, F Dela, H Galbo |
Acta Diabetologica | 1995 |
Implications of host pancreatic hormones in the restart of grafted liver
T Kiuchi, ER Kuse, KJ Oldhafer, B Ringe, S Okamoto, A Bornscheuer, G Brabant, Y Yamaoka, R Pichlmayr |
Hepatology | 1995 |
Hyperglycemia facilitates urinary excretion of C-peptide by increasing glomerular filtration rate in non-insulin-dependent diabetes mellitus
T Wasada, H Kuroki, H Arii, A Maruyama, K Katsumori, K Aoki, S Saito, Y Omori |
Metabolism | 1995 |
How to measure insulin clearance
MJ Castillo, AJ Scheen, MR Letiexhe, PJ Lefèbvre |
Diabetes / Metabolism Reviews | 1994 |
How to measure insulin secretion
R Hovorka, RH Jones |
Diabetes / Metabolism Reviews | 1994 |
Mathematical models of insulin secretion in physiological and clinical investigations
G Pacini |
Computer Methods and Programs in Biomedicine | 1994 |
Splanchnic and systemic absorption of intraperitoneal insulin using a new double-tracer method
J Radziuk, S Pye, DE Seigler, JS Skyler, R Offord, G Davies |
American journal of physiology. Endocrinology and metabolism | 1994 |
The effects of the menopause on insulin sensitivity, secretion and elimination in non-obese, healthy women
C Walton, IF Godsland, AJ Proudler, V Wynn, JC Stevenson |
European Journal of Clinical Investigation | 1993 |
Dose-response effects of lactate infusions on gluconeogenesis from lactate in normal man
T Jenssen, N Nurjhan, A Consoli, JE Gerich |
European Journal of Clinical Investigation | 1993 |
Insulin hypersecretion: A distinctive feature between essential and secondary hypertension
LA Sechi, A Melis, R Tedde |
Metabolism | 1992 |
Short- and long-term gliclazide effects on pancreatic islet cell function and hepatic insulin extraction in non-insulin-dependent diabetes mellitus
BL Wajchenberg, AT Santomauro, D Giannella-Neto, VC Borghi, RN Porrelli |
Diabetes Research and Clinical Practice | 1992 |
Studies on the mechanism of action of sulphonylureas in type II diabetic subjects: gliquidone
E Bonora, P Moghetti, M Querena, M Zenere, V Cacciatori, F Tosi, D Travia, G Zoppini, M Muggeo |
Journal of Endocrinological Investigation | 1992 |
Posthepatic rate of appearance of insulin: measurement and validation in the nonsteady state
T Morishima, S Pye, C Bradshaw, J Radziuk |
American journal of physiology. Endocrinology and metabolism | 1992 |
Exercise Training in Obese Diabetic Patients: Special Considerations
JR Zierath, H Wallberg-Henriksson |
Sports Medicine | 1992 |
Pathogenesis of type 2 (non-insulin dependent) diabetes mellitus: a balanced overview.
DeFronzo RA |
Diabetologia | 1992 |
Obesity and the metabolic response to severe multiple trauma in man
M Jeevanandam, DH Young, WR Schiller |
Journal of Clinical Investigation | 1991 |
Relationship between insulin sensitivity, insulin secretion and glucose tolerance in cirrhosis
YT Kruszynska, PD Home, N McIntyre |
Hepatology | 1991 |
Renal and splanchnic exchange of human biosynthetic C-peptide in Type 1 (insulin-dependent) diabetes mellitus
S Sjberg, , J stman, J Wahren |
Diabetologia | 1991 |
Immediate effect of vagotomy on pancreatic insulin secretion
I Nordback, E Harju |
Gut | 1991 |
Quantitative and qualitative differences in basal and glucose- and arginine-stimulated insulin secretion in healthy subjects and different stages of NIDDM
K Ratheiser, W Reitgruber, M Komjati, P Bratusch-Marrain, H Vierhapper, WK Waldhäusl |
Acta Diabetologica Latina | 1990 |
Dose-response characteristics for glucose-stimulated insulin release in man and assessment of influence of glucose on arginine-stimulated insulin release
TW van Haeften, E Boonstra, TF Veneman, JE Gerich, EA van der Veen |
Metabolism | 1990 |
Plasma C-peptide response to oral glucose load in hyperthyroidism
E Bonora, V Manicardi, M Zenere, P Moghetti, C Coscelli, M Muggeo |
Journal of Endocrinological Investigation | 1990 |
Suppression of Insulin Secretion by Falling Plasma Glucose Levels is Impaired in Type 2 Diabetes
