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Citations to this article

Superoxide generation by digitonin-stimulated guinea pig granulocytes. A basis for a continuous assay for monitoring superoxide production and for the study of the activation of the generating system.
H J Cohen, M E Chovaniec
H J Cohen, M E Chovaniec
Published April 1, 1978
Citation Information: J Clin Invest. 1978;61(4):1081-1087. https://doi.org/10.1172/JCI109007.
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Research Article

Superoxide generation by digitonin-stimulated guinea pig granulocytes. A basis for a continuous assay for monitoring superoxide production and for the study of the activation of the generating system.

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Abstract

Stimulation of guinea pig granolocytes by digitonin results in superoxide (O-2) generation. A continuous assay shows that there is a lag between the addition of digitonin and the onset of O-2 production. The rate of activation of the O-2 generating system is dependent upon the concentration of digitonin and the temperature. The final linear rate of O-2 production is affected by the concentration of digitonin, temperature, pH, and the presence of exogenous reduced pyridine nucleotides. Thus, factors which alter either the activation process or the activity of the O-2 generating system can affect O-2 production by stimulated granolocytes.

Authors

H J Cohen, M E Chovaniec

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Journal of Investigative Dermatology 1991
Hydrogen peroxide-induced oxidative stress to the mammalian heart-muscle cell (cardiomyocyte): Lethal peroxidative membrane injury
DR Janero, D Hreniuk, HM Sharif
Journal of Cellular Physiology 1991
3-Aminobenzamide inhibits cytotoxicity and adhesion of phorbol-ester-stimulated granulocytes to fibroblast monolayer cultures
T MEYER, H LENGYEL, W FANICK, H HILZ
European Journal of Biochemistry 1991
Synthesis and properties of chemotactic peptide analogs I. Crystal structure and molecular conformation of HCO-Met-Leu-Ain-OMe
E Gavuzzo, G Lucente, F Mazza, GP Zecchini, MP Paradisi, G Pochetti, I Torrini
International Journal of Peptide and Protein Research 1991
Modulation of the inhibition of respiratory burst in mouse macrophages by cyclosporin A: effect of in vivo treatment, glucocorticoids and the state of activation of cells
MD Chiara, F Sobrino
Immunology 1991
Demethoxyviridin and wortmannin block phospholipase C and D activation in the human neutrophil
RW Bonser, NT Thompson, RW Randall, JE Tateson, GD Spacey, HF Hodson, LG Garland
British Journal of Pharmacology 1991
Adhesion protein GMP140 inhibits superoxide anion release by human neutrophils
CS Wong, JR Gamble, MP Skinner, CM Lucas, MC Berndt, MA Vadas
Proceedings of the National Academy of Sciences 1991
Depolarization of polymorphonuclear leukocytes by Porphyromonas (Bacteroides) gingivalis 381 in the absence of respiratory burst activation
MJ Novak, HJ Cohen
Infection and immunity 1991
Superoxide anion release (O2−) after ischemia and reperfusion
JA Freischlag, D Hanna
Journal of Surgical Research 1991
Inhibition of the myeloperoxidase-H2O2-Cl− system of neutrophils by indomethacin and other non-steroidal anti-inflammatory drugs
E Shacter, RL Lopez, S Pati
Biochemical Pharmacology 1991
The protective effect of frusemide on the generation of superoxide anions by human bronchial epithelial cells and pulmonary macrophages in vitro
M Soloperto, M Marini, C Brasca, A Fasoli, S Mattoli
Pulmonary Pharmacology 1991
Spin traps inhibit formation of hydrogen peroxide via the dismutation of superoxide: implications for spin trapping the hydroxyl free radical
BE Britigan, TL Roeder, GR Buettner
Biochimica et Biophysica Acta (BBA) - General Subjects 1991
Calcium changes in immune complex-stimulated human neutrophils. Simultaneous measurement of receptor occupancy and activation reveals full population stimulus binding but subpopulation activation
BA Brunkhorst, KG Lazzari, G Strohmeier, G Weil, ER Simons
The Journal of biological chemistry 1991
Apolipoprotein A-I decreases neutrophil degranulation and superoxide production
WD Blackburn, JG Dohlman, YV Venkatachalapathi, DJ Pillion, WJ Koopman, JP Segrest, GM Anantharamaiah
Journal of lipid research 1991
Arachidonate activation of the neutrophil NADPH-oxidase. Synergistic effects of protein phosphatase inhibitors compared with protein kinase activators
MJ Steinbeck, GG Hegg, MJ Karnovsky
The Journal of biological chemistry 1991
Platelet-activating factor induces tyrosine phosphorylation in human neutrophils
J Gomez-Cambronero, E Wang, G Johnson, CK Huang, RI Sha'afi
The Journal of biological chemistry 1991
Suppression of cytoskeletal rearrangement in activated human neutrophils by botulinum C2 toxin. Impact on cellular signal transduction
F Grimminger, U Sibelius, K Aktories, I Just, W Seeger
The Journal of biological chemistry 1991
Differential inhibition by nedocromil sodium of superoxide generation elicited by platelet activating factor in human neutrophils
RP Rubin, RH Thompson, MS Naps
Agents and Actions 1990
Temporal adaptation of human neutrophil metabolic responsiveness to the peptide formylmethionyl-leucyl phenylalanine: A comparison between human neutrophils and granule-depleted neutrophil cytoplasts
