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Citations to this article

Kinetics of human connecting peptide in normal and diabetic subjects.
O K Faber, … , A H Rubenstein, N Rossing
O K Faber, … , A H Rubenstein, N Rossing
Published July 1, 1978
Citation Information: J Clin Invest. 1978;62(1):197-203. https://doi.org/10.1172/JCI109106.
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Kinetics of human connecting peptide in normal and diabetic subjects.

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Abstract

The metabolic clearance rate (MCR) of synthetic human connecting peptide (C-peptide) was measured with a single-dose injection technique in six normal and seven diabetic subjects and with a constant infusion technique in one normal subject. The MCR of C-peptide did not differ in normal subjects (4.4 ml/min per kg; range, 3.7-4.9) and in diabetic subjects (4.7 ml/min per kg; range, 3.7-5.8). Employment of both techniques in one subject gave similar MCR. The average half-life of C-peptide in plasma calculated from the last 1-h period of the single-dose injection studies was longer in the insulin-dependent diabetics (42.5 min; range, 39.4-48.5) than in the normal subjects (33.5 min; range, 24.9-45.3). These results indicate that the beta-cell secretory capacity of normal and insulin-dependent diabetic subjects can be compared by measuring the C-peptide concentration in peripheral venous plasma. The difference in the half-life of C-peptide in plasma between diabetics and normals suggests an altered kinetics of the disappearance of the peptide, while the overall metabolism, as expressed by the MCR, is similar.

Authors

O K Faber, C Hagen, C Binder, J Markussen, V K Naithani, P M Blix, H Kuzuya, D L Horwitz, A H Rubenstein, N Rossing