JP Hosker, MA Burnett, DR Matthews, RC Turner |
Diabetic Medicine | 1988 |
The beta cell glucose stimulus-response curve in normal humans assessed by insulin and C-peptide secretion rates
AS Rudenski, JP Hosker, MA Burnett, DR Matthews, RC Turner |
Metabolism | 1988 |
First-phase insulin response to glucose in nonobeser or obese subjects with glucose intolerance: Analysis by C-peptide secretion rate
A Kanatsuka, H Makino, M Sakurada, N Hashimoto, H Iwaoka, T Yamaguchi, M Taira, S Yoshida, A Yoshida |
Metabolism | 1988 |
The beta-cell response to glucagon and mixed meal stimulation in non-insulin dependent diabetes
HJ Gjessing, EM Damsgaard, LE Matzen, OK Faber, A Frøland |
Scandinavian Journal of Clinical & Laboratory Investigation | 1988 |
Investigations on Insulin Kinetics
J Radziuk, S Pye, T Morishima, G Davies, DE Seigler, ML Reeves |
IFAC Proceedings Volumes | 1988 |
Dose-dependent effects of oral and intravenous glucose on insulin secretion and clearance in normal humans
H Tillil, ET Shapiro, MA Miller, T Karrison, BH Frank, JA Galloway, AH Rubenstein, KS Polonsky |
American journal of physiology. Endocrinology and metabolism | 1988 |
Reduced insulin removal and erythrocyte insulin binding in obese children
M Knip, P Lautala, R Puukka |
European Journal of Pediatrics | 1988 |
Insulin and C-peptide plasma levels in patients with severe chronic pancreatitis and fasting normoglycemia
E Bonora, C Rizzi, C Lesi, P Berra, C Coscelli, U Butturini |
Digestive Diseases and Sciences | 1988 |
Metabolism and placental transfer of 125I-proinsulin and 125I-tyrosylated C-peptide in the pregnant rhesus monkey
PA Gruppuso, JB Susa, P Sehgal, B Frank, R Schwartz |
Journal of Clinical Investigation | 1987 |
The kinetics of insulin in man. II. Role of the liver
E Ferrannini, C Cobelli |
Diabetes / Metabolism Reviews | 1987 |
Basal and 24-h C-peptide and insulin secretion rate in normal man
YT Kruszynska, PD Home, I Hanning, KG Alberti |
Diabetologia | 1987 |
Gastrointestinal peptides and insulin secretion
R Ebert, W Creutzfeldt |
Diabetes / Metabolism Reviews | 1987 |
Kinetics of circulating endogenous insulin, C-peptide, and proinsulin in fasting nondiabetic man
JH Henriksen, B Tronier, JB Bülow |
Metabolism | 1987 |
Insulin and C-peptide Secretory Responses to Glucagon in Man: Studies on the Dose-Response Relationships
B Ahrén, A Nobin, B Scherstén |
Acta Medica Scandinavica | 1987 |
Accuracy of C-peptide:insulin molar ratio as a measure of hepatic removal of insulin
R Berzins, KR Wieczorek, RV Rajotte, GD Molnar, YK Tam, JR McGregor, DM Fawcett |
Diabetes Research and Clinical Practice | 1987 |
Fractional hepatic extraction of insulin in man: is it constant?
E Bonora, L Capretti, V Manicardi, I Zavaroni, C Coscelli, U Butturini |
Journal of Endocrinological Investigation | 1987 |
Glucose, insulin and C-peptide kinetics during an oral glucose tolerance test in patients with chronic liver disease
Y K Min, K I Suh, S J Choi, H K Lee, C Y Kim, C S Koh, H K Min |
The Korean Journal of Internal Medicine | 1987 |
Glucose, Insulin and C-peptide Kinetics during an Oral Glucose Tolerance Test in Patients with Chronic Liver Disease
YK Min, KI Suh, SJ Choi, HK Lee, CY Kim, CS Koh, HK Min |
The Korean Journal of Internal Medicine | 1987 |
Use of biosynthetic human C-peptide in the measurement of insulin secretion rates in normal volunteers and type I diabetic patients
KS Polonsky, J Licinio-Paixao, BD Given, W Pugh, P Rue, J Galloway, T Karrison, B Frank |
Journal of Clinical Investigation | 1986 |
Splanchnic insulin metabolism in obesity. Influence of body fat distribution
AN Peiris, RA Mueller, GA Smith, MF Struve, AH Kissebah |
Journal of Clinical Investigation | 1986 |
Reduced incretin effect in Type 2 (non-insulin-dependent) diabetes
M Nauck, F Stöckmann, R Ebert, W Creutzfeldt |
Diabetologia | 1986 |
Why is there still Disagreement over Insulin Secretion in Non-insulin-dependent Diabetes?