C Dahlgren
Cell Biochemistry and Function 1990
COMPARISON OF THEOPHYLLINE AND ENPROFYLLINE EFFECTS ON HUMAN NEUTROPHIL SUPEROXIDE PRODUCTION
M Kaneko, K Suzuki, H Furui, K Takagi, T Satake
Clinical and Experimental Pharmacology and Physiology 1990
Biochemical changes associated with the mechanism controlling superoxide radical formation in the aging rotifer
M Sawada, JC Carlson
Journal of Cellular Biochemistry 1990
Signal transduction in N-formyl-methionyl-leucyl-phenylalanine and concanavalin A stimulated human neutrophils: Superoxide production without a rise in intracellular free calcium
S Liang, TJ Woodlock, JC Whitin, MA Lichtman, GB Segel
Journal of Cellular Physiology 1990
Epithelioid macrophages secrete a deactivating factor for superoxide release
VC Camarero, VB Junqueira, P Colepicolo, ML Karnovsky, M Mariano
Journal of Cellular Physiology 1990
Superoxide production by rat neutrophils in the oleic acid model of lung injury
FL Watts, BL Oliver, GM Johnson, RS Thrall
Free radical biology & medicine 1990
The temporal relationship between phospholipase activation, diradylglycerol formation and superoxide production in the human neutrophil
NT Thompson, JE Tateson, RW Randall, GD Spacey, RW Bonser, LG Garland
Biochemical Journal 1990
Impaired Release of Colony Stimulating Activity by Monocytes from Hodgkin's Disease in Response to Phorbol Myristate Acetate Activation
J Hansz, K Sawiński, T Woźny
Immunobiology 1990
Effect of glutaraldehyde on NADPH oxidase system of guinea pig polymorphonuclear leukocytes
T Katayama, T Ohtsuka, K Wakamura, K Yoshida, N Okamura, S Ishibashi
Archives of Biochemistry and Biophysics 1990
A sensitive and specific assay for superoxide anion released by neutrophils or macrophages based on bioluminescence of polynoidin
P Colepicolo, VC Camarero, MT Nicolas, JM Bassot, ML Karnovsky, JW Hastings
Analytical Biochemistry 1990
Biological Oxidation Systems
SW Ryter, RE Pacifici, KJ Davies
Biological Oxidation Systems 1990
Altered production ratio by in vitro and in vivo primed human neutrophils
P Follin, C Dahlgren
Biochemical and Biophysical Research Communications 1990
Studies of cellular mechanisms for the generation of superoxide by guinea-pig eosinophils and its dissociation from granule peroxidase release
JK Shute, SJ Rimmer, CL Akerman, MK Church, ST Holgate
Biochemical Pharmacology 1990
Brief Inhalation of Asbestos Compromises Superoxide Production in Cells from Bronchoalveolar Lavage
JM Petruska, J Marsh, M Bergeron, BT Mossman
American journal of respiratory cell and molecular biology 1990
Tumor Necrosis Factor Primes Neutrophils by Shortening the Lag Period of the Respiratory Burst
JR Humbert, EL Winsor
The American Journal of the Medical Sciences 1990
Degranulation in human neutrophils primes the cells for subsequent responsiveness to the chemoattractant N-formylmethionylleucylphenylalanine but does not increase the sensitivity of the NADPH-oxidase to an intracellular calcium rise
C Dahlgren, P Follin
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1990
DNA damage induced by phorbol ester-stimulated neutrophils is augmented by extracellular cofactors. Role of histidine and metals
E Shacter, RL Lopez, EJ Beecham, S Janz
The Journal of biological chemistry 1990
Hydroxyl radical is not a product of the reaction of xanthine oxidase and xanthine. The confounding problem of adventitious iron bound to xanthine oxidase
BE Britigan, S Pou, GM Rosen, DM Lilleg, GR Buettner
The Journal of biological chemistry 1990
EFFECT OF COLFORSIN ON HUMAN NEUTROPHIL SUPEROXIDE PRODUCTION AND INTRACELLULAR CALCIUM MOBILIZATION
H Furui, K Suzuki, K Takagi, T Satake
Clinical and Experimental Pharmacology and Physiology 1989
Phospholipase D activation is functionally linked to superoxide generation in the human neutrophil
RW Bonser, NT Thompson, RW Randall, LG Garland
Biochemical Journal 1989
Neutrophil activation by surface bound IgG is via a pertussis toxin insensitive G protein
WD Blackburn, LW Heck
Biochemical and Biophysical Research Communications 1989
Synergism between protein kinase C activator and fatty acids in stimulating superoxide anion production in guinea pig polymorphonuclear leukocytes
M Ozawa, T Ohtsuka, N Okamura, S Ishibashi
Archives of Biochemistry and Biophysics 1989
Further studies on a chemoattractant derived from Aleurites fordii hemsl. seed
S Shigeki, T Rika, S Masato, I Mitsunori, S Hideki, MM Yokoyama
International Journal of Biochemistry 1989
Tyrosine phosphorylation in human neutrophil
J Gomez-Cambronero, CK Huang, VA Bonak, E Wang, JE Casnellie, T Shiraishi, RI Sha'afi
Biochemical and Biophysical Research Communications 1989
Influence of cardioprotective cyclooxygenase and lipoxygenase inhibitors on peroxidative injury to myocardial-membrane phospholipid
DR Janero, B Burghardt, R Lofez, M Cardell
Biochemical Pharmacology 1989
Cationic Polyelectrolytes: Potent Opsonic Agents which Activate the Respiratory Burst in Leukocytes
I Ginsburg
Free Radical Research 1989
Difference in hydrogen peroxide release between human neutrophils and neutrophil cytoplasts following calcium ionophore activation. A role of the subcellular granule in activation of the NADPH-oxidase in human neutrophils?
