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Research Article Free access | 10.1172/JCI109042

The Role of Cyclic Adenosine Monophosphate in Adrenergic Effects on Ventricular Vulnerability to Fibrillation in the Isolated Perfused Rat Heart

W. F. Lubbe, Th. Podzuweit, P. S. Daries, and L. H. Opie

Medical Research Council Ischemic Heart Disease Research Unit, Department of Medicine, University of Cape Town and Groote Schuur Hospital, Observatory, 7925, Cape, Republic of South Africa

Find articles by Lubbe, W. in: JCI | PubMed | Google Scholar

Medical Research Council Ischemic Heart Disease Research Unit, Department of Medicine, University of Cape Town and Groote Schuur Hospital, Observatory, 7925, Cape, Republic of South Africa

Find articles by Podzuweit, T. in: JCI | PubMed | Google Scholar

Medical Research Council Ischemic Heart Disease Research Unit, Department of Medicine, University of Cape Town and Groote Schuur Hospital, Observatory, 7925, Cape, Republic of South Africa

Find articles by Daries, P. in: JCI | PubMed | Google Scholar

Medical Research Council Ischemic Heart Disease Research Unit, Department of Medicine, University of Cape Town and Groote Schuur Hospital, Observatory, 7925, Cape, Republic of South Africa

Find articles by Opie, L. in: JCI | PubMed | Google Scholar

Published May 1, 1978 - More info

Published in Volume 61, Issue 5 on May 1, 1978
J Clin Invest. 1978;61(5):1260–1269. https://doi.org/10.1172/JCI109042.
© 1978 The American Society for Clinical Investigation
Published May 1, 1978 - Version history
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Abstract

The relation between myocardial tissue cyclic AMP (cAMP) and the vulnerability to ventricular fibrillation was assessed in the isolated perfused rat heart by measurement of ventricular fibrillation threshold (VFT) and vulnerable period duration (VP). Exogenous dibutyryl cyclic AMP (DBcAMP) reduced VFT and increased VP by a concentration-related action whereas exogenous cAMP did not. Theophylline (1.0 mmol/liter) increased the tissue content of cAMP by 58% (P < 0.001) and caused a leftward shift in the concentration-response curve to DBcAMP. An effect of cAMP on VFT and VP could be shown in the presence of phosphodiesterase inhibition by theophylline. β-1-Adrenergic receptor blockade with atenolol did not alter the concentration-response curve for VFT when DBcAMP was administered. Epinephrine (100 nmol/liter to 1 μmol/liter) also increased vulnerability to VF; this effect was accompanied by a concentration-related increase in tissue cAMP, but inconsistent changes in tissue ATP, phosphocreatine and potassium. The concentration-response curve of VFT to epinephrine was shifted leftward by theophylline and rightward by atenolol.

The increases in vulnerability to fibrillation in the isolated perfused rat heart, in response to DBcAMP, theophylline or epinephrine, could be related more closely to changes of tissue cAMP than to effects on tissue high energy phosphates or potassium. The effect of epinephrine and theophylline on vulnerability to ventricular fibrillation is mediated via alterations in the intracellular level of cAMP in the isolated perfused rat heart.

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