RE Ferner, KG Alberti |
Diabetic Medicine | 1986 |
Current approaches to measurement of insulin secretion
KS Polonsky, AH Rubenstein |
Diabetes / Metabolism Reviews | 1986 |
C-peptide: An index of insulin secretion
OK Faber, C Binder |
Diabetes / Metabolism Reviews | 1986 |
Effect of muscular exercise on plasma C-peptide and insulin in obese non-diabetics and diabetics, Type II
M Krotkiewski, J Górski |
Clinical Physiology | 1986 |
Reduced hepatic insulin clearance in rats with dietary-induced obesity
G Strömblad, P Björntorp |
Metabolism | 1986 |
Infusion of synthetic human C-peptide does not affect plasma glucose, serum insulin, or plasma glucagon in healthy subjects
BJ Hoogwerf, JP Bantle, HE Gaenslen, BZ Greenberg, BJ Senske, R Francis, FC Goetz |
Metabolism | 1986 |
Further evidence that insulin metabolism is a major determinant of peripheral insulin response to oral glucose in subjects with mild glucose intolerance
E Bonora, I Zavaroni, V Manicardi, C Coscelli, U Butturini |
Journal of Endocrinological Investigation | 1986 |
On linearity of insulin kinetics
C Cobelli, A Mari, E Ferrannini |
American journal of physiology. Endocrinology and metabolism | 1986 |
The measurement and validation of the nonsteady-state rates of C-peptide appearance in the dog
T Morishima, S Pye, K Polonsky, J Radziuk |
Diabetologia | 1986 |
THE HALF-LIFE OF ENDOGENOUS INSULIN AND C-PEPTIDE IN MAN ASSESSED BY SOMATOSTATIN SUPPRESSION
DR Matthews, AS Rudenski, MA Burnett, P Darling, RC Turner |
Clinical Endocrinology | 1985 |
Pharmacokinetics and metabolic effects of glibenclamide and glipizide in type 2 diabetics
L Groop, E W�hlin-Boll, PH Groop, KJ T�tterman, A Melander, EM Tolppanen, F Fyhrqvist |
European Journal of Clinical Pharmacology | 1985 |
New developments in the incretin concept
W Creutzfeldt, R Ebert |
Diabetologia | 1985 |
Comparison of Type I and Type II Diabetes
M Vranic, CH Hollenberg, G Steiner |
1985 | |
The effects of physical training on insulin secretion and effectiveness and on glucose metabolism in obesity and Type 2 (non-insulin-dependent) diabetes mellitus
M Krotkiewski, P Lnnroth, K Mandroukas, Z Wroblewski, M Rebuff-Scrive, G Holm, U Smith, P Bjrntorp |
Diabetologia | 1985 |
Pharmacokinetics and metabolic effects of glibenclamide and glipizide in type 2 diabetics
L Groop, E Whlin-Boll, , , A Melander, , F Fyhrqvist |
European Journal of Clinical Pharmacology | 1985 |
Mechanisms of glucagon secretion during insulin-induced hypoglycemia in man. Role of the beta cell and arterial hyperinsulinemia
G Bolli, PD Feo, G Perriello, SD Cosmo, P Compagnucci, F Santeusanio, P Brunetti, RH Unger |
Journal of Clinical Investigation | 1984 |
Defective glucose counterregulation after subcutaneous insulin in noninsulin-dependent diabetes mellitus. Paradoxical suppression of glucose utilization and lack of compensatory increase in glucose production, roles of insulin resistance, abnormal neuroen
GB Bolli, E Tsalikian, MW Haymond, PE Cryer, JE Gerich |
Journal of Clinical Investigation | 1984 |
Relationships between insulin secretion, insulin action, and fasting plasma glucose concentration in nondiabetic and noninsulin-dependent diabetic subjects
C Bogardus, S Lillioja, BV Howard, G Reaven, D Mott |
Journal of Clinical Investigation | 1984 |