C Dahlgren, A Johansson, K Orselius
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1989
Lysophosphatides enhance superoxide responses of stimulated human neutrophils
I Ginsburg, PA Ward, J Varani
Inflammation 1989
Pathology Reviews · 1989
E Rubin, I Damjanov
1989
ADP-Ribose Transfer Reactions
MK Jacobson, EL Jacobson
1989
Studies of Signal Transduction in the Respiratory Burst-associated Stimulation of fMet-Leu-Phe-induced Tubulin Tyrosinolation and Phorbol 12-Myristate 13-Acetate-induced Posttranslational Incorporation of Tyrosine into Multiple Proteins in Activated Neutrophils and HL-60 Cells
J Nath, A Powledge, DG Wright
The Journal of biological chemistry 1989
Cultured human endothelial cells stimulated with cytokines or endotoxin produce an inhibitor of leukocyte adhesion
ME Wheeler, FW Luscinskas, MP Bevilacqua, MA Gimbrone
Journal of Clinical Investigation 1988
Lipoteichoic acid-antilipoteichoic acid complexes induce superoxide generation by human neutrophils
I Ginsburg, SE Fligiel, PA Ward, J Varani
Inflammation 1988
Bile and bile salts potentiate superoxide anion release from activated, rat peritoneal neutrophils
LJ Dahm, JA Hewett, RA Roth
Toxicology and Applied Pharmacology 1988
Characteristics of the granulocyte chemiluminescence reaction following an interaction between human neutrophils andSalmonella typhimuriumbacteria
R Lock, C Dahlgren
APMIS 1988
Analysis of luminol-dependent chemiluminescence from granule depleted neutrophil cytoplasts reveals two different light-emitting mechanisms
C Dahlgren
Journal of Bioluminescence and Chemiluminescence 1988
Activation of the neutrophil respiratory burst by chemoattractants: Regulation of the N-formyl peptide receptor in the plasma membrane
AJ Jesaitis, RA Allen
Journal of Bioenergetics and Biomembranes 1988
Effect of Mycobacterium tuberculosis-derived sulfolipid I on human phagocytic cells
L Zhang, MB Goren, TJ Holzer, BR Andersen
Infection and immunity 1988
Neutrophil activation by surface bound IgG: Pertussis toxin insensitive activation
WD Blackburn, LW Heck
Biochemical and Biophysical Research Communications 1988
Temperature-dependent inhibition of fmet-leu-phe-stimulated superoxide generation by C-I and H-7 in human neutrophils
J Nath, A Powledge
Biochemical and Biophysical Research Communications 1988
Activation of macrophages by Entamoeba histolytica extracts in mice
E Ghadirian, PA Kongshavn
Microbial Pathogenesis 1988
Analysis of horseradish peroxidase-amplified chemiluminescence produced by human neutrophils reveals a role for the superoxide anion in the light emitting reaction
R Lock, A Johansson, K Orselius, C Dahlgren
Analytical Biochemistry 1988
Protease inhibitor eglin-c affects superoxide anion release but not bacterial killing by human polymorphonuclear leukocytes
A L Esposito, C A Clark, W J Poirier, P A Kephart
Experimental Lung Research 1988
Enhanced Neutrophil Stimulation by Phorbol Ester Encapsulated in pH-Sensitive Liposomes
S Kanda, L Huang
Journal of Liposome Research 1988
The Respiratory Burst and Its Physiological Significance
AJ Sbarra, RR Strauss
1988
Increased breakdown of phosphatidylinositol 4,5-bisphosphate is not an initiating factor for actin assembly in human neutrophils
T Bengtsson, I Rundquist, O Stendahl, MP Wymann, T Andersson
The Journal of biological chemistry 1988
Cell surface expression of fMet-Leu-Phe receptors on human neutrophils. Correlation to changes in the cytosolic free Ca2+ level and action of phorbol myristate acetate
T Andersson, C Dahlgren, PD Lew, O Stendahl
Journal of Clinical Investigation 1987
Recombinant interferon gamma augments phagocyte superoxide production and X-chronic granulomatous disease gene expression in X-linked variant chronic granulomatous disease
RA Ezekowitz, SH Orkin, PE Newburger
Journal of Clinical Investigation 1987
Polymorphonuclear leukocyte chemiluminescence induced by formylmethionyl-leucyl-phenylalanine and phorbol myristate acetate: Effects of catalase and superoxide dismutase
C Dahlgren
Agents and Actions 1987
The effect of chlorhexidine on blood cells
WL Gabler, D Roberts, W Harold
Journal of Periodontal Research 1987
The influence of chlorhexidine on superoxide generation by induced human neutrophils
WL Gabler, WW Bullock, HR Creamer
Journal of Periodontal Research 1987
A series of six ligands for the human formyl peptide receptor: tetrapeptides with high chemotactic potency and efficacy
A Rot, LE Henderson, TD Copeland, EJ Leonard
Proceedings of the National Academy of Sciences 1987
Reduction of ferricytochrome C may underestimate superoxide production by monocytes
MJ Arthur, P Kowalski-Saunders, S Gurney, R Tolcher, FG Bull, R Wright
Journal of Immunological Methods 1987
Oxidation of reduced cytochrome c by hydrogen peroxide
PL Vandewalle, NO Petersen
FEBS Letters 1987
Calcium ionophore A23187 enhances human neutrophil superoxide release, stimulated by phorbol dibutyrate, by converting phorbol ester receptors from a low- to high-affinity state
JK French, NP Hurst, PD Zaiewski, L Valente, IJ Forbes
