The urine of patients with proteinuria of various etiologies was examined to determine if proteinuria alone was associated with significant glycosphingolipiduria. In all cases of proteinuria examined, the level of glycosphingolipids in the urine was found to be markedly elevated. There was no evidence of a glycosphingolipid storage disorder in any case. It was concluded that significant glycosphingolipiduria may occur in proteinuria as well as in the glycosphingolipid storage disorders.
R R Townsend, R M Orth, C M Clawson, S C Li, Y T Li
Title and authors | Publication | Year |
---|---|---|
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A Fornoni, S Merscher, JB Kopp |
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L der Tol, E Svarstad, A Ortiz, C Tøndel, JP Oliveira, L Vogt, S Waldek, DA Hughes, RH Lachmann, W Terryn, CE Hollak, S Florquin, MA van Weerman, C Wanner, ML West, M Biegstraaten, GE Linthorst |
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Phenotypical characterization of α-galactosidase A gene mutations identified in a large Fabry disease screening program in stroke in the young
ID Brabander, L Yperzeele, CC Groote, R Brouns, R Baker, S Belachew, J Delbecq, GD Keulenaer, S Dethy, F Eyskens, A Fumal, D Hemelsoet, D Hughes, S Jeangette, D Nuytten, P Redondo, B Sadzot, C Sindic, R Sheorajpanday, V Thijs, CV Broeckhoven, PP de Deyn |
Clinical Neurology and Neurosurgery | 2013 |
Activator protein required for the enzymatic hydrolysis of cerebroside sulfate. Deficiency in urine of patients affected with cerebroside sulfatase activator deficiency and identity with activators for the enzymatic hydrolysis of GM1 ganglioside and globotriaosylceramide
SC Li, H Kihara, S Serizawa, YT Li, AL Fluharty, JS Mayes, LJ Shapiro |
The Journal of biological chemistry | 1985 |
Increased urinary excretion of glycosphingolipids in familial hypercholesterolemia
S Chatterjee, CS Sekerke, PO Kwiterovich |
Journal of lipid research | 1982 |