C-peptide and insulin secretion. Relationship between peripheral concentrations of C-peptide and insulin and their secretion rates in the dog
KS Polonsky, W Pugh, JB Jaspan, DM Cohen, T Karrison, HS Tager, AH Rubenstein |
Journal of Clinical Investigation | 1984 |
HYPERINSULINAEMIA AND INSULIN RESISTANCE OF CIRRHOSIS: THE IMPORTANCE OF INSULIN HYPERSECRETION
J Proietto, FJ Dudley, P Aitken, FP Alford |
Clinical Endocrinology | 1984 |
Hepatic disposal of biosynthetic human insulin and porcine C-peptide in humans
PR Bratusch-Marrain, WK Waldhäusl, S Gasić, A Hofer |
Metabolism | 1984 |
Plasma concentrations and transperitoneal transport of native insulin and C-peptide in patients on continuous ambulatory peritoneal dialysis
TE Wideröe, LC Smeby, OL Myking |
Kidney International | 1984 |
Glucose counterregulation during prolonged hypoglycemia in normal humans
GB Bolli, IS Gottesman, PE Cryer, JE Gerich |
American journal of physiology. Endocrinology and metabolism | 1984 |
Effect of beta-blocking drugs on beta-cell function and insulin sensitivity in hypertensive non-diabetic patients
K Ttterman, L Groop, , R Kala, , F Fyhrquist |
European Journal of Clinical Pharmacology | 1984 |
The expanding clinical use of C-peptide radioimmunoassay
M Rendell |
Acta Diabetologica Latina | 1983 |
Decreased hepatic insulin extraction in subjects with mild glucose intolerance
E Bonora, I Zavaroni, C Coscelli, U Butturini |
Metabolism | 1983 |
Splanchnic and renal metabolism of insulin in human subjects: a dose-response study
E Ferrannini, J Wahren, OK Faber, P Felig, C Binder, RA DeFronzo |
American journal of physiology. Endocrinology and metabolism | 1983 |
Hyperinsulinemia of obesity is due to decreased clearance of insulin
MT Meistas, S Margolis, AA Kowarski |
American journal of physiology. Endocrinology and metabolism | 1983 |
THE SIGNIFICANCE OF THE PORTAL INSULIN SECRETION IN INSULIN DEPENDENT PATIENTS WITH RESIDUAL β-CELL FUNCTION: A SAFEGUARD AGAINST HORMONAL AND METABOLIC DERANGEMENT
S Madsbad, OK Faber, A Kurtz, T Krarup, L Regeur, B Tronier, H Ørskov, C Binder, KG Alberti |
Clinical Endocrinology | 1982 |
The transient effect of strict glycaemic control on B cell function in newly diagnosed Type 1 (insulin-dependent) diabetic patients
S Madsbad, T Krarup, OK Faber, C Binder, L Regeur |
Diabetologia | 1982 |
Effect of strict blood glucose control on residual B-cell function in insulin-dependent diabetics
S Madsbad, T Krarup, L Regeur, OK Faber, C Binder |
Diabetologia | 1981 |
Pankreatische B-Zellen-Peptide: Kinetik und Konzentration von Proinsulin, Insulin und C-Peptid in Plasma und Urin, Probleme der Meßmethoden, klinische Aussage und Literaturübersicht
KD Gerbitz |
Clinical Chemistry and Laboratory Medicine | 1980 |
IMPORTANCE OF INSULIN ABSORPTION, SUBCUTANEOUS BLOOD FLOW, AND RESIDUAL BETA-CELL FUNCTION IN INSULIN THERAPY
T Lauritzen, C Binder, OK Faber |
Acta Paediatrica | 1980 |
Diagnosis of pancreatic islet hyperplasia causing hypoglycemia in a patient with portacaval anastomosis
MD Brennan, FJ Service, AM Carpenter, AH Rubenstein, AJ Edis |
The American Journal of Medicine | 1980 |
Evaluation of insulin secretory capacity in diabetes mellitus
DL Horwitz, AH Rubenstein |
Human Pathology | 1979 |
Advances in Metabolic Disorders
G Aurbach, JT Potts |
Advances in Metabolic Disorders | 1964 |