FEBS Letters 1987
Diclofenac binding to human polymorphonuclear neutrophils: Effect on respiratory burst and N-formylated peptide binding
A Perianin, MA Gougerot-Pocidalo, JP Giroud, J Hakim
Biochemical Pharmacology 1987
The bioflavonoid quercetin inhibits neutrophil degranulation, superoxide production, and the phosphorylation of specific neutrophil proteins
WD Blackburn, LW Heck, RW Wallace
Biochemical and Biophysical Research Communications 1987
Peripheral benzodiazepines enhance the respiratory burst of macrophage-like P388D1 cells stimulated by arachidonic acid
F Zavala, M Lenfant
International Journal of Immunopharmacology 1987
The diacylglycerol kinase inhibitor R59022 potentiates superoxide production but not secretion induced by fMet-Leu-Phe: Effects of leupeptin and the protein kinase C inhibitor H-7
J Gomez-Cambronero, TF Molski, EL Becker, RI Sha'afi
Biochemical and Biophysical Research Communications 1987
Stimulation of superoxide anion formation by the non-TPA type tumor promoters palytoxin and thapsigargin in porcine and human neutrophils
S Kano, T Iizuka, Y Ishimura, H Fujiki, T Sugimura
Biochemical and Biophysical Research Communications 1987
A dual role for calcium in regulation of superoxide generation by stimulated rat alveolar macrophages
RJ Dorio, J Nelson, HJ Forman
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1987
Dynamics of chemotactic peptide-induced superoxide generation by human monocytes
EJ Leonard, A Shenai, A Skeel
Inflammation 1987
Interaction of anthracycline antibiotics with human neutrophils: superoxide production, free radical formation and intracellular penetration
ML Schinetti, D Rossini, A Bertelli
Journal of Cancer Research and Clinical Oncology 1987
Diacylglycerol accumulation and superoxide anion production in stimulated human neutrophils
LG Rider, JE Niedel
The Journal of biological chemistry 1987
NADPH oxidase of human neutrophils. Subcellular localization and characterization of an arachidonate-activatable superoxide-generating system
RA Clark, KG Leidal, DW Pearson, WM Nauseef
The Journal of biological chemistry 1987
Generation of superoxide anion and hydrogen peroxide by erythrocytes from individuals with sickle trait or normal haemoglobin
LP Schacter
European Journal of Clinical Investigation 1986
The Role of Superoxide Anion and Lysosomal Enzymes in Anti-Listerial Activity of Elicited Peritoneal Macrophages
S Hashimoto, K Nomoto, T Yokokura
Scandinavian Journal of Immunology 1986
Monoclonal antibodies to a particulate superoxide-forming system stimulate a respiratory burst in intact guinea pig neutrophils
G Berton, H Rosen, RA Ezekowitz, P Bellavite, MC Serra, F Rossi, S Gordon
Proceedings of the National Academy of Sciences 1986
Identification of a second class of IgG Fc receptors on human neutrophils. A 40 kilodalton molecule also found on eosinophils
RJ Looney, DH Ryan, K Takahashi, HB Fleit, HJ Cohen, GN Abraham, CL Anderson
Journal of Experimental Medicine 1986
Dietary cholesterol-induced changes in macrophage characteristics. Relationship to atherosclerosis
KA Rogers, RL Hoover, JJ Castellot, JM Robinson, MJ Karnovsky
The American Journal of Pathology 1986
Effect of interferon-γ and 1α,25-dihydroxyvitamin D3 on superoxide anion, prostaglandins E2, and mononuclear cell factor production by U937 cells
P Roux-Lombard, A Cruchaud, JM Dayer
Cellular Immunology 1986
Defective chemiluminescence response in differentiated HL60 cells due to impaired degranulation
O Stendahl, T Andersson, C Dahlgren, KE Magnusson
Biochimica et Biophysica Acta (BBA) - General Subjects 1986
Comparison of blood and peritoneal neutrophil activity in rabbits with and without peritonitis
J Freischlag, B Backstrom, D Kelly, G Keehn, RW Busuttil
Journal of Surgical Research 1986
Bacterial clearance and granulocyte response in experimental peritonitis
T Skau, PO Nyström, L Öhman, O Stendahl
Journal of Surgical Research 1986
Inhibition of Superoxide Generation by Human Polymorphonuclear Leukocytes with Chlorhexidine : Its Possible Relation to Periodontal Disease
J Goultschin, H Levy
Journal of Periodontology 1986
Stimulation of superoxide release in neutrophils by 1-oleoyl-2-acetylglycerol incorporated into pH-sensitive liposomes
BE Tsusaki, S Kanda, L Huang
Biochemical and Biophysical Research Communications 1986
Cell alkalinization is not necessary and increased sodium influx is not sufficient for stimulated superoxide production
TF Molski, C Ford, SJ Weisman, RI Sha'afi
FEBS Letters 1986
Superoxide production and chemiluminescence induced in differentiated HL-60 cells by the chemoattractant formyl-methionyl-leucyl-phenylalanine
C Dahlgren, T Andersson, O Stendahl
Journal of Free Radicals in Biology & Medicine 1986
Progressive loss of the macrophage respiratory burst in oxygen toxicity
G Harrison, HJ Forman
Journal of Free Radicals in Biology & Medicine 1986
Inhibition of phorbol ester stimulated superoxide production by 1-oleoyl-2-acetyl-sn-glycerol (OAG); fact or artefact?