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Current approaches to measurement of insulin secretion
KS Polonsky, AH Rubenstein
Diabetes / Metabolism Reviews 1986
C-peptide: An index of insulin secretion
OK Faber, C Binder
Diabetes / Metabolism Reviews 1986
Effect of muscular exercise on plasma C-peptide and insulin in obese non-diabetics and diabetics, Type II
M Krotkiewski, J Górski
Clinical Physiology 1986
Reduced hepatic insulin clearance in rats with dietary-induced obesity
G Strömblad, P Björntorp
Metabolism 1986
Infusion of synthetic human C-peptide does not affect plasma glucose, serum insulin, or plasma glucagon in healthy subjects
BJ Hoogwerf, JP Bantle, HE Gaenslen, BZ Greenberg, BJ Senske, R Francis, FC Goetz
Metabolism 1986
Further evidence that insulin metabolism is a major determinant of peripheral insulin response to oral glucose in subjects with mild glucose intolerance
E Bonora, I Zavaroni, V Manicardi, C Coscelli, U Butturini
Journal of Endocrinological Investigation 1986
On linearity of insulin kinetics
C Cobelli, A Mari, E Ferrannini
American journal of physiology. Endocrinology and metabolism 1986
The measurement and validation of the nonsteady-state rates of C-peptide appearance in the dog
T Morishima, S Pye, K Polonsky, J Radziuk
Diabetologia 1986
THE HALF-LIFE OF ENDOGENOUS INSULIN AND C-PEPTIDE IN MAN ASSESSED BY SOMATOSTATIN SUPPRESSION
DR Matthews, AS Rudenski, MA Burnett, P Darling, RC Turner
Clinical Endocrinology 1985
Pharmacokinetics and metabolic effects of glibenclamide and glipizide in type 2 diabetics
L Groop, E W�hlin-Boll, PH Groop, KJ T�tterman, A Melander, EM Tolppanen, F Fyhrqvist
European Journal of Clinical Pharmacology 1985
New developments in the incretin concept
W Creutzfeldt, R Ebert
Diabetologia 1985
Comparison of Type I and Type II Diabetes
M Vranic, CH Hollenberg, G Steiner
1985
The effects of physical training on insulin secretion and effectiveness and on glucose metabolism in obesity and Type 2 (non-insulin-dependent) diabetes mellitus
M Krotkiewski, P Lnnroth, K Mandroukas, Z Wroblewski, M Rebuff-Scrive, G Holm, U Smith, P Bjrntorp
Diabetologia 1985
Pharmacokinetics and metabolic effects of glibenclamide and glipizide in type 2 diabetics
L Groop, E Whlin-Boll, , , A Melander, , F Fyhrqvist
European Journal of Clinical Pharmacology 1985
Mechanisms of glucagon secretion during insulin-induced hypoglycemia in man. Role of the beta cell and arterial hyperinsulinemia
G Bolli, PD Feo, G Perriello, SD Cosmo, P Compagnucci, F Santeusanio, P Brunetti, RH Unger
Journal of Clinical Investigation 1984
Defective glucose counterregulation after subcutaneous insulin in noninsulin-dependent diabetes mellitus. Paradoxical suppression of glucose utilization and lack of compensatory increase in glucose production, roles of insulin resistance, abnormal neuroen
GB Bolli, E Tsalikian, MW Haymond, PE Cryer, JE Gerich
Journal of Clinical Investigation 1984
Relationships between insulin secretion, insulin action, and fasting plasma glucose concentration in nondiabetic and noninsulin-dependent diabetic subjects
C Bogardus, S Lillioja, BV Howard, G Reaven, D Mott
Journal of Clinical Investigation 1984
C-peptide and insulin secretion. Relationship between peripheral concentrations of C-peptide and insulin and their secretion rates in the dog
KS Polonsky, W Pugh, JB Jaspan, DM Cohen, T Karrison, HS Tager, AH Rubenstein
Journal of Clinical Investigation 1984
HYPERINSULINAEMIA AND INSULIN RESISTANCE OF CIRRHOSIS: THE IMPORTANCE OF INSULIN HYPERSECRETION
J Proietto, FJ Dudley, P Aitken, FP Alford
Clinical Endocrinology 1984
Hepatic disposal of biosynthetic human insulin and porcine C-peptide in humans
PR Bratusch-Marrain, WK Waldhäusl, S Gasić, A Hofer
Metabolism 1984
Plasma concentrations and transperitoneal transport of native insulin and C-peptide in patients on continuous ambulatory peritoneal dialysis
TE Wideröe, LC Smeby, OL Myking
Kidney International 1984
Glucose counterregulation during prolonged hypoglycemia in normal humans
GB Bolli, IS Gottesman, PE Cryer, JE Gerich
American journal of physiology. Endocrinology and metabolism 1984
Effect of beta-blocking drugs on beta-cell function and insulin sensitivity in hypertensive non-diabetic patients
K Ttterman, L Groop, , R Kala, , F Fyhrquist
European Journal of Clinical Pharmacology 1984
The expanding clinical use of C-peptide radioimmunoassay
M Rendell
Acta Diabetologica Latina 1983
Decreased hepatic insulin extraction in subjects with mild glucose intolerance
E Bonora, I Zavaroni, C Coscelli, U Butturini
Metabolism 1983
Splanchnic and renal metabolism of insulin in human subjects: a dose-response study
E Ferrannini, J Wahren, OK Faber, P Felig, C Binder, RA DeFronzo
American journal of physiology. Endocrinology and metabolism 1983
Hyperinsulinemia of obesity is due to decreased clearance of insulin
MT Meistas, S Margolis, AA Kowarski
American journal of physiology. Endocrinology and metabolism 1983
THE SIGNIFICANCE OF THE PORTAL INSULIN SECRETION IN INSULIN DEPENDENT PATIENTS WITH RESIDUAL β-CELL FUNCTION: A SAFEGUARD AGAINST HORMONAL AND METABOLIC DERANGEMENT
S Madsbad, OK Faber, A Kurtz, T Krarup, L Regeur, B Tronier, H Ørskov, C Binder, KG Alberti
Clinical Endocrinology 1982
The transient effect of strict glycaemic control on B cell function in newly diagnosed Type 1 (insulin-dependent) diabetic patients
S Madsbad, T Krarup, OK Faber, C Binder, L Regeur
Diabetologia 1982
Effect of strict blood glucose control on residual B-cell function in insulin-dependent diabetics
S Madsbad, T Krarup, L Regeur, OK Faber, C Binder
Diabetologia 1981
Pankreatische B-Zellen-Peptide: Kinetik und Konzentration von Proinsulin, Insulin und C-Peptid in Plasma und Urin, Probleme der Meßmethoden, klinische Aussage und Literaturübersicht
KD Gerbitz
Clinical Chemistry and Laboratory Medicine 1980
IMPORTANCE OF INSULIN ABSORPTION, SUBCUTANEOUS BLOOD FLOW, AND RESIDUAL BETA-CELL FUNCTION IN INSULIN THERAPY
T Lauritzen, C Binder, OK Faber
Acta Paediatrica 1980
Diagnosis of pancreatic islet hyperplasia causing hypoglycemia in a patient with portacaval anastomosis
MD Brennan, FJ Service, AM Carpenter, AH Rubenstein, AJ Edis
The American Journal of Medicine 1980
Evaluation of insulin secretory capacity in diabetes mellitus
DL Horwitz, AH Rubenstein
Human Pathology 1979
Advances in Metabolic Disorders
G Aurbach, JT Potts
Advances in Metabolic Disorders 1964

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