RW Bonser, J Dawson, NT Thompson, HF Hodson, LG Garland
FEBS Letters 1986
Advances in Immunopharmacology
R Lewis, K Austen
Advances in Immunopharmacology 1986
Gentisic acid: an aspirin metabolite with multiple effects on human blood polymorphonuclear leukocytes
A Lorico, P Masturzo, S Villa, M Salmona, N Semeraro, GD Gaetano
Biochemical Pharmacology 1986
Effect of doxycycline on oxygen-dependent killing mechanisms of human neutrophils
I Sinco-Durieux, MA Gougerot-Pocidalo, A Perianin, J Hakim
Biochemical Pharmacology 1986
Human neutrophils permeabilized with digitonin respond with lysosomal enzyme release when exposed to micromolar levels of free calcium
JE Smolen, SJ Stoehr, LA Boxer
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1986
Role of extracellular calcium in neutrophil responsiveness to chemotactic tripeptides
WL Gabler, HR Creamer, WW Bullock
Inflammation 1986
Bee venom melittin blocks neutrophil O2 ? production
SD Somerfield, , C Mraz, F Gervais, E Skamene
Inflammation 1986
A possible role for protein phosphorylation in the activation of the respiratory burst in human neutrophils. Evidence from studies with cells from patients with chronic granulomatous disease
T Hayakawa, K Suzuki, S Suzuki, PC Andrews, BM Babior
The Journal of biological chemistry 1986
Monoclonal antibodies to Fc receptors for IgG on human mononuclear phagocytes. Antibody characterization and induction of superoxide production in a monocyte cell line
CL Anderson, PM Guyre, JC Whitin, DH Ryan, RJ Looney, MW Fanger
The Journal of biological chemistry 1986
Bidirectional effect of met-enkephalin on macrophage effector functions
G Fris, GA Medgyesi, M Hauck
Molecular and Cellular Biochemistry 1986
Self-perpetuating mechanisms of immunoglobulin G aggregation in rheumatoid inflammation
J Lunec, DR Blake, SJ McCleary, S Brailsford, PA Bacon
Journal of Clinical Investigation 1985
NADPH and ?cocktails? containing polyarginine reactivate superoxide generation in leukocytes lysed by membrane-damaging agents
I Ginsburg, R Borinski, M Pabst
Inflammation 1985
Identification of a Cell-Surface Glycoprotein Mediating Adhesion in Human Granulocytes
M Patarroyo, PG Beatty, CN Serhan, CG Gahmberg
Scandinavian Journal of Immunology 1985
Production of oxygen-centered radicals by neutrophils and macrophages as studied by electron spin resonance (ESR)
JV Bannister, WH Bannister
Environmental Health Perspectives 1985
Release of superoxide and change in morphology by neutrophils in response to phorbol esters: antagonism by inhibitors of calcium-binding proteins
JM Robinson, JA Badwey, ML Karnovsky, MJ Karnovsky
The Journal of Cell Biology 1985
Diverse involvements of Ni protein in superoxide anion production in polymorphonuclear leukocytes depending on the type of membrane stimulants
N Okamura, M Uchida, T Ohtsuka, M Kawanishi, S Ishibashi
Biochemical and Biophysical Research Communications 1985
Rapid microassays of phagocytosis, bacterial killing, superoxide and hydrogen peroxide production by human neutrophils in vitro
IA Rajkovic, R Williams
Journal of Immunological Methods 1985
Effects of gold sodium thiomalate on functional correlates of human monocyte maturation
BH Littman, RE Hall
Arthritis & Rheumatism 1985
Bryostatin, a non-phorbol macrocyclic lactone, activates intact human polymorphonuclear leukocytes and binds to the phorbol ester receptor
RL Berkow, AS Kraft
Biochemical and Biophysical Research Communications 1985
Measurement of free radical oxygen generation by cyrochrome c reduction requirement for cytochrome c oxidase blockade
LP Schacter
Biochemical and Biophysical Research Communications 1985
Effects of t-butyl hydroperoxide on NADPH, glutathione, and the respiratory burst of rat alveolar macrophages
MW Sutherland, J Nelson, G Harrison, HJ Forman
Archives of Biochemistry and Biophysics 1985
Oxygen toxicity: Loss of lung macrophage function without metabolite depletion
MW Sutherland, M Glass, J Nelson, Y Lyen, HJ Forman
Journal of Free Radicals in Biology & Medicine 1985
Activation of superoxide generation and enhancement of resistance against compatible races of Phytophthora infestans in potato plants treated with digitonin
N Doke
Physiologial Plant Pathology 1985
Oxidative Stress
A Stern
Oxidative Stress 1985
Stimulation and inhibition of secretion by phorbol myristate acetate in different cell types
GJ Blackwell, RW Bonser, J Dawson, LG Garland
Biochemical and Biophysical Research Communications 1985
The mechanism of antibody-dependent cellular cytotoxicity stimulation by somatostatin in rat peritoneal macrophages
G Fóris, E Gyimesi, I Komáromi
Cellular Immunology 1985
Low levels of mercury inhibit the respiratory burst in human polymorphonuclear leukocytes
D Malamud, SA Dietrich, IM Shapiro
Biochemical and Biophysical Research Communications 1985
Purification and properties of a superoxide-generating oxidase from bovine polymorphonuclear neutrophils
J Doussiere, PV Vignais
Biochemistry 1985
Activation of guinea-pig and bovine neutrophil NADPH oxidase by N,N′-dicyclohexylcarbodiimide
A Aviram, I Aviram
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1985
Slow exponential decay of rate of superoxide production in phorbol ester-activated human neutrophils
K Wong, C Chew
Inflammation 1985
Generalised glucosephosphate isomerase (GPI) deficiency causing haemolytic anaemia, neuromuscular symptoms and impairment of granulocytic function: a new syndrome due to a new stable GPI variant with diminished specific activity (GPI Homburg)
W Schrter, SW Eber, A Bardosi, M Gahr, M Gabriel, FC Sitzmann
European Journal of Pediatrics 1985
In Vitro Effects of Mineral Dusts
EG Beck, J Bignon
1985
Activation of NADPH-dependent superoxide production in a cell-free system by sodium dodecyl sulfate
Y Bromberg, E Pick
The Journal of biological chemistry 1985
Myeloperoxidase modulates the phagocytic activity of polymorphonuclear neutrophil leukocytes. Studies with cells from a myeloperoxidase-deficient patient
O Stendahl, BI Coble, C Dahlgren, J Hed, L Molin
Journal of Clinical Investigation 1984
Specific susceptibility to mucormycosis in murine diabetes and bronchoalveolar macrophage defense against Rhizopus
AR Waldorf, N Ruderman, RD Diamond
Journal of Clinical Investigation 1984
Bee venom inhibits superoxide production by human neutrophils
SD Somerfield, JL Stach, C Mraz, F Gervais, E Skamene
Inflammation 1984
Oxygen Radicals in Chemistry and Biology
C Pasquier, S Laoussadi, B Amor
Oxygen Radicals in Chemistry and Biology 1984
Effect of maleimide derivatives on superoxide-generating system of guinea-pig neutrophils stimulated by different soluble stimuli
T YAMASHITA, A SOMEYA, Y TSUZAWA-KIDO
European Journal of Biochemistry 1984
Free-radical-mediated aggregation of human IgG stimulates neutrophils to generate superoxide radicals
J Lunec
Agents and Actions 1984
Functional heterogeneity of macrophages in age-dependent modulation of oxidative metabolism and secretion of proteases
V Klimetzek, HD Schlumberger
Agents and Actions 1984
Studies on Low-Dose Hydroxyethyl Starch Leukapheresis: Rate of Elimination of HES in vivo and Function of the Harvested Granulocytes in vitro
IO Szymanski, RA Teno, JG Gandhi, PE Newburger
Vox Sanguinis 1984
COMPARISON BETWEEN LUMINOL- AND LUCIGENINDEPENDENT CHEMILUMINESCENCE OF POLYMORPHONUCLEAR LEUKOCYTES
H Anansson, O Stendahl, C Dahlgren
Acta Pathologica Microbiologica Scandinavica Series C: Immunology 1984
Comparative superoxide-generating system of granulocytes from blood and peritoneal exudates
W Zimmerli, PD Lew, HJ Cohen, FA Waldvogel
Infection and immunity 1984
Control of cellular influx in lung and its role in pulmonary toxicology
WS Lynn
Environmental Health Perspectives 1984
Changes in protein phosphorylation in guinea pig polymorphonuclear leukocytes by treatment with membrane-perturbing agents which stimulate superoxide anion production
N Okamura, S Ohashi, N Nagahisa, S Ishibashi
Archives of Biochemistry and Biophysics 1984
Activation of nadph oxidase of human neutrophils. Potentiation of chemotactic peptide by a diacylglycerol
B Dewald, TG Payne, M Baggiolini
Biochemical and Biophysical Research Communications 1984
Superoxide release by neutrophils: Synergistic effects of a phorbol ester and a calcium ionophore
JM Robinson, JA Badwey, ML Karnovsky, MJ Karnovsky
Biochemical and Biophysical Research Communications 1984
Relationship of cyclic-AMP levels in leukotriene B4-stimulated leukocytes to lysosomal enzyme release and the generation of superoxide anions
HE Claesson, SJ Feinmark
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1984
Oxygen metabolism of phagocytosing human polymorphonuclear leucocytes in diabetes mellitus
M Markert, P Cech, J Frei
Blut Zeitschrift für die Gesamte Blutforschung 1984
Effect of antiinflammatory agents on neutrophil superoxide production in rheumatoid arthritis
S Spisani, C Marangoni, L Dovigo, S Traniello
Inflammation 1984
Regulation of Leukocyte Function
R Snyderman
1984
Differential inhibition of neutrophil superoxide generation by nonsteroidal antiinflammatory drugs
JC Gay, JN Lukens, DK English
Inflammation 1984
Fluorescent redox dyes: I. Production of fluorescent formazan by unstimulated and phorbol ester- or digitonin-stimulated Ehrlich ascites tumor cells
J Stellmach
Histochemistry 1984
Studies on the mechanism of superoxide release from human neutrophils stimulated with arachidonate
JT Curnutte, JA Badwey, JM Robinson, MJ Karnovsky, ML Karnovsky
The Journal of biological chemistry 1984
Reversible blockade of the respiratory burst in human neutrophils by a cleavable cross-linking agent
I Aviram, ER Simons, BM Babior
The Journal of biological chemistry 1984
Effects of free fatty acids on release of superoxide and on change of shape by human neutrophils. Reversibility by albumin
JA Badwey, JT Curnutte, JM Robinson, CB Berde, MJ Karnovsky, ML Karnovsky
The Journal of biological chemistry 1984
Stimulus response coupling in the human neutrophil. II. Temporal analysis of changes in cytosolic calcium and calcium efflux
HM Korchak, K Vienne, LE Rutherford, C Wilkenfeld, MC Finkelstein, G Weissmann
The Journal of biological chemistry 1984
Rheumatoid arthritis: The role of neutrophil activation
G Weissmann, H Korchak
Inflammation 1984
Activation of the respiratory burst of guinea pig neutrophils by dicyclohexylcarbodiimide
A Aviram, I Aviram
FEBS Letters 1983
Comparative biochemical and cytochemical studies on superoxide and peroxide in mouse macrophages
JA Badwey, JM Robinson, JK Lazdins, RT Briggs, MJ Karnovsky, ML Karnovsky
Journal of Cellular Physiology 1983
Effect of maleimide derivatives, sulfhydryl reagents, on stimulation of neutrophil superoxide anion generation with concanavalin A
T Yamashita
FEBS Letters 1983
Early changes in cyclic AMP and calcium efflux during phagocytosis by neutrophils from normals and patients with chronic granulomatous disease
T Herlin, N Borregaard
Immunology 1983
Role of myeloperoxidase in luminol-dependent chemiluminescence of polymorphonuclear leukocytes
C Dahlgren, O Stendahl
Infection and immunity 1983
Polymorphonuclear function in Behçet's syndrome
C Friman, P Davis
Annals of the rheumatic diseases 1983
Depolarization and increased conductance precede superoxide release by concanavalin A-stimulated rat alveolar macrophages
AR Cameron, J Nelson, HJ Forman
Proceedings of the National Academy of Sciences 1983
Long-term cryopreservation of dog granulocytes
FW Luscinskas, FJ Lionetti, AJ Melaragno, CR Valeri
Cryobiology 1983
Role of macrophage lipids in regulating tumoricidal activity
SI Schlager, LD Madden, MS Meltzer, S Bara, MJ Mamula
Cellular Immunology 1983
Disorders of Stimulus-Response Coupling in Neutrophils
JE Smolen, LA Boxer
Clinics in Laboratory Medicine 1983
The kinetics of lysosomal degranulation of human neutrophils as measured by 9-aminoacridine quenching
JE Smolen, HM Korchak, G Weissmann
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1983
Impaired metabolic function of polymorphonuclear leukocytes in glycogen storage disease Ib
M Gahr, K Heyne
European Journal of Pediatrics 1983
The NADPH-dependent O-.2-generating oxidase from human neutrophils
TG Gabig
The Journal of biological chemistry 1983
Killing of gram-negative bacteria by polymorphonuclear leukocytes: role of an O2-independent bactericidal system
J Weiss, M Victor, O Stendhal, P Elsbach
Journal of Clinical Investigation 1982
Enhancement of rat and human phagocyte superoxide anion radical production by cadmium in vitro
MA Amoruso, G Witz, BD Goldstein
Toxicology Letters 1982
Stimulus—response coupling in neutrophils
JE Smolen, HM Korchak, G Weissmann
Trends in Pharmacological Sciences 1982
Increased fluorescence polarization of 1,6-diphenyl-1,3,5-hexatriene in the phorbol myristate acetate-stimulated plasma membrane of human neutrophils
R Stocker, KH Winterhalter, C Richter
FEBS Letters 1982
Differences in superoxide production by nonmigrating and migrating human monocyte subpopulations
L Harvath, JK Lazdins, E Alteri, EJ Leonard
Biochemical and Biophysical Research Communications 1982
Kinetic analysis of superoxide anion production by activated and resident murine peritoneal macrophages
SM Bryant, RE Lynch, HR Hill
Cellular Immunology 1982
The effect of various stimuli and calcium antagonists on the fluorescence response of chlorotetracycline-loaded human neutrophils
JE Smolen, G Weissmann
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1982
Effect of Calcium on Superoxide Production by Phagocytic Vesicles from Rabbit Alveolar Macrophages
PD Lew, TP Stossel
Journal of Clinical Investigation 1981
Receptor-mediated regulation of superoxide production in human neutrophils stimulated by phorbol myristate acetate
RI Lehrer, L Cohen
Journal of Clinical Investigation 1981
The onset of polymorphonuclear leucocyte membrane-stimulated metabolic activity
AJ Williams, PJ Cole
Immunology 1981
Stimulation of human and canine neutrophil metabolism by amphotericin B
SR Supapidhayakul, LR Kizlaitis, BR Andersen
Antimicrobial agents and chemotherapy 1981
Rapid microassays for the measurement of superoxide and hydrogen peroxide production by macrophages in culture using an automatic enzyme immunoassay reader
E Pick, D Mizel
Journal of Immunological Methods 1981
Adenosine deaminase activity and superoxide formation during phagocytosis at different cell densities
GL Tritsch, PW Niswander
Biochemical Medicine 1981
cis-Polyunsaturated fatty acids induce high levels of superoxide production by human neutrophils
JA Badwey, JT Curnutte, ML Karnovsky
The Journal of biological chemistry 1981
Effects of the myeloperoxidase system on fluorescent probes of granulocyte membrane potential
JC Whitin, RA Clark, ER Simons, HJ Cohen
The Journal of biological chemistry 1981
Reduction of adriamycin to a semiquinone-free radical by NADPH cytochrome P-450 reductase produces DNA cleavage in a reaction mediated by molecular oxygen
V Berlin, WA Haseltine
The Journal of biological chemistry 1981
Increased levels of cyclic adenosine-3',5'-monophosphate in human polymorphonuclear leukocytes after surface stimulation
JE Smolen, HM Korchak, G Weissmann
Journal of Clinical Investigation 1980
Receptor-directed inhibition of chemotactic factor-induced neutrophil hyperactivity by pyrazolon derivatives. Definition of a chemotactic peptide antagonist
C Dahinden, J Fehr
Journal of Clinical Investigation 1980
Continuous monitoring of oxygen consumption and superoxide production by particle-stimulated human polymorphonuclear leukocytes
M Markert, MJ Allaz, J Frei
FEBS Letters 1980
Comparative aspects of oxidative metabolism of neutrophils from human blood and guinea pig peritonea: Magnitude of the respiratory burst, dependence upon stimulating agents, and localization of the oxidases
JA Badwey, JT Curnutte, JM Robinson, JK Lazdins, RT Briggs, MJ Karnovsky, ML Karnovsky
Journal of Cellular Physiology 1980
Stimulus-response coupling in the human neutrophil Transmembrane potential and the role of extracellular Na+
HM Korchak, G Weissmann
Biochimica et Biophysica Acta (BBA) - Biomembranes 1980
Dissociation of opsonized particle phagocytosis and respiratory burst activity in an Epstein-Barr virus-infected myeloid cell line
PE Newburger, JS Pagano, JS Greenberger, A Karpas, HJ Cohen
The Journal of Cell Biology 1980
Superoxide Anion-Generating Activities of Macrophages as Studied by Using Cytochalasin E and Lectins as Synergistic Stimulants for Superoxide Release
K Kayashima, K Onoue, A Nakagawara, S Minakami
Microbiology and Immunology 1980
Initial kinetics of lysosomal enzyme secretion and superoxide anion generation by human polymorphonuclear leukocytes
JE Smolen, HM Korchak, G Weissmann
Inflammation 1980
Correlation between membrane potential changes and superoxide production in human granulocytes stimulated by phorbol myristate acetate. Evidence for defective activation in chronic granulomatous disease
JC Whitin, CE Chapman, ER Simons, ME Chovaniec, HJ Cohen
The Journal of biological chemistry 1980
NAD(P)H-dependent superoxide production by phagocytic vesicles from guinea pig and human granulocytes
HJ Cohen, PE Newburger, ME Chovaniec
The Journal of biological chemistry 1980
Rat alveolar macrophages require NADPH for superoxide production in the respiratory burst. Effect of NADPH depletion by paraquat
HJ Forman, J Nelson, AB Fisher
The Journal of biological chemistry 1980
Control of leukocyte functions: Role of internal H+ concentration and a membrane-bound esterase
WS Lynn, N Mohapatra
Inflammation 1980
Fluoride-mediated activation of the respiratory burst in human neutrophils. A reversible process
JT Curnutte, BM Babior, ML Karnovsky
Journal of Clinical Investigation 1979
Extracellular cytolysis by activated macrophages and granulocytes. I. Pharmacologic triggering of effector cells and the release of hydrogen peroxide
CF Nathan, LH Brukner, SC Silverstein, ZA Cohn
Journal of Experimental Medicine 1979
Proteoglycans, proteases, chemotaxis, and aggregation of inflammatory, cells
WS Lynn, C Mukherjee
Infection and immunity 1979
Functional changes in human leukemic cell line HL-60. A model for myeloid differentiation
PE Newburger, ME Chovaniec, JS Greenberger, HJ Cohen
The Journal of Cell Biology 1979
Protease inhibitors antagonize the activation of polymorphonuclear leukocyte oxygen consumption
BD Goldstein, G Witz, M Amoruso, W Troll
Biochemical and Biophysical Research Communications 1979
Production of superoxide by neutrophils: a reappraisal
AW Segal, T Meshulam
FEBS Letters 1979
Prenatal Diagnosis of Chronic Granulomatous Disease
PE Newburger, HJ Cohen, SB Rothchild, JC Hobbins, SE Malawista, MJ Mahoney
New England Journal of Medicine 1979
A displaceable surface-bound superoxide stimulating factor on circulating human polymorphonuclear leukocytes
AK Tanswell, WS Lynn
Biochemical and Biophysical Research Communications 1979
Superoxide Production by Digitonin-Stimulated Guinea Pig Granulocytes THE EFFECTS OF N-ETHYL MALEIMIDE, DIVALENT CATIONS, AND GLYCOLYTIC AND MITOCHONDRIAL INHIBITORS ON THE ACTIVATION OF THE SUPEROXIDE GENERATING SYSTEM
HJ Cohen, ME Chovaniec
Journal of Clinical Investigation 1978

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